KR790000084B1 - Process for preparation of antibiotics of cephalosphorin and penicillin series - Google Patents

Process for preparation of antibiotics of cephalosphorin and penicillin series

Info

Publication number
KR790000084B1
KR790000084B1 KR7200155A KR720000155A KR790000084B1 KR 790000084 B1 KR790000084 B1 KR 790000084B1 KR 7200155 A KR7200155 A KR 7200155A KR 720000155 A KR720000155 A KR 720000155A KR 790000084 B1 KR790000084 B1 KR 790000084B1
Authority
KR
South Korea
Prior art keywords
cephalosphorin
antibiotics
preparation
carboxylic acid
isomer
Prior art date
Application number
KR7200155A
Other languages
Korean (ko)
Inventor
M Ch Cook
M Gregson
Ian Gregory Gordon
Original Assignee
Glaxo Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB353171A priority Critical patent/GB1389194A/en
Priority claimed from GB353171A external-priority patent/GB1389194A/en
Priority to DE19722204108 priority patent/DE2204108A1/en
Priority to DK38172A priority patent/DK143853C/en
Priority to ZA720568A priority patent/ZA72568B/en
Priority to IE117/72A priority patent/IE36041B1/en
Priority to AT70272*#A priority patent/AT327375B/en
Priority to CH124072A priority patent/CH598261A5/xx
Priority to AT70172A priority patent/AT326814B/en
Priority to AU38450/72A priority patent/AU474062B2/en
Priority to BE778630A priority patent/BE778630A/xx
Priority to NL7201157A priority patent/NL7201157A/xx
Priority to CA133,364A priority patent/CA1022924A/en
Priority to DE2264676*A priority patent/DE2264676A1/en
Priority to DE19722204060 priority patent/DE2204060A1/en
Priority to BE778631A priority patent/BE778631A/xx
Priority to NL7201156A priority patent/NL7201156A/xx
Priority to ES399267A priority patent/ES399267A1/en
Priority to FR7203093A priority patent/FR2123545A1/en
Priority to FR7203092A priority patent/FR2123544B1/fr
Application filed by Glaxo Lab Ltd filed Critical Glaxo Lab Ltd
Priority to KR7200155A priority patent/KR790000084B1/en
Priority to US466780A priority patent/US3926957A/en
Priority to ES427859A priority patent/ES427859A1/en
Priority to AT671474A priority patent/AT345452B/en
Priority to SE7415536A priority patent/SE7415536L/xx
Priority to US05/554,014 priority patent/US4024134A/en
Priority to CH774277A priority patent/CH621790A5/en
Priority to US05/951,761 priority patent/US4209616A/en
Publication of KR790000084B1 publication Critical patent/KR790000084B1/en
Application granted granted Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

7β-acylamidoceph-3-em-4-carboxylic acids and 6β-acylamidopenam-3-carboxylic acid, and their alk. salts or acid salts, esters and sulfoxides with antibacterial activity and high stability to β-lactamase, were synthesized. 7-aminoceph-3-em-4-carboxylic acid or 6-aminopenam-3-carboxylic acid was related with acylating agent at -20-20≰C in the inactive inog. solvent to give syn- or anti- isomer, or the mixt. contg. more than 75% one isomer.
KR7200155A 1971-01-29 1972-02-03 Process for preparation of antibiotics of cephalosphorin and penicillin series KR790000084B1 (en)

Priority Applications (27)

Application Number Priority Date Filing Date Title
GB353171A GB1389194A (en) 1971-01-29 1971-01-29 Antibiotics
ES399267A ES399267A1 (en) 1971-01-29 1972-01-28 Antibiotics
NL7201156A NL7201156A (en) 1971-01-29 1972-01-28
IE117/72A IE36041B1 (en) 1971-01-29 1972-01-28 Improvements in or relating to antibiotics
DK38172A DK143853C (en) 1971-01-29 1972-01-28 METHOD OF ANALOGY FOR THE PREPARATION OF CEPHALOSPORINE COMPOUNDS OR UNTOXIC SALTS OR HYDRATES THEREOF
CH124072A CH598261A5 (en) 1971-01-29 1972-01-28
AT70172A AT326814B (en) 1971-01-29 1972-01-28 PROCESS FOR THE MANUFACTURING OF NEW CEPHALOSPORINES AND PENICILLINES
AU38450/72A AU474062B2 (en) 1971-01-29 1972-01-28 &- hydroxyiminoacylamido and & - acyloxyiminoacylamido penicillin and cephalosporin antibiotics
BE778630A BE778630A (en) 1971-01-29 1972-01-28
NL7201157A NL7201157A (en) 1971-01-29 1972-01-28
CA133,364A CA1022924A (en) 1971-01-29 1972-01-28 Preparation of syn alpha-hydroxylminoacylamido and alpha-acyloxylminoacylamido penicillins and cephalosporins
DE19722204060 DE2204060A1 (en) 1971-01-29 1972-01-28 Cephalosporin and penicillin antibiotics
DE19722204108 DE2204108A1 (en) 1971-01-29 1972-01-28 Cephalosporin and penicillin antibiotics
BE778631A BE778631A (en) 1971-01-29 1972-01-28
ZA720568A ZA72568B (en) 1971-01-29 1972-01-28 Improvements in or relating to antibiotics
AT70272*#A AT327375B (en) 1971-01-29 1972-01-28 PROCESS FOR THE MANUFACTURING OF NEW CEPHALOSPORINES AND PENICILLINES
DE2264676*A DE2264676A1 (en) 1971-01-29 1972-01-28 PENICILLIN ANTIBIOTICS
FR7203093A FR2123545A1 (en) 1971-01-29 1972-01-31 (2-hydroxy (or alkoxy)imino)acylamido penicillanic and - cephalosporanic acids - useful as antibiotics and intermediates
FR7203092A FR2123544B1 (en) 1971-01-29 1972-01-31
KR7200155A KR790000084B1 (en) 1971-01-29 1972-02-03 Process for preparation of antibiotics of cephalosphorin and penicillin series
US466780A US3926957A (en) 1971-01-29 1974-05-03 Penicillin antibiotics
ES427859A ES427859A1 (en) 1971-01-29 1974-07-01 Antibiotics
AT671474A AT345452B (en) 1971-01-29 1974-08-16 PROCESS FOR PRODUCING NEW CEPHALOSPORINES
SE7415536A SE7415536L (en) 1971-01-29 1974-12-11
US05/554,014 US4024134A (en) 1971-01-29 1975-02-28 Syn isomers of cephalosporins having α-hydroximino- or α-acyloxyiminoacylamido groups at position-7
CH774277A CH621790A5 (en) 1971-01-29 1977-06-24 Process for the preparation of a syn-isomer or of a mixture of syn- and anti-isomers of novel antibiotically active 7beta-acylamidocephem-4-carboxylic acids
US05/951,761 US4209616A (en) 1971-01-29 1978-10-16 Syn isomers of cephalosporins having α-hydroximino- or α-acyloxyiminoacylamido groups at position-7

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB353171A GB1389194A (en) 1971-01-29 1971-01-29 Antibiotics
KR7200155A KR790000084B1 (en) 1971-01-29 1972-02-03 Process for preparation of antibiotics of cephalosphorin and penicillin series

Publications (1)

Publication Number Publication Date
KR790000084B1 true KR790000084B1 (en) 1979-03-12

Family

ID=26238388

Family Applications (1)

Application Number Title Priority Date Filing Date
KR7200155A KR790000084B1 (en) 1971-01-29 1972-02-03 Process for preparation of antibiotics of cephalosphorin and penicillin series

Country Status (3)

Country Link
KR (1) KR790000084B1 (en)
DK (1) DK143853C (en)
ZA (1) ZA72568B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7826723B2 (en) 2003-10-15 2010-11-02 Cntek, Corp. Automatic circulation device of warm water

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1399086A (en) * 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7826723B2 (en) 2003-10-15 2010-11-02 Cntek, Corp. Automatic circulation device of warm water

Also Published As

Publication number Publication date
DK143853C (en) 1982-04-05
ZA72568B (en) 1972-10-25
DK143853B (en) 1981-10-19

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