ES399267A1 - Antibiotics - Google Patents
AntibioticsInfo
- Publication number
- ES399267A1 ES399267A1 ES399267A ES399267A ES399267A1 ES 399267 A1 ES399267 A1 ES 399267A1 ES 399267 A ES399267 A ES 399267A ES 399267 A ES399267 A ES 399267A ES 399267 A1 ES399267 A1 ES 399267A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- formula
- compound
- acid
- see formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/02—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Abstract
A procedure for the preparation of cephalosporin compounds of the formula <br/> <br/> ** (See formula) ** <br/> <br/> (where R is a hydrogen atom or an organic group, Ra is hydrogen or an acyl group, B is > S or > S > 0, and Z is a group in which 1 or 2 carbon atoms bond the core sulfur atom and the carbon atom that carries the carboxyl group) and derivatives thereof, which comprises condensing a compound of the formula <br/> <br/> ** (See formula) ** <br/> <br/> (where B and Z have the meanings defined above and R1 is hydrogen or a carboxyl blocking group) with an acylating agent corresponding to acid <br/> <br/> ** (See formula) ** <br/> <br/> (where R and Ra have the meanings defined above) or with an acylating agent corresponding to an acid that is a precursor of acid (VI) and converting the resulting precursor acyl group to the desired acyl group, after which, if necessary or if desired in each case, is carried out when Any of the following reactions: <br/> <br/> (i) conversion of a precursor from the group <br/> <br/> (see formula) desired in said group, (ii) conversion of an Δ2 isomer at the desired Δ3 isomer, (iii) removal of any carboxyl blocking groups, (iv) reduction of a compound where Z is > S → 0 to form the desired compound Z = S, and (v) recovery of the desired compound of formula (i) in the form without or anti or as a mixture containing 75% of one of such isomers.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB353171A GB1389194A (en) | 1971-01-29 | 1971-01-29 | Antibiotics |
GB4588571 | 1971-10-01 | ||
KR7200155A KR790000084B1 (en) | 1971-01-29 | 1972-02-03 | Process for preparation of antibiotics of cephalosphorin and penicillin series |
Publications (1)
Publication Number | Publication Date |
---|---|
ES399267A1 true ES399267A1 (en) | 1975-06-16 |
Family
ID=27254286
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES399267A Expired ES399267A1 (en) | 1971-01-29 | 1972-01-28 | Antibiotics |
ES427859A Expired ES427859A1 (en) | 1971-01-29 | 1974-07-01 | Antibiotics |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES427859A Expired ES427859A1 (en) | 1971-01-29 | 1974-07-01 | Antibiotics |
Country Status (9)
Country | Link |
---|---|
AT (2) | AT326814B (en) |
AU (1) | AU474062B2 (en) |
BE (2) | BE778631A (en) |
CH (2) | CH598261A5 (en) |
DE (3) | DE2204060A1 (en) |
ES (2) | ES399267A1 (en) |
FR (1) | FR2123544B1 (en) |
GB (1) | GB1389194A (en) |
NL (2) | NL7201156A (en) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4064346A (en) * | 1971-05-14 | 1977-12-20 | Glaxo Laboratories Limited | 3-Acetoxymethyl-7β-(2-carboxy-methoxyimino-2-arylacetamido)ceph-3-em-4-carboxylic acids and salts thereof |
GB1443950A (en) * | 1972-10-25 | 1976-07-28 | Glaxo Lab Ltd | Acylamido-penam-carboxylic acids and their derivatives |
US4033950A (en) * | 1971-05-14 | 1977-07-05 | Glaxo Laboratories Limited | 3-Hydroxymethyl-7β-(2-alkoxy-or benzyloxyimino-2-arylacetamido)ceph-3-em-4-carboxylic acids and salts thereof |
US4079178A (en) * | 1971-05-14 | 1978-03-14 | Glaxo Laboratories Limited | Cephalosporins having (α-etherified oximino) acylamido groups at the 7-position |
GB1447114A (en) * | 1973-02-20 | 1976-08-25 | Glaxo Lab Ltd | Process for the preparation of 2-aryl-2-hydroxyiminoacetic acid |
GB1472534A (en) * | 1973-07-06 | 1977-05-04 | Glaxo Lab Ltd | 7beta-hydroxyiminoacylamido-cephalosporins |
US4144393A (en) | 1973-12-21 | 1979-03-13 | Glaxo Laboratories Limited | 3-Acetoxymethyl cephalosporins having at position-7 a carboxy substituted α-etherified hydroxyiminoarylacetamido group |
US4144392A (en) | 1973-12-21 | 1979-03-13 | Glaxo Laboratories Limited | Cephalosporins having at position-7 a carboxy substituted α-etherified hydroxyimino-arylacetamido group and at position-3 the residue of a sulphur nucleophile |
US4020058A (en) * | 1974-10-03 | 1977-04-26 | Glaxo Laboratories Limited | Improvements in or relating to cephalosporin antibiotics |
US4200746A (en) | 1974-12-20 | 1980-04-29 | Glaxo Laboratories, Ltd. | Cephalosporins |
FI66005C (en) * | 1975-02-04 | 1984-08-10 | Fujisawa Pharmaceutical Co | FRUIT PROTECTION FOR ANTIBACTERIAL VERIFICATION OF 7-ALPHA ALPHA-DISUBSTITUTE-ACETAMIDO) -3-SUBSTITUTER-3-CEFE M - CARBOXYL SYRINE SYN-ISOMER |
GB1555471A (en) * | 1975-06-19 | 1979-11-14 | Glaxo Lab Ltd | 7 carbamoylalkoxyimino acetamido 3 em 4 carboxylic acidsand derivatives thereof |
US4165430A (en) | 1976-03-19 | 1979-08-21 | Glaxo Laboratories Limited | Cephalosporins having a 7-carboxy substituted α-etherified oximinoarylacetamido) group |
US4166115A (en) * | 1976-04-12 | 1979-08-28 | Fujisawa Pharmaceutical Co., Ltd. | Syn 7-oxoimino substituted derivatives of cephalosporanic acid |
FR2384779A1 (en) * | 1977-03-25 | 1978-10-20 | Roussel Uclaf | NEW OXIMES DERIVED FROM 3-CHLORO OR 3-METHOXY 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
DE2716677C2 (en) | 1977-04-15 | 1985-10-10 | Hoechst Ag, 6230 Frankfurt | Cephem derivatives and processes for their preparation |
DE2714880A1 (en) * | 1977-04-02 | 1978-10-26 | Hoechst Ag | CEPHEMDER DERIVATIVES AND PROCESS FOR THEIR PRODUCTION |
FR2418233A2 (en) * | 1978-02-22 | 1979-09-21 | Roussel Uclaf | Antibiotic syn isomers of oxime(s) - of 3-alkylthio or acylamino 7-amino thiazolyl acetamido cephalosporanic acids |
US4409214A (en) | 1979-11-19 | 1983-10-11 | Fujisawa Pharmaceutical, Co., Ltd. | 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof |
US4409215A (en) * | 1979-11-19 | 1983-10-11 | Fujisawa Pharmaceutical Co., Ltd. | 7-Acylamino-3-substituted cephalosporanic acid derivatives and processes for the preparation thereof |
IL63207A (en) * | 1980-07-24 | 1985-09-29 | Lonza Ag | Process for the preparation of 2-(2-aminothiazole-4-yl)-2-(syn)-methoxyiminoacetic acid esters |
US4443374A (en) * | 1982-02-01 | 1984-04-17 | E. R. Squibb & Sons, Inc. | Process for preparing (3S)-3-[[(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]-acetyl]amino]-2-oxo-1-azetidinesulfonic acid, and 4-substituted derivatives |
EP0201999A1 (en) * | 1985-04-16 | 1986-11-20 | Imperial Chemical Industries Plc | Substituted 2-cyano-2-oximino-acetamides, processes for their production and their use as fungicides |
GB8927871D0 (en) * | 1989-12-08 | 1990-02-14 | Beecham Group Plc | Novel compounds |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1159449B (en) * | 1961-03-22 | 1963-12-19 | Gruenenthal Chemie | Process for the preparation of 6-acylaminopenicillanic acids and their salts |
SE311519B (en) * | 1962-12-14 | 1969-06-16 | Astra Ab | |
GB1208014A (en) * | 1967-03-23 | 1970-10-07 | Glaxo Lab Ltd | Cephalosporins |
GB1208015A (en) * | 1967-03-23 | 1970-10-07 | Glaxo Lab Ltd | Cephalosporins |
-
1971
- 1971-01-29 GB GB353171A patent/GB1389194A/en not_active Expired
-
1972
- 1972-01-28 ES ES399267A patent/ES399267A1/en not_active Expired
- 1972-01-28 CH CH124072A patent/CH598261A5/xx not_active IP Right Cessation
- 1972-01-28 AT AT70172A patent/AT326814B/en not_active IP Right Cessation
- 1972-01-28 AU AU38450/72A patent/AU474062B2/en not_active Expired
- 1972-01-28 BE BE778631A patent/BE778631A/xx unknown
- 1972-01-28 AT AT70272*#A patent/AT327375B/en active
- 1972-01-28 NL NL7201156A patent/NL7201156A/xx not_active Application Discontinuation
- 1972-01-28 BE BE778630A patent/BE778630A/xx not_active IP Right Cessation
- 1972-01-28 NL NL7201157A patent/NL7201157A/xx unknown
- 1972-01-28 DE DE19722204060 patent/DE2204060A1/en not_active Ceased
- 1972-01-28 DE DE2264676*A patent/DE2264676A1/en active Pending
- 1972-01-28 DE DE19722204108 patent/DE2204108A1/en active Pending
- 1972-01-31 FR FR7203092A patent/FR2123544B1/fr not_active Expired
-
1974
- 1974-07-01 ES ES427859A patent/ES427859A1/en not_active Expired
-
1977
- 1977-06-24 CH CH774277A patent/CH621790A5/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
BE778631A (en) | 1972-07-28 |
AT326814B (en) | 1975-12-29 |
FR2123544B1 (en) | 1975-10-10 |
DE2204108A1 (en) | 1972-08-24 |
AU3845072A (en) | 1973-08-02 |
AU474062B2 (en) | 1976-07-15 |
NL7201157A (en) | 1972-08-01 |
FR2123544A1 (en) | 1972-09-08 |
CH598261A5 (en) | 1978-04-28 |
DE2204060A1 (en) | 1972-08-10 |
ATA70272A (en) | 1975-04-15 |
CH621790A5 (en) | 1981-02-27 |
BE778630A (en) | 1972-07-28 |
GB1389194A (en) | 1975-04-03 |
DE2264676A1 (en) | 1974-08-08 |
ES427859A1 (en) | 1976-08-01 |
ATA70172A (en) | 1975-03-15 |
AT327375B (en) | 1976-01-26 |
NL7201156A (en) | 1972-08-01 |
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