ES399267A1 - Un procedimiento para la preparacion de cefalosporinas. - Google Patents
Un procedimiento para la preparacion de cefalosporinas.Info
- Publication number
- ES399267A1 ES399267A1 ES399267A ES399267A ES399267A1 ES 399267 A1 ES399267 A1 ES 399267A1 ES 399267 A ES399267 A ES 399267A ES 399267 A ES399267 A ES 399267A ES 399267 A1 ES399267 A1 ES 399267A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- formula
- compound
- acid
- see formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 229940088710 antibiotic agent Drugs 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
- 238000006243 chemical reaction Methods 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000002243 precursor Substances 0.000 abstract 3
- 230000000903 blocking effect Effects 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 229930186147 Cephalosporin Natural products 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229940124587 cephalosporin Drugs 0.000 abstract 1
- -1 cephalosporin compounds Chemical class 0.000 abstract 1
- ONCCWDRMOZMNSM-FBCQKBJTSA-N compound Z Chemical compound N1=C2C(=O)NC(N)=NC2=NC=C1C(=O)[C@H]1OP(O)(=O)OC[C@H]1O ONCCWDRMOZMNSM-FBCQKBJTSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000000962 organic group Chemical group 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/02—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB353171A GB1389194A (en) | 1971-01-29 | 1971-01-29 | Antibiotics |
| GB4588571 | 1971-10-01 | ||
| KR7200155A KR790000084B1 (en) | 1971-01-29 | 1972-02-03 | Process for preparation of antibiotics of cephalosphorin and penicillin series |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES399267A1 true ES399267A1 (es) | 1975-06-16 |
Family
ID=27254286
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES399267A Expired ES399267A1 (es) | 1971-01-29 | 1972-01-28 | Un procedimiento para la preparacion de cefalosporinas. |
| ES427859A Expired ES427859A1 (es) | 1971-01-29 | 1974-07-01 | Un procedimiento para la preparacion de compuestos de cefa-losporina. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES427859A Expired ES427859A1 (es) | 1971-01-29 | 1974-07-01 | Un procedimiento para la preparacion de compuestos de cefa-losporina. |
Country Status (9)
| Country | Link |
|---|---|
| AT (2) | AT326814B (enrdf_load_stackoverflow) |
| AU (1) | AU474062B2 (enrdf_load_stackoverflow) |
| BE (2) | BE778631A (enrdf_load_stackoverflow) |
| CH (2) | CH598261A5 (enrdf_load_stackoverflow) |
| DE (3) | DE2204060A1 (enrdf_load_stackoverflow) |
| ES (2) | ES399267A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2123544B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1389194A (enrdf_load_stackoverflow) |
| NL (2) | NL7201157A (enrdf_load_stackoverflow) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4079178A (en) * | 1971-05-14 | 1978-03-14 | Glaxo Laboratories Limited | Cephalosporins having (α-etherified oximino) acylamido groups at the 7-position |
| US4033950A (en) * | 1971-05-14 | 1977-07-05 | Glaxo Laboratories Limited | 3-Hydroxymethyl-7β-(2-alkoxy-or benzyloxyimino-2-arylacetamido)ceph-3-em-4-carboxylic acids and salts thereof |
| GB1443950A (en) * | 1972-10-25 | 1976-07-28 | Glaxo Lab Ltd | Acylamido-penam-carboxylic acids and their derivatives |
| US4064346A (en) * | 1971-05-14 | 1977-12-20 | Glaxo Laboratories Limited | 3-Acetoxymethyl-7β-(2-carboxy-methoxyimino-2-arylacetamido)ceph-3-em-4-carboxylic acids and salts thereof |
| GB1447114A (en) * | 1973-02-20 | 1976-08-25 | Glaxo Lab Ltd | Process for the preparation of 2-aryl-2-hydroxyiminoacetic acid |
| GB1472534A (en) * | 1973-07-06 | 1977-05-04 | Glaxo Lab Ltd | 7beta-hydroxyiminoacylamido-cephalosporins |
| US4144393A (en) | 1973-12-21 | 1979-03-13 | Glaxo Laboratories Limited | 3-Acetoxymethyl cephalosporins having at position-7 a carboxy substituted α-etherified hydroxyiminoarylacetamido group |
| US4144392A (en) | 1973-12-21 | 1979-03-13 | Glaxo Laboratories Limited | Cephalosporins having at position-7 a carboxy substituted α-etherified hydroxyimino-arylacetamido group and at position-3 the residue of a sulphur nucleophile |
| US4020058A (en) * | 1974-10-03 | 1977-04-26 | Glaxo Laboratories Limited | Improvements in or relating to cephalosporin antibiotics |
| US4200746A (en) | 1974-12-20 | 1980-04-29 | Glaxo Laboratories, Ltd. | Cephalosporins |
| PH15487A (en) * | 1975-02-04 | 1983-01-31 | Fujisawa Pharmaceutical Co | 7((2-hydroxyamino-2-disubstituted phenyl-acetamido)-)3-heterocyclithio-3-cephem-4-carboxylic acids |
| GB1555471A (en) * | 1975-06-19 | 1979-11-14 | Glaxo Lab Ltd | 7 carbamoylalkoxyimino acetamido 3 em 4 carboxylic acidsand derivatives thereof |
| US4165430A (en) | 1976-03-19 | 1979-08-21 | Glaxo Laboratories Limited | Cephalosporins having a 7-carboxy substituted α-etherified oximinoarylacetamido) group |
| US4166115A (en) * | 1976-04-12 | 1979-08-28 | Fujisawa Pharmaceutical Co., Ltd. | Syn 7-oxoimino substituted derivatives of cephalosporanic acid |
| FR2384779A1 (fr) * | 1977-03-25 | 1978-10-20 | Roussel Uclaf | Nouvelles oximes derivees de l'acide 3-chloro ou 3-methoxy 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
| DE2716677C2 (de) | 1977-04-15 | 1985-10-10 | Hoechst Ag, 6230 Frankfurt | Cephemderivate und Verfahren zu ihrer Herstellung |
| DE2714880A1 (de) * | 1977-04-02 | 1978-10-26 | Hoechst Ag | Cephemderivate und verfahren zu ihrer herstellung |
| FR2418233A2 (fr) * | 1978-02-22 | 1979-09-21 | Roussel Uclaf | Nouvelles oximes derivees de l'acide 3-alkylthio ou 3-acylamino 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
| US4409215A (en) * | 1979-11-19 | 1983-10-11 | Fujisawa Pharmaceutical Co., Ltd. | 7-Acylamino-3-substituted cephalosporanic acid derivatives and processes for the preparation thereof |
| US4409214A (en) * | 1979-11-19 | 1983-10-11 | Fujisawa Pharmaceutical, Co., Ltd. | 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof |
| IL63207A (en) * | 1980-07-24 | 1985-09-29 | Lonza Ag | Process for the preparation of 2-(2-aminothiazole-4-yl)-2-(syn)-methoxyiminoacetic acid esters |
| US4443374A (en) * | 1982-02-01 | 1984-04-17 | E. R. Squibb & Sons, Inc. | Process for preparing (3S)-3-[[(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]-acetyl]amino]-2-oxo-1-azetidinesulfonic acid, and 4-substituted derivatives |
| EP0201999A1 (en) * | 1985-04-16 | 1986-11-20 | Imperial Chemical Industries Plc | Substituted 2-cyano-2-oximino-acetamides, processes for their production and their use as fungicides |
| GB8927871D0 (en) * | 1989-12-08 | 1990-02-14 | Beecham Group Plc | Novel compounds |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1159449B (de) * | 1961-03-22 | 1963-12-19 | Gruenenthal Chemie | Verfahren zur Herstellung von 6-Acylaminopenicillansaeuren und deren Salzen |
| SE311519B (enrdf_load_stackoverflow) * | 1962-12-14 | 1969-06-16 | Astra Ab | |
| GB1208015A (en) * | 1967-03-23 | 1970-10-07 | Glaxo Lab Ltd | Cephalosporins |
| GB1208014A (en) * | 1967-03-23 | 1970-10-07 | Glaxo Lab Ltd | Cephalosporins |
-
1971
- 1971-01-29 GB GB353171A patent/GB1389194A/en not_active Expired
-
1972
- 1972-01-28 CH CH124072A patent/CH598261A5/xx not_active IP Right Cessation
- 1972-01-28 DE DE19722204060 patent/DE2204060A1/de not_active Ceased
- 1972-01-28 NL NL7201157A patent/NL7201157A/xx unknown
- 1972-01-28 ES ES399267A patent/ES399267A1/es not_active Expired
- 1972-01-28 BE BE778631A patent/BE778631A/xx unknown
- 1972-01-28 BE BE778630A patent/BE778630A/xx not_active IP Right Cessation
- 1972-01-28 NL NL7201156A patent/NL7201156A/xx not_active Application Discontinuation
- 1972-01-28 DE DE2264676*A patent/DE2264676A1/de active Pending
- 1972-01-28 AT AT70172A patent/AT326814B/de not_active IP Right Cessation
- 1972-01-28 DE DE19722204108 patent/DE2204108A1/de active Pending
- 1972-01-28 AT AT70272*#A patent/AT327375B/de active
- 1972-01-28 AU AU38450/72A patent/AU474062B2/en not_active Expired
- 1972-01-31 FR FR7203092A patent/FR2123544B1/fr not_active Expired
-
1974
- 1974-07-01 ES ES427859A patent/ES427859A1/es not_active Expired
-
1977
- 1977-06-24 CH CH774277A patent/CH621790A5/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE2204108A1 (de) | 1972-08-24 |
| ES427859A1 (es) | 1976-08-01 |
| CH598261A5 (enrdf_load_stackoverflow) | 1978-04-28 |
| AU474062B2 (en) | 1976-07-15 |
| ATA70172A (de) | 1975-03-15 |
| GB1389194A (en) | 1975-04-03 |
| FR2123544B1 (enrdf_load_stackoverflow) | 1975-10-10 |
| DE2264676A1 (de) | 1974-08-08 |
| ATA70272A (de) | 1975-04-15 |
| AT327375B (de) | 1976-01-26 |
| BE778630A (enrdf_load_stackoverflow) | 1972-07-28 |
| NL7201157A (enrdf_load_stackoverflow) | 1972-08-01 |
| NL7201156A (enrdf_load_stackoverflow) | 1972-08-01 |
| DE2204060A1 (de) | 1972-08-10 |
| AU3845072A (en) | 1973-08-02 |
| AT326814B (de) | 1975-12-29 |
| BE778631A (enrdf_load_stackoverflow) | 1972-07-28 |
| FR2123544A1 (enrdf_load_stackoverflow) | 1972-09-08 |
| CH621790A5 (en) | 1981-02-27 |
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