GB1369259A - Acylxylidide local anaesthetics - Google Patents
Acylxylidide local anaestheticsInfo
- Publication number
- GB1369259A GB1369259A GB5937771A GB5937771A GB1369259A GB 1369259 A GB1369259 A GB 1369259A GB 5937771 A GB5937771 A GB 5937771A GB 5937771 A GB5937771 A GB 5937771A GB 1369259 A GB1369259 A GB 1369259A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- reacting
- pharmaceutically acceptable
- formula
- xylidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229960005015 local anesthetics Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 abstract 3
- CDULGHZNHURECF-UHFFFAOYSA-N 2,3-dimethylaniline 2,4-dimethylaniline 2,5-dimethylaniline 2,6-dimethylaniline 3,4-dimethylaniline 3,5-dimethylaniline Chemical group CC1=CC=C(N)C(C)=C1.CC1=CC=C(C)C(N)=C1.CC1=CC(C)=CC(N)=C1.CC1=CC=C(N)C=C1C.CC1=CC=CC(N)=C1C.CC1=CC=CC(C)=C1N CDULGHZNHURECF-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000001412 amines Chemical class 0.000 abstract 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- UFFBMTHBGFGIHF-UHFFFAOYSA-N 2,6-dimethylaniline Chemical group CC1=CC=CC(C)=C1N UFFBMTHBGFGIHF-UHFFFAOYSA-N 0.000 abstract 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- DROZQELYZZXYSX-UHFFFAOYSA-N 2-bromobutanoyl chloride Chemical compound CCC(Br)C(Cl)=O DROZQELYZZXYSX-UHFFFAOYSA-N 0.000 abstract 1
- YAQLSKVCTLCIIE-UHFFFAOYSA-N 2-bromobutyric acid Chemical compound CCC(Br)C(O)=O YAQLSKVCTLCIIE-UHFFFAOYSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- 239000002168 alkylating agent Substances 0.000 abstract 1
- 229940100198 alkylating agent Drugs 0.000 abstract 1
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229960001270 d- tartaric acid Drugs 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- FEWJPZIEWOKRBE-LWMBPPNESA-N levotartaric acid Chemical compound OC(=O)[C@@H](O)[C@H](O)C(O)=O FEWJPZIEWOKRBE-LWMBPPNESA-N 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/38—Acyl halides
- C07C53/46—Acyl halides containing halogen outside the carbonyl halide group
- C07C53/50—Acyl halides containing halogen outside the carbonyl halide group of acids containing three or more carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10077770A | 1970-12-22 | 1970-12-22 | |
| US00164022A US3812147A (en) | 1970-12-22 | 1971-07-19 | Acylxylidide local anaesthetics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1369259A true GB1369259A (en) | 1974-10-23 |
Family
ID=26797539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5937771A Expired GB1369259A (en) | 1970-12-22 | 1971-12-21 | Acylxylidide local anaesthetics |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US3812147A (enExample) |
| JP (1) | JPS5644063B1 (enExample) |
| AR (1) | AR193840A1 (enExample) |
| AT (1) | AT319205B (enExample) |
| AU (1) | AU468489B2 (enExample) |
| BE (1) | BE776656A (enExample) |
| BR (1) | BR7108466D0 (enExample) |
| CA (1) | CA943966A (enExample) |
| DD (1) | DD99779A5 (enExample) |
| DE (1) | DE2162744C3 (enExample) |
| DK (1) | DK139814B (enExample) |
| ES (2) | ES398210A1 (enExample) |
| FI (1) | FI55027C (enExample) |
| FR (1) | FR2118985B1 (enExample) |
| GB (1) | GB1369259A (enExample) |
| HU (1) | HU163373B (enExample) |
| IE (1) | IE35909B1 (enExample) |
| IT (1) | IT1066334B (enExample) |
| NL (2) | NL172149C (enExample) |
| NO (1) | NO135934C (enExample) |
| PL (1) | PL83097B1 (enExample) |
| SE (1) | SE393374B (enExample) |
| SU (1) | SU419023A3 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990009986A1 (en) * | 1989-02-28 | 1990-09-07 | Aktiebolaget Astra | New local anaesthetic compounds and a process for their preparation |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4237068A (en) * | 1971-07-28 | 1980-12-02 | Astra Pharmaceutical Products, Inc. | Primary aminoacylanilides |
| US3957996A (en) * | 1971-12-08 | 1976-05-18 | Astra Pharmaceutical Products, Inc. | Pharmaceutical local anesthetic compositions |
| US3966934A (en) * | 1971-12-08 | 1976-06-29 | Astra Pharmaceutical Products, Inc. | Synergistic local anesthetic compositions |
| US3975443A (en) * | 1972-06-06 | 1976-08-17 | Allen & Hanburys Limited | 1-(3,4-dichlorobenzamidomethyl)-cyclohexyldimethylamine |
| JPS598269B2 (ja) * | 1975-08-22 | 1984-02-23 | 萬有製薬株式会社 | オメガ − アミノアルカンサンアリ−ルアミドノ セイホウ |
| EP0062322A1 (en) * | 1981-04-03 | 1982-10-13 | The B.F. GOODRICH Company | Improved process for synthesis of hindered amine stabilizers for polymeric materials |
| US4891058A (en) * | 1988-07-18 | 1990-01-02 | Ici Americas Inc. | 1-alkyl-3-aryl imidazolidine-2,4-diones and herbicidal use |
| US5153226A (en) * | 1989-08-31 | 1992-10-06 | Warner-Lambert Company | Acat inhibitors for treating hypocholesterolemia |
| KR20090082507A (ko) | 2006-11-20 | 2009-07-30 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 통증 및 소양증 치료용 방법, 조성물 및 키트 |
| WO2011006073A1 (en) | 2009-07-10 | 2011-01-13 | President And Fellows Of Harvard College | Permanently charged sodium and calcium channel blockers as anti-inflammatory agents |
| US11021443B2 (en) | 2015-08-03 | 2021-06-01 | President And Fellows Of Harvard College | Charged ion channel blockers and methods for use |
| US11377422B2 (en) | 2019-03-11 | 2022-07-05 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| US10780083B1 (en) | 2019-03-11 | 2020-09-22 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| US10828287B2 (en) | 2019-03-11 | 2020-11-10 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| CA3129089A1 (en) | 2019-03-11 | 2020-09-17 | Bridget Mccarthy Cole | Ester substituted ion channel blockers and methods for use |
| CN113811305A (zh) | 2019-03-11 | 2021-12-17 | 诺西恩医疗公司 | 带电的离子通道阻滞剂及其使用方法 |
| CA3155568A1 (en) | 2019-11-06 | 2021-05-14 | Bridget Mccarthy Cole | Charged ion channel blockers and methods for use |
| AU2020380118B2 (en) | 2019-11-06 | 2026-06-11 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| US12162851B2 (en) | 2020-03-11 | 2024-12-10 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| US11332446B2 (en) | 2020-03-11 | 2022-05-17 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1124837A (en) * | 1966-06-03 | 1968-08-21 | Wyeth John & Brother Ltd | Substituted anilides |
-
1971
- 1971-07-19 US US00164022A patent/US3812147A/en not_active Expired - Lifetime
- 1971-12-07 SE SE7115656A patent/SE393374B/xx unknown
- 1971-12-14 BE BE776656A patent/BE776656A/xx not_active IP Right Cessation
- 1971-12-15 SU SU1726195A patent/SU419023A3/ru active
- 1971-12-16 HU HUAA690A patent/HU163373B/hu unknown
- 1971-12-17 DE DE2162744A patent/DE2162744C3/de not_active Expired
- 1971-12-17 NO NO4669/71A patent/NO135934C/no unknown
- 1971-12-17 DK DK619771AA patent/DK139814B/da not_active IP Right Cessation
- 1971-12-18 IT IT54845/71A patent/IT1066334B/it active
- 1971-12-20 IE IE1609/71A patent/IE35909B1/xx unknown
- 1971-12-20 AU AU37099/71A patent/AU468489B2/en not_active Expired
- 1971-12-20 AT AT1089671A patent/AT319205B/de not_active IP Right Cessation
- 1971-12-21 PL PL1971152331A patent/PL83097B1/pl unknown
- 1971-12-21 CA CA130,662A patent/CA943966A/en not_active Expired
- 1971-12-21 GB GB5937771A patent/GB1369259A/en not_active Expired
- 1971-12-21 DD DD159785A patent/DD99779A5/xx unknown
- 1971-12-21 FR FR7145983A patent/FR2118985B1/fr not_active Expired
- 1971-12-21 AR AR239721A patent/AR193840A1/es active
- 1971-12-21 ES ES398210A patent/ES398210A1/es not_active Expired
- 1971-12-21 BR BR8466/71A patent/BR7108466D0/pt unknown
- 1971-12-22 JP JP10453571A patent/JPS5644063B1/ja active Pending
- 1971-12-22 FI FI3658/71A patent/FI55027C/fi active
- 1971-12-22 NL NLAANVRAGE7117644,A patent/NL172149C/xx not_active IP Right Cessation
-
1974
- 1974-04-24 ES ES425626A patent/ES425626A1/es not_active Expired
-
1982
- 1982-10-26 NL NL8204126A patent/NL8204126A/nl not_active Application Discontinuation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990009986A1 (en) * | 1989-02-28 | 1990-09-07 | Aktiebolaget Astra | New local anaesthetic compounds and a process for their preparation |
| GR900100108A (el) * | 1989-02-28 | 1991-06-28 | Astra Ab | Νεες ενωσεις τοπικης αναισθησιας και μεθοδος για την παρασκευη τους. |
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PE20 | Patent expired after termination of 20 years |