GB1471901A - Styrylamidines - Google Patents

Abstract

1471901 Styrylamidines BRISTOL MYERS CO 10 June 1974 [11 June 1973 8 April 1974] 25649/74 Heading C2C Novel compounds of Formula I wherein R 1 is hydrogen, alkyl nitro, amino, halogen, cyclohexyl, carbamoyl, lower alkylsulphonyl of from 1 to 4 carbon atoms inclusive, sulphamoyl, or lower alkanoylamido of from 2 to 4 carbon atoms inclusive; R 2 is hydrogen, alkyl or halogen; R 3 is lower alkyl or from 1 to 4 carbon atoms inclusive or hydrogen; and A is lower alkyl of from 1 to 3 carbon atoms inclusive, di-(lower)-alkylaminophenyl, phenyl, benzyl, #-naphthyl, styryl, phenylbutadienyl, or wherein X is lower alkoxy of from 1 to 4 carbon atoms inclusive, halogen, nitro, amino, or lower alkanoylamido of from 2 to 4 carbon atoms inclusive, and n is 1 or 2; and pharmaceutically acceptable acid addition salts thereof are prepared by heating with NaOH a compound of formula or for N acyl compounds acylation of the amine which may be obtained by reduction of the nitro compound. The compounds of Formula V are prepared in divisional application 48601/75. Pharmaceutical compositions in conventional forms for oral and parenteral administration and having antithrombogenic and analgesic activity comprise an above novel compound and a carrier or diluent.