GB1180164A - Dibenzazepine Derivatives and their preparation - Google Patents
Dibenzazepine Derivatives and their preparationInfo
- Publication number
- GB1180164A GB1180164A GB2858/68A GB285868A GB1180164A GB 1180164 A GB1180164 A GB 1180164A GB 2858/68 A GB2858/68 A GB 2858/68A GB 285868 A GB285868 A GB 285868A GB 1180164 A GB1180164 A GB 1180164A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- compound
- hydrogen
- phenylalkyl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- LCGTWRLJTMHIQZ-UHFFFAOYSA-N 5H-dibenzo[b,f]azepine Chemical class C1=CC2=CC=CC=C2NC2=CC=CC=C21 LCGTWRLJTMHIQZ-UHFFFAOYSA-N 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 18
- 150000001875 compounds Chemical class 0.000 abstract 17
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 10
- 229910052739 hydrogen Inorganic materials 0.000 abstract 9
- 239000001257 hydrogen Substances 0.000 abstract 9
- -1 nitro, amino Chemical group 0.000 abstract 7
- 125000003545 alkoxy group Chemical group 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 6
- 150000002367 halogens Chemical class 0.000 abstract 6
- 150000002431 hydrogen Chemical class 0.000 abstract 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 3
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- 125000001453 quaternary ammonium group Chemical group 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 2
- PWMOKXUOXHJSFP-UHFFFAOYSA-N 11-methyl-5,6-dihydrobenzo[b][1]benzazepin-5-amine Chemical compound C1C(N)C2=CC=CC=C2N(C)C2=CC=CC=C21 PWMOKXUOXHJSFP-UHFFFAOYSA-N 0.000 abstract 1
- NLHOLNFWRSKUFX-UHFFFAOYSA-N 4-methyl-N-(11-methyl-5,6-dihydrobenzo[b][1]benzazepin-5-yl)benzenesulfonamide Chemical compound CN1C2=C(CC(C3=C1C=CC=C3)NS(=O)(=O)C3=CC=C(C)C=C3)C=CC=C2 NLHOLNFWRSKUFX-UHFFFAOYSA-N 0.000 abstract 1
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- URAKPRSEUAOSCK-UHFFFAOYSA-N N,4-dimethyl-N-(11-methyl-5,6-dihydrobenzo[b][1]benzazepin-5-yl)benzenesulfonamide Chemical compound CN1C2=C(CC(C3=C1C=CC=C3)N(S(=O)(=O)C3=CC=C(C)C=C3)C)C=CC=C2 URAKPRSEUAOSCK-UHFFFAOYSA-N 0.000 abstract 1
- RBSVEQCQZAHLGE-UHFFFAOYSA-N N-(11-methyl-5,6-dihydrobenzo[b][1]benzazepin-5-yl)formamide Chemical compound CN1C2=C(CC(C3=C1C=CC=C3)NC=O)C=CC=C2 RBSVEQCQZAHLGE-UHFFFAOYSA-N 0.000 abstract 1
- KGHMFPFRLWYZNF-UHFFFAOYSA-N N-methyl-N-(11-methyl-5,6-dihydrobenzo[b][1]benzazepin-5-yl)formamide Chemical compound CN1C2=C(CC(C3=C1C=CC=C3)N(C)C=O)C=CC=C2 KGHMFPFRLWYZNF-UHFFFAOYSA-N 0.000 abstract 1
- 238000005903 acid hydrolysis reaction Methods 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000001773 anti-convulsant effect Effects 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 229960003965 antiepileptics Drugs 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 150000002148 esters Chemical group 0.000 abstract 1
- RWBHWFCYFXFOJA-UHFFFAOYSA-N ethyl N-(6,11-dihydro-5H-benzo[b][1]benzazepin-4-yl)-N-ethylcarbamate Chemical class C(C)OC(=O)N(CC)C1=CC=CC=2NC3=C(CCC=21)C=CC=C3 RWBHWFCYFXFOJA-UHFFFAOYSA-N 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 125000005113 hydroxyalkoxy group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- ZDYVPIFPVZTJAL-UHFFFAOYSA-N methyl-(11-methyl-5,6-dihydrobenzo[b][1]benzazepin-5-yl)cyanamide Chemical compound CN1C2=C(CC(C3=C1C=CC=C3)N(C)C#N)C=CC=C2 ZDYVPIFPVZTJAL-UHFFFAOYSA-N 0.000 abstract 1
- 230000011987 methylation Effects 0.000 abstract 1
- 238000007069 methylation reaction Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- 230000002936 tranquilizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Combustion Methods Of Internal-Combustion Engines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Securing Globes, Refractors, Reflectors Or The Like (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR91646A FR1532301A (fr) | 1967-01-18 | 1967-01-18 | Nouveaux dérivés de la dibenzazépine et leur préparation |
| FR127611A FR94320E (fr) | 1967-01-18 | 1967-11-09 | Nouveaux dérives de la dibenzazépine et leur préparation. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1180164A true GB1180164A (en) | 1970-02-04 |
Family
ID=26174548
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2858/68A Expired GB1180164A (en) | 1967-01-18 | 1968-01-18 | Dibenzazepine Derivatives and their preparation |
| GB23183/69A Expired GB1180165A (en) | 1967-01-18 | 1968-01-18 | Novel Ketoximes and their preparation |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB23183/69A Expired GB1180165A (en) | 1967-01-18 | 1968-01-18 | Novel Ketoximes and their preparation |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US3622565A (enExample) |
| AT (6) | AT279631B (enExample) |
| BE (1) | BE709523A (enExample) |
| CH (1) | CH482677A (enExample) |
| DE (1) | DE1695666C3 (enExample) |
| DK (2) | DK120950B (enExample) |
| ES (5) | ES349459A1 (enExample) |
| FI (1) | FI48927C (enExample) |
| FR (2) | FR1532301A (enExample) |
| GB (2) | GB1180164A (enExample) |
| IE (1) | IE31926B1 (enExample) |
| IL (1) | IL29340A (enExample) |
| LU (1) | LU55297A1 (enExample) |
| NL (1) | NL156137B (enExample) |
| NO (2) | NO125677B (enExample) |
| OA (1) | OA03401A (enExample) |
| SE (2) | SE338995B (enExample) |
| SU (1) | SU464112A3 (enExample) |
| YU (2) | YU32142B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3882235A (en) * | 1969-06-24 | 1975-05-06 | Rhone Poulenc Sa | Fungicidal compositions comprising A 10, 11 dihydrodibenzo {8 b,f{9 {0 azepine derivative |
| FR2198942B1 (enExample) * | 1972-09-12 | 1975-03-14 | Rhone Poulenc Ind | |
| FI75561C (fi) * | 1979-10-30 | 1988-07-11 | Ciba Geigy Ag | Foerfarande foer framstaellning av 5- karbamoyl-10-oxo-10,11-dihydro-5h-dibens/b,f/azepin och daertill noedvaendiga mellanprodukter. |
| TWI435729B (zh) | 2005-11-09 | 2014-05-01 | Combinatorx Inc | 治療病症之方法，組合物及套組 |
| WO2009073154A1 (en) | 2007-11-28 | 2009-06-11 | Nektar Therapeutics Al, Corporation | Oligomer-tricyclic conjugates |
| WO2011091050A1 (en) | 2010-01-19 | 2011-07-28 | Nektar Therapeutics | Oligomer-tricyclic conjugates |
| EP2648707B1 (en) | 2010-12-10 | 2016-05-11 | Nektar Therapeutics | Hydroxylated tricyclic compounds |
| MX2021003730A (es) | 2018-09-28 | 2021-06-18 | Univ Griffith | Agentes y métodos para modular la actividad patógena. |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH457447A (de) * | 1965-07-26 | 1968-06-15 | Geigy Ag J R | Verfahren zur Herstellung von neuen Azepinderivaten |
-
1967
- 1967-01-18 FR FR91646A patent/FR1532301A/fr not_active Expired
- 1967-11-09 FR FR127611A patent/FR94320E/fr not_active Expired
-
1968
- 1968-01-09 OA OA53156A patent/OA03401A/xx unknown
- 1968-01-10 NL NL6800363.A patent/NL156137B/xx not_active IP Right Cessation
- 1968-01-16 SE SE00553/68A patent/SE338995B/xx unknown
- 1968-01-16 SE SE04482/70A patent/SE350971B/xx unknown
- 1968-01-16 DK DK15068AA patent/DK120950B/da not_active IP Right Cessation
- 1968-01-16 FI FI680114A patent/FI48927C/fi active
- 1968-01-17 IE IE57/68A patent/IE31926B1/xx unknown
- 1968-01-17 LU LU55297D patent/LU55297A1/xx unknown
- 1968-01-17 NO NO0200/68A patent/NO125677B/no unknown
- 1968-01-17 IL IL29340A patent/IL29340A/en unknown
- 1968-01-17 BE BE709523A patent/BE709523A/fr unknown
- 1968-01-17 US US698436A patent/US3622565A/en not_active Expired - Lifetime
- 1968-01-18 SU SU1313323A patent/SU464112A3/ru active
- 1968-01-18 AT AT03860/69A patent/AT279631B/de not_active IP Right Cessation
- 1968-01-18 ES ES349459A patent/ES349459A1/es not_active Expired
- 1968-01-18 AT AT385769A patent/AT279629B/de not_active IP Right Cessation
- 1968-01-18 AT AT03858/69A patent/AT281842B/de not_active IP Right Cessation
- 1968-01-18 DE DE1695666A patent/DE1695666C3/de not_active Expired
- 1968-01-18 AT AT03859/69A patent/AT279630B/de not_active IP Right Cessation
- 1968-01-18 GB GB2858/68A patent/GB1180164A/en not_active Expired
- 1968-01-18 AT AT53668A patent/AT279619B/de not_active IP Right Cessation
- 1968-01-18 YU YU0121/68A patent/YU32142B/xx unknown
- 1968-01-18 AT AT386169A patent/AT279632B/de not_active IP Right Cessation
- 1968-01-18 GB GB23183/69A patent/GB1180165A/en not_active Expired
- 1968-01-18 CH CH76368A patent/CH482677A/fr not_active IP Right Cessation
- 1968-05-30 ES ES354500A patent/ES354500A1/es not_active Expired
- 1968-05-30 ES ES354501A patent/ES354501A1/es not_active Expired
- 1968-05-30 ES ES354502A patent/ES354502A1/es not_active Expired
- 1968-05-30 ES ES354499A patent/ES354499A1/es not_active Expired
-
1969
- 1969-01-14 DK DK19669AA patent/DK118135B/da not_active IP Right Cessation
-
1971
- 1971-11-05 NO NO4096/71*[A patent/NO126527B/no unknown
-
1972
- 1972-10-30 YU YU2692/72A patent/YU33110B/xx unknown
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