GB1179849A - Method of Producing Indole Derivatives - Google Patents

Method of Producing Indole Derivatives

Info

Publication number
GB1179849A
GB1179849A GB5048266A GB5048266A GB1179849A GB 1179849 A GB1179849 A GB 1179849A GB 5048266 A GB5048266 A GB 5048266A GB 5048266 A GB5048266 A GB 5048266A GB 1179849 A GB1179849 A GB 1179849A
Authority
GB
United Kingdom
Prior art keywords
hydrogen
indole derivatives
carbon atoms
prepared
acetic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5048266A
Inventor
Svend Age Christensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Priority to GB5048266A priority Critical patent/GB1179849A/en
Priority to DK663566A priority patent/DK123171B/en
Priority to NL6715202A priority patent/NL6715202A/xx
Priority to DE1967A0057329 priority patent/DE1670001C3/en
Priority to AT1011467A priority patent/AT281010B/en
Priority to SE1541667A priority patent/SE329160B/xx
Publication of GB1179849A publication Critical patent/GB1179849A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,179,849. Indole acetic acids. MERCK & CO. Inc. 24 Jan., 1968 [10 Nov., 1966], No. 50482/66. Heading C2C. Indole derivatives of formula in which R<SP>1</SP> represents a hydrogen or halogen atom, an alkoxy group of not more than 4 carbon atoms, or a nitro group, R<SP>2</SP> represents a hydrogen atom or an alkyl group of 1-4 carbon atoms, and R<SP>3</SP> represents a hydrogen or halogen atom or a nitro group, are prepared by reacting the corresponding phenacyl esters with an alkali metal salt of thiophenol. 1 - p - Chlorobenzoyl - 5 - methoxy - 2 - methyl- 3-indolyl acetic acid phenacyl ester is prepared from the corresponding 3-unsubstituted compound by action of diazo acetic acid phenacyl ester in presence of Cu powder.
GB5048266A 1966-11-10 1966-11-10 Method of Producing Indole Derivatives Expired GB1179849A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
GB5048266A GB1179849A (en) 1966-11-10 1966-11-10 Method of Producing Indole Derivatives
DK663566A DK123171B (en) 1966-11-10 1966-12-22 Process for the preparation of indoleacetic acid compounds.
NL6715202A NL6715202A (en) 1966-11-10 1967-11-09
DE1967A0057329 DE1670001C3 (en) 1966-11-10 1967-11-09 Process for the preparation of indole-3-acetic acid derivatives
AT1011467A AT281010B (en) 1966-11-10 1967-11-10 Process for the production of indole derivatives
SE1541667A SE329160B (en) 1966-11-10 1967-11-10

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5048266A GB1179849A (en) 1966-11-10 1966-11-10 Method of Producing Indole Derivatives

Publications (1)

Publication Number Publication Date
GB1179849A true GB1179849A (en) 1970-02-04

Family

ID=10456053

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5048266A Expired GB1179849A (en) 1966-11-10 1966-11-10 Method of Producing Indole Derivatives

Country Status (6)

Country Link
AT (1) AT281010B (en)
DE (1) DE1670001C3 (en)
DK (1) DK123171B (en)
GB (1) GB1179849A (en)
NL (1) NL6715202A (en)
SE (1) SE329160B (en)

Also Published As

Publication number Publication date
SE329160B (en) 1970-10-05
DE1670001A1 (en) 1971-01-21
NL6715202A (en) 1968-05-13
DE1670001B2 (en) 1979-05-17
DE1670001C3 (en) 1980-01-10
DK123171B (en) 1972-05-23
AT281010B (en) 1970-05-11

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