ES385419A1 - Derivatives of thiophene acetic acid and processes for preparing them - Google Patents

Derivatives of thiophene acetic acid and processes for preparing them

Info

Publication number
ES385419A1
ES385419A1 ES385419A ES385419A ES385419A1 ES 385419 A1 ES385419 A1 ES 385419A1 ES 385419 A ES385419 A ES 385419A ES 385419 A ES385419 A ES 385419A ES 385419 A1 ES385419 A1 ES 385419A1
Authority
ES
Spain
Prior art keywords
radical
general formula
hydrogen atom
compound
alcohol radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES385419A
Other languages
Spanish (es)
Inventor
Clemence Francois
Martret Odile Le
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9042907&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES385419(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to ES396495A priority Critical patent/ES396495A2/en
Publication of ES385419A1 publication Critical patent/ES385419A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedure for preparing new thiophene-acetic acid derivatives of general formula: in which R1 represents a hydrogen atom or a linear or branched alcohol radical containing from 1 to 4 carbon atoms, R2 represents a hydrogen atom, a linear or branched alcohol radical possibly substituted by one or more hydroxy groups, a radical betadialkoxylaminoalcoyl, an N-heterocyclic-alcohol radical or an alkali or alkaline-earth metal atom and Ar represents a phenyl radical optionally mono- or poly-substituted by a halogen atom, an alcohol radical, a trihalo-methylmethyl group or an alkoxy radical, a cyclohexyl radical or a heterocyclic radical, characterized in that an acylating agent derived from an acid Ar COOH is reacted, in the presence of a Lewis acid, in which Ar retains the meanings mentioned above and hereinafter, with a compound of general formula **(See formula)** in which R1 represents here and in the following the above meanings, to obtain a compound of general formula **(See formula)** in which R2 represents a hydrogen atom, which eventually can be split, esterified or salified by the usual methods to obtain the desired compound. (Machine-translation by Google Translate, not legally binding)
ES385419A 1969-11-12 1970-11-11 Derivatives of thiophene acetic acid and processes for preparing them Expired ES385419A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES396495A ES396495A2 (en) 1969-11-12 1971-10-29 Procedure for the preparation of new derivatives of thiophene-acetic acid. (Machine-translation by Google Translate, not legally binding)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR696938734A FR2068425B1 (en) 1969-11-12 1969-11-12

Publications (1)

Publication Number Publication Date
ES385419A1 true ES385419A1 (en) 1973-04-16

Family

ID=9042907

Family Applications (2)

Application Number Title Priority Date Filing Date
ES385419A Expired ES385419A1 (en) 1969-11-12 1970-11-11 Derivatives of thiophene acetic acid and processes for preparing them
ES396495A Expired ES396495A2 (en) 1969-11-12 1971-10-29 Procedure for the preparation of new derivatives of thiophene-acetic acid. (Machine-translation by Google Translate, not legally binding)

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES396495A Expired ES396495A2 (en) 1969-11-12 1971-10-29 Procedure for the preparation of new derivatives of thiophene-acetic acid. (Machine-translation by Google Translate, not legally binding)

Country Status (12)

Country Link
AT (1) AT298480B (en)
BE (1) BE758741A (en)
CH (2) CH533635A (en)
DK (1) DK126203B (en)
ES (2) ES385419A1 (en)
FR (1) FR2068425B1 (en)
GB (1) GB1331505A (en)
IL (1) IL35485A (en)
NL (1) NL168837C (en)
OA (1) OA03518A (en)
SE (1) SE377570B (en)
ZA (1) ZA707669B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2203625A1 (en) * 1972-10-24 1974-05-17 Roussel Uclaf 2-Benzoyl-5-thiazolyl alkanoic acids - as anti-inflammatories and analgesics prepdfrom a phenyl thio glyoxylamide and a 3-bromo 3-benzoyl alkanoic ester
FR2319340A1 (en) * 1975-07-28 1977-02-25 Roussel Uclaf NEW SALT OF A-METHYL BENZOYL-5-THIOPHENE-2 ACETIC ACID, METHOD OF PREPARATION AND APPLICATION AS A MEDICINAL PRODUCT
FR2545085B1 (en) * 1983-04-28 1985-10-25 Roussel Uclaf NOVEL PROCESS FOR THE PREPARATION OF A-HYDROXY 2-THIOPHENE ACETIC ACID DERIVATIVES
GB8525716D0 (en) * 1985-10-18 1985-11-20 Roussel Lab Ltd Chemical compounds
WO1993017680A1 (en) * 1992-03-13 1993-09-16 Sepracor, Inc. Antipyretic and analgesic methods and compositions containing optically pure r-etodolac
US5859042A (en) * 1995-09-27 1999-01-12 Ono Pharmaceutical Co., Ltd. Five membered heterocyclic compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1139164A (en) * 1966-12-05 1969-01-08 Parke Davis & Co New heterocyclic acetic acid compounds and methods for their production
SE338993B (en) * 1967-07-26 1971-09-27 Mcneilab Inc

Also Published As

Publication number Publication date
NL168837C (en) 1982-05-17
ES396495A2 (en) 1974-05-16
AT298480B (en) 1972-05-10
CH533635A (en) 1973-02-15
IL35485A0 (en) 1970-12-24
SE377570B (en) 1975-07-14
CH534172A (en) 1973-02-28
DK126203B (en) 1973-06-18
OA03518A (en) 1971-03-30
BE758741A (en) 1971-05-10
DE2055264A1 (en) 1971-05-19
FR2068425A1 (en) 1971-08-27
GB1331505A (en) 1973-09-26
FR2068425B1 (en) 1973-01-12
ZA707669B (en) 1971-12-29
NL7016412A (en) 1971-05-14
IL35485A (en) 1974-03-14
DE2055264B2 (en) 1975-09-25

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19930215