ES396701A1 - Procedure for preparation of new derivatives of the thiophene-acetic acid. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for preparation of new derivatives of the thiophene-acetic acid. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES396701A1
ES396701A1 ES396701A ES396701A ES396701A1 ES 396701 A1 ES396701 A1 ES 396701A1 ES 396701 A ES396701 A ES 396701A ES 396701 A ES396701 A ES 396701A ES 396701 A1 ES396701 A1 ES 396701A1
Authority
ES
Spain
Prior art keywords
radical
general formula
thiophene
compound
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES396701A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES396701A1 publication Critical patent/ES396701A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Abstract

Preparation procedure of new thiophene-acetic acid derivatives of general formula **(See formula)** in which R1 represents a hydrogen atom or a linear or branched alcohol radical containing from 1 to 4 carbon atoms; R2 represents a hydrogen atom, a linear or branched alcohol radical, optionally substituted by one or more hydroxy groups, a beta-dialkoxylaminoalcoyl radical or an N-heterocyclo-alcohol radical; and Ar represents a phenyl radical, optionally mono- or poly-substituted by a halogen atom, an alcohol radical, a trihalo-methyl group, an alkoxy radical or a carboxylic group, a cyclohexyl radical or a heterocyclic radical; R3 represents a methyl radical in one of the two beta positions in relation to the sulfur atom of the thiophene nucleus, characterized in that an acylating agent derived from an Ar-COOH acid is reacted, in the presence of a Lewis acid, in which Ar has the above meaning with a compound of general formula **(See formula)** in which R1, R2 and R3 have the aforementioned meaning, to obtain a compound of general formula I: **(See formula)** in which R1, R2, R3 and Ar have the aforementioned meaning, which may eventually be split or esterified, to obtain a compound of general formula I, in which R2 has a different meaning from a hydrogen atom. (Machine-translation by Google Translate, not legally binding)
ES396701A 1970-11-10 1971-11-05 Procedure for preparation of new derivatives of the thiophene-acetic acid. (Machine-translation by Google Translate, not legally binding) Expired ES396701A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7040370A FR2113760A1 (en) 1970-11-10 1970-11-10 5-Arylcarbonyl-3(or 4)-methylthien-2-yl alkanoic acids and esters - with antiinflammatory and analgesic activity

Publications (1)

Publication Number Publication Date
ES396701A1 true ES396701A1 (en) 1974-05-16

Family

ID=9064010

Family Applications (1)

Application Number Title Priority Date Filing Date
ES396701A Expired ES396701A1 (en) 1970-11-10 1971-11-05 Procedure for preparation of new derivatives of the thiophene-acetic acid. (Machine-translation by Google Translate, not legally binding)

Country Status (2)

Country Link
ES (1) ES396701A1 (en)
FR (1) FR2113760A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1007643A (en) * 1972-10-24 1977-03-29 Janssen Pharmaceutica Naamloze Vennootschap Aroyl-substituted phenylacetic acid derivatives
FR2600065B1 (en) * 1986-06-13 1988-09-09 Roussel Uclaf NOVEL 5 - ((2-BENZOFURANYL) CARBONYL) THIOPHENE ACETIC ACID DERIVATIVES, THEIR SALTS, THEIR PREPARATION METHODS, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
FR2113760A1 (en) 1972-06-30
FR2113760B1 (en) 1975-04-18

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