GB1140748A - New carboxylic acid derivatives - Google Patents

New carboxylic acid derivatives

Info

Publication number
GB1140748A
GB1140748A GB28198/66A GB2819866A GB1140748A GB 1140748 A GB1140748 A GB 1140748A GB 28198/66 A GB28198/66 A GB 28198/66A GB 2819866 A GB2819866 A GB 2819866A GB 1140748 A GB1140748 A GB 1140748A
Authority
GB
United Kingdom
Prior art keywords
carboxylic acid
formula
amide
ester
resulting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB28198/66A
Other languages
English (en)
Inventor
Thomas Leigh
Leslie Arthur Mcardle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Priority to GB28198/66A priority Critical patent/GB1140748A/en
Priority to US644489A priority patent/US3549690A/en
Priority to DE1967J0033909 priority patent/DE1618568B2/de
Priority to BE700110D priority patent/BE700110A/xx
Priority to DK318767AA priority patent/DK117823B/da
Priority to SE8887/67A priority patent/SE343572B/xx
Priority to CH884567A priority patent/CH506467A/de
Priority to FR111745A priority patent/FR1532701A/fr
Priority to NL6708766.A priority patent/NL158779B/xx
Priority to FR122014A priority patent/FR8486M/fr
Publication of GB1140748A publication Critical patent/GB1140748A/en
Priority to US37317A priority patent/US3658967A/en
Priority to MY197361A priority patent/MY7300061A/xx
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
    • C07C17/2637—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions between a compound containing only oxygen and possibly halogen as hetero-atoms and a halogenated hydrocarbon
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/19—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB28198/66A 1966-06-23 1966-06-23 New carboxylic acid derivatives Expired GB1140748A (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
GB28198/66A GB1140748A (en) 1966-06-23 1966-06-23 New carboxylic acid derivatives
US644489A US3549690A (en) 1966-06-23 1967-06-08 Carboxylic acid derivatives
DE1967J0033909 DE1618568B2 (de) 1966-06-23 1967-06-14 Benzyloxycarbonsaeuren und deren derivate, verfahren zur herstellung derselben und diese verbindungen enthaltende arzneimittel
BE700110D BE700110A (enExample) 1966-06-23 1967-06-16
DK318767AA DK117823B (da) 1966-06-23 1967-06-20 Analogifremgangsmåde til fremstilling af karboksylsyrederivater samt esterne og amiderne og saltene deraf.
SE8887/67A SE343572B (enExample) 1966-06-23 1967-06-21
CH884567A CH506467A (de) 1966-06-23 1967-06-22 Verfahren zur Herstellung von Carbonsäuren und deren Derivaten
FR111745A FR1532701A (fr) 1966-06-23 1967-06-23 Nouveaux dérivés aryliques d'acides carboxyliques
NL6708766.A NL158779B (nl) 1966-06-23 1967-06-23 Werkwijze ter bereiding van een farmaceutisch preparaat met cholesterolspiegel verlagende werking en van een verbinding, die gebruikt kan worden in zo'n preparaat.
FR122014A FR8486M (enExample) 1966-06-23 1967-09-22
US37317A US3658967A (en) 1966-06-23 1970-05-14 Carboxylic acid derivatives for lowering the concentration of triglycerides in the blood
MY197361A MY7300061A (en) 1966-06-23 1973-12-31 New carboxylic acid derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2820066 1966-06-23
GB28198/66A GB1140748A (en) 1966-06-23 1966-06-23 New carboxylic acid derivatives

Publications (1)

Publication Number Publication Date
GB1140748A true GB1140748A (en) 1969-01-22

Family

ID=26259251

Family Applications (1)

Application Number Title Priority Date Filing Date
GB28198/66A Expired GB1140748A (en) 1966-06-23 1966-06-23 New carboxylic acid derivatives

Country Status (10)

Country Link
US (1) US3549690A (enExample)
BE (1) BE700110A (enExample)
CH (1) CH506467A (enExample)
DE (1) DE1618568B2 (enExample)
DK (1) DK117823B (enExample)
FR (1) FR8486M (enExample)
GB (1) GB1140748A (enExample)
MY (1) MY7300061A (enExample)
NL (1) NL158779B (enExample)
SE (1) SE343572B (enExample)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2461069A1 (de) * 1973-12-27 1975-07-17 Siegfried Ag Neue cholesterinsenkende verbindungen
EP0009306A1 (en) * 1978-09-08 1980-04-02 Imperial Chemical Industries Plc Anti-arthritic hydroxyacetic acid derivatives, pharmaceutical compositions thereof, and processes for their manufacture
EP0037698A1 (en) * 1980-04-03 1981-10-14 Imperial Chemical Industries Plc Benzaldehyde derivatives for use as a chemical intermediate
US4348322A (en) 1980-04-03 1982-09-07 Imperial Chemical Industries Limited Dioxolane derivatives
WO1990014334A1 (en) * 1989-05-25 1990-11-29 Farmitalia Carlo Erba S.R.L. N-PHENYLALKYL SUBSTITUTED α-AMINO CARBOXAMIDE DERIVATIVES AND PROCESS FOR THEIR PREPARATION
US5446066A (en) * 1993-04-01 1995-08-29 Farmitalia Carlo Erba S.R.L. Substituted (arylalkoxybenzyl)aminopropanamide derivatives and process for their preparation
US5449692A (en) * 1993-04-01 1995-09-12 Farmitalia Carlo Erba S.R.L. Substituted (arylalkylaminobenzyl) aminopropionamide derivatives and process for their preparation
WO1999062507A1 (en) * 1998-06-02 1999-12-09 Arthromics Plc Compounds which interact with the thyroid hormone receptor for the treatment of fibrotic disease
EP1586559A1 (en) * 2004-04-13 2005-10-19 Cephalon, Inc. Biaryl-methanethio-, -sulphinyl- and sulphonyl derivatives
JP2008505058A (ja) * 2004-04-13 2008-02-21 セフアロン・インコーポレーテツド チオ−置換ビアリールメタンスルティニル誘導体
USRE40259E1 (en) 1997-12-31 2008-04-22 Newron Pharmaceuticals, S.P.A. Alpha-aminoamide derivatives useful as analgesic agents
EP2070526A1 (en) 2003-04-11 2009-06-17 Newron Pharmaceuticals S.p.A. "Methods for treatment of Parkinson's disease"
US7709523B2 (en) 2003-01-16 2010-05-04 Newron Pharmaceuticals Spa Alpha-aminoamide derivatives useful as antimigraine agents
US8084447B2 (en) 2001-09-03 2011-12-27 Newron Pharmaceuticals S.P.A. Pharmaceutical composition comprising gabapentin or an analogue thereof and an α-aminoamide and its analgesic use
US8445513B2 (en) 2004-04-22 2013-05-21 Newron Pharmaceuticals S.P.A. α-Aminoamide derivatives useful in the treatment of restless legs syndrome
US8741957B2 (en) 2006-06-15 2014-06-03 Newron Pharmaceuticals S.P.A. Alpha-aminoamide derivatives useful in the treatment of cognitive disorders

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT336589B (de) * 1974-05-20 1977-05-10 Thomae Gmbh Dr K Verfahren zur herstellung von neuen biphenylderivaten
US4107329A (en) * 1974-12-06 1978-08-15 Imperial Chemical Industries Limited Fluorinated compounds as therapeutics
GB1499508A (en) * 1974-12-06 1978-02-01 Ici Ltd 3,3,3-trifluoropropionic acid derivatives
US4214004A (en) * 1978-12-04 1980-07-22 Fmc Corporation Insecticidal cyclopropanecarboxylates from substituted [1,1'-biphenyl]-3-ylmethyl compounds
JPS58150563A (ja) * 1982-03-04 1983-09-07 Taisho Pharmaceut Co Ltd ３−ベンゾイル−２−メルカプトプロピオン酸誘導体
US4864038A (en) * 1986-05-05 1989-09-05 Merck & Co., Inc. Antihypercholesterolemic compounds
US5307735A (en) * 1992-11-05 1994-05-03 Gross-Given Manufacturing Co. Beverage brewing device
KR101277520B1 (ko) * 2004-09-10 2013-06-21 뉴론 파마슈티칼즈 에스. 피. 에이. （할로벤질옥시）벤질아미노－프로판아미드를 포함하는 선택적 나트륨 및／또는 칼슘 채널 조절제로서 유용한 약제학적 조성물

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3332842A (en) * 1963-08-30 1967-07-25 Ciba Geigy Corp Ether acids and derivatives thereof
US3364249A (en) * 1964-01-30 1968-01-16 Merck & Co Inc N-carboxyalkyl-phenoxyalkanoic acid amide

Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2461069A1 (de) * 1973-12-27 1975-07-17 Siegfried Ag Neue cholesterinsenkende verbindungen
EP0009306A1 (en) * 1978-09-08 1980-04-02 Imperial Chemical Industries Plc Anti-arthritic hydroxyacetic acid derivatives, pharmaceutical compositions thereof, and processes for their manufacture
US4304788A (en) 1978-09-08 1981-12-08 Imperial Chemical Industries Limited Hydroxyalkanoic acid derivatives
US4310544A (en) 1978-09-08 1982-01-12 Imperial Chemical Industries Limited Hydroxyacetic acid derivatives with anti-arthritic properties
EP0037698A1 (en) * 1980-04-03 1981-10-14 Imperial Chemical Industries Plc Benzaldehyde derivatives for use as a chemical intermediate
US4348322A (en) 1980-04-03 1982-09-07 Imperial Chemical Industries Limited Dioxolane derivatives
WO1990014334A1 (en) * 1989-05-25 1990-11-29 Farmitalia Carlo Erba S.R.L. N-PHENYLALKYL SUBSTITUTED α-AMINO CARBOXAMIDE DERIVATIVES AND PROCESS FOR THEIR PREPARATION
EP0400495A1 (en) * 1989-05-25 1990-12-05 FARMITALIA CARLO ERBA S.r.l. N-phenylalkyl substituted alfa-amino carboxamide derivatives and process for their preparation
US5236957A (en) * 1989-05-25 1993-08-17 Farmitalia Carlo Erba Srl N-phenylalkyl substituted α-amino carboxamide derivatives and process for their preparation
US5446066A (en) * 1993-04-01 1995-08-29 Farmitalia Carlo Erba S.R.L. Substituted (arylalkoxybenzyl)aminopropanamide derivatives and process for their preparation
US5449692A (en) * 1993-04-01 1995-09-12 Farmitalia Carlo Erba S.R.L. Substituted (arylalkylaminobenzyl) aminopropionamide derivatives and process for their preparation
USRE40259E1 (en) 1997-12-31 2008-04-22 Newron Pharmaceuticals, S.P.A. Alpha-aminoamide derivatives useful as analgesic agents
WO1999062507A1 (en) * 1998-06-02 1999-12-09 Arthromics Plc Compounds which interact with the thyroid hormone receptor for the treatment of fibrotic disease
US6348497B1 (en) 1998-06-02 2002-02-19 Arthromics Plc Compounds which interact with the thyroid hormone receptor for the treatment of fibrotic disease
US6414026B1 (en) 1998-06-02 2002-07-02 Arthromics Plc Compounds which interact with the thyroid hormone receptor for the treatment of fibrotic disease
US8084447B2 (en) 2001-09-03 2011-12-27 Newron Pharmaceuticals S.P.A. Pharmaceutical composition comprising gabapentin or an analogue thereof and an α-aminoamide and its analgesic use
US8710040B2 (en) 2001-09-03 2014-04-29 Newron Pharmaceuticals S.P.A. Pharmaceutical composition comprising gabapentin or an analogue thereof and an α-aminoamide and its analgesic use
US7709523B2 (en) 2003-01-16 2010-05-04 Newron Pharmaceuticals Spa Alpha-aminoamide derivatives useful as antimigraine agents
US8283380B2 (en) 2003-04-11 2012-10-09 Newron Pharmaceuticals S.P.A. Methods for treatment of parkinson's disease
US9492410B2 (en) 2003-04-11 2016-11-15 Newron Pharmaceuticals S.P.A. Methods for treatment of Parkinson's disease
EP2070526A1 (en) 2003-04-11 2009-06-17 Newron Pharmaceuticals S.p.A. "Methods for treatment of Parkinson's disease"
US8901176B2 (en) 2003-04-11 2014-12-02 Newron Pharmaceuticals, S.P.A. Methods for treatment of Parkinson's disease
JP4859828B2 (ja) * 2004-04-13 2012-01-25 セフアロン・インコーポレーテツド チオ−置換ビアリールメタンスルティニル誘導体
JP2008505058A (ja) * 2004-04-13 2008-02-21 セフアロン・インコーポレーテツド チオ−置換ビアリールメタンスルティニル誘導体
EP1586559A1 (en) * 2004-04-13 2005-10-19 Cephalon, Inc. Biaryl-methanethio-, -sulphinyl- and sulphonyl derivatives
US7981907B2 (en) 2004-04-13 2011-07-19 Cephalon, Inc. Thio-substituted biarylmethanesulfinyl derivatives
US7449481B2 (en) 2004-04-13 2008-11-11 Cephalon, Inc. Thio-substituted biaryl-methanesulfinyl derivatives
US8445513B2 (en) 2004-04-22 2013-05-21 Newron Pharmaceuticals S.P.A. α-Aminoamide derivatives useful in the treatment of restless legs syndrome
US8697738B2 (en) 2004-04-22 2014-04-15 Newron Pharmaceuticals S.P.A. Alpha-aminoamide derivatives useful in the treatment of addictive disorders
US8741957B2 (en) 2006-06-15 2014-06-03 Newron Pharmaceuticals S.P.A. Alpha-aminoamide derivatives useful in the treatment of cognitive disorders

Also Published As

Publication number Publication date
BE700110A (enExample) 1967-12-18
DK117823B (da) 1970-06-08
US3549690A (en) 1970-12-22
DE1618568A1 (de) 1971-02-25
SE343572B (enExample) 1972-03-13
NL158779B (nl) 1978-12-15
MY7300061A (en) 1973-12-31
DE1618568B2 (de) 1976-07-01
NL6708766A (enExample) 1967-12-27
CH506467A (de) 1971-04-30
FR8486M (enExample) 1973-07-27

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