GB1091403A - Therapeutically active phenylalkane derivatives - Google Patents

Therapeutically active phenylalkane derivatives

Info

Publication number
GB1091403A
GB1091403A GB3223/64A GB322364A GB1091403A GB 1091403 A GB1091403 A GB 1091403A GB 3223/64 A GB3223/64 A GB 3223/64A GB 322364 A GB322364 A GB 322364A GB 1091403 A GB1091403 A GB 1091403A
Authority
GB
United Kingdom
Prior art keywords
hydrogen
alkyl
acid
prepared
biphenylyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3223/64A
Other languages
English (en)
Inventor
Stewart Sanders Adams
Bernard John Armitage
John Stuart Nicholson
Antonio Libera Blancafor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boots Pure Drug Co Ltd
Original Assignee
Boots Pure Drug Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boots Pure Drug Co Ltd filed Critical Boots Pure Drug Co Ltd
Priority to GB3223/64A priority Critical patent/GB1091403A/en
Priority to IL22772A priority patent/IL22772A/en
Priority to DE1518528A priority patent/DE1518528B2/de
Priority to BE658723D priority patent/BE658723A/xx
Priority to FI650151A priority patent/FI42712C/fi
Priority to FR2895A priority patent/FR5737M/fr
Priority to NL656500865A priority patent/NL152540B/xx
Priority to SE855/65A priority patent/SE324759B/xx
Priority to CH92065A priority patent/CH454822A/fr
Priority to CH422167A priority patent/CH501577A/fr
Priority to FR2899A priority patent/FR1430359A/fr
Priority to DK38265AA priority patent/DK127251B/da
Priority to CS508A priority patent/CS163156B2/cs
Priority to CS173A priority patent/CS163157B2/cs
Priority to DK191466AA priority patent/DK116794B/da
Priority to FR67159A priority patent/FR5738M/fr
Priority to SE10115/67A priority patent/SE329843B/xx
Publication of GB1091403A publication Critical patent/GB1091403A/en
Priority to US00845033A priority patent/US3755427A/en
Priority to US00885280A priority patent/US3821293A/en
Priority to US00308557A priority patent/US3784705A/en
Priority to US00308558A priority patent/US3793457A/en
Priority to US05/391,759 priority patent/US4053639A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/06—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C07C205/12—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings the six-membered aromatic ring or a condensed ring system containing that ring being substituted by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/12—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom
    • C07C245/14—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C07C33/48—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
    • C07C33/486—Polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
GB3223/64A 1964-01-24 1964-01-24 Therapeutically active phenylalkane derivatives Expired GB1091403A (en)

Priority Applications (22)

Application Number Priority Date Filing Date Title
GB3223/64A GB1091403A (en) 1964-01-24 1964-01-24 Therapeutically active phenylalkane derivatives
IL22772A IL22772A (en) 1964-01-24 1965-01-12 B-phenyl history with drug activity
DE1518528A DE1518528B2 (de) 1964-01-24 1965-01-19 Biphenylalkan- oder -alkenderivate und sie enthaltende therapeutische Zubereitungen mit antünflammatorischer, antipyretischer und analgetischer Wirkung
BE658723D BE658723A (de) 1964-01-24 1965-01-22
FI650151A FI42712C (fi) 1964-01-24 1965-01-22 Menetelmä terapeuttisesti vaikuttavien bifenyylialkaanijohdannaisten valmistamiseksi
FR2895A FR5737M (de) 1964-01-24 1965-01-22
NL656500865A NL152540B (nl) 1964-01-24 1965-01-22 Werkwijze voor de bereiding van bifenylderivaten met therapeutische eigenschappen, werkwijze voor de bereiding van een therapeutisch preparaat en vormstukken, vervaardigd met de laatstgenoemde werkwijze.
SE855/65A SE324759B (de) 1964-01-24 1965-01-22
CH92065A CH454822A (fr) 1964-01-24 1965-01-22 Procédé de préparation d'acides carboxyliques thérapeutiquement actifs
CH422167A CH501577A (fr) 1964-01-24 1965-01-22 Procédé de préparation d'acides phénylalcanoïques thérapeutiquement actifs
FR2899A FR1430359A (fr) 1964-01-24 1965-01-22 Nouveaux dérivés de phénylalcanes et leur procédé de préparation
DK38265AA DK127251B (da) 1964-01-24 1965-01-23 Fremgangsmåde til fremstilling af bifenylderivater.
CS508A CS163156B2 (de) 1964-01-24 1965-01-25
CS173A CS163157B2 (de) 1964-01-24 1965-01-25
DK191466AA DK116794B (da) 1964-01-24 1966-04-14 Fremgangsmåde til fremstilling af bifenylderivater eller salte deraf.
FR67159A FR5738M (de) 1964-01-24 1966-06-28
SE10115/67A SE329843B (de) 1964-01-24 1967-06-30
US00845033A US3755427A (en) 1964-01-24 1969-07-25 2-(mono-and difluoro-4-biphenyl)propionic acids
US00885280A US3821293A (en) 1964-01-24 1969-12-15 2-(4'-chloro-4-biphenylyl)propionic acid
US00308557A US3784705A (en) 1964-01-24 1972-11-21 Therapeutically active phenylalkane derivatives
US00308558A US3793457A (en) 1964-01-24 1972-11-21 Therapeutically active phenylalkane derivatives
US05/391,759 US4053639A (en) 1964-01-24 1973-10-04 Therapeutically active phenylalkane derivatives

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB3223/64A GB1091403A (en) 1964-01-24 1964-01-24 Therapeutically active phenylalkane derivatives
US42562465A 1965-01-14 1965-01-14
US84503369A 1969-07-25 1969-07-25
US00885280A US3821293A (en) 1964-01-24 1969-12-15 2-(4'-chloro-4-biphenylyl)propionic acid
US30855872A 1972-11-12 1972-11-12

Publications (1)

Publication Number Publication Date
GB1091403A true GB1091403A (en) 1967-11-15

Family

ID=27515717

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3223/64A Expired GB1091403A (en) 1964-01-24 1964-01-24 Therapeutically active phenylalkane derivatives

Country Status (12)

Country Link
US (3) US3755427A (de)
BE (1) BE658723A (de)
CH (1) CH454822A (de)
CS (2) CS163157B2 (de)
DE (1) DE1518528B2 (de)
DK (2) DK127251B (de)
FI (1) FI42712C (de)
FR (3) FR5737M (de)
GB (1) GB1091403A (de)
IL (1) IL22772A (de)
NL (1) NL152540B (de)
SE (2) SE324759B (de)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2173886A1 (de) * 1972-02-08 1973-10-12 Thomae Gmbh Dr K
US3957861A (en) * 1973-11-07 1976-05-18 The Upjohn Company Biphenylylpropionic acids and esters
US3969402A (en) * 1972-06-15 1976-07-13 The Boots Company Limited Phenylalkanoic acids
US4048332A (en) * 1972-06-15 1977-09-13 The Boots Company Limited Phenylalkanoic acids
US4052514A (en) * 1971-03-26 1977-10-04 The Boots Company Limited Trihalosubstituted biphenylyl propionic acids
US4304931A (en) * 1975-04-04 1981-12-08 The Boots Company Limited Biphenylhydroxypropionic acid derivatives
WO1999041224A1 (en) * 1998-02-13 1999-08-19 Merck Frosst Canada & Co. Biaryl-acetic acid derivatives and their use as cox-2 inhibitors

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4053639A (en) * 1964-01-24 1977-10-11 The Boots Company Limited Therapeutically active phenylalkane derivatives
FR2043467A1 (de) * 1969-05-12 1971-02-19 Clin Byla Ets
US3671580A (en) * 1969-12-22 1972-06-20 Merck & Co Inc Substituted biphenyl acetic acids and ester derivatives thereof
GB1312642A (en) * 1970-07-13 1973-04-04 Science Union & Cie Pyrazole compounds and process for their manufacture
GB1359987A (en) * 1970-10-12 1974-07-17 Boots Co Ltd 2-substituted biphenylyl propionic acids
FR2115026B1 (de) * 1970-11-24 1974-03-22 Logeais Labor Jacques
US3987197A (en) * 1972-08-17 1976-10-19 Boehringer Ingelheim Gmbh 3-(2'-fluoro-4-biphenylyl)-butyric acid and salts thereof
ATA785173A (de) * 1972-08-17 1975-01-15 Thomae Gmbh Dr K Verfahren zur herstellung von neuen 4-(4-biphenylyl)-4-hydroxy-buttersaeureamiden
US4278516A (en) * 1979-06-28 1981-07-14 Ethyl Corporation Method for the preparation of 2-fluoro-4-monobromomethylbiphenyl
US4371473A (en) * 1979-06-28 1983-02-01 Ethyl Corporation Preparation of 2-(2-fluoro-4-biphenylyl)propionic acid and corresponding nitride
EP0089426B1 (de) * 1979-07-12 1986-06-11 A.H. Robins Company, Incorporated 2-Amino-6-biphenylessigsäuren
US4230724A (en) * 1979-07-16 1980-10-28 Allergan Pharmaceuticals, Inc. Method of treating vascularization of the eye with Flurbiprofen
NL8006488A (nl) * 1979-12-19 1981-07-16 Upjohn Co Werkwijze voor het bereiden van arylpropionzuren.
US4324904A (en) * 1979-12-19 1982-04-13 The Upjohn Company Processes for the preparation of hydratropic acids and esters
GB2075837B (en) * 1980-05-14 1984-03-14 Hisamitsu Pharmaceutical Co Topical pharmaceutical gel containing anti-inflammatory analgesic agents
DE3026402A1 (de) * 1980-07-11 1982-02-04 Syntex Corp., Palo Alto, Calif. Die verwendung analgetischer und nicht-hormonaler, entzuendungshemmender mittel bei der behandlung von mikrovaskulaeren erkrankungen
US4422979A (en) * 1980-09-22 1983-12-27 Ethyl Corporation Fluoro-substituted biphenylyl compounds and processes
US4443476A (en) * 1981-07-20 1984-04-17 The Upjohn Company Treatment of adult respiratory distress syndrome
FR2514355A1 (fr) * 1981-10-14 1983-04-15 Fabre Sa Pierre Derives de biphenyl alcoyl carboxylates, leur procede de preparation et leur utilisation comme medicaments
US4502995A (en) * 1981-11-02 1985-03-05 Ethyl Corporation Nucleophilic substitution process
US4370278A (en) * 1981-11-02 1983-01-25 Ethyl Corporation Nucleophilic substitution process
ZA828453B (en) * 1981-12-08 1983-12-28 Boots Co Plc Therapeutic agents
DE3209178A1 (de) * 1982-03-13 1983-09-15 Merck Patent Gmbh, 6100 Darmstadt Polyhalogenaromaten
FR2524463A1 (fr) * 1982-04-05 1983-10-07 Fabre Sa Pierre Obtention du metbufene par synthese malonique
US4404211A (en) * 1982-06-30 1983-09-13 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and flurbiprofen
JPS59152348A (ja) * 1983-02-19 1984-08-31 Kaken Pharmaceut Co Ltd ビフエニリルプロピオン酸エステル誘導体およびその製造法
CA1201127A (en) * 1982-09-10 1986-02-25 Katsuhiro Uchida Biphenylylpropionic acid derivative, process for preparing the same and pharmaceutical composition containing the same
US5196567A (en) * 1983-02-19 1993-03-23 Kaken Pharmaceutical Co., Ltd. Biphenylylpropionic acid derivative, process for preparing the same and pharmaceutical composition containing the same
US4540795A (en) * 1983-02-25 1985-09-10 Ethyl Corporation Fluoronitroaralkyloxazolines, derivatives thereof, and nucleophilic substitution processes for preparing them
IT1194209B (it) * 1983-04-21 1988-09-14 Medea Res Srl Composti fluorurati ad attivita' analgesica e antiinfiammatoria
IT1212821B (it) * 1983-06-03 1989-11-30 Scharper Spa Derivati dell'acido fenil-etil-acetico ad attivita'antiinfiammatoria.
JPS601122A (ja) * 1983-06-20 1985-01-07 Green Cross Corp:The ビフエニリルプロピオン酸誘導体脂肪乳剤
FR2564459B1 (fr) * 1984-05-16 1986-10-31 Delalande Sa Procede de preparation d'acides hydratropiques et de leurs esters, a partir de propiophenones
US5286751A (en) * 1987-12-24 1994-02-15 Analgesic Associates Sustained/enhanced antipyretic response
US4927854A (en) * 1987-12-24 1990-05-22 Analgesic Associates Sustained/enhanced analgesia
AU659106B2 (en) * 1990-11-06 1995-05-11 Fgn, Inc. Method for treating colonic polyps by the use of esters and amides of substituted phenyl and pyridyl amino carboxylates
US5955504A (en) * 1995-03-13 1999-09-21 Loma Linda University Medical Center Colorectal chemoprotective composition and method of preventing colorectal cancer
US6160018A (en) * 1995-03-13 2000-12-12 Loma Linda University Medical Center Prophylactic composition and method for alzheimer's Disease
US5981592A (en) * 1995-03-13 1999-11-09 Loma Linda University Medical Center Method and composition for treating cystic fibrosis
US6348216B1 (en) * 1996-06-10 2002-02-19 Knoll Pharmaceutical Company Ibuprofen and narcotic analgesic compositions
US6361794B1 (en) 1996-06-12 2002-03-26 Basf Corporation Method of making ibuprofen and narcotic analgesic composition
US6080888A (en) * 1997-01-08 2000-06-27 Albemarle Corporation Preparation of olefinic compounds and carboxylic derivatives thereof
US5792886A (en) * 1997-01-08 1998-08-11 Albemarle Corporation Production of racemic 2-(6-methoxy-2-naphthyl) propionic acid of precursors thereof
US6096920A (en) * 1997-01-08 2000-08-01 Albemarle Corporation Preparation of carboxylic compounds and their derivatives
DE19808261A1 (de) * 1998-02-27 1999-10-28 Bayer Ag Arylphenylsubstituierte cyclische Ketoenole
US6268526B1 (en) 1998-12-16 2001-07-31 Albemarle Corporation Palladium catalyzed carbonylation process utilizing aromatic substituted alcohols and/or aromatic substituted alkyl halides
IT1308633B1 (it) 1999-03-02 2002-01-09 Nicox Sa Nitrossiderivati.
AU2001257022B2 (en) * 2000-04-13 2005-02-03 Mayo Foundation For Medical Education And Research Abeta 42 lowering agents
FR2811664B1 (fr) * 2000-07-17 2002-09-13 Rhodia Chimie Sa Procede de preparation d'un compose polyaromatique
IT1318673B1 (it) * 2000-08-08 2003-08-27 Nicox Sa Farmaci per le disfunzioni sessuali.
IT1318674B1 (it) * 2000-08-08 2003-08-27 Nicox Sa Faramaci per l'incontinenza.
AU2002247284A1 (en) 2001-04-02 2002-10-15 Alcon, Inc. Method of treating ocular inflammatory and angiogenesis-related disorders using an amide derivative of flubiprofen or ketorolac
US20030027867A1 (en) * 2001-06-29 2003-02-06 Myriad Genetics, Incorporated Use of R-NSAID compounds for anti-HIV treatment
TW200413009A (en) * 2002-10-04 2004-08-01 Univ Pennsylvania Biphenyls and fluorenes as imaging agents in alzheimer's disease
JP2006335639A (ja) * 2003-01-23 2006-12-14 Nagase & Co Ltd 光学活性なフルルビプロフェンの製造方法
WO2004071431A2 (en) * 2003-02-05 2004-08-26 Myriad Genetics, Inc. Method and composition for treating neurodegenerative disorders
JP2007528857A (ja) * 2003-07-11 2007-10-18 ミリアド ジェネティクス， インコーポレイテッド アルツハイマー病の処置のための薬学的方法、投与レジメンおよび投薬形態
US20050171207A1 (en) * 2003-09-26 2005-08-04 Myriad Genetics, Incorporated Method and composition for combination treatment of neurodegenerative disorders
WO2006001877A2 (en) * 2004-04-13 2006-01-05 Myriad Genetics, Inc. Combination treatment for neurodegenerative disorders comprising r-flurbiprofen
KR20070004036A (ko) * 2004-04-29 2007-01-05 키스톤 리테이닝 월 시스템스, 아이엔씨 벽, 옹벽 및 그 외 유사한 것을 위한 베니어
WO2006020852A2 (en) * 2004-08-11 2006-02-23 Myriad Genetics, Inc. Pharmaceutical composition and method for treating neurodegenerative disorders
BRPI0514303A (pt) * 2004-08-11 2008-06-10 Myriad Genetics Inc composição farmacêutica e método para tratar distúrbios neurodegenerativos
WO2006020850A2 (en) * 2004-08-11 2006-02-23 Myriad Genetics, Inc. Pharmaceutical composition and method for treating neurodegenerative disorders
WO2006021441A1 (en) * 2004-08-25 2006-03-02 Cellzome Ag Biphenyl-carboxylic acids and derivatives thereof and their use in therapy
US20070015832A1 (en) * 2005-07-14 2007-01-18 Myriad Genetics, Incorporated Methods of treating overactive bladder and urinary incontinence
WO2008006099A2 (en) * 2006-07-07 2008-01-10 Myriad Genetics, Inc. Treatment of psychiatric disorders
WO2008095186A1 (en) * 2007-02-01 2008-08-07 Myriad Genetics, Inc. Drug substance preparations, pharmaceutical compositions and dosage forms
EA201491238A1 (ru) 2012-01-31 2014-12-30 Сановел Илач Санайи Ве Тиджарет Аноним Ширкети Новая фармацевтическая композиция флурбипрофена и глюкозамина
EP2948133B1 (de) 2013-01-28 2016-09-07 Sanovel Ilac Sanayi ve Ticaret A.S. Pharmazeutische kombinationen aus flurbiprofen, glucosamin und capsaicin
CN109553533A (zh) * 2017-09-27 2019-04-02 江苏瑞科医药科技有限公司 氟比洛芬中间体及其制备方法
CN116875296A (zh) * 2023-09-08 2023-10-13 东营玺诺石油科技有限公司 一种储层改造用固态酸前体

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4052514A (en) * 1971-03-26 1977-10-04 The Boots Company Limited Trihalosubstituted biphenylyl propionic acids
FR2173886A1 (de) * 1972-02-08 1973-10-12 Thomae Gmbh Dr K
US3969402A (en) * 1972-06-15 1976-07-13 The Boots Company Limited Phenylalkanoic acids
US4048332A (en) * 1972-06-15 1977-09-13 The Boots Company Limited Phenylalkanoic acids
US3957861A (en) * 1973-11-07 1976-05-18 The Upjohn Company Biphenylylpropionic acids and esters
US4304931A (en) * 1975-04-04 1981-12-08 The Boots Company Limited Biphenylhydroxypropionic acid derivatives
WO1999041224A1 (en) * 1998-02-13 1999-08-19 Merck Frosst Canada & Co. Biaryl-acetic acid derivatives and their use as cox-2 inhibitors

Also Published As

Publication number Publication date
US3821293A (en) 1974-06-28
FR1430359A (fr) 1966-03-04
US3793457A (en) 1974-02-19
CS163157B2 (de) 1975-08-29
CH454822A (fr) 1968-04-30
SE324759B (de) 1970-06-15
DE1518528B2 (de) 1974-04-18
FI42712C (fi) 1970-10-12
US3755427A (en) 1973-08-28
DK127251B (da) 1973-10-08
DE1518528A1 (de) 1969-02-27
NL152540B (nl) 1977-03-15
FR5737M (de) 1968-03-04
CS163156B2 (de) 1975-08-29
SE329843B (de) 1970-10-26
IL22772A (en) 1969-02-27
FR5738M (de) 1968-01-29
DE1518528C3 (de) 1974-12-05
DK116794B (da) 1970-02-16
NL6500865A (de) 1965-07-26
FI42712B (de) 1970-06-30
BE658723A (de) 1965-07-22

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