GB1003308A - Novel pregnane derivatives and processes for their preparation - Google Patents

Novel pregnane derivatives and processes for their preparation

Info

Publication number
GB1003308A
GB1003308A GB32839/64A GB3283964A GB1003308A GB 1003308 A GB1003308 A GB 1003308A GB 32839/64 A GB32839/64 A GB 32839/64A GB 3283964 A GB3283964 A GB 3283964A GB 1003308 A GB1003308 A GB 1003308A
Authority
GB
United Kingdom
Prior art keywords
preparation
sulphonic
processes
group
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB32839/64A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of GB1003308A publication Critical patent/GB1003308A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B1/00—Multi-cylinder machines or pumps characterised by number or arrangement of cylinders
    • F04B1/04—Multi-cylinder machines or pumps characterised by number or arrangement of cylinders having cylinders in star- or fan-arrangement
    • F04B1/06—Control

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises a 21-hydroxy-pregnane sulphonate of the general formula <FORM:1003308/C2/1> wherein R1 represents = O, or H together with a hydroxy or acyloxy group in which said acyloxy group is derived from an organic carboxylic acid having 1-18 carbon atoms, R2 represents two hydrogen atoms, = O, or H together with a b -orientated hydroxyl group, Y represents either a halogen atom or the group -O.SO2.Y; and the A ring may contain a double bond at the 4(5) position and a process for the preparation thereof wherein a compound of the formula <FORM:1003308/C2/2> (wherein R1 and R2 are as defined above and the A ring may contain a 4(5) double bond) is reacted with the functional derivative of a sulphonic acid to form the corresponding sulphonate e.g. methane sulphonic, p-toluene-sulphonic, benzenesulphonic or naphthalene sulphonic acid may be employed. Specifications 967,078, 970,586 and 1,003,308 are referred to.
GB32839/64A 1961-06-09 1962-06-08 Novel pregnane derivatives and processes for their preparation Expired GB1003308A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR864451A FR1373654A (en) 1961-06-09 1961-06-09 Hydroxymethyl pregnane derivatives and method of preparation

Publications (1)

Publication Number Publication Date
GB1003308A true GB1003308A (en) 1965-09-02

Family

ID=8756914

Family Applications (3)

Application Number Title Priority Date Filing Date
GB32839/64A Expired GB1003308A (en) 1961-06-09 1962-06-08 Novel pregnane derivatives and processes for their preparation
GB32840/64A Expired GB1003309A (en) 1961-06-09 1962-06-08 Novel derivatives of the pregnane series and their production
GB22347/62A Expired GB1003307A (en) 1961-06-09 1962-06-08 Novel therapeutically-active steroid compounds, their preparation and formulation into pharmaceutical compositions

Family Applications After (2)

Application Number Title Priority Date Filing Date
GB32840/64A Expired GB1003309A (en) 1961-06-09 1962-06-08 Novel derivatives of the pregnane series and their production
GB22347/62A Expired GB1003307A (en) 1961-06-09 1962-06-08 Novel therapeutically-active steroid compounds, their preparation and formulation into pharmaceutical compositions

Country Status (8)

Country Link
BE (1) BE618714A (en)
CH (1) CH411866A (en)
DK (1) DK103125C (en)
ES (1) ES278091A1 (en)
FR (2) FR1373654A (en)
GB (3) GB1003308A (en)
NL (1) NL279265A (en)
SE (1) SE310674B (en)

Also Published As

Publication number Publication date
GB1003307A (en) 1965-09-02
CH411866A (en) 1966-04-30
ES278091A1 (en) 1962-12-01
NL279265A (en)
SE310674B (en) 1969-05-12
BE618714A (en) 1962-12-14
DK103125C (en) 1965-11-22
FR1508M (en) 1962-10-01
FR1373654A (en) 1964-10-02
GB1003309A (en) 1965-09-02

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