GB830009A - Hexahydrobenzoate of 19-nor-testosterone - Google Patents

Hexahydrobenzoate of 19-nor-testosterone

Info

Publication number
GB830009A
GB830009A GB35507/56A GB3550756A GB830009A GB 830009 A GB830009 A GB 830009A GB 35507/56 A GB35507/56 A GB 35507/56A GB 3550756 A GB3550756 A GB 3550756A GB 830009 A GB830009 A GB 830009A
Authority
GB
United Kingdom
Prior art keywords
testosterone
condensation
halide
hexahydrobenzoyl
hexahydrobenzoate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB35507/56A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Francais de Chimiotherapie SA
Original Assignee
Laboratoires Francais de Chimiotherapie SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Francais de Chimiotherapie SA filed Critical Laboratoires Francais de Chimiotherapie SA
Publication of GB830009A publication Critical patent/GB830009A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises the hexahydrobenzoate of 19-nor-testosterone and the preparation thereof by condensing in the presence of a condensation agent a hexahydrobenzoyl halide, hexahydrobenzoic acid or hexahydrobenzoic acid anhydride with 19-nor-testosterone, the condensation being effected in solution. The condensation agent may be a substance capable of taking up hydrogen halide, e.g. a tertiary organic base such as pyridine, particularly when a hexahydrobenzoyl halide is used in the condensation. A suitable reaction temperature is in the range of from 10 DEG to 35 DEG C. The above process may be modified in that a known intermediate compound occurring in the production of 19-nor-testosterone, said intermediate having a free hydroxy group in the 17-position, is hexahydrobenzoylated by condensation with a hexahydrobenzoyl halide, hexahydrobenzoic acid or its anhydride, and the resulting 17-hexahydrobenzoylated derivative is converted to the hexahydrobenzoate of 19-nor-testosterone by known methods. One detailed example is given.
GB35507/56A 1955-12-06 1956-11-20 Hexahydrobenzoate of 19-nor-testosterone Expired GB830009A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR830009X 1955-12-06

Publications (1)

Publication Number Publication Date
GB830009A true GB830009A (en) 1960-03-09

Family

ID=9284690

Family Applications (1)

Application Number Title Priority Date Filing Date
GB35507/56A Expired GB830009A (en) 1955-12-06 1956-11-20 Hexahydrobenzoate of 19-nor-testosterone

Country Status (1)

Country Link
GB (1) GB830009A (en)

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