GB922597A - - Google Patents

Info

Publication number
GB922597A
GB922597A GB2732059A GB2732059A GB922597A GB 922597 A GB922597 A GB 922597A GB 2732059 A GB2732059 A GB 2732059A GB 2732059 A GB2732059 A GB 2732059A GB 922597 A GB922597 A GB 922597A
Authority
GB
United Kingdom
Prior art keywords
halogen
androsten
oxido
hydrogen halide
androstan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2732059A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of GB922597A publication Critical patent/GB922597A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises 2 2-halogen-D 1-androsten-17b -ol-3-ones (including a 1- or 17a -methyl homologue thereof, or a corresponding 19-nor compound of the said D 1-androsten or homologue thereof), and the corresponding 17b -acylates, and the preparation thereof by introducing halogen at the 2-position of the required D 1-androsten-17b -ol-3-one by a method known per se for the introduction of halogen at the 2-position and, when required, acylating the product to form a 17b -acylate. The halogenation at the 2-position may be carried out by adding halogen to the 1,2-double bond and then eliminating the halogen at the 1-position as hydrogen halide from the resulting 1,2-di-halogenoandrostan- 17b -ol-3-one, e.g. by means of pyridine, or by treating a 1,2-oxido-androstan-17b -ol-3-one with a hydrogen halide in chloroform which also eliminates water from the intermediate 1-hydroxy-2-halogenandrostan- 17b -ol- 3-one, or by treating an alcoholysis product of a 1,2-oxido-androstan-17b -ol-3-one (obtainable, for example, by treatment of the oxido compound with alcohol such as methanol, in the presence of perchloric acid) with hydrogen halide in an inert solvent.
GB2732059A 1958-08-30 1959-08-10 Expired GB922597A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DESCH24647A DE1076127B (en) 1958-08-30 1958-08-30 Process for the production of anabolic steroids with low androgenic side effects

Publications (1)

Publication Number Publication Date
GB922597A true GB922597A (en) 1963-04-03

Family

ID=7429931

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2732059A Expired GB922597A (en) 1958-08-30 1959-08-10

Country Status (2)

Country Link
DE (1) DE1076127B (en)
GB (1) GB922597A (en)

Also Published As

Publication number Publication date
DE1076127B (en) 1960-02-25

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