ES235037A1 - Procedure for the preparation of new compounds 19-nesteroidicos biologically active (Machine-translation by Google Translate, not legally binding)
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Procedure for the preparation of new compounds 19-nesteroidicos biologically active (Machine-translation by Google Translate, not legally binding)
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Organon NV
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Organon NV
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Publication of ES235037A1publicationCriticalpatent/ES235037A1/en
Process for the preparation of new biologically active 19-nor-steroid compounds, characterized in that a steroid compound with an aromatic ring A, which in position 3 has an etherified hydroxyl group, in position 17 a free or functionally converted hydroxyl group and an atom of hydrogen, or a free or functionally converted hydroxyl group and a lower aliphatic hydrocarbon radical, and which may further contain one or more double bonds, hydroxyl groups and free or functionally converted oxo groups, lower alkyl groups and halogen atoms, is reacted with an alkali metal in a lower aliphatic primary amine, as a result of which a Δ 4-19-nor-androstenic compound is formed which is not oxygenated in the 3-position, after which if the double is desired (s) link (s) present (s) are reduced (n) and/or one or more of the secondary hydroxyl groups live or functionally present converted they are oxidized, or respectively hydrolyzed, and oxidized to an oxo group. (Machine-translation by Google Translate, not legally binding)
ES0235037A1956-12-051957-04-24Procedure for the preparation of new compounds 19-nesteroidicos biologically active (Machine-translation by Google Translate, not legally binding)
ExpiredES235037A1
(en)
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