GB0203193D0 - Nicotinamide derivatives useful as pde4 inhibitors - Google Patents

Nicotinamide derivatives useful as pde4 inhibitors

Info

Publication number
GB0203193D0
GB0203193D0 GBGB0203193.8A GB0203193A GB0203193D0 GB 0203193 D0 GB0203193 D0 GB 0203193D0 GB 0203193 A GB0203193 A GB 0203193A GB 0203193 D0 GB0203193 D0 GB 0203193D0
Authority
GB
United Kingdom
Prior art keywords
pde4 inhibitors
derivatives useful
nicotinamide derivatives
nicotinamide
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB0203193.8A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Priority to GBGB0203193.8A priority Critical patent/GB0203193D0/en
Publication of GB0203193D0 publication Critical patent/GB0203193D0/en
Priority to AU2003245812A priority patent/AU2003245812A1/en
Priority to EP03700974A priority patent/EP1476157A1/en
Priority to MXPA04007736A priority patent/MXPA04007736A/es
Priority to PCT/IB2003/000377 priority patent/WO2003068232A1/en
Priority to JP2003567414A priority patent/JP2005522449A/ja
Priority to AU2003202116A priority patent/AU2003202116A1/en
Priority to PCT/IB2003/000379 priority patent/WO2003068234A1/en
Priority to BR0307574-5A priority patent/BR0307574A/pt
Priority to CA002475708A priority patent/CA2475708A1/en
Priority to TW092102415A priority patent/TW200304824A/zh
Priority to US10/360,122 priority patent/US20030191158A1/en
Priority to US10/361,083 priority patent/US6756392B2/en
Priority to TW092102422A priority patent/TW200307545A/zh
Priority to ARP030100406A priority patent/AR038404A1/es
Priority to HN2003000062A priority patent/HN2003000062A/es
Priority to SV2003001481A priority patent/SV2004001481A/es
Priority to GT200300034A priority patent/GT200300034A/es
Priority to GT200300033A priority patent/GT200300033A/es
Priority to UY27657A priority patent/UY27657A1/es
Priority to PA20038566501A priority patent/PA8566501A1/es
Priority to UY27658A priority patent/UY27658A1/es
Priority to PE2003000148A priority patent/PE20030921A1/es
Priority to PA20038566601A priority patent/PA8566601A1/es
Priority to PE2003000149A priority patent/PE20030860A1/es
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
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    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

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GBGB0203193.8A 2002-02-11 2002-02-11 Nicotinamide derivatives useful as pde4 inhibitors Ceased GB0203193D0 (en)

Priority Applications (25)

Application Number Priority Date Filing Date Title
GBGB0203193.8A GB0203193D0 (en) 2002-02-11 2002-02-11 Nicotinamide derivatives useful as pde4 inhibitors
AU2003245812A AU2003245812A1 (en) 2002-02-11 2003-02-03 Nicotinamide derivatives and a tiotropium salt in combination for the treatment of e.g. inflammatory, allergic and respiratory diseases
EP03700974A EP1476157A1 (en) 2002-02-11 2003-02-03 Nicotinamide derivatives useful as pde4 inhibitors
MXPA04007736A MXPA04007736A (es) 2002-02-11 2003-02-03 Derivados de nicotinamida utiles como inhibidores de pde4.
PCT/IB2003/000377 WO2003068232A1 (en) 2002-02-11 2003-02-03 Nicotinamide derivatives useful as pde4 inhibitors
JP2003567414A JP2005522449A (ja) 2002-02-11 2003-02-03 Ｐｄｅ４阻害剤として有用なニコチンアミド誘導体
AU2003202116A AU2003202116A1 (en) 2002-02-11 2003-02-03 Nicotinamide derivatives useful as pde4 inhibitors
PCT/IB2003/000379 WO2003068234A1 (en) 2002-02-11 2003-02-03 Nicotinamide derivatives and a tiotropium salt in combination for the treatment of e.g. inflammatory, allergic and respiratory diseases
BR0307574-5A BR0307574A (pt) 2002-02-11 2003-02-03 Derivados de nicotinamida úteis como inibidores de pde4
CA002475708A CA2475708A1 (en) 2002-02-11 2003-02-03 Nicotinamide derivatives useful as pde4 inhibitors
TW092102422A TW200307545A (en) 2002-02-11 2003-02-06 Nicotinamide derivatives and a tiotropium salt in combination for the treatment of diseases
US10/361,083 US6756392B2 (en) 2002-02-11 2003-02-06 Nicotinamide derivatives useful as PDE4 inhibitors
US10/360,122 US20030191158A1 (en) 2002-02-11 2003-02-06 Nicotinamide derivatives and a tiotropium salt in combination for the treatment of diseases
TW092102415A TW200304824A (en) 2002-02-11 2003-02-06 Nicotinamide derivatives useful as PDE4 inhibitors
GT200300033A GT200300033A (es) 2002-02-11 2003-02-10 Derivados de nicotinamida utiles como inhibidores de pde4
GT200300034A GT200300034A (es) 2002-02-11 2003-02-10 Derivados de nicotinamida y una sal de tiotropio en combinacion para el tratamiento de enfermedades
HN2003000062A HN2003000062A (es) 2002-02-11 2003-02-10 Derivados de nicotinamida utiles como inhibidores de pde4
SV2003001481A SV2004001481A (es) 2002-02-11 2003-02-10 Derivados de nicotinamida utiles como inhibidores de pde4" ref. pc22065a
ARP030100406A AR038404A1 (es) 2002-02-11 2003-02-10 Derivados de nicotinamida utiles como inhibidores de pde4, procedimiento para la preparacion del compuesto y composicion farmaceutica que lo incluye
UY27657A UY27657A1 (es) 2002-02-11 2003-02-11 Derivados de nicotinamida útiles como inhibidores de pde4
PA20038566501A PA8566501A1 (es) 2002-02-11 2003-02-11 Derivados de nicotinamida y una sal de tiotropio en combinacion para el tratamiento de enfermedades
UY27658A UY27658A1 (es) 2002-02-11 2003-02-11 Derivados de nicotinamida y una sal de tiotropio en combinación para el tratamiento de enfermedades
PE2003000148A PE20030921A1 (es) 2002-02-11 2003-02-11 Derivados de nicotinamida y una sal de tiotropio en combinacion para el tratamiento de enfermedades
PA20038566601A PA8566601A1 (es) 2002-02-11 2003-02-11 Derivados de nicotinamida utiles como inhibidores de pde4
PE2003000149A PE20030860A1 (es) 2002-02-11 2003-02-11 Derivados de nicotamida utiles como inhibidores de pde4

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0203193.8A GB0203193D0 (en) 2002-02-11 2002-02-11 Nicotinamide derivatives useful as pde4 inhibitors

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GB0203193D0 true GB0203193D0 (en) 2002-03-27

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GBGB0203193.8A Ceased GB0203193D0 (en) 2002-02-11 2002-02-11 Nicotinamide derivatives useful as pde4 inhibitors

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JP (1) JP2005522449A (ja)
AR (1) AR038404A1 (ja)
AU (2) AU2003202116A1 (ja)
BR (1) BR0307574A (ja)
CA (1) CA2475708A1 (ja)
GB (1) GB0203193D0 (ja)
GT (2) GT200300034A (ja)
HN (1) HN2003000062A (ja)
MX (1) MXPA04007736A (ja)
PA (2) PA8566601A1 (ja)
PE (2) PE20030921A1 (ja)
SV (1) SV2004001481A (ja)
TW (2) TW200304824A (ja)
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WO (2) WO2003068232A1 (ja)

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US7105682B2 (en) 2001-01-12 2006-09-12 Amgen Inc. Substituted amine derivatives and methods of use
US7102009B2 (en) 2001-01-12 2006-09-05 Amgen Inc. Substituted amine derivatives and methods of use
US6878714B2 (en) 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
US6995162B2 (en) 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
RS70104A (en) 2002-02-11 2007-02-05 Pfizer Limited, Nicotinamide derivatives useful as pde4 inhibitors
US7307088B2 (en) 2002-07-09 2007-12-11 Amgen Inc. Substituted anthranilic amide derivatives and methods of use
GB0317484D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as pde4 inhibitors
GB0317482D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as pde4 inhibitors
GB0317516D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as PDE4 inhibitors
US7153870B2 (en) 2003-07-25 2006-12-26 Pfizer Inc. Nicotinamide derivatives useful as PDE4 inhibitors
GB0317509D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as PDE4 inhibitors
JPWO2005026132A1 (ja) * 2003-09-17 2007-11-08 日本新薬株式会社 ホスホジエステラーゼのｃＡＭＰ基質特異的阻害剤
SI2067779T1 (sl) 2003-11-03 2013-08-30 Boehringer Ingelheim International Gmbh Tiotropijeve soli, postopek za njihovo pripravo in formulacije zdravil, ki jih vsebujejo
JP2007517820A (ja) * 2004-01-09 2007-07-05 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング スコピンエステル及びニコチンアミド誘導体を基にした新規な医薬組成物
WO2006106711A1 (ja) * 2005-03-30 2006-10-12 Eisai R & D Management Co., Ltd. ピリジン誘導体を含有する抗真菌剤
JP2009504602A (ja) * 2005-08-08 2009-02-05 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング チオトロピウム塩類を投与することを含む心疾患のリスクに対する保護の方法
DE102005049429A1 (de) 2005-10-15 2007-04-19 Cognis Ip Management Gmbh Verfahren zur Ausrüstung von Textilien
JP2009512677A (ja) * 2005-10-19 2009-03-26 ランバクシー ラボラトリーズ リミテッド ホスホジエステラーゼタイプｉｖ阻害剤の組成物
US8247556B2 (en) 2005-10-21 2012-08-21 Amgen Inc. Method for preparing 6-substituted-7-aza-indoles
TWI385169B (zh) 2005-10-31 2013-02-11 Eisai R&D Man Co Ltd 經雜環取代之吡啶衍生物及含有彼之抗真菌劑
PL2068873T3 (pl) * 2006-09-14 2012-05-31 Bridge Bioresearch Rights Jersey Ltd Mediowane przez izoniazyd gojenie ran i owrzodzeń
US8513287B2 (en) 2007-12-27 2013-08-20 Eisai R&D Management Co., Ltd. Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same
CN109020825B (zh) * 2017-06-12 2021-03-19 重庆医科大学 抗流感病毒化合物及其制备方法

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DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
BR9810733A (pt) * 1997-04-04 2000-09-12 Pfizer Prod Inc Derivados de nicotinamida

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WO2003068232A1 (en) 2003-08-21
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AU2003245812A1 (en) 2003-09-04
HN2003000062A (es) 2003-09-24
PE20030860A1 (es) 2003-10-25
PA8566601A1 (es) 2003-11-12
AU2003202116A1 (en) 2003-09-04
AR038404A1 (es) 2005-01-12
TW200307545A (en) 2003-12-16
MXPA04007736A (es) 2004-10-15
PE20030921A1 (es) 2003-11-05
GT200300033A (es) 2003-10-11
UY27657A1 (es) 2003-09-30
JP2005522449A (ja) 2005-07-28
SV2004001481A (es) 2004-05-07
PA8566501A1 (es) 2003-11-12
CA2475708A1 (en) 2003-08-21
EP1476157A1 (en) 2004-11-17
UY27658A1 (es) 2003-09-30
BR0307574A (pt) 2004-12-21

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