GB0002952D0 - Process for producing kahalalide F compounds - Google Patents

Process for producing kahalalide F compounds

Info

Publication number
GB0002952D0
GB0002952D0 GBGB0002952.0A GB0002952A GB0002952D0 GB 0002952 D0 GB0002952 D0 GB 0002952D0 GB 0002952 A GB0002952 A GB 0002952A GB 0002952 D0 GB0002952 D0 GB 0002952D0
Authority
GB
United Kingdom
Prior art keywords
kahalalide
compounds
producing
leads
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB0002952.0A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmamar SA
Original Assignee
Pharmamar SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmamar SA filed Critical Pharmamar SA
Priority to GBGB0002952.0A priority Critical patent/GB0002952D0/en
Publication of GB0002952D0 publication Critical patent/GB0002952D0/en
Priority to PT01904169T priority patent/PT1254162E/pt
Priority to EP01904169A priority patent/EP1254162B1/en
Priority to HU0301817A priority patent/HUP0301817A3/hu
Priority to PL356800A priority patent/PL207121B1/pl
Priority to CN01807743A priority patent/CN1422278A/zh
Priority to CA2399187A priority patent/CA2399187C/en
Priority to US10/182,881 priority patent/US7482429B2/en
Priority to DK01904169T priority patent/DK1254162T3/da
Priority to KR1020027010355A priority patent/KR100871489B1/ko
Priority to SK1124-2002A priority patent/SK11242002A3/sk
Priority to HK02108862.6A priority patent/HK1047290B/en
Priority to PCT/GB2001/000576 priority patent/WO2001058934A2/en
Priority to ES01904169T priority patent/ES2292558T3/es
Priority to CZ2002-2740A priority patent/CZ304258B6/cs
Priority to AU32086/01A priority patent/AU783542B2/en
Priority to CN200810178807.9A priority patent/CN101597326B/zh
Priority to NZ520488A priority patent/NZ520488A/en
Priority to AT01904169T priority patent/ATE371667T1/de
Priority to JP2001558081A priority patent/JP5188665B2/ja
Priority to EP07010878A priority patent/EP1829889A3/en
Priority to DE60130192T priority patent/DE60130192T2/de
Priority to BR0108213-2A priority patent/BR0108213A/pt
Priority to RU2002123877/04A priority patent/RU2280039C2/ru
Priority to IL15098101A priority patent/IL150981A0/xx
Priority to MXPA02007760A priority patent/MXPA02007760A/es
Priority to EP10178150A priority patent/EP2258715A1/en
Priority to UA2002097267A priority patent/UA76949C2/uk
Priority to IL150981A priority patent/IL150981A/en
Priority to NO20023749A priority patent/NO331847B1/no
Priority to BG107020A priority patent/BG65926B1/bg
Priority to CY20071101442T priority patent/CY1106992T1/el
Priority to US12/198,013 priority patent/US20080318849A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Optical Record Carriers And Manufacture Thereof (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Detergent Compositions (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
GBGB0002952.0A 2000-02-09 2000-02-09 Process for producing kahalalide F compounds Ceased GB0002952D0 (en)

Priority Applications (33)

Application Number Priority Date Filing Date Title
GBGB0002952.0A GB0002952D0 (en) 2000-02-09 2000-02-09 Process for producing kahalalide F compounds
EP10178150A EP2258715A1 (en) 2000-02-09 2001-02-09 Kahalalide compounds
CN200810178807.9A CN101597326B (zh) 2000-02-09 2001-02-09 kahalalide F 及相关化合物
NZ520488A NZ520488A (en) 2000-02-09 2001-02-09 Kahalalide compounds
HU0301817A HUP0301817A3 (en) 2000-02-09 2001-02-09 Kahalalide compounds, process for preparing thereof, pharmaceutical compositions comprising them and their use
PL356800A PL207121B1 (pl) 2000-02-09 2001-02-09 Związek kahalalidowy, zastosowanie związku, kompozycja farmaceutyczna oraz sposób wytwarzania związku kahalalidowego
CN01807743A CN1422278A (zh) 2000-02-09 2001-02-09 kahalalide F及相关化合物
CA2399187A CA2399187C (en) 2000-02-09 2001-02-09 Kahalalide compounds
US10/182,881 US7482429B2 (en) 2000-02-09 2001-02-09 Kahalalide F and related compounds
DK01904169T DK1254162T3 (da) 2000-02-09 2001-02-09 Kahalalid F og beslægtede forbindelser
KR1020027010355A KR100871489B1 (ko) 2000-02-09 2001-02-09 카할라이드 화합물
SK1124-2002A SK11242002A3 (sk) 2000-02-09 2001-02-09 Zlúčenina, spôsob prípravy zlúčeniny, farmaceutický prostriedok a spôsob liečenia rakoviny
HK02108862.6A HK1047290B (en) 2000-02-09 2001-02-09 Kahalalide f and related compounds
PCT/GB2001/000576 WO2001058934A2 (en) 2000-02-09 2001-02-09 Kahalalide f and related compounds
ES01904169T ES2292558T3 (es) 2000-02-09 2001-02-09 Kahalalido f y compuestos relacionados.
CZ2002-2740A CZ304258B6 (cs) 2000-02-09 2001-02-09 Kahalalidová sloučenina, způsob její přípravy, farmaceutický prostředek ji obsahující a její použití
AU32086/01A AU783542B2 (en) 2000-02-09 2001-02-09 Kahalalide compounds
PT01904169T PT1254162E (pt) 2000-02-09 2001-02-09 Kahalalide f e compostos relacionados
JP2001558081A JP5188665B2 (ja) 2000-02-09 2001-02-09 カハラリド化合物
EP01904169A EP1254162B1 (en) 2000-02-09 2001-02-09 Kahalalide f and related compounds
AT01904169T ATE371667T1 (de) 2000-02-09 2001-02-09 Kahalalide f und verwandte verbindungen
EP07010878A EP1829889A3 (en) 2000-02-09 2001-02-09 Kahalalide f and related compounds
DE60130192T DE60130192T2 (de) 2000-02-09 2001-02-09 Kahalalide f und verwandte verbindungen
BR0108213-2A BR0108213A (pt) 2000-02-09 2001-02-09 Compostos de cahalalida
RU2002123877/04A RU2280039C2 (ru) 2000-02-09 2001-02-09 Кахалалидные соединения
IL15098101A IL150981A0 (en) 2000-02-09 2001-02-09 Kahalalide derivatives and pharmaceutical compositions containing the same
MXPA02007760A MXPA02007760A (es) 2000-02-09 2001-02-09 Compuestos de kahalalida.
UA2002097267A UA76949C2 (en) 2000-02-09 2001-09-02 Kahalalide compounds
IL150981A IL150981A (en) 2000-02-09 2002-07-30 Khalalid's History and Pharmaceuticals containing them
NO20023749A NO331847B1 (no) 2000-02-09 2002-08-08 Kahalalid-forbindelse, farmasoytisk preparat som omfatter forbindelsen, anvendelse av forbindelsen for fremstilling av et medikament for behandling av kreft og fremgangsmate for syntetisering av en forbindelse.
BG107020A BG65926B1 (bg) 2000-02-09 2002-08-21 Кахалалидни съединения
CY20071101442T CY1106992T1 (el) 2000-02-09 2007-11-08 Καχαλαλιδη f και συναφεις ενωσεις
US12/198,013 US20080318849A1 (en) 2000-02-09 2008-08-25 Kahalalide F and Related Compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0002952.0A GB0002952D0 (en) 2000-02-09 2000-02-09 Process for producing kahalalide F compounds

Publications (1)

Publication Number Publication Date
GB0002952D0 true GB0002952D0 (en) 2000-03-29

Family

ID=9885232

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB0002952.0A Ceased GB0002952D0 (en) 2000-02-09 2000-02-09 Process for producing kahalalide F compounds

Country Status (27)

Country Link
US (2) US7482429B2 (https=)
EP (3) EP1829889A3 (https=)
JP (1) JP5188665B2 (https=)
KR (1) KR100871489B1 (https=)
CN (2) CN101597326B (https=)
AT (1) ATE371667T1 (https=)
AU (1) AU783542B2 (https=)
BG (1) BG65926B1 (https=)
BR (1) BR0108213A (https=)
CA (1) CA2399187C (https=)
CY (1) CY1106992T1 (https=)
CZ (1) CZ304258B6 (https=)
DE (1) DE60130192T2 (https=)
DK (1) DK1254162T3 (https=)
ES (1) ES2292558T3 (https=)
GB (1) GB0002952D0 (https=)
HU (1) HUP0301817A3 (https=)
IL (2) IL150981A0 (https=)
MX (1) MXPA02007760A (https=)
NO (1) NO331847B1 (https=)
NZ (1) NZ520488A (https=)
PL (1) PL207121B1 (https=)
PT (1) PT1254162E (https=)
RU (1) RU2280039C2 (https=)
SK (1) SK11242002A3 (https=)
UA (1) UA76949C2 (https=)
WO (1) WO2001058934A2 (https=)

Families Citing this family (24)

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Publication number Priority date Publication date Assignee Title
US6274551B1 (en) * 1994-02-03 2001-08-14 Pharmamar, S.A. Cytotoxic and antiviral compound
GB0002952D0 (en) * 2000-02-09 2000-03-29 Pharma Mar Sa Process for producing kahalalide F compounds
NZ525243A (en) 2000-10-31 2005-01-28 Pharma Mar S A lyophilised formulation comprising kahalalide F, a peptide isolated from a herbivorous marine species of mollusc, Elysia rufescens, to treat cancer
US20050054555A1 (en) * 2001-10-19 2005-03-10 Jose Jimeno Kahalalide compounds for use in cancer therapy
GB0304367D0 (en) * 2003-02-26 2003-04-02 Pharma Mar Sau Methods for treating psoriasis
US7507708B2 (en) * 2003-02-26 2009-03-24 Pharma Mar, S.A.U. Antitumoral compounds
GB0321066D0 (en) * 2003-09-09 2003-10-08 Pharma Mar Sau New antitumoral compounds
GB0408958D0 (en) * 2004-04-22 2004-05-26 Pharma Mar Sa Convergent synthesis for kahalalide compounds
CN100396696C (zh) * 2004-04-23 2008-06-25 中国科学院海洋研究所 一种海洋绿藻在提取抗肿瘤活性环肽组分中的应用
WO2009052379A2 (en) * 2007-10-19 2009-04-23 Pharma Mar, S.A. Improved antitumoral treatments
EP2252315A1 (en) * 2008-01-30 2010-11-24 Pharma Mar, S.A. Improved antitumoral treatments
EP2262522A1 (en) * 2008-03-07 2010-12-22 Pharma Mar, S.A. Improved antitumoral treatments
CN103641891B (zh) * 2013-05-23 2017-03-22 深圳翰宇药业股份有限公司 一种制备Kahalalide F的方法
CA2999367C (en) 2015-09-23 2023-09-26 Xw Laboratories Inc. Prodrugs of gamma-hydroxybutyric acid, compositions and uses thereof
EP3601235B1 (en) 2017-03-30 2026-03-04 XWPharma Ltd. Bicyclic heteroaryl derivatives, preparation and therapeutic uses thereof
KR102491180B1 (ko) 2017-04-27 2023-01-20 파르마 마르 에스.에이. 항종양 화합물
CN114042070A (zh) 2018-09-30 2022-02-15 凯瑞康宁生物工程（武汉）有限公司 作为神经元组胺受体-3拮抗剂的化合物及其用途
TWI899126B (zh) 2019-12-20 2025-10-01 香港商凱瑞康寧有限公司 ４－纈胺醯氧基丁酸的合成方法
AU2021293941B2 (en) 2020-06-18 2024-03-28 XWPharma Ltd. Pharmaceutical granulations of water-soluble active pharmaceutical ingredients
CN115038432B (zh) 2020-06-18 2023-12-26 凯瑞康宁生物工程（武汉）有限公司 水溶性活性药物成分的控制释放制粒
WO2022020621A1 (en) 2020-07-24 2022-01-27 XWPharma Ltd. Pharmaceutical compositions and pharmacokinetics of a gamma-hydroxybutyric acid derivative
EP4225274A1 (en) 2020-10-05 2023-08-16 XWPharma Ltd. Modified release compositions of a gamma-hydroxybutyric acid derivative
JP2024511991A (ja) 2021-03-19 2024-03-18 エックスダブリューファーマ リミテッド ガンマ－ヒドロキシ酪酸誘導体の組み合わされた放出製剤の薬物動態
IL314441A (en) 2022-04-21 2024-09-01 Zevra Therapeutics Inc Gamma-Hydroxybutyrate providing compounds and processes for their production and use

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GB0304367D0 (en) * 2003-02-26 2003-04-02 Pharma Mar Sau Methods for treating psoriasis
US7507708B2 (en) * 2003-02-26 2009-03-24 Pharma Mar, S.A.U. Antitumoral compounds
GB0321066D0 (en) * 2003-09-09 2003-10-08 Pharma Mar Sau New antitumoral compounds
GB0408958D0 (en) * 2004-04-22 2004-05-26 Pharma Mar Sa Convergent synthesis for kahalalide compounds

Also Published As

Publication number Publication date
CN101597326B (zh) 2014-07-09
US7482429B2 (en) 2009-01-27
DE60130192D1 (de) 2007-10-11
RU2280039C2 (ru) 2006-07-20
IL150981A (en) 2013-05-30
UA76949C2 (en) 2006-10-16
BR0108213A (pt) 2003-03-05
IL150981A0 (en) 2003-02-12
SK11242002A3 (sk) 2003-06-03
AU3208601A (en) 2001-08-20
PL356800A1 (en) 2004-07-12
EP1254162A2 (en) 2002-11-06
KR100871489B1 (ko) 2008-12-05
JP5188665B2 (ja) 2013-04-24
PT1254162E (pt) 2007-12-03
BG65926B1 (bg) 2010-05-31
CN1422278A (zh) 2003-06-04
MXPA02007760A (es) 2002-10-23
JP2003522198A (ja) 2003-07-22
EP1829889A3 (en) 2007-09-26
CN101597326A (zh) 2009-12-09
NZ520488A (en) 2005-03-24
ATE371667T1 (de) 2007-09-15
HK1047290A1 (en) 2003-02-14
NO20023749D0 (no) 2002-08-08
KR20020092951A (ko) 2002-12-12
AU783542B2 (en) 2005-11-10
CY1106992T1 (el) 2012-09-26
US20040214755A1 (en) 2004-10-28
CZ20022740A3 (cs) 2003-01-15
EP1829889A2 (en) 2007-09-05
BG107020A (bg) 2003-05-30
DE60130192T2 (de) 2008-05-21
PL207121B1 (pl) 2010-11-30
RU2002123877A (ru) 2004-01-10
ES2292558T3 (es) 2008-03-16
US20080318849A1 (en) 2008-12-25
DK1254162T3 (da) 2008-01-02
CA2399187C (en) 2011-04-19
EP2258715A1 (en) 2010-12-08
NO331847B1 (no) 2012-04-23
WO2001058934A3 (en) 2002-03-21
CA2399187A1 (en) 2001-08-16
CZ304258B6 (cs) 2014-02-05
HUP0301817A3 (en) 2011-10-28
WO2001058934A2 (en) 2001-08-16
HUP0301817A2 (hu) 2003-09-29
NO20023749L (no) 2002-10-07
EP1254162B1 (en) 2007-08-29

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