FR3091649A1 - Composition cosmetique ou pharmaceutique permettant de reduire l’immunosuppression induite par une exposition au rayonnement ultraviolet - Google Patents
Composition cosmetique ou pharmaceutique permettant de reduire l’immunosuppression induite par une exposition au rayonnement ultraviolet Download PDFInfo
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- FR3091649A1 FR3091649A1 FR1900285A FR1900285A FR3091649A1 FR 3091649 A1 FR3091649 A1 FR 3091649A1 FR 1900285 A FR1900285 A FR 1900285A FR 1900285 A FR1900285 A FR 1900285A FR 3091649 A1 FR3091649 A1 FR 3091649A1
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- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229940100460 peg-100 stearate Drugs 0.000 description 1
- 229940031709 peg-30-dipolyhydroxystearate Drugs 0.000 description 1
- 230000037368 penetrate the skin Effects 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 231100000589 photocarcinogenesis Toxicity 0.000 description 1
- 239000000467 phytic acid Substances 0.000 description 1
- 229940068041 phytic acid Drugs 0.000 description 1
- 235000002949 phytic acid Nutrition 0.000 description 1
- 229940068065 phytosterols Drugs 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000166 polytrimethylene carbonate Polymers 0.000 description 1
- IHWPQGIYXJKCOV-UHFFFAOYSA-N pongamol Natural products C1=CC=2OC=CC=2C(OC)=C1C(=O)C=C(O)C1=CC=CC=C1 IHWPQGIYXJKCOV-UHFFFAOYSA-N 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 235000010388 propyl gallate Nutrition 0.000 description 1
- 239000000473 propyl gallate Substances 0.000 description 1
- 229940075579 propyl gallate Drugs 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229960002662 propylthiouracil Drugs 0.000 description 1
- 235000019833 protease Nutrition 0.000 description 1
- 239000013635 pyrimidine dimer Substances 0.000 description 1
- 235000005875 quercetin Nutrition 0.000 description 1
- 229960001285 quercetin Drugs 0.000 description 1
- 239000000018 receptor agonist Substances 0.000 description 1
- 229940044601 receptor agonist Drugs 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229940108325 retinyl palmitate Drugs 0.000 description 1
- 235000019172 retinyl palmitate Nutrition 0.000 description 1
- 239000011769 retinyl palmitate Substances 0.000 description 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
- 229960004555 rutoside Drugs 0.000 description 1
- 229940116351 sebacate Drugs 0.000 description 1
- CXMXRPHRNRROMY-UHFFFAOYSA-L sebacate(2-) Chemical compound [O-]C(=O)CCCCCCCCC([O-])=O CXMXRPHRNRROMY-UHFFFAOYSA-L 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 229960002718 selenomethionine Drugs 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229920005573 silicon-containing polymer Polymers 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- YRWWOAFMPXPHEJ-OFBPEYICSA-K sodium L-ascorbic acid 2-phosphate Chemical compound [Na+].[Na+].[Na+].OC[C@H](O)[C@H]1OC(=O)C(OP([O-])([O-])=O)=C1[O-] YRWWOAFMPXPHEJ-OFBPEYICSA-K 0.000 description 1
- 229940048058 sodium ascorbyl phosphate Drugs 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 229940001941 soy protein Drugs 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- ARCJQKUWGAZPFX-UHFFFAOYSA-N stilbene oxide Chemical compound O1C(C=2C=CC=CC=2)C1C1=CC=CC=C1 ARCJQKUWGAZPFX-UHFFFAOYSA-N 0.000 description 1
- 150000001629 stilbenes Chemical class 0.000 description 1
- 235000021286 stilbenes Nutrition 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 125000005555 sulfoximide group Chemical group 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 230000009182 swimming Effects 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229960002663 thioctic acid Drugs 0.000 description 1
- 235000019303 thiodipropionic acid Nutrition 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 108060008226 thioredoxin Proteins 0.000 description 1
- 229940094937 thioredoxin Drugs 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 229940068778 tocotrienols Drugs 0.000 description 1
- ZRVDANDJSTYELM-FXAWDEMLSA-N totarol Chemical compound CC([C@@H]1CC2)(C)CCC[C@]1(C)C1=C2C(C(C)C)=C(O)C=C1 ZRVDANDJSTYELM-FXAWDEMLSA-N 0.000 description 1
- 229940074347 totarol Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- PJANXHGTPQOBST-UHFFFAOYSA-N trans-Stilbene Natural products C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 description 1
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 description 1
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
- ZRVDANDJSTYELM-UHFFFAOYSA-N trans-totarol Natural products C1CC2C(C)(C)CCCC2(C)C2=C1C(C(C)C)=C(O)C=C2 ZRVDANDJSTYELM-UHFFFAOYSA-N 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229960000306 zinc gluconate Drugs 0.000 description 1
- 239000011670 zinc gluconate Substances 0.000 description 1
- 235000011478 zinc gluconate Nutrition 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 239000011686 zinc sulphate Substances 0.000 description 1
- 235000009529 zinc sulphate Nutrition 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Alternative & Traditional Medicine (AREA)
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- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
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- Cosmetics (AREA)
Abstract
Description
- le filtre correspondant à la désignation INCI disodium phenyl dibenzimidazole tetrasulfonate, notamment disponible sous la dénomination Neo Heliopan® AP commercialisé par la société SYMRISE ;
- le filtre correspondant à la désignation INCI phenylbenzimidazole sulfonic acid, notamment disponible sous la dénomination Neo Heliopan® hydro commercialisé par la société SYMRISE, de préférence en combinaison avec un acide aminé basique, avantageusement de l’arginine. En pratique, l’acide aminé basique représente entre 0,5 et 2% en poids de la composition, de préférence entre 1 et 1,5%.
- le buytloctyl salicylate (INCI), photostabilisant représentant avantageusement entre 0,01% et 10% en poids de la composition, encore plus avantageusement ente 0,1% et 2%. Cette matière première est par exemple commercialisée par la société HALLSTAR sous le nom de Hallbrite®BHB ;
- le benzotriazolyl dodecyl p-cresol (INCI), photostabilisant représentant avantageusement entre 0,01% et 10% en poids de la composition, encore plus avantageusement entre 0,1% et 2%. Cette matière première est par exemple commercialisée par la société BASF sous le nom de TINOGARD®TL ;
- le pongamol (INCI), molécule végétale absorbant dans les UV-A, représentant avantageusement entre 0,5 et 2% en poids de la composition, encore plus avantageusement de l’ordre de 1%. A titre d’exemple, la matière première Pongamia Extract commercialisée par la société GIVAUDAN peut être utilisée dans le cadre la présente invention ;
- l’ethylhexyl methoxycrylene (INCI), photostabilisant, solubilisant et « booster » de SPF représentant avantageusement entre 1% et 5% en poids de la composition. La matière première SolaStay®S1 commercialisée par la société HALLSTAR peut être utilisée dans le cadre de la présente invention ;
- un copolymère de styrène acrylate (INCI : styrene/acrylate copolymer), représentant de préférence entre 1% et 10% en poids de la composition. Les matières premières SunSpheres®H53 et SunSpheres®PGL Polymer, commercialisées par la société DOW CHEMICALS, peuvent être utilisées dans le cadre de la présente invention ;
- le diethylhexyl syringylidene malonate (INCI), représentant avantageusement entre 1% et 10% en poids de la composition. La matière première OXYNET®ST, commercialisée par la société MERCK, peut être utilisée dans le cadre de la présente invention ;
- un polyester hydrodispersible, correspondant aux désignations INCI polyester-5 (and) Sodium silicoaluminate, représentant avantageusement entre 1% et 10% en poids de la composition, notamment l’EASTMANN AQTM38S Polymer commercialisé par la société SAFIC-ALCAN ;
- un copolymère d'acrylate ayant une température de transition vitreuse de -5°C à -15°C telle que mesurée par calorimétrie différentielle à balayage, ledit copolymère représentant avantageusement entre 1% et 10% en poids de la composition. Par exemple, un polymère correspondant à la désignation INCI Acrylate copolymer, tel que la matière première EPITEX 66, commercialisée par la société DOW CHEMICALS, peut être utilisée dans le cadre de la présente invention.
- un agent antiradicalaire préservant les structures cellulaires, tel que par exemple la vitamine E et/ou ses dérivés liposolubles ou hydrosolubles, en particulier le tocotriénol et/ou le tocophérol, représentant avantageusement entre 0,001 et 10% en poids total de la composition, encore plus avantageusement entre 0,02 et 2%, de préférence de l'ordre de 0,04% ;
- la vitamine PP, représentant avantageusement entre 0,001 et 1% en poids total de la composition, encore plus avantageusement de 0,01% à 0,3%;
- un agent protecteur de la protéine p53, tel que par exemple l'épigallocatéchine gallate (EGCG), représentant avantageusement entre 0,001 et 0,1% en poids total de la composition, encore plus avantageusement de 0,005% à 0,05%.
- de l’azéilate de lysine, ou d’autres dérivés ou sels de l’acide azélaïque
- de l’andrographolide, notamment l’extrait d’Andrographis paniculatacorrespondant à la désignation INCIAndrographis paniculataleaf extract ;
- de l’acide ascorbique natif (vitamine C) ou ses dérivés, notamment les dérivés correspondant aux INCI Ascorbyl Glucoside Ethyl ascorbic acid, Ascorbyl methylsilanol pectinate, Sodium ascorbyl phosphate et Ascorbyl tetraisopalmitate ;
- de l’arbutine ou un extrait végétal la contenant, notamment l’extrait de busserole correspondant à la désignation INCIArctostaphylos uva-ursileaf extract ;
- de la glabridine ou un extrait végétal la contenant, notamment les extraits de réglisse correspondant à la désignation INCIGlycyrrhiza glabraroot extract,Glycyrrhiza inflataroot extract,Glycyrrhiza uralensisroot extract ;
- les peptides biomimétiques correspondant aux désignations INCI hexapeptide 2 et/ou nonapeptide-1 ;
- un extrait aqueux d'une algue dénomméePalmaria palmata, notamment l’extrait correspondant à la désignation INCIPalmaria palmataextract ;
- le 4-n-butylresorcinol ;
- de la vitamine PP, également appelée niacinamide ou nicotinamide, et ses dérivés ;
- ou leurs mélanges.
- un agent photostabilisant ;
- un agent apte à filtrer la lumière visible, en particulier la lumière bleue ;
- un extrait de la bactérieArthrobacter agilis, avantageusement riche en caroténoïdes ;
- au moins un polyol choisi parmi le xylitol, le rhamnose, le sorbitol et le mannitol ;
- un extrait des alguesLaminaria ochroleuca,Blidingia minimaouLaminaria saccharina;
- un extrait de la planteZanthoxylum alatum;
- du panthénol ;
- de la vitamine E ou un de ses dérivés hydrophiles ou lipophiles, ou un de leurs sels, avantageusement le tocotriénol ou le tocophérol ;
- de l’acide salicylique ou un de ses dérivés ;
- un extrait de bois de cade ;
- un extrait de Boldo ;
- un extrait de Reine des prés ;
- de l’acide glycyrrhétinique ou un de ses dérivés ou sels ;
- la vitamine PP ;
- un agent protecteur de la protéine p53, avantageusement l’épigallocathéchine gallate (EGCG) ;
- un extrait d’huile de karanja issue duPongamia glabra;
- des paraffines linéaires ;
- de l'ATP (adénosine-5 tri-phosphate), du Gp4G (diguanosine tétraphosphate) ou de l’Ap4A (diadénosine tétraphosphate) ;
- un agent limitant l’action des ions fer impliqués dans la formation des radicaux libres, avantageusement l’EDTA ;
- un extrait peptidique de soja et/ou de blé ;
- un acide aminé choisi dans le groupe constitué de l’ectoïne, la créatine, l'ergothionéine, la carnosine, la tyrosine, la décarboxycarnosine, la glutamine et leurs sels ;
- un agent bronzant ou autobronzant ;
- un agent dépigmentant ;
- un agent cicatrisant ;
- un agent sébocorrecteur, kératolytique, séborégulateur et/ou antiacnéique.
Nom INCI | % |
Aqua/water/eau | 55,78800 |
Dicaprylyl carbonate | 24,99730 |
Glycerin | 5,00000 |
Dimethicone | 3,00000 |
Tribehenin PEG-20 esters | 3,00000 |
C10-18 triglycerides | 2,00000 |
Methylpropanediol | 1,40000 |
Calophyllum inophyllumseed oil | 1,00000 |
Sucrose stearate | 1,00000 |
Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer | 0,88000 |
Pentylene glycol | 0,50000 |
Tocopheryl acetate | 0,50000 |
Sodium citrate | 0,20000 |
1,2-hexanediol | 0,12500 |
Caprylyl glycol | 0,12500 |
Mannitol | 0,10000 |
Xylitol | 0,10000 |
Citric acid | 0,09000 |
Polysorbate 60 | 0,06000 |
Sorbitan isostearate | 0,06000 |
Rhamnose | 0,05000 |
Ectoin | 0,01000 |
Glycyrrhiza glabra(licorice) root extract | 0,01000 |
Tocopherol | 0,00270 |
Fructooligosaccharides | 0,00100 |
Caprylic/capric triglyceride | 0,00095 |
Laminaria ochroleucaextract | 0,00005 |
Nom INCI | % |
Aqua/water/eau | 49,81600 |
Octocrylene | 9,00000 |
Dicaprylyl carbonate | 8,49730 |
Methylene bis-benzotriazolyl tetramethylbutylphenol [nano] | 6,00000 |
Glycerin | 5,00000 |
Butyl methoxydibenzoylmethane | 4,50000 |
Dimethicone | 3,00000 |
Tribehenin PEG-20 esters | 3,00000 |
Bis-ethylhexyloxyphenol methoxyphenyl triazine | 2,50000 |
C10-18 triglycerides | 2,00000 |
Methylpropanediol | 1,40000 |
Sucrose stearate | 1,00000 |
Decyl glucoside | 0,90000 |
Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer | 0,88000 |
Pentylene glycol | 0,50000 |
Oryzanol | 0,50000 |
Tocopheryl acetate | 0,50000 |
Sodium citrate | 0,20000 |
1,2-hexanediol | 0,12500 |
Caprylyl glycol | 0,12500 |
Mannitol | 0,10000 |
Xylitol | 0,10000 |
Citric acid | 0,09000 |
Polysorbate 60 | 0,06000 |
Sorbitan isostearate | 0,06000 |
Rhamnose | 0,05000 |
Propylene glycol | 0,04800 |
Xanthan gum | 0,02400 |
Ectoin | 0,01000 |
Glycyrrhiza glabra(licorice) root extract | 0,01000 |
Tocopherol | 0,00270 |
Fructooligosaccharides | 0,00100 |
Caprylic/capric triglyceride | 0,00095 |
Laminaria ochroleucaextract | 0,00005 |
- Etape A : Détermination des conditions expérimentales permettant d’induire un maximum d’isomérisation :
- Concentration d’UCA : 10µg/ml
- Dose d’UV (UV-A + UV-B) (0,5 ; 0,8 ; 1 ; 2 ; 4 et 8 DEM ou Dose Erythémateuse Minimale)
- Solvants : eau et mélange eau/méthanol (MeOH)
- Présence ou non de papier aluminium autour de la plaque 6 puits.
Le test a été réalisé en présence de produit solaire (1mg/cm2) déposé sur une plaque de quartz au-dessus de la solution d’UCA, selon les conditions déterminées dans l’étape A en ajustant la dose d’irradiation UV afin de pouvoir observer une isomérisation en présence de produits solaires.
- Concentration d’UCA : 10µg/ml
- dose d’UV (UV-A + UV-B) : 2 DEM soit 9 J/cm2UV-A+ 300 mJ/cm2UV-B. Pour cette irradiation, on observe autant de disparition d’UCAtransque d’apparition d’UCAcis
- L’association du mélange Eau/MeOH et la présence du film aluminium présentent les conditions optimales pour les tests d’application d’actifs en présence ou non de produit solaires.
- Contrôle négatif (CN) correspondant au témoin non irradié de la solution contenant de l’UCAtrans;
- Contrôle positif (CP) avec ou sans crème, correspondant au contrôle négatif irradié, protégé ou non par les produits placés sur la plaque ;
- Conditions irradiées avec ou sans produit solaire + γ-oryzanol ou huile de tamanu correspondant aux autres conditions qui mesurent l’efficacité du γ -oryzanol ou de l’huile de tamanu en solution avec le UCAtrans, avec et sans filtration UV.
Doses | Correspondance |
0,5 DEM | 2,25 J/cm2UV-A + 75 mJ/cm2UV-B |
0,8 DEM | 3,6 J/cm2UV-A +120 mJ/cm2UV-B |
1 DEM | 4,5 J/cm2UV-A + 150 mJ/cm2UV-B |
2 DEM | 9 J/cm2UV-A+ 300 mJ/cm2UV-B |
4 DEM | 18 J/cm2UV-A + 600 mJ/cm2UV-B |
8 DEM | 36 J/cm2UV-A + 1200 mJ/cm2UV-B |
Protection solaire | Produits |
SPF15 | Institut Esthederm - Adaptasun SPF15 crème |
SPF50+ | Bioderma - Photoderm Max SP50+ |
Crème Adaptasun SPF15 – Ingrédients (INCI) | % |
Homosalate | 0,1 à 10 |
Ethylhexyl methoxycrylene | 0,1 à 10 |
Ethylhexyl salicylate | 0,1 à 5 |
Butyl methoxydibenzoylmethane | 0,1 à 5 |
Photoderm Max SPF50+ – Ingrédients (INCI) | % |
Octocrylene | 0,1 à 10 |
Methylene bis-benzotriazolyl tetramethylbutylphenol [nano] | 0,1 à 10 |
Butyl methoxydibenzoylmethane | 0,1 à 5 |
Bis-ethylhexyloxyphenol methoxyphenyl triazine | 0,1 à 5 |
Code | Nom de la molécule |
Nom commercial | Fournisseur | N° lot | Aspect |
O | γ-oryzanol | ORYZAGAMMA-V | Nikko | 1780000406 | Poudre |
Ny | Huile de tamanu | Nyamplung oil | Givaudan | J-15 | Huileux |
-Spectrophotomètre UV visible 650S de Perkin Elmer
-Cuve en quartz
-Fiole jaugée de 100mL
-Propipette
[UCAtrans] en µg/ml (IP) | ||||
2 DEM | ||||
Sans filtre | SPF15 | SPF50 | ||
CN (non irradié) | 100 | 100 | 100 | |
CP sans crème | 6,0 | / | / | |
CP avec crème | / | 24,7 | 32,6 | |
γ-oryzanol | 1% | 54,7 | 70,5 | 89,4 |
0,5% | 44,7 | 59,9 | 78,3 | |
0,1% | 36,1 | 53,0 | 70,7 | |
Huile de tamanu | 2% | 68,9 | 80,3 | 94,6 |
1% | 53,6 | 68,3 | 84,1 | |
0,5% | 37,6 | 57,3 | 70,8 |
BIBLIOGRAPHIE
Claims (10)
- Composition comprenant du γ-oryzanol et/ou de l’huile de tamanu pour utilisation comme agent immunoprotecteur.
- Composition pour son utilisation selon la revendication 1, caractérisée en ce que l’agent protège contre une immunosuppression induite par une exposition au rayonnement ultraviolet, avantageusement aux UV-B.
- Composition pour son utilisation selon la revendication 1 ou 2, caractérisée en ce que le γ-oryzanol représente entre 0,001% et 20% en poids de la composition, de préférence entre 0,01% et 10%, avantageusement entre 0,1% et 5%.
- Composition pour son utilisation selon l’une des revendications précédentes, caractérisée en ce que l’huile de tamanu représente entre 0,001% et 20% en poids de la composition, de préférence entre 0,01% et 10%, avantageusement entre 0,1% et 5%.
- Composition pour son utilisation selon l’une des revendications précédentes, caractérisée en ce que la composition comprend en outre au moins un filtre organique et/ou écran minéral, avantageusement un filtre organique.
- Composition pour son utilisation selon la revendication 5, caractérisée en ce que le filtre organique est choisi dans le groupe constitué des désignations INCI suivantes : tris biphenyl triazine, bis ethylhexyloxyphenol methoxyphenyl triazine, methylene bis-benzotriazolyl tetramethylbutylphenol, diethylhexyl butamido triazone, phenylene bis-diphenyltriazine, et leurs mélanges.
- Composition pour son utilisation selon la revendication 5 ou 6, caractérisée en ce que les filtres organiques et/ou écrans minéraux représentent entre 0,1% et 30% en poids de la composition, avantageusement entre 0,5 % et 20 %, encore plus avantageusement entre 1% et 15%.
- Composition pour son utilisation selon l’une des revendications précédentes, caractérisée en ce qu’elle comprend en outre au moins un ingrédient choisi parmi :
- un agent amplificateur du facteur de protection solaire ;
- un agent photostabilisant ;
- un agent apte à filtrer la lumière visible, en particulier la lumière bleue ;
- un extrait de la bactérieArthrobacter agilis, avantageusement riche en caroténoïdes ;
- au moins un polyol choisi parmi le xylitol, le rhamnose, le sorbitol et le mannitol, avantageusement le mannitol ;
- un extrait des alguesLaminaria ochroleuca,Blidingia minimaouLaminaria saccharina;
- un extrait deZanthoxylum alatum;
- du panthénol ;
- de la vitamine E ou un de ses dérivés hydrophile ou lipophile, ou un de leurs sels, avantageusement le tocotriénol ou le tocophérol ;
- de l’acide salicylique ou un de ses dérivés ;
- un extrait de bois de cade ;
- un extrait de Boldo ;
- un extrait de Reine des prés ;
- de l’acide glycyrrhétinique ou un de ses dérivés ou sels ;
- la vitamine PP ;
- un agent protecteur de la protéine p53, avantageusement l’épigallocathéchine gallate (EGCG) ;
- un extrait d’huile de karanja issue duPongamia glabra;
- des paraffines linéaires ;
- de l'ATP (adénosine-5 tri-phosphate), du Gp4G (diguanosine tétraphosphate) ou de l’Ap4A (diadénosine tétraphosphate),
- un agent limitant l’action des ions fer impliqués dans la formation des radicaux libres, avantageusement l’EDTA (acide éthylène diamine tétraacétique) ;
- un extrait peptidique de soja et/ou de blé ;
- un acide aminé choisi parmi l’ectoïne, la créatine, l'ergothionéine, la carnosine, la tyrosine, la décarboxycarnosine, la glutamine et leurs sels, avantageusement l’ectoïne ;
- un agent bronzant ou autobronzant ;
- un agent dépigmentant ;
- un agent cicatrisant ;
- un agent sébocorrecteur, kératolytique, séborégulateur et/ou antiacnéique. - Composition pour son utilisation selon l’une des revendications précédentes, caractérisée en ce qu’elle est sous une forme adaptée pour une administration par voie topique.
- Utilisationin vitrod’une composition telle que définie dans les revendications 1 à 9, pour protéger la formetransde l’acide urocanique ou réduire son isomérisation en formecis.
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FR1900285A FR3091649A1 (fr) | 2019-01-11 | 2019-01-11 | Composition cosmetique ou pharmaceutique permettant de reduire l’immunosuppression induite par une exposition au rayonnement ultraviolet |
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FR1900285A FR3091649A1 (fr) | 2019-01-11 | 2019-01-11 | Composition cosmetique ou pharmaceutique permettant de reduire l’immunosuppression induite par une exposition au rayonnement ultraviolet |
FR1900285 | 2019-01-11 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023214065A1 (fr) * | 2022-05-05 | 2023-11-09 | Pierre Fabre Dermo-Cosmetique | Utilisation de la phénylène bis-diphényltriazine pour la préservation des défenses immunitaires de la peau |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023214065A1 (fr) * | 2022-05-05 | 2023-11-09 | Pierre Fabre Dermo-Cosmetique | Utilisation de la phénylène bis-diphényltriazine pour la préservation des défenses immunitaires de la peau |
FR3135203A1 (fr) * | 2022-05-05 | 2023-11-10 | Pierre Fabre Dermo-Cosmetique | Utilisation de la phénylène bis-diphényltriazine pour la préservation des défenses immunitaires de la peau |
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