FR3052452B1 - Nouveaux derives de piperidinyle, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents
Nouveaux derives de piperidinyle, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Download PDFInfo
- Publication number
- FR3052452B1 FR3052452B1 FR1655392A FR1655392A FR3052452B1 FR 3052452 B1 FR3052452 B1 FR 3052452B1 FR 1655392 A FR1655392 A FR 1655392A FR 1655392 A FR1655392 A FR 1655392A FR 3052452 B1 FR3052452 B1 FR 3052452B1
- Authority
- FR
- France
- Prior art keywords
- preparation
- pharmaceutical compositions
- compositions containing
- containing same
- piperidinyl derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- -1 PIPERIDINYL Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Priority Applications (46)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1655392A FR3052452B1 (fr) | 2016-06-10 | 2016-06-10 | Nouveaux derives de piperidinyle, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CA3027014A CA3027014C (en) | 2016-06-10 | 2017-06-09 | Piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them |
| EP17727927.0A EP3468974B1 (en) | 2016-06-10 | 2017-06-09 | New piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them |
| UY0001037288A UY37288A (es) | 2016-06-10 | 2017-06-09 | Nuevos derivados piperidinilo, un proceso para su preparación y composiciones farmacéuticas que los contienen |
| HRP20200361TT HRP20200361T1 (hr) | 2016-06-10 | 2017-06-09 | Novi derivati piperidinila, postupak za njihovu pripravu i farmaceutski pripravci koji ih sadrže |
| RS20200266A RS60029B1 (sr) | 2016-06-10 | 2017-06-09 | Novi derivati piperidinila, postupak za njihovo dobijanje i farmaceutske kompozicije koje ih sadrže |
| LTEP17727927.0T LT3468974T (lt) | 2016-06-10 | 2017-06-09 | Nauji piperidinilo dariniai, jų gamybos būdas ir juos turinčios farmacinės kompozicijos |
| PT177279270T PT3468974T (pt) | 2016-06-10 | 2017-06-09 | Novos derivados de piperidinilo, um processo para a sua preparação e composições farmacêuticas que os contêm |
| CU2018000145A CU20180145A7 (es) | 2016-06-10 | 2017-06-09 | Compuestos derivados (piperidin-1-il)(piperidin-4-il) metanona, método de preparación de los mismos y composiciones farmacéuticas que los contienen |
| JP2018564356A JP6928005B2 (ja) | 2016-06-10 | 2017-06-09 | 新規なピペリジニル誘導体、それらの調製方法及びそれらを含有する医薬組成物 |
| MA45222A MA45222B1 (fr) | 2016-06-10 | 2017-06-09 | Nouveaux dérivés de pipéridinyle, procédé de préparation de ceux-ci et compositions pharmaceutiques les contenant |
| SI201730260T SI3468974T1 (sl) | 2016-06-10 | 2017-06-09 | Novi derivati piperidinila, postopek za njihovo pripravo in farmacevtski sestavki, ki jih vsebujejo |
| RU2018147430A RU2743163C2 (ru) | 2016-06-10 | 2017-06-09 | Новые пиперидинильные производные, способ их получения и фармацевтические композиции, содержащие их |
| MX2018015216A MX374794B (es) | 2016-06-10 | 2017-06-09 | Nuevos derivados piperidinilo, un proceso para su preparacion y composiciones farmaceuticas que los contienen |
| BR112018075433-1A BR112018075433A2 (pt) | 2016-06-10 | 2017-06-09 | derivados de piperidinila, processo para sua preparação e composições farmacêuticas contendo-os |
| NZ748946A NZ748946A (en) | 2016-06-10 | 2017-06-09 | New piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them |
| AU2017277734A AU2017277734B2 (en) | 2016-06-10 | 2017-06-09 | New piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them |
| TW106119242A TWI620750B (zh) | 2016-06-10 | 2017-06-09 | 新穎之哌啶基衍生物、其製備方法及含其之醫藥組合物 |
| CN201780035584.8A CN109311888B (zh) | 2016-06-10 | 2017-06-09 | 哌啶基衍生物，其制备方法和含有它们的药物组合物 |
| DK17727927.0T DK3468974T3 (da) | 2016-06-10 | 2017-06-09 | Nye piperidinyl-derivativer, en fremgangsmåde til deres fremstilling og farmaceutiske sammensætninger indeholdende dem |
| KR1020197000834A KR20190016106A (ko) | 2016-06-10 | 2017-06-09 | 새로운 피페리디닐 유도체, 이의 제조를 위한 방법 및 이를 함유하는 약학적 조성물 |
| SG11201810629QA SG11201810629QA (en) | 2016-06-10 | 2017-06-09 | New piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them |
| PE2018003159A PE20220567A1 (es) | 2016-06-10 | 2017-06-09 | Nuevos derivados piperidinilo, un proceso para su preparacion y composiciones farmaceuticas que los contienen |
| CR20180564A CR20180564A (es) | 2016-06-10 | 2017-06-09 | Nuevos derivados piperidinilo, un proceso para su preparación y composiciones farmacéuticas que lo contienen |
| UAA201900217A UA123794C2 (uk) | 2016-06-10 | 2017-06-09 | Нові похідні піперидинілу, спосіб їхнього отримання та фармaцевтичні композиції, що їх містять |
| US16/306,933 US11046681B2 (en) | 2016-06-10 | 2017-06-09 | Substituted piperidines for the treatment of cancer |
| GEAP201714978A GEP20207160B (en) | 2016-06-10 | 2017-06-09 | New piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them |
| EA201892838A EA037211B1 (ru) | 2016-06-10 | 2017-06-09 | Пиперидинильные производные, способ их получения и фармацевтические композиции, содержащие их |
| ARP170101587A AR108706A1 (es) | 2016-06-10 | 2017-06-09 | Derivados piperidinilo, un proceso para su preparación, y composiciones farmacéuticas que los contienen |
| TNP/2018/000410A TN2018000410A1 (en) | 2016-06-10 | 2017-06-09 | New piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them |
| PCT/EP2017/064067 WO2017212012A1 (en) | 2016-06-10 | 2017-06-09 | New piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them |
| HUE17727927A HUE049507T2 (hu) | 2016-06-10 | 2017-06-09 | Új piperidinil származékok, eljárás elõállításukra és ezeket tartalmazó gyógyszerészeti készítmények |
| MDE20190460T MD3468974T2 (ro) | 2016-06-10 | 2017-06-09 | Noi derivați de piperidinil, procedeu pentru prepararea lor și compoziții farmaceutice care ii conțin |
| PL17727927T PL3468974T3 (pl) | 2016-06-10 | 2017-06-09 | Nowe pochodne piperydynylu, sposób ich wytwarzania oraz zawierające je kompozycje farmaceutyczne |
| MYPI2018002416A MY196562A (en) | 2016-06-10 | 2017-06-09 | New Piperidinyl Derivatives, a Process for Their Preparation and Pharmaceutical Compositions Containing Them |
| ES17727927T ES2775789T3 (es) | 2016-06-10 | 2017-06-09 | Nuevos derivados de piperidinilo, un proceso para su preparación y composiciones farmacéuticas que los contienen |
| MEP-2020-47A ME03670B (en) | 2016-06-10 | 2017-06-09 | New piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them |
| PH12018502515A PH12018502515B1 (en) | 2016-06-10 | 2018-11-28 | New piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them |
| SV2018005791A SV2018005791A (es) | 2016-06-10 | 2018-11-29 | Nuevos derivados piperidinilo, un proceso para su preparación y composiciones farmacéuticas que los contienen |
| IL263463A IL263463B (en) | 2016-06-10 | 2018-12-03 | New piperidinyl compounds, a process for their preparation and pharmaceutical preparations containing them |
| ECSENADI201890144A ECSP18090144A (es) | 2016-06-10 | 2018-12-04 | Nuevos derivados piperidinilo, un proceso para su preparación y composiciones farmacéuticas que los contienen |
| CL2018003474A CL2018003474A1 (es) | 2016-06-10 | 2018-12-04 | Nuevos derivados piperidinilo, un proceso para su preparación y composiciones farmacéuticas que los contienen. |
| DO2018000270A DOP2018000270A (es) | 2016-06-10 | 2018-12-06 | Nuevos derivados piperidinilo, un proceso para su preparación y composiciones farmacéuticas que los contienen |
| CONC2018/0013210A CO2018013210A2 (es) | 2016-06-10 | 2018-12-06 | Nuevos derivados piperidinilo, un proceso para su preparación y composiciones farmacéuticas que los contienen |
| NI201800132A NI201800132A (es) | 2016-06-10 | 2018-12-07 | Nuevos derivados piperidinilo, un proceso para su preparación y composiciones farmacéuticas que los contienen |
| CY20201100414T CY1122870T1 (el) | 2016-06-10 | 2020-05-06 | Νεα πιπεριδινυλ παραγωγα, μεθοδος για παρασκευη αυτων και φαρμακευτικες συνθεσεις που τα περιεχουν |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1655392A FR3052452B1 (fr) | 2016-06-10 | 2016-06-10 | Nouveaux derives de piperidinyle, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR1655392 | 2016-06-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR3052452A1 FR3052452A1 (enExample) | 2017-12-15 |
| FR3052452B1 true FR3052452B1 (fr) | 2018-06-22 |
Family
ID=56943687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR1655392A Expired - Fee Related FR3052452B1 (fr) | 2016-06-10 | 2016-06-10 | Nouveaux derives de piperidinyle, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Country Status (46)
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109069488B (zh) | 2016-03-07 | 2021-09-07 | 英安塔制药有限公司 | 乙型肝炎抗病毒剂 |
| CA3060416A1 (en) | 2017-04-21 | 2018-10-25 | Epizyme, Inc. | Combination therapies with ehmt2 inhibitors |
| TWI811236B (zh) | 2017-08-28 | 2023-08-11 | 美商因那塔製藥公司 | B型肝炎抗病毒試劑 |
| EA202091260A1 (ru) | 2017-11-29 | 2020-09-07 | Ле Лаборатуар Сервье | Новые пиперидинильные производные в качестве ингибиторов убиквитин-специфической протеазы 7 |
| GB201801562D0 (en) * | 2018-01-31 | 2018-03-14 | Almac Diagnostics Ltd | Pharmaceutical compounds |
| UY38291A (es) * | 2018-07-05 | 2020-06-30 | Servier Lab | Nuevos derivados de amino-pirimidonilo un proceso para su preparación y composiciones farmacéuticas |
| US10865211B2 (en) | 2018-09-21 | 2020-12-15 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| UY38423A (es) * | 2018-10-19 | 2021-02-26 | Servier Lab | Nuevos derivados amino-pirimidonil-piperidinilo, un proceso para su preparación y composiciones farmacéuticas que los contienen |
| US11198693B2 (en) | 2018-11-21 | 2021-12-14 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| BR112021010644A2 (pt) * | 2018-12-06 | 2021-09-28 | Almac Discovery Limited | Composto, estereoisômero, tautômero, hidrato, derivado de n-óxido ou sal farmaceuticamente aceitável, composição farmacêutica, métodos para tratamento de obesidade, resistência a insulina, diabetes tipo ii, atrofia muscular e câncer e para redução de perda de massa muscular em um indivíduo, e, inibidor de usp19 |
| US11236111B2 (en) | 2019-06-03 | 2022-02-01 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US11472808B2 (en) | 2019-06-04 | 2022-10-18 | Enanta Pharmaceuticals, Inc. | Substituted pyrrolo[1,2-c]pyrimidines as hepatitis B antiviral agents |
| WO2020247561A1 (en) | 2019-06-04 | 2020-12-10 | Enanta Pharmaceuticals, Inc, | Hepatitis b antiviral agents |
| US11738019B2 (en) | 2019-07-11 | 2023-08-29 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| US11236108B2 (en) | 2019-09-17 | 2022-02-01 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| CN113087718B (zh) * | 2020-01-09 | 2024-02-09 | 四川科伦博泰生物医药股份有限公司 | 噻吩并嘧啶酮类化合物及其医药应用 |
| CN112608320B (zh) * | 2020-01-16 | 2023-03-17 | 中国药科大学 | 哌啶类化合物及其制备方法和医药用途 |
| GB202001980D0 (en) | 2020-02-13 | 2020-04-01 | Almac Discovery Ltd | Therapeutic mentods |
| US11802125B2 (en) | 2020-03-16 | 2023-10-31 | Enanta Pharmaceuticals, Inc. | Functionalized heterocyclic compounds as antiviral agents |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2634235A1 (en) * | 2005-12-21 | 2007-07-05 | Schering Corporation | Combination of an h3 antagonist/inverse agonist and an appetite suppressant |
| EP2136805A2 (en) * | 2007-03-02 | 2009-12-30 | Schering Corporation | Piperidinyl-piperidine and piperazinyl-piperidine for use in the treatment of diabetes or pain |
| EP2565186A1 (en) * | 2011-09-02 | 2013-03-06 | Hybrigenics S.A. | Selective and reversible inhibitors of ubiquitin specific protease 7 |
| AR103297A1 (es) * | 2014-12-30 | 2017-05-03 | Forma Therapeutics Inc | Pirrolo y pirazolopirimidinas como inhibidores de la proteasa 7 específica de ubiquitina |
| MD3468971T2 (ro) * | 2016-06-10 | 2020-06-30 | Servier Lab | Noi derivați de piperidinil (hetero)aril-substituiţi, procedeu de obţinere a acestora și compoziții farmaceutice care îi conțin |
-
2016
- 2016-06-10 FR FR1655392A patent/FR3052452B1/fr not_active Expired - Fee Related
-
2017
- 2017-06-09 CN CN201780035584.8A patent/CN109311888B/zh active Active
- 2017-06-09 DK DK17727927.0T patent/DK3468974T3/da active
- 2017-06-09 EA EA201892838A patent/EA037211B1/ru unknown
- 2017-06-09 PT PT177279270T patent/PT3468974T/pt unknown
- 2017-06-09 US US16/306,933 patent/US11046681B2/en not_active Expired - Fee Related
- 2017-06-09 GE GEAP201714978A patent/GEP20207160B/en unknown
- 2017-06-09 LT LTEP17727927.0T patent/LT3468974T/lt unknown
- 2017-06-09 RU RU2018147430A patent/RU2743163C2/ru active
- 2017-06-09 AR ARP170101587A patent/AR108706A1/es unknown
- 2017-06-09 MD MDE20190460T patent/MD3468974T2/ro unknown
- 2017-06-09 EP EP17727927.0A patent/EP3468974B1/en active Active
- 2017-06-09 CA CA3027014A patent/CA3027014C/en active Active
- 2017-06-09 BR BR112018075433-1A patent/BR112018075433A2/pt not_active Application Discontinuation
- 2017-06-09 RS RS20200266A patent/RS60029B1/sr unknown
- 2017-06-09 NZ NZ748946A patent/NZ748946A/en unknown
- 2017-06-09 HU HUE17727927A patent/HUE049507T2/hu unknown
- 2017-06-09 PL PL17727927T patent/PL3468974T3/pl unknown
- 2017-06-09 TN TNP/2018/000410A patent/TN2018000410A1/en unknown
- 2017-06-09 AU AU2017277734A patent/AU2017277734B2/en active Active
- 2017-06-09 KR KR1020197000834A patent/KR20190016106A/ko not_active Withdrawn
- 2017-06-09 TW TW106119242A patent/TWI620750B/zh not_active IP Right Cessation
- 2017-06-09 UY UY0001037288A patent/UY37288A/es unknown
- 2017-06-09 HR HRP20200361TT patent/HRP20200361T1/hr unknown
- 2017-06-09 SG SG11201810629QA patent/SG11201810629QA/en unknown
- 2017-06-09 UA UAA201900217A patent/UA123794C2/uk unknown
- 2017-06-09 CR CR20180564A patent/CR20180564A/es unknown
- 2017-06-09 JP JP2018564356A patent/JP6928005B2/ja active Active
- 2017-06-09 SI SI201730260T patent/SI3468974T1/sl unknown
- 2017-06-09 MA MA45222A patent/MA45222B1/fr unknown
- 2017-06-09 ME MEP-2020-47A patent/ME03670B/me unknown
- 2017-06-09 ES ES17727927T patent/ES2775789T3/es active Active
- 2017-06-09 MY MYPI2018002416A patent/MY196562A/en unknown
- 2017-06-09 CU CU2018000145A patent/CU20180145A7/es unknown
- 2017-06-09 PE PE2018003159A patent/PE20220567A1/es unknown
- 2017-06-09 WO PCT/EP2017/064067 patent/WO2017212012A1/en not_active Ceased
- 2017-06-09 MX MX2018015216A patent/MX374794B/es active IP Right Grant
-
2018
- 2018-11-28 PH PH12018502515A patent/PH12018502515B1/en unknown
- 2018-11-29 SV SV2018005791A patent/SV2018005791A/es unknown
- 2018-12-03 IL IL263463A patent/IL263463B/en active IP Right Grant
- 2018-12-04 EC ECSENADI201890144A patent/ECSP18090144A/es unknown
- 2018-12-04 CL CL2018003474A patent/CL2018003474A1/es unknown
- 2018-12-06 CO CONC2018/0013210A patent/CO2018013210A2/es unknown
- 2018-12-06 DO DO2018000270A patent/DOP2018000270A/es unknown
- 2018-12-07 NI NI201800132A patent/NI201800132A/es unknown
-
2020
- 2020-05-06 CY CY20201100414T patent/CY1122870T1/el unknown
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| MA50450A (fr) | Nouveaux derives macrocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
| FR2943342B1 (fr) | Nouveaux derives de benzothiadiazepines,leur procede de preparation et les compositions pharmaceutiques qui les contiennent. | |
| LT3674298T (lt) | Pakeistieji indazolai, jų gavimo būdas, juos turinčios farmacinės kompozicijos ir jų panaudojimas vaistų gamybai | |
| DK3312177T3 (da) | Tricyklisk derivatforbindelse, fremgangsmåde til at fremstille samme og farmaceutisk sammensætning omfattende samme | |
| HUE048590T2 (hu) | Új (hetero)aril-szubsztituált piperidinil-származékok, eljárás ezek elõállítására és ezeket tartalmazó gyógyszerkészítmények | |
| SI3378859T1 (sl) | Derivat benzofurana, postopek za njegovo pripravo in njegova uporaba v medicini | |
| EP3481831A4 (en) | INNOVATIVE 4-AMINOPYRAZOLO [3,4-D] PYRIMIDINYLAZABICYCLO DERIVATIVES AND PHARMACEUTICAL COMPOSITION THEREFOR | |
| IL256609A (en) | History of pyridine, their preparation and pharmaceutical preparations containing them | |
| FR2929276B1 (fr) | Nouveaux derives de diosmetine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
| IL250022B (en) | 1-(pyrimidin-2-yl)-6-(heterocyclyl-carbonyl)-(indoline/2,3-dihydroazaindole) derivatives, process for their preparation and pharmaceutical compositions comprising them | |
| EP3556769A4 (en) | POLYMYXINE DERIVATIVE, MANUFACTURING PROCESS AND APPLICATION OF IT | |
| EP3731833A4 (en) | COMPOSITIONS CONTAINING THYMOHYDROQUINONE AND METHOD FOR MANUFACTURING THEREOF | |
| MA29725B1 (fr) | Nouveaux derives tricycliques, leur procede de prepapation et les compositions pharmaceutiques qui les contiennent | |
| EP3545957A4 (en) | PHARMACEUTICAL COMPOSITION OF PYRIDONE DERIVATIVES AND PROCESS FOR PREPARATION | |
| FR3046793B1 (fr) | Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
| FR3052451B1 (fr) | Nouveaux derives de piperidinyle hetero(aryl)-substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
| FR2948372B1 (fr) | Nouveaux derives chromeniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
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