CL2018003474A1 - Nuevos derivados piperidinilo, un proceso para su preparación y composiciones farmacéuticas que los contienen. - Google Patents

Nuevos derivados piperidinilo, un proceso para su preparación y composiciones farmacéuticas que los contienen.

Info

Publication number
CL2018003474A1
CL2018003474A1 CL2018003474A CL2018003474A CL2018003474A1 CL 2018003474 A1 CL2018003474 A1 CL 2018003474A1 CL 2018003474 A CL2018003474 A CL 2018003474A CL 2018003474 A CL2018003474 A CL 2018003474A CL 2018003474 A1 CL2018003474 A1 CL 2018003474A1
Authority
CL
Chile
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
piperidinyl derivatives
new piperidinyl
Prior art date
Application number
CL2018003474A
Other languages
English (en)
Inventor
András Kotschy
Olivier Geneste
Maïa Chanrion
Didier Demarles
Csaba Wéber
Attila Vasas
Balázs Molnár
Árpád Kiss
Elodie Lewkowicz
James Brooke Murray
Alba Macias
Original Assignee
Servier Lab
Vernalis R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab, Vernalis R&D Ltd filed Critical Servier Lab
Publication of CL2018003474A1 publication Critical patent/CL2018003474A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems

Abstract

COMPUESTOS DE FÓRMULA (I), EN LA QUE R1, R2, R3, N Y W SON COMO SE HAN DEFINIDO EN LA DESCRIPCIÓN.
CL2018003474A 2016-06-10 2018-12-04 Nuevos derivados piperidinilo, un proceso para su preparación y composiciones farmacéuticas que los contienen. CL2018003474A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1655392A FR3052452B1 (fr) 2016-06-10 2016-06-10 Nouveaux derives de piperidinyle, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
CL2018003474A1 true CL2018003474A1 (es) 2019-05-24

Family

ID=56943687

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2018003474A CL2018003474A1 (es) 2016-06-10 2018-12-04 Nuevos derivados piperidinilo, un proceso para su preparación y composiciones farmacéuticas que los contienen.

Country Status (45)

Country Link
US (1) US11046681B2 (es)
EP (1) EP3468974B1 (es)
JP (1) JP6928005B2 (es)
KR (1) KR20190016106A (es)
CN (1) CN109311888B (es)
AR (1) AR108706A1 (es)
AU (1) AU2017277734B2 (es)
BR (1) BR112018075433A2 (es)
CA (1) CA3027014C (es)
CL (1) CL2018003474A1 (es)
CO (1) CO2018013210A2 (es)
CR (1) CR20180564A (es)
CU (1) CU20180145A7 (es)
CY (1) CY1122870T1 (es)
DK (1) DK3468974T3 (es)
DO (1) DOP2018000270A (es)
EA (1) EA037211B1 (es)
EC (1) ECSP18090144A (es)
ES (1) ES2775789T3 (es)
FR (1) FR3052452B1 (es)
GE (1) GEP20207160B (es)
HR (1) HRP20200361T1 (es)
HU (1) HUE049507T2 (es)
IL (1) IL263463B (es)
LT (1) LT3468974T (es)
MA (1) MA45222B1 (es)
MD (1) MD3468974T2 (es)
ME (1) ME03670B (es)
MX (1) MX2018015216A (es)
MY (1) MY196562A (es)
NI (1) NI201800132A (es)
PE (1) PE20220567A1 (es)
PH (1) PH12018502515A1 (es)
PL (1) PL3468974T3 (es)
PT (1) PT3468974T (es)
RS (1) RS60029B1 (es)
RU (1) RU2743163C2 (es)
SG (1) SG11201810629QA (es)
SI (1) SI3468974T1 (es)
SV (1) SV2018005791A (es)
TN (1) TN2018000410A1 (es)
TW (1) TWI620750B (es)
UA (1) UA123794C2 (es)
UY (1) UY37288A (es)
WO (1) WO2017212012A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102398439B1 (ko) 2016-03-07 2022-05-16 이난타 파마슈티칼스, 인코포레이티드 B형 간염 항바이러스제
AU2018254577A1 (en) 2017-04-21 2019-12-05 Epizyme, Inc. Combination therapies with EHMT2 inhibitors
AR112481A1 (es) 2017-08-28 2019-10-30 Enanta Pharm Inc Agentes antivirales contra la hepatitis b
EA202091260A1 (ru) * 2017-11-29 2020-09-07 Ле Лаборатуар Сервье Новые пиперидинильные производные в качестве ингибиторов убиквитин-специфической протеазы 7
GB201801562D0 (en) * 2018-01-31 2018-03-14 Almac Diagnostics Ltd Pharmaceutical compounds
UY38291A (es) * 2018-07-05 2020-06-30 Servier Lab Nuevos derivados de amino-pirimidonilo un proceso para su preparación y composiciones farmacéuticas
KR20210065965A (ko) 2018-09-21 2021-06-04 이난타 파마슈티칼스, 인코포레이티드 항바이러스제로서 작용화된 헤테로사이클
UY38423A (es) * 2018-10-19 2021-02-26 Servier Lab Nuevos derivados amino-pirimidonil-piperidinilo, un proceso para su preparación y composiciones farmacéuticas que los contienen
CA3119973A1 (en) 2018-11-21 2020-05-28 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
MX2021006540A (es) * 2018-12-06 2021-07-07 Almac Discovery Ltd Compuestos farmaceuticos y su uso como inhibidores de proteasa 19 especifica de ubiquitina (usp19).
US11236111B2 (en) 2019-06-03 2022-02-01 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
WO2020247575A1 (en) 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
WO2020247561A1 (en) 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc, Hepatitis b antiviral agents
US11738019B2 (en) 2019-07-11 2023-08-29 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
WO2021055425A2 (en) 2019-09-17 2021-03-25 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
CN113087718B (zh) * 2020-01-09 2024-02-09 四川科伦博泰生物医药股份有限公司 噻吩并嘧啶酮类化合物及其医药应用
CN112608320B (zh) * 2020-01-16 2023-03-17 中国药科大学 哌啶类化合物及其制备方法和医药用途
GB202001980D0 (en) 2020-02-13 2020-04-01 Almac Discovery Ltd Therapeutic mentods
US11802125B2 (en) 2020-03-16 2023-10-31 Enanta Pharmaceuticals, Inc. Functionalized heterocyclic compounds as antiviral agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070142369A1 (en) * 2005-12-21 2007-06-21 Margaret Van Heek Combination of an H3 antagonist/inverse agonist and an appetite suppressant
TW200840571A (en) * 2007-03-02 2008-10-16 Schering Corp Piperidine derivatives and methods of use thereof
EP2565186A1 (en) * 2011-09-02 2013-03-06 Hybrigenics S.A. Selective and reversible inhibitors of ubiquitin specific protease 7
AR103297A1 (es) * 2014-12-30 2017-05-03 Forma Therapeutics Inc Pirrolo y pirazolopirimidinas como inhibidores de la proteasa 7 específica de ubiquitina
WO2017212010A1 (en) * 2016-06-10 2017-12-14 Les Laboratoires Servier New (hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
IL263463A (en) 2019-01-31
DK3468974T3 (da) 2020-05-11
SG11201810629QA (en) 2018-12-28
US11046681B2 (en) 2021-06-29
FR3052452A1 (es) 2017-12-15
CA3027014A1 (en) 2017-12-14
CO2018013210A2 (es) 2018-12-28
SV2018005791A (es) 2019-01-16
US20190144448A1 (en) 2019-05-16
IL263463B (en) 2021-01-31
AU2017277734B2 (en) 2021-07-01
CN109311888A (zh) 2019-02-05
RS60029B1 (sr) 2020-04-30
JP6928005B2 (ja) 2021-09-01
MA45222B1 (fr) 2020-04-30
MA45222A (fr) 2019-04-17
LT3468974T (lt) 2020-04-10
KR20190016106A (ko) 2019-02-15
GEP20207160B (en) 2020-10-12
MD3468974T2 (ro) 2020-05-31
RU2018147430A3 (es) 2020-07-10
PH12018502515B1 (en) 2019-09-30
UY37288A (es) 2018-01-02
JP2019517556A (ja) 2019-06-24
CU20180145A7 (es) 2019-07-04
FR3052452B1 (fr) 2018-06-22
AU2017277734A1 (en) 2018-12-20
MX2018015216A (es) 2019-04-25
CA3027014C (en) 2021-01-05
ECSP18090144A (es) 2019-01-31
DOP2018000270A (es) 2019-05-15
EA201892838A1 (ru) 2019-06-28
AR108706A1 (es) 2018-09-19
TN2018000410A1 (en) 2020-06-15
SI3468974T1 (sl) 2020-07-31
EA037211B1 (ru) 2021-02-19
RU2743163C2 (ru) 2021-02-15
MY196562A (en) 2023-04-19
EP3468974A1 (en) 2019-04-17
ME03670B (en) 2020-10-20
HRP20200361T1 (hr) 2020-06-12
TWI620750B (zh) 2018-04-11
HUE049507T2 (hu) 2020-09-28
PH12018502515A1 (en) 2019-09-30
PL3468974T3 (pl) 2020-07-13
RU2018147430A (ru) 2020-07-10
PE20220567A1 (es) 2022-04-13
UA123794C2 (uk) 2021-06-02
EP3468974B1 (en) 2020-02-12
CN109311888B (zh) 2021-09-14
ES2775789T3 (es) 2020-07-28
BR112018075433A2 (pt) 2019-03-19
TW201802092A (zh) 2018-01-16
CY1122870T1 (el) 2021-05-05
NI201800132A (es) 2019-04-08
WO2017212012A1 (en) 2017-12-14
CR20180564A (es) 2019-03-04
PT3468974T (pt) 2020-03-25

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