SI3468974T1 - Novi derivati piperidinila, postopek za njihovo pripravo in farmacevtski sestavki, ki jih vsebujejo - Google Patents

Novi derivati piperidinila, postopek za njihovo pripravo in farmacevtski sestavki, ki jih vsebujejo

Info

Publication number
SI3468974T1
SI3468974T1 SI201730260T SI201730260T SI3468974T1 SI 3468974 T1 SI3468974 T1 SI 3468974T1 SI 201730260 T SI201730260 T SI 201730260T SI 201730260 T SI201730260 T SI 201730260T SI 3468974 T1 SI3468974 T1 SI 3468974T1
Authority
SI
Slovenia
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
piperidinyl derivatives
new piperidinyl
Prior art date
Application number
SI201730260T
Other languages
English (en)
Slovenian (sl)
Inventor
Andras Kotschy
Csaba Weber
Attila Vasas
Balazs Molnar
Arpad Kiss
Alba Macias
James Brooke Murray
Elodie Lewkowicz
Olivier Geneste
Maia Chanrion
Didier Demarles
Original Assignee
Les Laboratoires Servier
Vernalis (R&D) Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier, Vernalis (R&D) Limited filed Critical Les Laboratoires Servier
Publication of SI3468974T1 publication Critical patent/SI3468974T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SI201730260T 2016-06-10 2017-06-09 Novi derivati piperidinila, postopek za njihovo pripravo in farmacevtski sestavki, ki jih vsebujejo SI3468974T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1655392A FR3052452B1 (fr) 2016-06-10 2016-06-10 Nouveaux derives de piperidinyle, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP17727927.0A EP3468974B1 (en) 2016-06-10 2017-06-09 New piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them
PCT/EP2017/064067 WO2017212012A1 (en) 2016-06-10 2017-06-09 New piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
SI3468974T1 true SI3468974T1 (sl) 2020-07-31

Family

ID=56943687

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201730260T SI3468974T1 (sl) 2016-06-10 2017-06-09 Novi derivati piperidinila, postopek za njihovo pripravo in farmacevtski sestavki, ki jih vsebujejo

Country Status (46)

Country Link
US (1) US11046681B2 (enExample)
EP (1) EP3468974B1 (enExample)
JP (1) JP6928005B2 (enExample)
KR (1) KR20190016106A (enExample)
CN (1) CN109311888B (enExample)
AR (1) AR108706A1 (enExample)
AU (1) AU2017277734B2 (enExample)
BR (1) BR112018075433A2 (enExample)
CA (1) CA3027014C (enExample)
CL (1) CL2018003474A1 (enExample)
CO (1) CO2018013210A2 (enExample)
CR (1) CR20180564A (enExample)
CU (1) CU20180145A7 (enExample)
CY (1) CY1122870T1 (enExample)
DK (1) DK3468974T3 (enExample)
DO (1) DOP2018000270A (enExample)
EA (1) EA037211B1 (enExample)
EC (1) ECSP18090144A (enExample)
ES (1) ES2775789T3 (enExample)
FR (1) FR3052452B1 (enExample)
GE (2) GEP20207160B (enExample)
HR (1) HRP20200361T1 (enExample)
HU (1) HUE049507T2 (enExample)
IL (1) IL263463B (enExample)
LT (1) LT3468974T (enExample)
MA (1) MA45222B1 (enExample)
MD (1) MD3468974T2 (enExample)
ME (1) ME03670B (enExample)
MX (1) MX374794B (enExample)
MY (1) MY196562A (enExample)
NI (1) NI201800132A (enExample)
NZ (1) NZ748946A (enExample)
PE (1) PE20220567A1 (enExample)
PH (1) PH12018502515B1 (enExample)
PL (1) PL3468974T3 (enExample)
PT (1) PT3468974T (enExample)
RS (1) RS60029B1 (enExample)
RU (1) RU2743163C2 (enExample)
SG (1) SG11201810629QA (enExample)
SI (1) SI3468974T1 (enExample)
SV (1) SV2018005791A (enExample)
TN (1) TN2018000410A1 (enExample)
TW (1) TWI620750B (enExample)
UA (1) UA123794C2 (enExample)
UY (1) UY37288A (enExample)
WO (1) WO2017212012A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102398439B1 (ko) 2016-03-07 2022-05-16 이난타 파마슈티칼스, 인코포레이티드 B형 간염 항바이러스제
WO2018195450A1 (en) 2017-04-21 2018-10-25 Epizyme, Inc. Combination therapies with ehmt2 inhibitors
SG11202001685TA (en) 2017-08-28 2020-03-30 Enanta Pharm Inc Hepatitis b antiviral agents
TW201925202A (zh) * 2017-11-29 2019-07-01 法商施維雅藥廠 新穎哌啶基衍生物、其製備方法及含其之醫藥組合物
GB201801562D0 (en) 2018-01-31 2018-03-14 Almac Diagnostics Ltd Pharmaceutical compounds
UY38291A (es) * 2018-07-05 2020-06-30 Servier Lab Nuevos derivados de amino-pirimidonilo un proceso para su preparación y composiciones farmacéuticas
TW202024093A (zh) 2018-09-21 2020-07-01 美商安塔製藥公司 作為抗病毒劑之官能化雜環
UY38423A (es) * 2018-10-19 2021-02-26 Servier Lab Nuevos derivados amino-pirimidonil-piperidinilo, un proceso para su preparación y composiciones farmacéuticas que los contienen
EP3883570A4 (en) 2018-11-21 2022-07-13 Enanta Pharmaceuticals, Inc. FUNCTIONALIZED HETEROCYCLES AS ANTIVIRAL AGENTS
US20220033397A1 (en) * 2018-12-06 2022-02-03 Almac Discovery Limited Pharmaceutical compounds and their use as inhibitors of ubiquitin specific protease 19 (usp19)
WO2020247444A1 (en) 2019-06-03 2020-12-10 Enanta Pharmaceuticals, Inc, Hepatitis b antiviral agents
WO2020247561A1 (en) 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc, Hepatitis b antiviral agents
US11472808B2 (en) 2019-06-04 2022-10-18 Enanta Pharmaceuticals, Inc. Substituted pyrrolo[1,2-c]pyrimidines as hepatitis B antiviral agents
WO2021007488A1 (en) 2019-07-11 2021-01-14 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
WO2021055425A2 (en) 2019-09-17 2021-03-25 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
CN113087718B (zh) * 2020-01-09 2024-02-09 四川科伦博泰生物医药股份有限公司 噻吩并嘧啶酮类化合物及其医药应用
CN112608320B (zh) * 2020-01-16 2023-03-17 中国药科大学 哌啶类化合物及其制备方法和医药用途
GB202001980D0 (en) 2020-02-13 2020-04-01 Almac Discovery Ltd Therapeutic mentods
US11802125B2 (en) 2020-03-16 2023-10-31 Enanta Pharmaceuticals, Inc. Functionalized heterocyclic compounds as antiviral agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2634235A1 (en) * 2005-12-21 2007-07-05 Schering Corporation Combination of an h3 antagonist/inverse agonist and an appetite suppressant
CA2679807A1 (en) * 2007-03-02 2008-09-12 Schering Corporation Piperidine derivatives and methods of use thereof
EP2565186A1 (en) * 2011-09-02 2013-03-06 Hybrigenics S.A. Selective and reversible inhibitors of ubiquitin specific protease 7
TWI698436B (zh) * 2014-12-30 2020-07-11 美商佛瑪治療公司 作為泛素特異性蛋白酶7抑制劑之吡咯并及吡唑并嘧啶
PL3468971T3 (pl) * 2016-06-10 2020-08-10 Les Laboratoires Servier Nowe pochodne (hetero)arylo-piperydynylowe, sposoby ich wytwarzania oraz zawierające je kompozycje

Also Published As

Publication number Publication date
FR3052452A1 (enExample) 2017-12-15
LT3468974T (lt) 2020-04-10
RS60029B1 (sr) 2020-04-30
JP2019517556A (ja) 2019-06-24
PL3468974T3 (pl) 2020-07-13
EA201892838A1 (ru) 2019-06-28
CA3027014C (en) 2021-01-05
ECSP18090144A (es) 2019-01-31
SV2018005791A (es) 2019-01-16
CO2018013210A2 (es) 2018-12-28
DK3468974T3 (da) 2020-05-11
UY37288A (es) 2018-01-02
EP3468974A1 (en) 2019-04-17
PE20220567A1 (es) 2022-04-13
GEAP202014978A (en) 2020-06-10
ES2775789T3 (es) 2020-07-28
PH12018502515B1 (en) 2021-11-10
MX2018015216A (es) 2019-04-25
CN109311888A (zh) 2019-02-05
AR108706A1 (es) 2018-09-19
MD3468974T2 (ro) 2020-05-31
JP6928005B2 (ja) 2021-09-01
HUE049507T2 (hu) 2020-09-28
CY1122870T1 (el) 2021-05-05
MY196562A (en) 2023-04-19
WO2017212012A1 (en) 2017-12-14
BR112018075433A2 (pt) 2019-03-19
MA45222A (fr) 2019-04-17
EP3468974B1 (en) 2020-02-12
TW201802092A (zh) 2018-01-16
TN2018000410A1 (en) 2020-06-15
AU2017277734A1 (en) 2018-12-20
DOP2018000270A (es) 2019-05-15
RU2018147430A3 (enExample) 2020-07-10
NI201800132A (es) 2019-04-08
UA123794C2 (uk) 2021-06-02
TWI620750B (zh) 2018-04-11
IL263463B (en) 2021-01-31
EA037211B1 (ru) 2021-02-19
CU20180145A7 (es) 2019-07-04
SG11201810629QA (en) 2018-12-28
MA45222B1 (fr) 2020-04-30
US20190144448A1 (en) 2019-05-16
PT3468974T (pt) 2020-03-25
NZ748946A (en) 2025-06-27
ME03670B (en) 2020-10-20
CN109311888B (zh) 2021-09-14
AU2017277734B2 (en) 2021-07-01
US11046681B2 (en) 2021-06-29
RU2018147430A (ru) 2020-07-10
IL263463A (en) 2019-01-31
CR20180564A (es) 2019-03-04
FR3052452B1 (fr) 2018-06-22
PH12018502515A1 (en) 2019-09-30
CL2018003474A1 (es) 2019-05-24
HRP20200361T1 (hr) 2020-06-12
KR20190016106A (ko) 2019-02-15
GEP20207160B (en) 2020-10-12
MX374794B (es) 2025-03-06
RU2743163C2 (ru) 2021-02-15
CA3027014A1 (en) 2017-12-14

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