FR2924345B1 - Utilisation de la mequitazine sous la forme de racemate ou d'enantiomeres pour la preparation d'un medicament destine au traitement ou a la prevention de pathologies impliquant les recepteurs histaminiques h4. - Google Patents

Utilisation de la mequitazine sous la forme de racemate ou d'enantiomeres pour la preparation d'un medicament destine au traitement ou a la prevention de pathologies impliquant les recepteurs histaminiques h4.

Info

Publication number
FR2924345B1
FR2924345B1 FR0854144A FR0854144A FR2924345B1 FR 2924345 B1 FR2924345 B1 FR 2924345B1 FR 0854144 A FR0854144 A FR 0854144A FR 0854144 A FR0854144 A FR 0854144A FR 2924345 B1 FR2924345 B1 FR 2924345B1
Authority
FR
France
Prior art keywords
histamic
mequitazine
racemate
enantiomers
receptors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0854144A
Other languages
English (en)
Other versions
FR2924345A1 (fr
Inventor
Thierry Clerc
Christophe Przybylski
Versailles Jacky Tisne
Didier Cussac
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Priority to FR0854144A priority Critical patent/FR2924345B1/fr
Priority to TW097145696A priority patent/TW200932242A/zh
Priority to PA20088805501A priority patent/PA8805501A1/es
Priority to CL2008003584A priority patent/CL2008003584A1/es
Priority to ARP080105280A priority patent/AR070673A1/es
Priority to MX2010006139A priority patent/MX2010006139A/es
Priority to KR1020107013817A priority patent/KR20100108347A/ko
Priority to RU2010125711/15A priority patent/RU2510273C2/ru
Priority to BRPI0820652A priority patent/BRPI0820652A2/pt
Priority to US12/746,115 priority patent/US20100273752A1/en
Priority to PCT/EP2008/066787 priority patent/WO2009071625A1/fr
Priority to CA2706898A priority patent/CA2706898A1/fr
Priority to AU2008333220A priority patent/AU2008333220B2/en
Priority to EP10177151A priority patent/EP2255811A1/fr
Priority to CN2008801188010A priority patent/CN101883566B/zh
Priority to EP08856761.5A priority patent/EP2227235B1/fr
Priority to NZ586212A priority patent/NZ586212A/xx
Priority to JP2010536457A priority patent/JP2011505411A/ja
Publication of FR2924345A1 publication Critical patent/FR2924345A1/fr
Priority to IL206073A priority patent/IL206073A0/en
Application granted granted Critical
Publication of FR2924345B1 publication Critical patent/FR2924345B1/fr
Priority to ZA2010/04312A priority patent/ZA201004312B/en
Priority to MA32940A priority patent/MA31930B1/fr
Priority to ZA2010/07626A priority patent/ZA201007626B/en
Priority to HK11102709.5A priority patent/HK1148667A1/xx
Priority to JP2013251130A priority patent/JP2014065726A/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
FR0854144A 2007-12-04 2008-06-23 Utilisation de la mequitazine sous la forme de racemate ou d'enantiomeres pour la preparation d'un medicament destine au traitement ou a la prevention de pathologies impliquant les recepteurs histaminiques h4. Expired - Fee Related FR2924345B1 (fr)

Priority Applications (24)

Application Number Priority Date Filing Date Title
FR0854144A FR2924345B1 (fr) 2007-12-04 2008-06-23 Utilisation de la mequitazine sous la forme de racemate ou d'enantiomeres pour la preparation d'un medicament destine au traitement ou a la prevention de pathologies impliquant les recepteurs histaminiques h4.
TW097145696A TW200932242A (en) 2007-12-04 2008-11-26 Use of mequitazine in racemate or enantiomer form to prepare a drug to treat or prevent pathologies involving histamine H4 receptors
PA20088805501A PA8805501A1 (es) 2007-12-04 2008-11-27 Uso de la mequitazina en forma de racemato o de enantiómeros para la preparacion de un medicamento destinado al tratamiento o a la prevencion de patologias que implican los receptores histamínicos h4
CL2008003584A CL2008003584A1 (es) 2007-12-04 2008-12-01 Uso de la 10-[(3r)-1-azabiciclo]oct-3-ilmetil]-10-h-fenotiazina, o una de sus sales farmaceuticamente aceptables para la preparación de un medicamento util para prevenir o tratar la bronconeumopatia obstructiva.
JP2010536457A JP2011505411A (ja) 2007-12-04 2008-12-04 ヒスタミンｈ４受容体が関与する病態を治療または予防するためのメキタジン
KR1020107013817A KR20100108347A (ko) 2007-12-04 2008-12-04 히스타민 ｈ4 수용체가 관여하는 병변을 치료하거나 예방하기 위한 메퀴타진
RU2010125711/15A RU2510273C2 (ru) 2007-12-04 2008-12-04 Меквитазин для лечения или предотвращения патологий, в которых задействованы н4 рецепторы гистамина
BRPI0820652A BRPI0820652A2 (pt) 2007-12-04 2008-12-04 mequitazina para tratar ou prevenir patologias envolvendo receptores h4 da histamina
US12/746,115 US20100273752A1 (en) 2007-12-04 2008-12-04 Mequitazine for treating or preventing pathologies involving histamine h4 receptors
PCT/EP2008/066787 WO2009071625A1 (fr) 2007-12-04 2008-12-04 Utilisation de méquitazine sous sa forme racémate ou énantiomère dans la préparation d'un médicament destiné à traiter ou à prévenir les pathologies impliquant les récepteurs h4 de l'histamine
CA2706898A CA2706898A1 (fr) 2007-12-04 2008-12-04 Utilisation de mequitazine sous sa forme racemate ou enantiomere dans la preparation d'un medicament destine a traiter ou a prevenir les pathologies impliquant les recepteurs h4 de l'histamine
AU2008333220A AU2008333220B2 (en) 2007-12-04 2008-12-04 Mequitazine for treating or preventing pathologies involving histamine H4 receptors
ARP080105280A AR070673A1 (es) 2007-12-04 2008-12-04 Uso de la mequitazina en forma de racemato o de enantiomeros para la preparacion de un medicamento destinado al tratamiento o a la prevencion de patologias que implican los receptores histaminicos h4
CN2008801188010A CN101883566B (zh) 2007-12-04 2008-12-04 用于治疗或预防涉及组胺h4受体的病症的美喹他嗪
EP08856761.5A EP2227235B1 (fr) 2007-12-04 2008-12-04 Méquitazine pour traiter ou à prévenir la bronchopneumopathie obstructive impliquant les récepteurs h4 de l'histamine
NZ586212A NZ586212A (en) 2007-12-04 2008-12-04 Mequitazine for treating or preventing pathologies involving histamine h4 receptors
MX2010006139A MX2010006139A (es) 2007-12-04 2008-12-04 Mequitacina para tratar o prevenir patologias qe implican receptores de histamina h4.
EP10177151A EP2255811A1 (fr) 2007-12-04 2008-12-04 Méquitazine pour traiter ou prévenir les pathologies impliquant les récepteurs histaminiques H4
IL206073A IL206073A0 (en) 2007-12-04 2010-05-30 Mequitazine for treating or preventing pathologies involving histamine h4 receptors
ZA2010/04312A ZA201004312B (en) 2007-12-04 2010-06-18 Mequitazine for treating or preventing pathologies involving histamine h4 receptors
MA32940A MA31930B1 (fr) 2007-12-04 2010-06-22 Utilisation de la méquitazine sous la forme de racémate ou d'énantiomères pour la préparation d'un médicament destiné au traitement ou à la prévention de pathologies impliquant les récepteurs histaminiques h4
ZA2010/07626A ZA201007626B (en) 2007-12-04 2010-10-26 Mequitazine for treating or preventing pathologies involving histamine h4 receptors
HK11102709.5A HK1148667A1 (en) 2007-12-04 2011-03-18 Mequitazine for treating or preventing pathologies involving histamine h4 receptors
JP2013251130A JP2014065726A (ja) 2007-12-04 2013-12-04 ヒスタミンｈ４受容体が関与する病態を治療または予防するためのメキタジン

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0759538A FR2924344B1 (fr) 2007-12-04 2007-12-04 Utilisation de la mequitazine sous la forme de racemate ou d'enantiomeres pour la preparation d'un medicament destine au traitement ou a la prevention de pathologies impliquant les recepteurs histaminiques h4.
FR0854144A FR2924345B1 (fr) 2007-12-04 2008-06-23 Utilisation de la mequitazine sous la forme de racemate ou d'enantiomeres pour la preparation d'un medicament destine au traitement ou a la prevention de pathologies impliquant les recepteurs histaminiques h4.

Publications (2)

Publication Number Publication Date
FR2924345A1 FR2924345A1 (fr) 2009-06-05
FR2924345B1 true FR2924345B1 (fr) 2010-06-04

Family

ID=39522380

Family Applications (2)

Application Number Title Priority Date Filing Date
FR0759538A Expired - Fee Related FR2924344B1 (fr) 2007-12-04 2007-12-04 Utilisation de la mequitazine sous la forme de racemate ou d'enantiomeres pour la preparation d'un medicament destine au traitement ou a la prevention de pathologies impliquant les recepteurs histaminiques h4.
FR0854144A Expired - Fee Related FR2924345B1 (fr) 2007-12-04 2008-06-23 Utilisation de la mequitazine sous la forme de racemate ou d'enantiomeres pour la preparation d'un medicament destine au traitement ou a la prevention de pathologies impliquant les recepteurs histaminiques h4.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR0759538A Expired - Fee Related FR2924344B1 (fr) 2007-12-04 2007-12-04 Utilisation de la mequitazine sous la forme de racemate ou d'enantiomeres pour la preparation d'un medicament destine au traitement ou a la prevention de pathologies impliquant les recepteurs histaminiques h4.

Country Status (22)

Country Link
US (1) US20100273752A1 (fr)
EP (2) EP2227235B1 (fr)
JP (2) JP2011505411A (fr)
KR (1) KR20100108347A (fr)
CN (1) CN101883566B (fr)
AR (1) AR070673A1 (fr)
AU (1) AU2008333220B2 (fr)
BR (1) BRPI0820652A2 (fr)
CA (1) CA2706898A1 (fr)
CL (1) CL2008003584A1 (fr)
FR (2) FR2924344B1 (fr)
HK (1) HK1148667A1 (fr)
IL (1) IL206073A0 (fr)
MA (1) MA31930B1 (fr)
MX (1) MX2010006139A (fr)
NZ (1) NZ586212A (fr)
PA (1) PA8805501A1 (fr)
RU (1) RU2510273C2 (fr)
TN (1) TN2010000241A1 (fr)
TW (1) TW200932242A (fr)
WO (1) WO2009071625A1 (fr)
ZA (2) ZA201004312B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2201982A1 (fr) 2008-12-24 2010-06-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Antagonistes du récepteur H4 de l'histamine pour le traitement de troubles vestibulaires
HUE039713T2 (hu) 2012-06-08 2019-02-28 Sensorion H4 receptor inhibitorok tinnitus kezelésére

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2440371A1 (fr) * 1978-10-31 1980-05-30 Fisons Ltd Nouveaux composes azotes heterocycliques, des compositions pharmaceutiques en contenant et des procedes pour les preparer
FR2522660A1 (fr) * 1982-03-05 1983-09-09 Pharmuka Lab Isomere levogyre de la mequitazine, son procede de preparation et medicaments le contenant
JPS6330420A (ja) * 1986-07-25 1988-02-09 Sekisui Chem Co Ltd 持続性抗アレルギ−固形塗布剤
JP2735122B2 (ja) * 1988-06-13 1998-04-02 旭化成工業株式会社 メキタジンの液状シロップ製剤
IT1251161B (it) * 1991-08-07 1995-05-04 Derivati ammonio quaternari di (-) e (+)-3-(10 h-fenotiazin-10-ilmetil)-l-azabiciclo (2.2.2.)ottano e composizioni farmaceutiche che li contengono
DE19653969A1 (de) * 1996-12-20 1998-06-25 Boehringer Ingelheim Kg Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole
FR2822709B1 (fr) * 2001-03-30 2007-01-19 Antialis Composition pharmaceutique anti-allergique comprenant au moins un allergene et au moins un compose antihistaminique
DE10158036B4 (de) * 2001-11-27 2007-05-03 Kosmas Kg Antiallergisches Mittel und dessen Verwendung
US20050090527A1 (en) * 2003-01-28 2005-04-28 Schering Corporation Combination of H1, H3 and H4 receptor antagonists for treatment of allergic and non-allergic pulmonary inflammation, congestion and allergic rhinitis
JP2005060233A (ja) * 2003-08-08 2005-03-10 Rohto Pharmaceut Co Ltd 皮膚外用剤
EP1526135A1 (fr) * 2003-10-24 2005-04-27 Warner-Lambert Company LLC Azabenzodiazepines utiles comme inhibiteurs de pde4
WO2005063253A1 (fr) * 2003-12-26 2005-07-14 Taiho Pharmaceutical Co., Ltd. Composition medicinale pour le traitement de symptomes allergiques
FR2896690B1 (fr) * 2006-01-30 2008-05-02 Pierre Fabre Medicament Sa Utilisation de l'enantiomere(s) de la mequitazine pour la preparation d'un medicament, tout en limitant la toxicite genomique

Also Published As

Publication number Publication date
US20100273752A1 (en) 2010-10-28
PA8805501A1 (es) 2009-12-16
CN101883566A (zh) 2010-11-10
FR2924344B1 (fr) 2010-04-16
AR070673A1 (es) 2010-04-28
WO2009071625A1 (fr) 2009-06-11
JP2014065726A (ja) 2014-04-17
EP2255811A1 (fr) 2010-12-01
EP2227235A1 (fr) 2010-09-15
TW200932242A (en) 2009-08-01
HK1148667A1 (en) 2011-09-16
CN101883566B (zh) 2013-03-06
FR2924345A1 (fr) 2009-06-05
MX2010006139A (es) 2010-10-15
EP2227235B1 (fr) 2014-11-12
ZA201007626B (en) 2011-08-31
AU2008333220B2 (en) 2014-04-24
NZ586212A (en) 2012-09-28
AU2008333220A1 (en) 2009-06-11
CA2706898A1 (fr) 2009-06-11
BRPI0820652A2 (pt) 2019-09-10
KR20100108347A (ko) 2010-10-06
CL2008003584A1 (es) 2009-05-22
RU2010125711A (ru) 2012-01-10
IL206073A0 (en) 2010-11-30
TN2010000241A1 (en) 2011-11-11
ZA201004312B (en) 2011-02-23
FR2924344A1 (fr) 2009-06-05
MA31930B1 (fr) 2010-12-01
JP2011505411A (ja) 2011-02-24
RU2510273C2 (ru) 2014-03-27

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Effective date: 20160229