IT1251161B - Derivati ammonio quaternari di (-) e (+)-3-(10 h-fenotiazin-10-ilmetil)-l-azabiciclo (2.2.2.)ottano e composizioni farmaceutiche che li contengono - Google Patents

Derivati ammonio quaternari di (-) e (+)-3-(10 h-fenotiazin-10-ilmetil)-l-azabiciclo (2.2.2.)ottano e composizioni farmaceutiche che li contengono

Info

Publication number
IT1251161B
IT1251161B ITMI912225A ITMI912225A IT1251161B IT 1251161 B IT1251161 B IT 1251161B IT MI912225 A ITMI912225 A IT MI912225A IT MI912225 A ITMI912225 A IT MI912225A IT 1251161 B IT1251161 B IT 1251161B
Authority
IT
Italy
Prior art keywords
azabicycle
pharmaceutical compositions
quaternary ammonium
compositions containing
ilmethyl
Prior art date
Application number
ITMI912225A
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of ITMI912225A0 publication Critical patent/ITMI912225A0/it
Priority to ITMI912225A priority Critical patent/IT1251161B/it
Priority to PCT/EP1992/001759 priority patent/WO1993003029A1/en
Priority to SK115-94A priority patent/SK11594A3/sk
Priority to JP5503276A priority patent/JPH06509570A/ja
Priority to BR9206339A priority patent/BR9206339A/pt
Priority to CA002114844A priority patent/CA2114844A1/en
Priority to EP92916942A priority patent/EP0599896A1/en
Priority to MA22900A priority patent/MA22611A1/fr
Priority to HU9400273A priority patent/HUT66570A/hu
Priority to AU24173/92A priority patent/AU2417392A/en
Priority to CS94248A priority patent/CZ24894A3/cs
Priority to ZA925852A priority patent/ZA925852B/xx
Priority to EC1992000859A priority patent/ECSP920859A/es
Priority to TNTNSN92073A priority patent/TNSN92073A1/fr
Priority to MX9204539A priority patent/MX9204539A/es
Priority to CN92109021A priority patent/CN1071667A/zh
Priority to PT100765A priority patent/PT100765A/pt
Publication of ITMI912225A1 publication Critical patent/ITMI912225A1/it
Priority to FI940530A priority patent/FI940530A/fi
Priority to NO940366A priority patent/NO940366D0/no
Priority to BG98439A priority patent/BG98439A/bg
Application granted granted Critical
Publication of IT1251161B publication Critical patent/IT1251161B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Sono descritti gli enantiomeri destrogiro (+) e levogiro (-) di derivati ammonio quaternari di 3-(10 H-fenotiazin-10-ilmetil)-1-azabiciclo 2. 2. 2. ottano di formula generale (I) (FORMULA I) in cui R = C1-4 alchile, ciclopropile ed X = alogeno, metilsolfato, p-toluensolfonato la loro preparazione e composizioni farmaceutiche che li contengono.
ITMI912225A 1991-08-07 1991-08-07 Derivati ammonio quaternari di (-) e (+)-3-(10 h-fenotiazin-10-ilmetil)-l-azabiciclo (2.2.2.)ottano e composizioni farmaceutiche che li contengono IT1251161B (it)

Priority Applications (20)

Application Number Priority Date Filing Date Title
ITMI912225A IT1251161B (it) 1991-08-07 1991-08-07 Derivati ammonio quaternari di (-) e (+)-3-(10 h-fenotiazin-10-ilmetil)-l-azabiciclo (2.2.2.)ottano e composizioni farmaceutiche che li contengono
CS94248A CZ24894A3 (en) 1991-08-07 1992-08-03 Quaternary ammonium derivatives (-) and (+)-10- (azabicyclo/2.2.2/-oct-3-yl-methyl)-10h-phenothiazine, process of their preparation and pharmaceutical preparations in which they are comprised
SK115-94A SK11594A3 (en) 1991-08-07 1992-08-03 (+) and (-) 10-(1-azabicyclo (2.2.2.) oct-3-yl methyl)-10 h-phenothiazine quaternary ammonium derivatives, pharmaceutical compositions containing them and process for their preparation
JP5503276A JPH06509570A (ja) 1991-08-07 1992-08-03 （−）および（＋）の１０−（１−アザビシクロ［２．２．２．］オクト−３−イル−メチル）−１０　ｈ−フェノチアジン第４アンモニウム誘導体を有する薬剤組成物およびその製剤プロセス
BR9206339A BR9206339A (pt) 1991-08-07 1992-08-03 (-) e (+) 10-(1-azabiciclo (2.2.2)OCT-3-IL-Metila) -10 H- Derivados de amônia de fenotiazina quaternária, composições farmacêuticas que os contem e processo para sua obtenção
CA002114844A CA2114844A1 (en) 1991-08-07 1992-08-03 (-) and (+) 10-(1-azabicyclo[2.2.2.]oct-3-yl-methyl)-10 h-phenothiazine quaternary ammonium derivatives, pharmaceutical compositions containing them and process for their preparation
EP92916942A EP0599896A1 (en) 1991-08-07 1992-08-03 (-) and (+) 10-(1-azabicyclo 2.2.2.]oct-3-yl-methyl)-10 h-phenothiazine quaternary ammonium derivatives, pharmaceutical compositions containing them and process for their preparation
MA22900A MA22611A1 (fr) 1991-08-07 1992-08-03 Derives d'ammonium quaternaire de (+) et (-) 10-(1-azabicyclo(2,2,2) oct-3-yl-methyl) -10-h-pheno-thiazine, compositions pharmaceutiques les contenant et procede pour leur preparation .
HU9400273A HUT66570A (en) 1991-08-07 1992-08-03 (-) and (+) 10-(1-azabicyclo[2,2,2]oct-3-yl-methyl)-10 h-phenothiazine quaternary ammonium derivatives, pharmaceutical compositions containing them and process for producing them
AU24173/92A AU2417392A (en) 1991-08-07 1992-08-03 (-) and (+) 10-(1-azabicyclo{2.2.2.}oct-3-yl-methyl)-10 h-phenothiazine quaternary ammonium derivatives, pharmaceutical compositions containing them and process for their preparation
PCT/EP1992/001759 WO1993003029A1 (en) 1991-08-07 1992-08-03 (-) and (+) 10-(1-azabicyclo[2.2.2.]oct-3-yl-methyl)-10 h-phenothiazine quaternary ammonium derivatives, pharmaceutical compositions containing them and process for their preparation
EC1992000859A ECSP920859A (es) 1991-08-07 1992-08-04 Derivados de amonio cuaternario (-) y (+)10- (1 - azabiciclo [2.2.2] oct - 3 - il - metil) - 10 h- fenotiazina, procedimiento para obtenerlos y composiciones farmaceuticas que los contienen
ZA925852A ZA925852B (en) 1991-08-07 1992-08-04 (-) and (+) 10-(1-azabicyclo(2.2.2.)oct-3-yl-methyl)-10 h-phenothiazine quaternary ammonium derivatives, pharmaceutical compositions containing them and process for their preparation.
TNTNSN92073A TNSN92073A1 (fr) 1991-08-07 1992-08-05 Derives d'ammonium quaternaire de (+) et (-) 10- (1-azabicyclo [2,2,2] oct-3-yl-methyl) -10-h-phenothiazine, compositions pharmaceutiques les contenant et procede pour leur preparation
MX9204539A MX9204539A (es) 1991-08-07 1992-08-05 Derivados de amonio cuaternario (-) y (+) 10-(1-azabiciclo (2.2.2)oct-3-il-metil)-10 h-fenotiazina, procedimiento para obtenerlos y composiciones farmaceuticas que los contienen.
CN92109021A CN1071667A (zh) 1991-08-07 1992-08-06 吩噻嗪季铵衍生物及其组合物制法
PT100765A PT100765A (pt) 1991-08-07 1992-08-07 Derivados de amonio quaternario de (-) e (+) 10-(1-azabiciclo{2.2.2.}oct-3-il-metil)-10h-fenotiazina, composicoes farmaceuticas que os contem e processo para a sua preparacao
FI940530A FI940530A (fi) 1991-08-07 1994-02-04 (-) ja (+) 10-(1-atsabisyklo(2.2.2.)okt-3-yylimetyyli-10-fenotiatsiinin kvaternääriset ammoniumjohdannaiset, farmaseuttiset koostumukset, joissa on niitä ja niiden valmistusmenetelmä
NO940366A NO940366D0 (no) 1991-08-07 1994-02-04 Kvarternaere (-) og (Q) 10-(1-azabicyklo (2.2.2. okt-3-yl-metyl)-10-H-fenotiazin-ammoniumderivater, farmasoetiske preparater inneholdende disse, og fremgangsmaater for deres fremstilling
BG98439A BG98439A (bg) 1991-08-07 1994-02-07 Кватернерни амониеви производни на (-) и (+) 10-(1-азобицикло /2.2.2/окт-3-ил-метил)-10н-фенотиазин,фармацевтични състави на тяхна основа и метод заполучаването им

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI912225A IT1251161B (it) 1991-08-07 1991-08-07 Derivati ammonio quaternari di (-) e (+)-3-(10 h-fenotiazin-10-ilmetil)-l-azabiciclo (2.2.2.)ottano e composizioni farmaceutiche che li contengono

Publications (3)

Publication Number Publication Date
ITMI912225A0 ITMI912225A0 (it) 1991-08-07
ITMI912225A1 ITMI912225A1 (it) 1993-02-08
IT1251161B true IT1251161B (it) 1995-05-04

Family

ID=11360550

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI912225A IT1251161B (it) 1991-08-07 1991-08-07 Derivati ammonio quaternari di (-) e (+)-3-(10 h-fenotiazin-10-ilmetil)-l-azabiciclo (2.2.2.)ottano e composizioni farmaceutiche che li contengono

Country Status (19)

Country Link
EP (1) EP0599896A1 (it)
JP (1) JPH06509570A (it)
CN (1) CN1071667A (it)
AU (1) AU2417392A (it)
BG (1) BG98439A (it)
BR (1) BR9206339A (it)
CA (1) CA2114844A1 (it)
CZ (1) CZ24894A3 (it)
EC (1) ECSP920859A (it)
FI (1) FI940530A (it)
HU (1) HUT66570A (it)
IT (1) IT1251161B (it)
MA (1) MA22611A1 (it)
MX (1) MX9204539A (it)
PT (1) PT100765A (it)
SK (1) SK11594A3 (it)
TN (1) TNSN92073A1 (it)
WO (1) WO1993003029A1 (it)
ZA (1) ZA925852B (it)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1216353C (zh) * 1996-10-18 2005-08-24 雅马哈株式会社 音乐教学系统和教学方法
US20050220888A1 (en) * 2002-01-31 2005-10-06 Lakahmi Putcha Controlled release compositions and methods for using same
FR2910814B1 (fr) * 2006-12-28 2011-06-17 Pf Medicament Utilisation du 10-°(r3)-1-azabicyclo°2.2.2!oct-3-ylmethyl!-10h- phenothiazine pour la preparation d'un medicament exercant une inhibition selective des recepteurs muscariniques m1,2,3
FR2911606B1 (fr) * 2007-01-18 2009-04-17 Pierre Fabre Medicament Sa Nouveau derive de la quinuclidine utile dans la preparation de la mequitazine
FR2924344B1 (fr) * 2007-12-04 2010-04-16 Pf Medicament Utilisation de la mequitazine sous la forme de racemate ou d'enantiomeres pour la preparation d'un medicament destine au traitement ou a la prevention de pathologies impliquant les recepteurs histaminiques h4.
FR2970255B1 (fr) * 2011-01-10 2013-09-06 Pf Medicament Vinyl quinuclidine utile en tant qu'intermediaire de synthese dans la preparation de la (r)-mequitazine.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2522660A1 (fr) * 1982-03-05 1983-09-09 Pharmuka Lab Isomere levogyre de la mequitazine, son procede de preparation et medicaments le contenant
FR2526433B1 (fr) * 1982-05-04 1985-10-18 Pharmuka Lab Isomeres dextrogyres de derives de l'aza-1 bicyclo (2,2,2) octane, leur procede de preparation et medicaments les contenant
IT1173445B (it) * 1984-03-16 1987-06-24 Guidotti & C Spa Labor Agenti ad attivita' antibroncospastica e composizioni farmaceutiche che li contengono

Also Published As

Publication number Publication date
MX9204539A (es) 1993-02-01
ECSP920859A (es) 1993-08-03
CA2114844A1 (en) 1993-02-18
BR9206339A (pt) 1994-11-08
EP0599896A1 (en) 1994-06-08
ZA925852B (en) 1993-03-05
CN1071667A (zh) 1993-05-05
HUT66570A (en) 1994-12-28
HU9400273D0 (en) 1994-05-30
WO1993003029A1 (en) 1993-02-18
JPH06509570A (ja) 1994-10-27
CZ24894A3 (en) 1994-07-13
PT100765A (pt) 1993-10-29
FI940530A0 (fi) 1994-02-04
MA22611A1 (fr) 1993-04-01
AU2417392A (en) 1993-03-02
TNSN92073A1 (fr) 1993-06-08
ITMI912225A0 (it) 1991-08-07
FI940530A (fi) 1994-02-04
SK11594A3 (en) 1994-12-07
ITMI912225A1 (it) 1993-02-08
BG98439A (bg) 1994-09-30

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Legal Events

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970828