ES8401943A1 - Procedimiento para la preparacion de derivados de 2-piridona. - Google Patents

Procedimiento para la preparacion de derivados de 2-piridona.

Info

Publication number
ES8401943A1
ES8401943A1 ES520986A ES520986A ES8401943A1 ES 8401943 A1 ES8401943 A1 ES 8401943A1 ES 520986 A ES520986 A ES 520986A ES 520986 A ES520986 A ES 520986A ES 8401943 A1 ES8401943 A1 ES 8401943A1
Authority
ES
Spain
Prior art keywords
alkyl
preparation
pyridone derivatives
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES520986A
Other languages
English (en)
Other versions
ES520986A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES8401943A1 publication Critical patent/ES8401943A1/es
Publication of ES520986A0 publication Critical patent/ES520986A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE 2-PIRIDONA.CONSISTE EN HACER REACCIONAR COMPUESTOS DE FORMULA (II) CON COMPUESTOS DE FORMULA GENERAL (III) A TEMPERATURAS COMPRENDIDAS ENTRE 30 Y 150JC Y EN PRESENCIA DE UNA BASE, EN AGUA O EN UN DISOLVENTE ORGANICO, PARA OBTENER DERIVADOS DE 2-PIRIDONA DE FORMULA GENERAL (I), DONDE R SIGNIFICA HIDROGENO O ALCOHILO C 1 A 6; R ES UN GRUPO -CH F 0, -COOR O -CH2-O-R, R ES HIDROGENO, ALCOHILO C 1 A 12 O BENCILO, R HIDROGENO, ALCOHILO C 1 A 4 ALCANOILO C 1 A 9, CICLOALCANOILO C 4 A 7 Y OTROS, R REPRESENTA 2-TIENILO,3-TIENILO, TERC-BUTILO, O EN GRUPO FENILO Y OTROS, X SIGNIFICA HALOGENO, ALCOHISULFONILOXILO, FENILSULFONILOXILO O EL RADICAL DE UN ESTER ACTIVO. COMO DISOLVENTES ORGANICOS INERTES SE UTILIZAN N,N-DIMETILFORMAMIDA, N-METILPIRROLIDONA-2, DIOXANO Y OTROS; Y COMO BASES SE UTILIZAN CARBONATOS, HIDROGENOCARBONATOS, HIDROXIDOS, ALCOHOLATOS O HIDRUROS.TIENEN APLICACIONES FARMACOLOGICAS POR SU EFECTO INHIBIDOR DE INFLAMACION CON BAJA TOXICIDAD.
ES520986A 1982-03-27 1983-03-25 Procedimiento para la preparacion de derivados de 2-piridona. Granted ES520986A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823211395 DE3211395A1 (de) 1982-03-27 1982-03-27 Pyridon-2-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
ES8401943A1 true ES8401943A1 (es) 1984-01-01
ES520986A0 ES520986A0 (es) 1984-01-01

Family

ID=6159523

Family Applications (1)

Application Number Title Priority Date Filing Date
ES520986A Granted ES520986A0 (es) 1982-03-27 1983-03-25 Procedimiento para la preparacion de derivados de 2-piridona.

Country Status (15)

Country Link
EP (1) EP0090353A1 (es)
JP (1) JPS58174365A (es)
KR (1) KR840004075A (es)
AU (1) AU1287083A (es)
CA (1) CA1193602A (es)
DE (1) DE3211395A1 (es)
DK (1) DK138383A (es)
ES (1) ES520986A0 (es)
FI (1) FI831008L (es)
GR (1) GR78498B (es)
IL (1) IL68240A0 (es)
NO (1) NO831094L (es)
PH (1) PH19639A (es)
PT (1) PT76449B (es)
ZA (1) ZA832138B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3346175A1 (de) * 1983-12-21 1985-07-11 Merck Patent Gmbh, 6100 Darmstadt Pyridylthiophene
FR2665159B1 (fr) * 1990-07-24 1992-11-13 Rhone Poulenc Sante Nouveaux derives de la pyridine et de la quinoleine, leur preparation et les compositions pharmaceutiques qui les contiennent.
DE4227748A1 (de) * 1992-08-21 1994-02-24 Bayer Ag Pyridyloxy-acrylsäureester

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3655897A (en) * 1971-01-25 1972-04-11 Merck & Co Inc Anti-inflammatory agents

Also Published As

Publication number Publication date
CA1193602A (en) 1985-09-17
JPS58174365A (ja) 1983-10-13
DE3211395A1 (de) 1983-09-29
EP0090353A1 (de) 1983-10-05
DK138383A (da) 1983-09-28
PT76449B (de) 1986-01-27
KR840004075A (ko) 1984-10-06
DK138383D0 (da) 1983-03-25
ES520986A0 (es) 1984-01-01
FI831008A0 (fi) 1983-03-24
ZA832138B (en) 1983-12-28
FI831008L (fi) 1983-09-28
AU1287083A (en) 1983-09-29
PT76449A (de) 1983-04-01
NO831094L (no) 1983-09-28
IL68240A0 (en) 1983-06-15
GR78498B (es) 1984-09-27
PH19639A (en) 1986-06-04

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971001