FR2794646B1 - Microgranules de sulfate de morphine, procede de preparation et composition les contenant - Google Patents

Microgranules de sulfate de morphine, procede de preparation et composition les contenant

Info

Publication number
FR2794646B1
FR2794646B1 FR9907259A FR9907259A FR2794646B1 FR 2794646 B1 FR2794646 B1 FR 2794646B1 FR 9907259 A FR9907259 A FR 9907259A FR 9907259 A FR9907259 A FR 9907259A FR 2794646 B1 FR2794646 B1 FR 2794646B1
Authority
FR
France
Prior art keywords
preparation
composition containing
morphine sulfate
sulfate microgranules
microgranules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR9907259A
Other languages
English (en)
French (fr)
Other versions
FR2794646A1 (fr
Inventor
Dominique Marechal
Pascal Suplie
Pascal Oury
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ethypharm SAS
Original Assignee
Ethypharm SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9546553&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2794646(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ethypharm SAS filed Critical Ethypharm SAS
Priority to FR9907259A priority Critical patent/FR2794646B1/fr
Priority to CO00041883A priority patent/CO5160317A1/es
Priority to ARP000102831A priority patent/AR024313A1/es
Priority to HK02105909.7A priority patent/HK1045107B/zh
Priority to AT00940460T priority patent/ATE354356T1/de
Priority to DK05111290.2T priority patent/DK1627631T3/da
Priority to JP2001501196A priority patent/JP4296562B2/ja
Priority to MXPA01012751A priority patent/MXPA01012751A/es
Priority to ES05111290T priority patent/ES2379688T3/es
Priority to BRPI0011404A priority patent/BRPI0011404B8/pt
Priority to CA2376339A priority patent/CA2376339C/fr
Priority to CNB008086052A priority patent/CN1267089C/zh
Priority to NZ516077A priority patent/NZ516077A/en
Priority to SI200030946T priority patent/SI1189602T1/sl
Priority to EP05111290A priority patent/EP1627631B1/fr
Priority to AT05111290T priority patent/ATE544448T1/de
Priority to PCT/FR2000/001573 priority patent/WO2000074659A1/fr
Priority to PT05111290T priority patent/PT1627631E/pt
Priority to DK00940460T priority patent/DK1189602T3/da
Priority to EP07102671A priority patent/EP1818051A1/fr
Priority to ES00940460T priority patent/ES2280226T3/es
Priority to KR1020017015784A priority patent/KR100676123B1/ko
Priority to US10/009,341 priority patent/US7063864B1/en
Priority to AU55394/00A priority patent/AU769160C/en
Priority to DE60033519T priority patent/DE60033519T2/de
Priority to EP00940460A priority patent/EP1189602B1/fr
Priority to PT00940460T priority patent/PT1189602E/pt
Priority to TW089111207A priority patent/TWI224510B/zh
Publication of FR2794646A1 publication Critical patent/FR2794646A1/fr
Publication of FR2794646B1 publication Critical patent/FR2794646B1/fr
Application granted granted Critical
Priority to ZA200110087A priority patent/ZA200110087B/xx
Priority to US11/441,349 priority patent/US20070003620A1/en
Priority to CY20071100489T priority patent/CY1107612T1/el
Priority to ARP080103672A priority patent/AR068015A2/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/501—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
FR9907259A 1999-06-09 1999-06-09 Microgranules de sulfate de morphine, procede de preparation et composition les contenant Expired - Lifetime FR2794646B1 (fr)

Priority Applications (32)

Application Number Priority Date Filing Date Title
FR9907259A FR2794646B1 (fr) 1999-06-09 1999-06-09 Microgranules de sulfate de morphine, procede de preparation et composition les contenant
CO00041883A CO5160317A1 (es) 1999-06-09 2000-06-06 Microgranulos de sulfato de morfina, procedimiento para su preparacion y composicion que los contiene
ARP000102831A AR024313A1 (es) 1999-06-09 2000-06-07 Microgranulos de sulfato de morfina, procedimiento para su preparacion y composicion que los contiene
PCT/FR2000/001573 WO2000074659A1 (fr) 1999-06-09 2000-06-08 Microgranules de sulfate de morphine, procede de preparation et composition les contenant
ES00940460T ES2280226T3 (es) 1999-06-09 2000-06-08 Microgranulos de sulfato de morfina, procedimiento de preparacion y composicion que los contiene.
DK05111290.2T DK1627631T3 (da) 1999-06-09 2000-06-08 Morfinsulfatmikrogranuler, fremgangsmåde til fremstilling deraf og præparat omfattende samme
JP2001501196A JP4296562B2 (ja) 1999-06-09 2000-06-08 硫酸モルヒネ微小顆粒、その調製方法およびそれを含有する組成物
MXPA01012751A MXPA01012751A (es) 1999-06-09 2000-06-08 Microgranulos de sulfato de morfina, procedimiento para su preparacion y composicion que los contiene.
ES05111290T ES2379688T3 (es) 1999-06-09 2000-06-08 Microgránulos de sulfato de morfina, procedimiento de preparación y composición que los contiene
BRPI0011404A BRPI0011404B8 (pt) 1999-06-09 2000-06-08 microgrânulos de sulfato de morfina de liberação prolongada, processo de preparação dos mesmos e composição farmacêutica.
CA2376339A CA2376339C (fr) 1999-06-09 2000-06-08 Microgranules de sulfate de morphine, procede de preparation et composition les contenant
CNB008086052A CN1267089C (zh) 1999-06-09 2000-06-08 硫酸吗啡微粒,其制备方法及含有该物质的组合物
NZ516077A NZ516077A (en) 1999-06-09 2000-06-08 Morphine sulphate microgranules, preparation process and compositions thereof
SI200030946T SI1189602T1 (sl) 1999-06-09 2000-06-08 Mikrogranule morfin sulfata, postopek izdelave in sestavek, ki jih vsebuje
EP05111290A EP1627631B1 (fr) 1999-06-09 2000-06-08 Microgranules de sulfate de morphine, procédé de préparation et composition les contenant
AT05111290T ATE544448T1 (de) 1999-06-09 2000-06-08 Morphinsulfat enthaltende mikrogranulate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen
HK02105909.7A HK1045107B (zh) 1999-06-09 2000-06-08 吗啡硫酸盐微粒，其制备方法及含有此物质的成份
PT05111290T PT1627631E (pt) 1999-06-09 2000-06-08 Microgrânulos de sulfato de morfina, processo de preparação e composição que os contem
DK00940460T DK1189602T3 (da) 1999-06-09 2000-06-08 Morfinmikrogranula, fremgangsmåde til fremstilling og præparat der indeholder dem
EP07102671A EP1818051A1 (fr) 1999-06-09 2000-06-08 Microgranules de sulfate de morphine, procédé de préparation et composition les contenant
AT00940460T ATE354356T1 (de) 1999-06-09 2000-06-08 Morphinsulfat enthaltende mikrogranulate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen
KR1020017015784A KR100676123B1 (ko) 1999-06-09 2000-06-08 모르핀술페이트 마이크로그래뉼, 이의 제조방법 및 이를함유하는 조성물
US10/009,341 US7063864B1 (en) 1999-06-09 2000-06-08 Morphine sulphate microgranules, method for preparing same and compositions containing same
AU55394/00A AU769160C (en) 1999-06-09 2000-06-08 Morphine sulphate microgranules, method for preparing same and compositions containing same
DE60033519T DE60033519T2 (de) 1999-06-09 2000-06-08 Morphinsulfat enthaltende mikrogranulate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen
EP00940460A EP1189602B1 (fr) 1999-06-09 2000-06-08 Microgranules de sulfate de morphine, procede de preparation et composition les contenant
PT00940460T PT1189602E (pt) 1999-06-09 2000-06-08 Microgrânulos de sulfato de morfina, processo de preparação e composição que os contêm
TW089111207A TWI224510B (en) 1999-06-09 2000-06-27 Morphine sulphate microgranules, and pharmaceutical composition containing them
ZA200110087A ZA200110087B (en) 1999-06-09 2001-12-07 Morphine sulphate microgranules, method for preparing same and compositions containing same.
US11/441,349 US20070003620A1 (en) 1999-06-09 2006-05-26 Morphine sulfate microgranules, method for preparing same and compositions containing same
CY20071100489T CY1107612T1 (el) 1999-06-09 2007-04-05 Μικροκοκκοι θειικης μορφινης, μεθοδος παρασκευης τους, και συνθεσεις περιεχουσες αυτους
ARP080103672A AR068015A2 (es) 1999-06-09 2008-08-22 Microgranulos de sulfato de morfina procedimiento para su preparacion y composicion que los contiene

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9907259A FR2794646B1 (fr) 1999-06-09 1999-06-09 Microgranules de sulfate de morphine, procede de preparation et composition les contenant

Publications (2)

Publication Number Publication Date
FR2794646A1 FR2794646A1 (fr) 2000-12-15
FR2794646B1 true FR2794646B1 (fr) 2001-09-21

Family

ID=9546553

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9907259A Expired - Lifetime FR2794646B1 (fr) 1999-06-09 1999-06-09 Microgranules de sulfate de morphine, procede de preparation et composition les contenant

Country Status (24)

Country Link
US (2) US7063864B1 (enExample)
EP (3) EP1189602B1 (enExample)
JP (1) JP4296562B2 (enExample)
KR (1) KR100676123B1 (enExample)
CN (1) CN1267089C (enExample)
AR (2) AR024313A1 (enExample)
AT (2) ATE354356T1 (enExample)
AU (1) AU769160C (enExample)
BR (1) BRPI0011404B8 (enExample)
CA (1) CA2376339C (enExample)
CO (1) CO5160317A1 (enExample)
CY (1) CY1107612T1 (enExample)
DE (1) DE60033519T2 (enExample)
DK (2) DK1189602T3 (enExample)
ES (2) ES2280226T3 (enExample)
FR (1) FR2794646B1 (enExample)
HK (1) HK1045107B (enExample)
MX (1) MXPA01012751A (enExample)
NZ (1) NZ516077A (enExample)
PT (2) PT1627631E (enExample)
SI (1) SI1189602T1 (enExample)
TW (1) TWI224510B (enExample)
WO (1) WO2000074659A1 (enExample)
ZA (1) ZA200110087B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2794646B1 (fr) * 1999-06-09 2001-09-21 Ethypharm Lab Prod Ethiques Microgranules de sulfate de morphine, procede de preparation et composition les contenant
JP4848101B2 (ja) * 2001-08-17 2011-12-28 株式会社フジモト・コーポレーション 徐放性マイクロペレット
EP1429739A1 (en) 2001-09-21 2004-06-23 Egalet A/S Polymer release system
EP1429744A1 (en) 2001-09-21 2004-06-23 Egalet A/S Morphine polymer release system
DE602004031096D1 (de) 2003-03-26 2011-03-03 Egalet As Morphin-system mit kontrollierter freisetzung
FR2883179B1 (fr) * 2005-03-18 2009-04-17 Ethypharm Sa Comprime enrobe
US20100233257A1 (en) * 2006-06-09 2010-09-16 Ethypharm Low dose sublingual tablets of opioid analgesics and preparation process
US20070286900A1 (en) * 2006-06-09 2007-12-13 Catherine Herry Low dose tablets of opioid analgesics and preparation process
CA2687192C (en) 2007-06-04 2015-11-24 Egalet A/S Controlled release pharmaceutical compositions for prolonged effect
NZ594207A (en) 2009-02-06 2013-03-28 Egalet Ltd Immediate release composition resistant to abuse by intake of alcohol
NZ597283A (en) 2009-06-24 2013-07-26 Egalet Ltd Controlled release formulations
US20190038769A1 (en) * 2010-12-01 2019-02-07 Gowey Research Group, Pllc Micro-rna profiling, compositions, and methods of treating diseases
JP2012250926A (ja) * 2011-06-01 2012-12-20 Nitto Denko Corp 粒子製剤
US9549899B2 (en) 2012-07-06 2017-01-24 Egalet Ltd. Abuse deterrent pharmaceutical compositions for controlled release
IL273627B2 (en) 2017-12-20 2025-03-01 Purdue Pharma Lp Morphine sulfate dosage forms for abuse deterrence

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8514665D0 (en) 1985-06-11 1985-07-10 Eroceltique Sa Oral pharmaceutical composition
CA2007181C (en) 1989-01-06 1998-11-24 Angelo Mario Morella Sustained release pharmaceutical composition
US5133974A (en) 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
GB9117361D0 (en) * 1991-08-12 1991-09-25 Euro Celtique Sa Oral dosage form
GB9119958D0 (en) 1991-09-18 1991-10-30 Unilever Plc Detergent compositions
US5286493A (en) 1992-01-27 1994-02-15 Euroceltique, S.A. Stabilized controlled release formulations having acrylic polymer coating
US5968551A (en) * 1991-12-24 1999-10-19 Purdue Pharma L.P. Orally administrable opioid formulations having extended duration of effect
US5478577A (en) * 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
SE9301057L (sv) 1993-03-30 1994-10-01 Pharmacia Ab Beredning med kontrollerad frisättning
HU218673B (hu) * 1993-10-07 2000-10-28 Euroceltique S.A. Opioid analgetikumot tartalmazó elnyújtott hatóanyag-felszabadítású orális gyógyszerkészítmény és eljárás előállítására
US5411745A (en) 1994-05-25 1995-05-02 Euro-Celtique, S.A. Powder-layered morphine sulfate formulations
US5460826A (en) 1994-06-27 1995-10-24 Alza Corporation Morphine therapy
GB9422154D0 (en) 1994-11-03 1994-12-21 Euro Celtique Sa Pharmaceutical compositions and method of producing the same
FR2771291B1 (fr) * 1997-11-21 2000-02-25 Ethypharm Lab Prod Ethiques Spheroides, procede de preparation et compositions pharmaceutiques
FR2794646B1 (fr) * 1999-06-09 2001-09-21 Ethypharm Lab Prod Ethiques Microgranules de sulfate de morphine, procede de preparation et composition les contenant

Also Published As

Publication number Publication date
US20070003620A1 (en) 2007-01-04
FR2794646A1 (fr) 2000-12-15
AU769160C (en) 2006-02-23
KR20020031338A (ko) 2002-05-01
CN1390121A (zh) 2003-01-08
MXPA01012751A (es) 2002-07-02
EP1627631A2 (fr) 2006-02-22
DE60033519T2 (de) 2007-10-31
WO2000074659A1 (fr) 2000-12-14
CO5160317A1 (es) 2002-05-30
AR024313A1 (es) 2002-09-25
AR068015A2 (es) 2009-10-28
HK1045107A1 (en) 2002-11-15
ATE544448T1 (de) 2012-02-15
BR0011404A (pt) 2002-03-05
JP2003520770A (ja) 2003-07-08
TWI224510B (en) 2004-12-01
KR100676123B1 (ko) 2007-01-31
EP1189602B1 (fr) 2007-02-21
DK1189602T3 (da) 2007-07-02
BR0011404B1 (pt) 2013-03-05
CY1107612T1 (el) 2013-03-13
EP1627631B1 (fr) 2012-02-08
HK1045107B (zh) 2007-05-11
ES2379688T3 (es) 2012-04-30
DE60033519D1 (de) 2007-04-05
DK1627631T3 (da) 2012-04-30
AU5539400A (en) 2000-12-28
US7063864B1 (en) 2006-06-20
EP1189602A1 (fr) 2002-03-27
ZA200110087B (en) 2003-03-03
ES2280226T3 (es) 2007-09-16
EP1818051A1 (fr) 2007-08-15
CN1267089C (zh) 2006-08-02
BRPI0011404B8 (pt) 2021-05-25
AU769160B2 (en) 2004-01-15
CA2376339A1 (fr) 2000-12-14
CA2376339C (fr) 2011-05-17
PT1189602E (pt) 2007-05-31
ATE354356T1 (de) 2007-03-15
NZ516077A (en) 2004-06-25
JP4296562B2 (ja) 2009-07-15
SI1189602T1 (sl) 2007-06-30
EP1627631A3 (fr) 2006-03-15
PT1627631E (pt) 2012-05-21

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