FR2794646B1 - morphine sulfate microgranules process for the preparation and composition containing them - Google Patents

morphine sulfate microgranules process for the preparation and composition containing them

Info

Publication number
FR2794646B1
FR2794646B1 FR9907259A FR9907259A FR2794646B1 FR 2794646 B1 FR2794646 B1 FR 2794646B1 FR 9907259 A FR9907259 A FR 9907259A FR 9907259 A FR9907259 A FR 9907259A FR 2794646 B1 FR2794646 B1 FR 2794646B1
Authority
FR
France
Prior art keywords
preparation
process
composition containing
morphine sulfate
sulfate microgranules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR9907259A
Other languages
French (fr)
Other versions
FR2794646A1 (en
Inventor
Dominique Marechal
Pascal Suplie
Pascal Oury
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ethypharm
Original Assignee
Ethypharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Application filed by Ethypharm filed Critical Ethypharm
Priority to FR9907259A priority Critical patent/FR2794646B1/en
Publication of FR2794646A1 publication Critical patent/FR2794646A1/en
Application granted granted Critical
Publication of FR2794646B1 publication Critical patent/FR2794646B1/en
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9546553&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2794646(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application status is Active legal-status Critical
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5026Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/501Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5036Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
FR9907259A 1999-06-09 1999-06-09 morphine sulfate microgranules process for the preparation and composition containing them Active FR2794646B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR9907259A FR2794646B1 (en) 1999-06-09 1999-06-09 morphine sulfate microgranules process for the preparation and composition containing them

Applications Claiming Priority (30)

Application Number Priority Date Filing Date Title
FR9907259A FR2794646B1 (en) 1999-06-09 1999-06-09 morphine sulfate microgranules process for the preparation and composition containing them
CO00041883A CO5160317A1 (en) 1999-06-09 2000-06-06 Microgranules morphine sulfate, process for their preparation and composition containing
ARP000102831 AR024313A1 (en) 1999-06-09 2000-06-07 Microgranules morphine sulfate, process for their preparation and composition containing
DE2000633519 DE60033519T2 (en) 1999-06-09 2000-06-08 Morphine sulphate-containing microgranules, processes for their preparation and pharmaceutical compositions
US10/009,341 US7063864B1 (en) 1999-06-09 2000-06-08 Morphine sulphate microgranules, method for preparing same and compositions containing same
ES00940460T ES2280226T3 (en) 1999-06-09 2000-06-08 Microgranules of morphine sulphate, preparation process and composition containing them.
CA 2376339 CA2376339C (en) 1999-06-09 2000-06-08 Morphine sulphate microgranules, method for preparing same and compositions containing same
MXPA01012751A MXPA01012751A (en) 1999-06-09 2000-06-08 Morphine sulphate microgranules, method for preparing same and compositions containing same.
BRPI0011404-9A BR0011404B1 (en) 1999-06-09 2000-06-08 Microgranules prolonged liberaÇço morphine sulfate, preparaÇço process thereof and pharmaceutical composiÇço.
PCT/FR2000/001573 WO2000074659A1 (en) 1999-06-09 2000-06-08 Morphine sulphate microgranules, method for preparing same and compositions containing same
AT00940460T AT354356T (en) 1999-06-09 2000-06-08 Morphine sulphate-containing microgranules, processes for their preparation and pharmaceutical compositions
DK05111290.2T DK1627631T3 (en) 1999-06-09 2000-06-08 Morfinsulfatmikrogranuler, process for the preparation thereof and composition comprising the same
ES05111290T ES2379688T3 (en) 1999-06-09 2000-06-08 Morphine sulfate microgranules, method of preparation and composition containing
AU55394/00A AU769160C (en) 1999-06-09 2000-06-08 Morphine sulphate microgranules, method for preparing same and compositions containing same
EP07102671A EP1818051A1 (en) 1999-06-09 2000-06-08 Microgranules of morphine sulphate, preparation method and composition containing them
PT05111290T PT1627631E (en) 1999-06-09 2000-06-08 Morphine sulphate microgranules, method for preparing same and composition comprising same
DK00940460T DK1189602T3 (en) 1999-06-09 2000-06-08 Morfinmikrogranula, method of preparation and composition containing them
AT05111290T AT544448T (en) 1999-06-09 2000-06-08 Morphine sulphate-containing microgranules, processes for their preparation and pharmaceutical compositions
JP2001501196A JP4296562B2 (en) 1999-06-09 2000-06-08 Morphine sulfate microgranules, their preparation and compositions containing the same
EP20000940460 EP1189602B1 (en) 1999-06-09 2000-06-08 Morphine sulphate microgranules, method for preparing same and compositions containing same
PT00940460T PT1189602E (en) 1999-06-09 2000-06-08 Morphine sulphate microgranules, method for preparing same and compositions containing same
EP05111290A EP1627631B1 (en) 1999-06-09 2000-06-08 Morphine sulphate microgranules, method for preparing same and composition comprising same
CN 00808605 CN1267089C (en) 1999-06-09 2000-06-08 Morphine sulphate microgranules, method for preparing same and compositions containing same
NZ51607700A NZ516077A (en) 1999-06-09 2000-06-08 Morphine sulphate microgranules, preparation process and compositions thereof
TW89111207A TWI224510B (en) 1999-06-09 2000-06-27 Morphine sulphate microgranules, and pharmaceutical composition containing them
ZA200110087A ZA200110087B (en) 1999-06-09 2001-12-07 Morphine sulphate microgranules, method for preparing same and compositions containing same.
HK02105909A HK1045107A1 (en) 1999-06-09 2002-08-13 Morphine sulphate microgranules, method for preparing same and compositions containing same
US11/441,349 US20070003620A1 (en) 1999-06-09 2006-05-26 Morphine sulfate microgranules, method for preparing same and compositions containing same
CY20071100489T CY1107612T1 (en) 1999-06-09 2007-04-05 Microgranules MORPHINE SULPHATE, METHOD OF PREPARATION THEREOF, COMPOSITIONS CONTAINING THEM and
ARP080103672 AR068015A2 (en) 1999-06-09 2008-08-22 Microgranules of morphine sulfate process for their preparation and composition containing

Publications (2)

Publication Number Publication Date
FR2794646A1 FR2794646A1 (en) 2000-12-15
FR2794646B1 true FR2794646B1 (en) 2001-09-21

Family

ID=9546553

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9907259A Active FR2794646B1 (en) 1999-06-09 1999-06-09 morphine sulfate microgranules process for the preparation and composition containing them

Country Status (22)

Country Link
US (2) US7063864B1 (en)
EP (3) EP1189602B1 (en)
JP (1) JP4296562B2 (en)
CN (1) CN1267089C (en)
AR (2) AR024313A1 (en)
AT (2) AT544448T (en)
AU (1) AU769160C (en)
BR (1) BR0011404B1 (en)
CA (1) CA2376339C (en)
CO (1) CO5160317A1 (en)
CY (1) CY1107612T1 (en)
DE (1) DE60033519T2 (en)
DK (2) DK1627631T3 (en)
ES (2) ES2280226T3 (en)
FR (1) FR2794646B1 (en)
HK (1) HK1045107A1 (en)
MX (1) MXPA01012751A (en)
NZ (1) NZ516077A (en)
PT (2) PT1189602E (en)
TW (1) TWI224510B (en)
WO (1) WO2000074659A1 (en)
ZA (1) ZA200110087B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2794646B1 (en) * 1999-06-09 2001-09-21 Ethypharm Lab Prod Ethiques morphine sulfate microgranules process for the preparation and composition containing them
JP4848101B2 (en) * 2001-08-17 2011-12-28 株式会社フジモト・コーポレーション Sustained-release micro pellets
EP1429744A1 (en) 2001-09-21 2004-06-23 Egalet A/S Morphine polymer release system
US20040234602A1 (en) 2001-09-21 2004-11-25 Gina Fischer Polymer release system
EP2301526B1 (en) 2003-03-26 2016-03-23 Egalet Ltd. Morphine controlled release system
FR2883179B1 (en) 2005-03-18 2009-04-17 Ethypharm Sa Coated tablet
US20100233257A1 (en) * 2006-06-09 2010-09-16 Ethypharm Low dose sublingual tablets of opioid analgesics and preparation process
US20070286900A1 (en) * 2006-06-09 2007-12-13 Catherine Herry Low dose tablets of opioid analgesics and preparation process
NZ580972A (en) 2007-06-04 2012-02-24 Egalet Ltd Controlled release pharmaceutical compositions for prolonged effect
AU2010211220B2 (en) 2009-02-06 2013-08-01 Egalet Ltd. Immediate release composition resistant to abuse by intake of alcohol
AU2010265213B2 (en) 2009-06-24 2012-08-23 Egalet Ltd. Controlled release formulations
JP2012250926A (en) * 2011-06-01 2012-12-20 Nitto Denko Corp Particulate formulation
EA201590165A1 (en) 2012-07-06 2015-08-31 Эгалет Лтд. Constraints abuse pharmaceutical composition for controlled release

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8514665D0 (en) 1985-06-11 1985-07-10 Eroceltique Sa Oral pharmaceutical composition
CA2007181C (en) 1989-01-06 1998-11-24 Angelo Mario Morella Sustained release pharmaceutical composition
US5133974A (en) 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
GB9117361D0 (en) * 1991-08-12 1991-09-25 Euro Celtique Sa Oral dosage form
GB9119958D0 (en) 1991-09-18 1991-10-30 Unilever Plc Detergent compositions
US5968551A (en) * 1991-12-24 1999-10-19 Purdue Pharma L.P. Orally administrable opioid formulations having extended duration of effect
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5286493A (en) 1992-01-27 1994-02-15 Euroceltique, S.A. Stabilized controlled release formulations having acrylic polymer coating
SE9301057L (en) 1993-03-30 1994-10-01 Pharmacia Ab Controlled release preparation
HU218673B (en) * 1993-10-07 2000-10-28 Euroceltique S.A. Controlled release pharmaceutical composition for orally administration comprising opioid analgesic and process for producing its
US5478577A (en) * 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US5411745A (en) 1994-05-25 1995-05-02 Euro-Celtique, S.A. Powder-layered morphine sulfate formulations
US5460826A (en) 1994-06-27 1995-10-24 Alza Corporation Morphine therapy
GB9422154D0 (en) 1994-11-03 1994-12-21 Euro Celtique Sa Pharmaceutical compositions and method of producing the same
FR2771291B1 (en) 1997-11-21 2000-02-25 Ethypharm Lab Prod Ethiques Spheroids, process for the preparation and pharmaceutical compositions
FR2794646B1 (en) * 1999-06-09 2001-09-21 Ethypharm Lab Prod Ethiques morphine sulfate microgranules process for the preparation and composition containing them

Also Published As

Publication number Publication date
CA2376339C (en) 2011-05-17
BR0011404B1 (en) 2013-03-05
EP1627631B1 (en) 2012-02-08
AT354356T (en) 2007-03-15
ES2280226T3 (en) 2007-09-16
WO2000074659A1 (en) 2000-12-14
CN1390121A (en) 2003-01-08
DE60033519D1 (en) 2007-04-05
EP1189602B1 (en) 2007-02-21
DK1627631T3 (en) 2012-04-30
AU769160C (en) 2006-02-23
PT1189602E (en) 2007-05-31
AU5539400A (en) 2000-12-28
US7063864B1 (en) 2006-06-20
JP2003520770A (en) 2003-07-08
NZ516077A (en) 2004-06-25
PT1627631E (en) 2012-05-21
ZA200110087B (en) 2003-03-03
EP1627631A3 (en) 2006-03-15
TWI224510B (en) 2004-12-01
US20070003620A1 (en) 2007-01-04
CO5160317A1 (en) 2002-05-30
BR0011404A (en) 2002-03-05
CY1107612T1 (en) 2013-03-13
CN1267089C (en) 2006-08-02
EP1627631A2 (en) 2006-02-22
EP1818051A1 (en) 2007-08-15
AT544448T (en) 2012-02-15
AR024313A1 (en) 2002-09-25
ES2379688T3 (en) 2012-04-30
SI1189602T1 (en) 2007-06-30
HK1045107A1 (en) 2007-05-11
MXPA01012751A (en) 2002-07-02
FR2794646A1 (en) 2000-12-15
AR068015A2 (en) 2009-10-28
CA2376339A1 (en) 2000-12-14
DE60033519T2 (en) 2007-10-31
AU769160B2 (en) 2004-01-15
EP1189602A1 (en) 2002-03-27
DK1189602T3 (en) 2007-07-02
JP4296562B2 (en) 2009-07-15

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Legal Events

Date Code Title Description
GC Lien (pledge) constituted
GC Lien (pledge) constituted

Effective date: 20140519

PLFP Fee payment

Year of fee payment: 17

GC Lien (pledge) constituted

Effective date: 20160120

RG Lien (pledge) cancelled

Effective date: 20160226

PLFP Fee payment

Year of fee payment: 18

RG Lien (pledge) cancelled

Effective date: 20170418

PLFP Fee payment

Year of fee payment: 19

PLFP Fee payment

Year of fee payment: 20