ATE544448T1 - Morphinsulfat enthaltende mikrogranulate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen - Google Patents

Morphinsulfat enthaltende mikrogranulate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen

Info

Publication number
ATE544448T1
ATE544448T1 AT05111290T AT05111290T ATE544448T1 AT E544448 T1 ATE544448 T1 AT E544448T1 AT 05111290 T AT05111290 T AT 05111290T AT 05111290 T AT05111290 T AT 05111290T AT E544448 T1 ATE544448 T1 AT E544448T1
Authority
AT
Austria
Prior art keywords
production
pharmaceutical compositions
morphine sulfate
containing morphine
microgranules containing
Prior art date
Application number
AT05111290T
Other languages
English (en)
Inventor
Dominique Marechal
Pascal Oury
Pascal Suplie
Original Assignee
Ethypharm Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9546553&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE544448(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ethypharm Sa filed Critical Ethypharm Sa
Application granted granted Critical
Publication of ATE544448T1 publication Critical patent/ATE544448T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/501—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
AT05111290T 1999-06-09 2000-06-08 Morphinsulfat enthaltende mikrogranulate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen ATE544448T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9907259A FR2794646B1 (fr) 1999-06-09 1999-06-09 Microgranules de sulfate de morphine, procede de preparation et composition les contenant

Publications (1)

Publication Number Publication Date
ATE544448T1 true ATE544448T1 (de) 2012-02-15

Family

ID=9546553

Family Applications (2)

Application Number Title Priority Date Filing Date
AT00940460T ATE354356T1 (de) 1999-06-09 2000-06-08 Morphinsulfat enthaltende mikrogranulate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen
AT05111290T ATE544448T1 (de) 1999-06-09 2000-06-08 Morphinsulfat enthaltende mikrogranulate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT00940460T ATE354356T1 (de) 1999-06-09 2000-06-08 Morphinsulfat enthaltende mikrogranulate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen

Country Status (24)

Country Link
US (2) US7063864B1 (de)
EP (3) EP1627631B1 (de)
JP (1) JP4296562B2 (de)
KR (1) KR100676123B1 (de)
CN (1) CN1267089C (de)
AR (2) AR024313A1 (de)
AT (2) ATE354356T1 (de)
AU (1) AU769160C (de)
BR (1) BRPI0011404B8 (de)
CA (1) CA2376339C (de)
CO (1) CO5160317A1 (de)
CY (1) CY1107612T1 (de)
DE (1) DE60033519T2 (de)
DK (2) DK1627631T3 (de)
ES (2) ES2379688T3 (de)
FR (1) FR2794646B1 (de)
HK (1) HK1045107B (de)
MX (1) MXPA01012751A (de)
NZ (1) NZ516077A (de)
PT (2) PT1627631E (de)
SI (1) SI1189602T1 (de)
TW (1) TWI224510B (de)
WO (1) WO2000074659A1 (de)
ZA (1) ZA200110087B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2794646B1 (fr) * 1999-06-09 2001-09-21 Ethypharm Lab Prod Ethiques Microgranules de sulfate de morphine, procede de preparation et composition les contenant
JP4848101B2 (ja) * 2001-08-17 2011-12-28 株式会社フジモト・コーポレーション 徐放性マイクロペレット
WO2003024430A1 (en) 2001-09-21 2003-03-27 Egalet A/S Morphine polymer release system
WO2003024429A1 (en) 2001-09-21 2003-03-27 Egalet A/S Polymer release system
ES2570454T3 (es) 2003-03-26 2016-05-18 Egalet Ltd Sistema de liberación controlada de morfina
FR2883179B1 (fr) 2005-03-18 2009-04-17 Ethypharm Sa Comprime enrobe
US20070286900A1 (en) 2006-06-09 2007-12-13 Catherine Herry Low dose tablets of opioid analgesics and preparation process
US20100233257A1 (en) * 2006-06-09 2010-09-16 Ethypharm Low dose sublingual tablets of opioid analgesics and preparation process
WO2008148798A2 (en) 2007-06-04 2008-12-11 Egalet A/S Controlled release pharmaceutical compositions for prolonged effect
EP2393484A1 (de) 2009-02-06 2011-12-14 Egalet Ltd. Gegen missbrauch durch alkoholeinnahme widerstandsfähige zusammensetzung mit unmittelbarer freisetzung
AU2010265213B2 (en) 2009-06-24 2012-08-23 Egalet Ltd. Controlled release formulations
US20190038769A1 (en) * 2010-12-01 2019-02-07 Gowey Research Group, Pllc Micro-rna profiling, compositions, and methods of treating diseases
JP2012250926A (ja) * 2011-06-01 2012-12-20 Nitto Denko Corp 粒子製剤
BR112015000150A2 (pt) 2012-07-06 2017-06-27 Egalet Ltd composições farmacêuticas dissuasoras de abuso de liberação controlada

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8514665D0 (en) 1985-06-11 1985-07-10 Eroceltique Sa Oral pharmaceutical composition
CA2007181C (en) * 1989-01-06 1998-11-24 Angelo Mario Morella Sustained release pharmaceutical composition
US5133974A (en) 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
GB9117361D0 (en) * 1991-08-12 1991-09-25 Euro Celtique Sa Oral dosage form
GB9119958D0 (en) 1991-09-18 1991-10-30 Unilever Plc Detergent compositions
US5478577A (en) * 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US5968551A (en) * 1991-12-24 1999-10-19 Purdue Pharma L.P. Orally administrable opioid formulations having extended duration of effect
US5286493A (en) 1992-01-27 1994-02-15 Euroceltique, S.A. Stabilized controlled release formulations having acrylic polymer coating
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
SE9301057L (sv) 1993-03-30 1994-10-01 Pharmacia Ab Beredning med kontrollerad frisättning
EP1442745A1 (de) * 1993-10-07 2004-08-04 Euro-Celtique Oral anzuwendende opioidhaltige Zusammensetzungen mit verlängerter Wirkung
US5411745A (en) 1994-05-25 1995-05-02 Euro-Celtique, S.A. Powder-layered morphine sulfate formulations
US5460826A (en) 1994-06-27 1995-10-24 Alza Corporation Morphine therapy
GB9422154D0 (en) 1994-11-03 1994-12-21 Euro Celtique Sa Pharmaceutical compositions and method of producing the same
FR2771291B1 (fr) * 1997-11-21 2000-02-25 Ethypharm Lab Prod Ethiques Spheroides, procede de preparation et compositions pharmaceutiques
FR2794646B1 (fr) * 1999-06-09 2001-09-21 Ethypharm Lab Prod Ethiques Microgranules de sulfate de morphine, procede de preparation et composition les contenant

Also Published As

Publication number Publication date
BR0011404B1 (pt) 2013-03-05
FR2794646A1 (fr) 2000-12-15
EP1189602A1 (de) 2002-03-27
ES2280226T3 (es) 2007-09-16
CO5160317A1 (es) 2002-05-30
CY1107612T1 (el) 2013-03-13
AU5539400A (en) 2000-12-28
CN1267089C (zh) 2006-08-02
PT1627631E (pt) 2012-05-21
HK1045107B (zh) 2007-05-11
CA2376339C (fr) 2011-05-17
FR2794646B1 (fr) 2001-09-21
TWI224510B (en) 2004-12-01
BR0011404A (pt) 2002-03-05
HK1045107A1 (en) 2002-11-15
EP1627631B1 (de) 2012-02-08
JP2003520770A (ja) 2003-07-08
US20070003620A1 (en) 2007-01-04
SI1189602T1 (sl) 2007-06-30
KR100676123B1 (ko) 2007-01-31
DK1627631T3 (da) 2012-04-30
ATE354356T1 (de) 2007-03-15
EP1627631A2 (de) 2006-02-22
AU769160B2 (en) 2004-01-15
AR068015A2 (es) 2009-10-28
CN1390121A (zh) 2003-01-08
WO2000074659A1 (fr) 2000-12-14
MXPA01012751A (es) 2002-07-02
CA2376339A1 (fr) 2000-12-14
DK1189602T3 (da) 2007-07-02
ES2379688T3 (es) 2012-04-30
AR024313A1 (es) 2002-09-25
US7063864B1 (en) 2006-06-20
KR20020031338A (ko) 2002-05-01
EP1189602B1 (de) 2007-02-21
DE60033519T2 (de) 2007-10-31
ZA200110087B (en) 2003-03-03
DE60033519D1 (de) 2007-04-05
AU769160C (en) 2006-02-23
EP1818051A1 (de) 2007-08-15
EP1627631A3 (de) 2006-03-15
PT1189602E (pt) 2007-05-31
NZ516077A (en) 2004-06-25
BRPI0011404B8 (pt) 2021-05-25
JP4296562B2 (ja) 2009-07-15

Similar Documents

Publication Publication Date Title
ATE370946T1 (de) 16-halogen-epothilon-derivate, verfahren zu deren herstellung und ihre pharmazeutische verwendung
ATE252562T1 (de) Pyrazolcarbonsäurederivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen
ATE317688T1 (de) Orale pharmazeutische zusammensetzung enthaltend ein benzimidazolderivat mit antiulcus wirkung und verfahren zu seiner herstellung
DE60030246D1 (de) Titanlegierung und verfahren zu deren herstellung
ATE307576T1 (de) Fenofibrathaltige arzneizusammensetzung mit erhöhter bioverfügbarkeit und verfahren zu deren herstellung
DE59809806D1 (de) Chemische mikroreaktoren und verfahren zu deren herstellung
DE69941054D1 (de) Isosorbid enthaltende poyester und verfahren zu deren herstellung
ATE288577T1 (de) Ladeluftkühler und verfahren zu dessen herstellung
DE69932361D1 (de) Trennschicht und verfahren zu deren herstellung
ATE429903T1 (de) Pharmazeutische zubereitung mit verzögerter wirkstoff-freisetzung enthaltend milchsäure- glycolsäure copolymer, und verfahren zu deren herstellung
ATE279506T1 (de) Tabletten und verfahren zu deren herstellung
ATA90122000A (de) Stabilisierte orale pharmazeutische zusammensetzung, die jodid und jodat enthält und verfahren zu deren herstellung
ATE332997T1 (de) Celluloseether und verfahren zu deren herstellung
ATE234103T1 (de) Feste, oral verabreichbare ribavirin dosisformen und verfahren zu deren herstellung
DE60022660D1 (de) Gasdichte beschichtungszusammensetzung, verfahren zu deren herstellung und gasdichter beschichtungsfilm
ATE354356T1 (de) Morphinsulfat enthaltende mikrogranulate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen
DE60020469D1 (de) Propylenharzzusammensetzung und verfahren zu deren herstellung
DE60036102D1 (de) Purinderivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen
DE60013463D1 (de) Pharmazeutische produkte und verfahren zu deren herstellung
DE69934781D1 (de) Morphinsulfat enthaltende mikrogranulate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen
ATE209219T1 (de) Synthetische polysaccharide, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen
ATE294175T1 (de) 4-sulfonamid-piperidin-derivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen
ATE290366T1 (de) Pharmazeutische formulierung mit überdecktem geschmack und verfahren zu ihrer herstellung
DE50010354D1 (de) Verbundteil und verfahren zu dessen herstellung
ATE264837T1 (de) N-guanidinalkylamide, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische präparate