AR068015A2 - Microgranulos de sulfato de morfina procedimiento para su preparacion y composicion que los contiene - Google Patents

Microgranulos de sulfato de morfina procedimiento para su preparacion y composicion que los contiene

Info

Publication number
AR068015A2
AR068015A2 ARP080103672A ARP080103672A AR068015A2 AR 068015 A2 AR068015 A2 AR 068015A2 AR P080103672 A ARP080103672 A AR P080103672A AR P080103672 A ARP080103672 A AR P080103672A AR 068015 A2 AR068015 A2 AR 068015A2
Authority
AR
Argentina
Prior art keywords
morphine sulfate
microgranules
release layer
procedure
preparation
Prior art date
Application number
ARP080103672A
Other languages
English (en)
Original Assignee
Ethypharm Lab Prod Ethiques
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9546553&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR068015(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ethypharm Lab Prod Ethiques filed Critical Ethypharm Lab Prod Ethiques
Publication of AR068015A2 publication Critical patent/AR068015A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/501—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose

Abstract

Microgránulos de sulfato de morfina de liberacion prolongada, cada uno de los cuales comprende un grano de soporte neutro, rodeado por una capa activa y por una capa de liberacion prolongada, donde la capa de liberacion prolongada contiene un copolímero de ácido metacrílico y de éster de metil metacrilato, siendo la proporcion relativa entre los grupos carboxilos libres y los grupos ésteres, igual a aproximadamente 0,5, y una sílice que presenta un carácter hidrofobo. Reivindicacion 5: Microgránulos de acuerdo con una cualquiera de las reivindicaciones 1 a 4, caracterizados porque la capa de liberacion prolongada contiene un plastificante tal como el trietil citrato, y un lubricante. Reivindicacion 6: Microgránulos de acuerdo con las reivindicaciones 4 y 5, caracterizados porque su composicion es la siguiente: Sulfato de morfina de 30 a 40%; Granos de soporte neutros de 30 a 40%; Ligante de 10 a 20%; Copolímero de ácido metacrílico de 5 a 15%; Plastificante de 1 a 2,5%; Lubricante de 2 a 4%; Sílice hidrofoba de 0,2 a 1%.
ARP080103672A 1999-06-09 2008-08-22 Microgranulos de sulfato de morfina procedimiento para su preparacion y composicion que los contiene AR068015A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9907259A FR2794646B1 (fr) 1999-06-09 1999-06-09 Microgranules de sulfate de morphine, procede de preparation et composition les contenant

Publications (1)

Publication Number Publication Date
AR068015A2 true AR068015A2 (es) 2009-10-28

Family

ID=9546553

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP000102831A AR024313A1 (es) 1999-06-09 2000-06-07 Microgranulos de sulfato de morfina, procedimiento para su preparacion y composicion que los contiene
ARP080103672A AR068015A2 (es) 1999-06-09 2008-08-22 Microgranulos de sulfato de morfina procedimiento para su preparacion y composicion que los contiene

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP000102831A AR024313A1 (es) 1999-06-09 2000-06-07 Microgranulos de sulfato de morfina, procedimiento para su preparacion y composicion que los contiene

Country Status (24)

Country Link
US (2) US7063864B1 (es)
EP (3) EP1189602B1 (es)
JP (1) JP4296562B2 (es)
KR (1) KR100676123B1 (es)
CN (1) CN1267089C (es)
AR (2) AR024313A1 (es)
AT (2) ATE354356T1 (es)
AU (1) AU769160C (es)
BR (1) BRPI0011404B8 (es)
CA (1) CA2376339C (es)
CO (1) CO5160317A1 (es)
CY (1) CY1107612T1 (es)
DE (1) DE60033519T2 (es)
DK (2) DK1189602T3 (es)
ES (2) ES2280226T3 (es)
FR (1) FR2794646B1 (es)
HK (1) HK1045107B (es)
MX (1) MXPA01012751A (es)
NZ (1) NZ516077A (es)
PT (2) PT1627631E (es)
SI (1) SI1189602T1 (es)
TW (1) TWI224510B (es)
WO (1) WO2000074659A1 (es)
ZA (1) ZA200110087B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2794646B1 (fr) * 1999-06-09 2001-09-21 Ethypharm Lab Prod Ethiques Microgranules de sulfate de morphine, procede de preparation et composition les contenant
JP4848101B2 (ja) * 2001-08-17 2011-12-28 株式会社フジモト・コーポレーション 徐放性マイクロペレット
WO2003024430A1 (en) 2001-09-21 2003-03-27 Egalet A/S Morphine polymer release system
EP2957281A1 (en) 2001-09-21 2015-12-23 Egalet Ltd. Polymer release system
ES2360102T3 (es) 2003-03-26 2011-05-31 Egalet A/S Sistema para la liberación controlada de morfina.
FR2883179B1 (fr) 2005-03-18 2009-04-17 Ethypharm Sa Comprime enrobe
US20070286900A1 (en) 2006-06-09 2007-12-13 Catherine Herry Low dose tablets of opioid analgesics and preparation process
US20100233257A1 (en) * 2006-06-09 2010-09-16 Ethypharm Low dose sublingual tablets of opioid analgesics and preparation process
EP2155167A2 (en) 2007-06-04 2010-02-24 Egalet A/S Controlled release pharmaceutical compositions for prolonged effect
EP2393484A1 (en) 2009-02-06 2011-12-14 Egalet Ltd. Immediate release composition resistant to abuse by intake of alcohol
AU2010265213B2 (en) 2009-06-24 2012-08-23 Egalet Ltd. Controlled release formulations
US20190038769A1 (en) * 2010-12-01 2019-02-07 Gowey Research Group, Pllc Micro-rna profiling, compositions, and methods of treating diseases
JP2012250926A (ja) * 2011-06-01 2012-12-20 Nitto Denko Corp 粒子製剤
US9549899B2 (en) 2012-07-06 2017-01-24 Egalet Ltd. Abuse deterrent pharmaceutical compositions for controlled release

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8514665D0 (en) 1985-06-11 1985-07-10 Eroceltique Sa Oral pharmaceutical composition
CA2007181C (en) 1989-01-06 1998-11-24 Angelo Mario Morella Sustained release pharmaceutical composition
US5133974A (en) 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
GB9117361D0 (en) * 1991-08-12 1991-09-25 Euro Celtique Sa Oral dosage form
GB9119958D0 (en) 1991-09-18 1991-10-30 Unilever Plc Detergent compositions
US5968551A (en) * 1991-12-24 1999-10-19 Purdue Pharma L.P. Orally administrable opioid formulations having extended duration of effect
US5286493A (en) 1992-01-27 1994-02-15 Euroceltique, S.A. Stabilized controlled release formulations having acrylic polymer coating
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5478577A (en) * 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
SE9301057L (sv) 1993-03-30 1994-10-01 Pharmacia Ab Beredning med kontrollerad frisättning
EP0647448A1 (en) * 1993-10-07 1995-04-12 Euroceltique S.A. Orally administrable opioid formulations having extended duration of effect
US5411745A (en) 1994-05-25 1995-05-02 Euro-Celtique, S.A. Powder-layered morphine sulfate formulations
US5460826A (en) 1994-06-27 1995-10-24 Alza Corporation Morphine therapy
GB9422154D0 (en) 1994-11-03 1994-12-21 Euro Celtique Sa Pharmaceutical compositions and method of producing the same
FR2771291B1 (fr) 1997-11-21 2000-02-25 Ethypharm Lab Prod Ethiques Spheroides, procede de preparation et compositions pharmaceutiques
FR2794646B1 (fr) * 1999-06-09 2001-09-21 Ethypharm Lab Prod Ethiques Microgranules de sulfate de morphine, procede de preparation et composition les contenant

Also Published As

Publication number Publication date
JP2003520770A (ja) 2003-07-08
CA2376339A1 (fr) 2000-12-14
AR024313A1 (es) 2002-09-25
AU5539400A (en) 2000-12-28
KR100676123B1 (ko) 2007-01-31
EP1627631A3 (fr) 2006-03-15
EP1818051A1 (fr) 2007-08-15
HK1045107B (zh) 2007-05-11
ATE354356T1 (de) 2007-03-15
EP1627631B1 (fr) 2012-02-08
BR0011404B1 (pt) 2013-03-05
WO2000074659A1 (fr) 2000-12-14
CO5160317A1 (es) 2002-05-30
CN1267089C (zh) 2006-08-02
PT1627631E (pt) 2012-05-21
HK1045107A1 (en) 2002-11-15
CN1390121A (zh) 2003-01-08
MXPA01012751A (es) 2002-07-02
ZA200110087B (en) 2003-03-03
FR2794646A1 (fr) 2000-12-15
ES2379688T3 (es) 2012-04-30
DK1627631T3 (da) 2012-04-30
DK1189602T3 (da) 2007-07-02
FR2794646B1 (fr) 2001-09-21
BRPI0011404B8 (pt) 2021-05-25
EP1627631A2 (fr) 2006-02-22
DE60033519T2 (de) 2007-10-31
KR20020031338A (ko) 2002-05-01
ES2280226T3 (es) 2007-09-16
JP4296562B2 (ja) 2009-07-15
SI1189602T1 (sl) 2007-06-30
CA2376339C (fr) 2011-05-17
ATE544448T1 (de) 2012-02-15
DE60033519D1 (de) 2007-04-05
NZ516077A (en) 2004-06-25
US7063864B1 (en) 2006-06-20
EP1189602A1 (fr) 2002-03-27
CY1107612T1 (el) 2013-03-13
US20070003620A1 (en) 2007-01-04
AU769160C (en) 2006-02-23
EP1189602B1 (fr) 2007-02-21
TWI224510B (en) 2004-12-01
PT1189602E (pt) 2007-05-31
AU769160B2 (en) 2004-01-15
BR0011404A (pt) 2002-03-05

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Legal Events

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