FR2778662B1 - Nouveaux composes cycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Nouveaux composes cycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

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Publication number
FR2778662B1
FR2778662B1 FR9805957A FR9805957A FR2778662B1 FR 2778662 B1 FR2778662 B1 FR 2778662B1 FR 9805957 A FR9805957 A FR 9805957A FR 9805957 A FR9805957 A FR 9805957A FR 2778662 B1 FR2778662 B1 FR 2778662B1
Authority
FR
France
Prior art keywords
sup
preparation
pharmaceutical compositions
compositions containing
substituted cyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9805957A
Other languages
English (en)
French (fr)
Other versions
FR2778662A1 (fr
Inventor
Daniel Lesieur
Frederique Klupsch
Gerald Guillaumet
Marie Claude Viaud
Michel Langlois
Caroline Bennejean
Pierre Renard
Philippe Delagrange
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9805957A priority Critical patent/FR2778662B1/fr
Application filed by ADIR SARL filed Critical ADIR SARL
Priority to CN99806053A priority patent/CN1300277A/zh
Priority to US09/700,098 priority patent/US6872851B1/en
Priority to NZ507691A priority patent/NZ507691A/en
Priority to ES99918037T priority patent/ES2255261T3/es
Priority to PL99344012A priority patent/PL344012A1/xx
Priority to DK99918037T priority patent/DK1077928T3/da
Priority to BR9911783-5A priority patent/BR9911783A/pt
Priority to DE69933147T priority patent/DE69933147T2/de
Priority to HU0101800A priority patent/HUP0101800A3/hu
Priority to US09/700,056 priority patent/US6605632B1/en
Priority to BR9911771-1A priority patent/BR9911771A/pt
Priority to PCT/FR1999/001100 priority patent/WO1999058495A1/fr
Priority to EP99918037A priority patent/EP1077928B1/fr
Priority to AT99918036T priority patent/ATE312072T1/de
Priority to PL99344048A priority patent/PL195613B1/pl
Priority to AT99918037T priority patent/ATE312073T1/de
Priority to JP2000548300A priority patent/JP2002514620A/ja
Priority to JP2000548299A priority patent/JP2002514619A/ja
Priority to HU0101813A priority patent/HUP0101813A3/hu
Priority to CN99806830A priority patent/CN1304400A/zh
Priority to DK99918036T priority patent/DK1077927T3/da
Priority to DE69933149T priority patent/DE69933149T2/de
Priority to EP99918036A priority patent/EP1077927B1/fr
Priority to AU36103/99A priority patent/AU748567B2/en
Priority to CA002331870A priority patent/CA2331870C/fr
Priority to AU36104/99A priority patent/AU747301B2/en
Priority to CA002331877A priority patent/CA2331877C/fr
Priority to ES99918036T priority patent/ES2255260T3/es
Priority to PCT/FR1999/001101 priority patent/WO1999058496A1/fr
Priority to NZ507692A priority patent/NZ507692A/en
Publication of FR2778662A1 publication Critical patent/FR2778662A1/fr
Application granted granted Critical
Publication of FR2778662B1 publication Critical patent/FR2778662B1/fr
Priority to ZA200006528A priority patent/ZA200006528B/en
Priority to ZA200006529A priority patent/ZA200006529B/en
Priority to NO20005714A priority patent/NO20005714L/no
Priority to NO20005715A priority patent/NO20005715D0/no
Priority to US10/462,331 priority patent/US7183318B2/en
Priority to US10/462,326 priority patent/US20040002490A1/en
Priority to US10/948,410 priority patent/US7115752B2/en
Priority to US10/947,757 priority patent/US7126012B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
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    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
    • C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
    • C04B35/632—Organic additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
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    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/62—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
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    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
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    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/48—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring being part of a condensed ring system of the same carbon skeleton
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    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
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    • C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
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    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
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    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
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    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
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    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
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    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
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    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
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    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
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    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
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    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
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    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
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    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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FR9805957A 1998-05-12 1998-05-12 Nouveaux composes cycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Expired - Fee Related FR2778662B1 (fr)

Priority Applications (39)

Application Number Priority Date Filing Date Title
FR9805957A FR2778662B1 (fr) 1998-05-12 1998-05-12 Nouveaux composes cycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DK99918036T DK1077927T3 (da) 1998-05-12 1999-05-10 Nye substituerede cykliske forbindelser, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse
NZ507691A NZ507691A (en) 1998-05-12 1999-05-10 (Dihydro)benzothiophenes compounds suitable for treating melatonergic system disorders
ES99918037T ES2255261T3 (es) 1998-05-12 1999-05-10 Nuevos compuestos ciclicos sustituidos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
PL99344012A PL344012A1 (en) 1998-05-12 1999-05-10 Novel substituted cyclic compounds, preparation method and pharmaceutical compositions containing them
DK99918037T DK1077928T3 (da) 1998-05-12 1999-05-10 Nye substituerede cykliske forbindelser, fremgangsmåder til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse
BR9911783-5A BR9911783A (pt) 1998-05-12 1999-05-10 Compostos cìclicos substituìdos, processo para sua preparação e composições farmacêuticas que os contêm
DE69933147T DE69933147T2 (de) 1998-05-12 1999-05-10 Sustiuierte cyclische verbindungen, verfahren zu ihrer herstellung sowie sie enthaltende pharmazeutische zusammesetzungen
HU0101800A HUP0101800A3 (en) 1998-05-12 1999-05-10 Novel substituted cyclic compounds, preparation method and pharmaceutical compositions containing them
US09/700,056 US6605632B1 (en) 1998-05-12 1999-05-10 Substituted cyclic compounds, preparation method and pharmaceutical compositions containing them
BR9911771-1A BR9911771A (pt) 1998-05-12 1999-05-10 Compostos cìclicos substituìdos, um processo para sua preparação e composições farmacêuticas que contêm os mesmos
PCT/FR1999/001100 WO1999058495A1 (fr) 1998-05-12 1999-05-10 Nouveaux composes cycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP99918037A EP1077928B1 (fr) 1998-05-12 1999-05-10 Nouveaux composes cycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AT99918036T ATE312072T1 (de) 1998-05-12 1999-05-10 Substituierte cyclische verbindungen, verfahren zu ihrer herstellung sowie sie enthaltende pharmazeutische zusammensetzungen
PL99344048A PL195613B1 (pl) 1998-05-12 1999-05-10 Nowe podstawione związki cykliczne, sposób ich wytwarzania, kompozycje farmaceutyczne je zawierające oraz zastosowanie kompozycji
AT99918037T ATE312073T1 (de) 1998-05-12 1999-05-10 Sustiuierte cyclische verbindungen, verfahren zu ihrer herstellung sowie sie enthaltende pharmazeutische zusammesetzungen
JP2000548300A JP2002514620A (ja) 1998-05-12 1999-05-10 新しい置換環状化合物、これらの製造方法及びこれらを含む薬剤組成物
EP99918036A EP1077927B1 (fr) 1998-05-12 1999-05-10 Nouveaux composes cycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
HU0101813A HUP0101813A3 (en) 1998-05-12 1999-05-10 Carboxylic acid derivatives substituted by homo- or heterocyclic group preparation method and pharmaceutical compositions containing them
CN99806830A CN1304400A (zh) 1998-05-12 1999-05-10 新的取代的环状化合物,其制备方法和含有它们的药物组合物
CN99806053A CN1300277A (zh) 1998-05-12 1999-05-10 新的取代的环状化合物,其制备方法和含有它们的药物组合物
JP2000548299A JP2002514619A (ja) 1998-05-12 1999-05-10 新しい置換環状化合物、これらの製造方法及びこれらを含む薬剤組成物
US09/700,098 US6872851B1 (en) 1998-05-12 1999-05-10 Substituted cyclic compounds, preparation method and pharmaceutical compositions containing them
AU36103/99A AU748567B2 (en) 1998-05-12 1999-05-10 Novel substituted cyclic compounds, preparation method and pharmaceutical compositions containing them
CA002331870A CA2331870C (fr) 1998-05-12 1999-05-10 Nouveaux composes cycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU36104/99A AU747301B2 (en) 1998-05-12 1999-05-10 Novel substituted cyclic compounds, preparation method and pharmaceutical compositions containing them
CA002331877A CA2331877C (fr) 1998-05-12 1999-05-10 Nouveaux composes cycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ES99918036T ES2255260T3 (es) 1998-05-12 1999-05-10 Nuevos compuestos ciclicos sustituidos, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
PCT/FR1999/001101 WO1999058496A1 (fr) 1998-05-12 1999-05-10 Nouveaux composes cycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
NZ507692A NZ507692A (en) 1998-05-12 1999-05-10 Retroamide chain benzofuran and benzothiophene compounds substituted by amides or carbamates for use in melatonergic system disorders
DE69933149T DE69933149T2 (de) 1998-05-12 1999-05-10 Substituierte cyclische verbindungen, verfahren zu ihrer herstellung sowie sie enthaltende pharmazeutische zusammensetzungen
ZA200006528A ZA200006528B (en) 1998-05-12 2000-11-10 Novel substituted cyclic compounds, preparation method and pharmaceutical compositions containing them.
ZA200006529A ZA200006529B (en) 1998-05-12 2000-11-10 Novel substituted cyclic compounds, preparation method and pharmaceutical compositions containing them.
NO20005714A NO20005714L (no) 1998-05-12 2000-11-13 Nye substituerte cykliske forbindelser, fremgangsmåte ved deres fremstilling og farmasöytiske sammensetninger inneholdende dem
NO20005715A NO20005715D0 (no) 1998-05-12 2000-11-13 Nye substituerte cykliske forbindelser, fremgangsmåte ved deres fremstilling og farmasöytiske sammensetninger inneholdende dem
US10/462,331 US7183318B2 (en) 1998-05-12 2003-06-16 Substituted cyclic compounds, preparation method and pharmaceutical compositions containing them
US10/462,326 US20040002490A1 (en) 1998-05-12 2003-06-16 Substituted cyclic compounds, preparation method and pharmaceutical compositions containing them
US10/948,410 US7115752B2 (en) 1998-05-12 2004-09-23 Substituted cyclic compounds
US10/947,757 US7126012B2 (en) 1998-05-12 2004-09-23 Substituted cyclic compounds

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US (6) US6605632B1 (enExample)
EP (2) EP1077928B1 (enExample)
JP (2) JP2002514620A (enExample)
CN (2) CN1300277A (enExample)
AT (2) ATE312072T1 (enExample)
AU (2) AU747301B2 (enExample)
BR (2) BR9911783A (enExample)
CA (2) CA2331870C (enExample)
DE (2) DE69933149T2 (enExample)
DK (2) DK1077927T3 (enExample)
ES (2) ES2255261T3 (enExample)
FR (1) FR2778662B1 (enExample)
HU (2) HUP0101813A3 (enExample)
NO (2) NO20005715D0 (enExample)
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EP1077928B1 (fr) 2005-12-07
ATE312072T1 (de) 2005-12-15
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CN1300277A (zh) 2001-06-20
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CA2331877C (fr) 2006-02-28
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