FR2752732B1 - Forme galenique a liberation prolongee de milnacipran - Google Patents

Forme galenique a liberation prolongee de milnacipran

Info

Publication number
FR2752732B1
FR2752732B1 FR9610528A FR9610528A FR2752732B1 FR 2752732 B1 FR2752732 B1 FR 2752732B1 FR 9610528 A FR9610528 A FR 9610528A FR 9610528 A FR9610528 A FR 9610528A FR 2752732 B1 FR2752732 B1 FR 2752732B1
Authority
FR
France
Prior art keywords
hours
milnacipran
mum
dose released
dose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9610528A
Other languages
English (en)
French (fr)
Other versions
FR2752732A1 (fr
Inventor
Bruno Paillard
Eric Goutay
Jean Louis Avan
Joel Bougaret
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9610528A priority Critical patent/FR2752732B1/fr
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Priority to JP51133798A priority patent/JP4549442B2/ja
Priority to DE69710757T priority patent/DE69710757T2/de
Priority to PCT/FR1997/001525 priority patent/WO1998008495A1/fr
Priority to EP97938949A priority patent/EP0939626B1/fr
Priority to DK97938949T priority patent/DK0939626T3/da
Priority to CA002264238A priority patent/CA2264238C/fr
Priority to CN97198442A priority patent/CN1108791C/zh
Priority to US09/254,014 priority patent/US6699506B1/en
Priority to PT97938949T priority patent/PT939626E/pt
Priority to ES97938949T priority patent/ES2171991T3/es
Priority to BR9711378A priority patent/BR9711378A/pt
Priority to AT97938949T priority patent/ATE213629T1/de
Priority to AU41212/97A priority patent/AU727018B2/en
Publication of FR2752732A1 publication Critical patent/FR2752732A1/fr
Application granted granted Critical
Publication of FR2752732B1 publication Critical patent/FR2752732B1/fr
Priority to JP2010053612A priority patent/JP5431214B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Polishing Bodies And Polishing Tools (AREA)
  • Medicines Containing Plant Substances (AREA)
FR9610528A 1996-08-28 1996-08-28 Forme galenique a liberation prolongee de milnacipran Expired - Fee Related FR2752732B1 (fr)

Priority Applications (15)

Application Number Priority Date Filing Date Title
FR9610528A FR2752732B1 (fr) 1996-08-28 1996-08-28 Forme galenique a liberation prolongee de milnacipran
ES97938949T ES2171991T3 (es) 1996-08-28 1997-08-26 Forma galenica de liberacion prolongada de milnacipran.
PCT/FR1997/001525 WO1998008495A1 (fr) 1996-08-28 1997-08-26 Forme galenique a liberation prolongee de milnacipran
EP97938949A EP0939626B1 (fr) 1996-08-28 1997-08-26 Forme galenique a liberation prolongee de milnacipran
DK97938949T DK0939626T3 (da) 1996-08-28 1997-08-26 Galenisk form til forlænget frigivelse af milnacipran
CA002264238A CA2264238C (fr) 1996-08-28 1997-08-26 Forme galenique a liberation prolongee de milnacipran
CN97198442A CN1108791C (zh) 1996-08-28 1997-08-26 延长释放米那普仑的盖仑制剂
US09/254,014 US6699506B1 (en) 1996-08-28 1997-08-26 Pharmaceutical composition with extended release of Milnacipran
JP51133798A JP4549442B2 (ja) 1996-08-28 1997-08-26 ミルナシプランの持続性放出を伴うガレヌス製剤形態
DE69710757T DE69710757T2 (de) 1996-08-28 1997-08-26 Milnacipranhaltige darreichungsform mit verzögerter wirkstoffabgabe
BR9711378A BR9711378A (pt) 1996-08-28 1997-08-26 Forma gal-ncia com libera-Æo prolongada
AT97938949T ATE213629T1 (de) 1996-08-28 1997-08-26 Milnacipranhaltige darreichungsform mit verzögerter wirkstoffabgabe
AU41212/97A AU727018B2 (en) 1996-08-28 1997-08-26 Galenic form with extended release of milnacipran
PT97938949T PT939626E (pt) 1996-08-28 1997-08-26 Forma galenica de libertacao prolongada de milnaciprano
JP2010053612A JP5431214B2 (ja) 1996-08-28 2010-03-10 ミルナシプランの持続性放出を伴うガレヌス製剤形態

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9610528A FR2752732B1 (fr) 1996-08-28 1996-08-28 Forme galenique a liberation prolongee de milnacipran

Publications (2)

Publication Number Publication Date
FR2752732A1 FR2752732A1 (fr) 1998-03-06
FR2752732B1 true FR2752732B1 (fr) 1998-11-20

Family

ID=9495256

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9610528A Expired - Fee Related FR2752732B1 (fr) 1996-08-28 1996-08-28 Forme galenique a liberation prolongee de milnacipran

Country Status (14)

Country Link
US (1) US6699506B1 (enExample)
EP (1) EP0939626B1 (enExample)
JP (2) JP4549442B2 (enExample)
CN (1) CN1108791C (enExample)
AT (1) ATE213629T1 (enExample)
AU (1) AU727018B2 (enExample)
BR (1) BR9711378A (enExample)
CA (1) CA2264238C (enExample)
DE (1) DE69710757T2 (enExample)
DK (1) DK0939626T3 (enExample)
ES (1) ES2171991T3 (enExample)
FR (1) FR2752732B1 (enExample)
PT (1) PT939626E (enExample)
WO (1) WO1998008495A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7820643B2 (en) 2001-11-05 2010-10-26 Cypress Bioscience, Inc. Methods of treating fibromyalgia syndrome, chronic fatigue syndrome and pain
US7994220B2 (en) 2005-09-28 2011-08-09 Cypress Bioscience, Inc. Milnacipran for the long-term treatment of fibromyalgia syndrome

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DE19928312A1 (de) * 1999-06-16 2000-12-21 Schering Ag Arzneimittelzubereitung mit verzögerter Wirkstoffabgabe
US8101209B2 (en) * 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
FR2830447B1 (fr) * 2001-10-09 2004-04-16 Flamel Tech Sa Forme galenique orale microparticulaire pour la liberation retardee et controlee de principes actifs pharmaceutiques
US6635675B2 (en) 2001-11-05 2003-10-21 Cypress Bioscience, Inc. Method of treating chronic fatigue syndrome
CA2480824A1 (fr) * 2002-04-09 2003-10-16 Flamel Technologies Formulation pharmaceutique orale sous forme de suspension aqueuse de microcapsules permettant la liberation modifiee d'amoxicilline
PT1492511E (pt) 2002-04-09 2009-04-09 Flamel Tech Sa Formulação farmacêutica oral na forma de suspensão aquosa de microcápsulas para libertação modificada de princípio(s) activo(s)
US20040132826A1 (en) * 2002-10-25 2004-07-08 Collegium Pharmaceutical, Inc. Modified release compositions of milnacipran
JP2006506461A (ja) * 2002-10-25 2006-02-23 コルジウム ファーマシューティカル， インコーポレイテッド ミルナシプランのパルス型放出組成物
US20060024366A1 (en) * 2002-10-25 2006-02-02 Collegium Pharmaceutical, Inc. Modified release compositions of milnacipran
US7704527B2 (en) * 2002-10-25 2010-04-27 Collegium Pharmaceutical, Inc. Modified release compositions of milnacipran
US20060003004A1 (en) * 2002-10-25 2006-01-05 Collegium Pharmaceutical, Inc. Pulsatile release compositions of milnacipran
EP1592453A1 (en) * 2003-01-28 2005-11-09 Collegium Pharmaceutical, Inc. Multiparticulate compositions of milnacipran for oral administration
FR2851163B1 (fr) * 2003-02-14 2007-04-27 Utilisation de l'enantiomere dextrogyre du milnacipran pour la preparation d'un medicament
PT1601349E (pt) * 2003-02-14 2008-10-27 Pf Medicament Utilização do enantiómero (1s, 2r) do milnaciprano para a preparação de um medicamento
WO2006132307A1 (ja) 2005-06-10 2006-12-14 Pierre Fabre Medicament S.A. 安定化されたミルナシプラン製剤
US20080319083A1 (en) * 2006-01-27 2008-12-25 Asahi Kasei Pharma Corporation Medicine for transnasal administration
WO2008109462A2 (en) * 2007-03-02 2008-09-12 Farnam Companies, Inc. Sustained release pellets comprising wax-like material
CN101301283B (zh) * 2007-05-10 2011-04-06 上海医药工业研究院 一种米那普仑的经鼻脑转运组合物
EP2110129A1 (en) 2008-04-18 2009-10-21 Pierre Fabre Medicament Use of enantiomer (1S, 2R) milnacipran hydrochloride for the preventive treatment of suicidal behaviour in depressed patients
ES2536736T3 (es) * 2008-09-04 2015-05-28 Farnam Companies, Inc. Formulaciones masticables de liberación sostenida
EP2448406B1 (en) 2009-02-26 2016-04-20 Relmada Therapeutics, Inc. Extended release oral pharmaceutical compositions of 3-hydroxy-n-methylmorphinan and method of use
US20100239681A1 (en) * 2009-03-20 2010-09-23 Biokey, Inc. Controlled Release Particulates Containing Water-Insoluble Drug
FR2943546A1 (fr) * 2009-03-31 2010-10-01 Nouveaux Produits Pharma Sas Excipient pharmaceutique fonctionnalise ameliorant la biodisponibilite de substances actives peu solubles, microgranules l'incorporant.
FR2945449B1 (fr) 2009-05-15 2012-10-05 Pf Medicament Procede d'impregnation par co2 supercritique
US9173845B2 (en) 2009-08-05 2015-11-03 Lupin Limited Controlled release pharmaceutical compositions of milnacipran
JP2013510176A (ja) 2009-11-06 2013-03-21 ピエール ファーブル メディカモン （１ｓ，２ｒ）−２−（アミノメチル）−ｎ，ｎ−ジエチル−１−フェニルシクロプロパンカルボキサミドの新規結晶形態
WO2011088331A1 (en) * 2010-01-14 2011-07-21 Forest Laboratories Holdings Limited Stable dosage forms of levomilnacipran
WO2011107921A2 (en) 2010-03-04 2011-09-09 Ranbaxy Laboratories Limited Modified release composition of milnacipran
WO2011107922A2 (en) 2010-03-04 2011-09-09 Ranbaxy Laboratories Limited Extended release composition of milnacipran
US8916194B2 (en) 2010-08-30 2014-12-23 Lupin Limited Controlled release pharmaceutical compositions of milnacipran
FR2978350B1 (fr) 2011-07-28 2013-11-08 Pf Medicament Medicament a base de levomilnacipran pour la rehabilitation fonctionnelle apres accident neurologique aigu
CN102793683B (zh) * 2012-09-04 2013-04-17 海南康虹医药科技开发有限公司 一种含左旋米那普仑的缓释组合物及其制备方法
WO2014078435A1 (en) 2012-11-14 2014-05-22 W. R. Grace & Co.-Conn. Compositions containing a biologically active material and a non-ordered inorganic oxide
JP6186139B2 (ja) * 2013-03-08 2017-08-23 杏林製薬株式会社 口腔内速崩壊性錠剤
CN105769823A (zh) * 2014-12-24 2016-07-20 上海星泰医药科技有限公司 一种左旋盐酸米那普仑缓释胶囊及其制备方法
EP3167879A1 (en) * 2015-11-10 2017-05-17 Evonik Technochemie GmbH Gastric retention active delivery systems
CN110711185A (zh) * 2018-07-11 2020-01-21 北京万全德众医药生物技术有限公司 左旋米那普仑缓释胶囊
JP7315383B2 (ja) * 2019-06-27 2023-07-26 株式会社Ｓｃｒｅｅｎホールディングス インクジェット用水性組成物及び固体製剤
CN114569566A (zh) * 2020-12-02 2022-06-03 四川科瑞德制药股份有限公司 一种盐酸米那普仑制剂的制备方法

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7820643B2 (en) 2001-11-05 2010-10-26 Cypress Bioscience, Inc. Methods of treating fibromyalgia syndrome, chronic fatigue syndrome and pain
US7888342B2 (en) 2001-11-05 2011-02-15 Cypress Bioscience, Inc. Methods of treating fibromyalgia syndrome, chronic fatigue syndrome and pain
US7915246B2 (en) 2001-11-05 2011-03-29 Cypress Bioscience, Inc. Methods of treating fibromyalgia syndrome, chronic fatigue syndrome and pain
US7994220B2 (en) 2005-09-28 2011-08-09 Cypress Bioscience, Inc. Milnacipran for the long-term treatment of fibromyalgia syndrome

Also Published As

Publication number Publication date
JP5431214B2 (ja) 2014-03-05
ATE213629T1 (de) 2002-03-15
WO1998008495A1 (fr) 1998-03-05
CA2264238A1 (fr) 1998-03-05
JP2010163447A (ja) 2010-07-29
ES2171991T3 (es) 2002-09-16
FR2752732A1 (fr) 1998-03-06
AU727018B2 (en) 2000-11-30
CN1232387A (zh) 1999-10-20
AU4121297A (en) 1998-03-19
US6699506B1 (en) 2004-03-02
PT939626E (pt) 2002-07-31
CA2264238C (fr) 2009-02-24
CN1108791C (zh) 2003-05-21
EP0939626A1 (fr) 1999-09-08
JP4549442B2 (ja) 2010-09-22
BR9711378A (pt) 1999-08-17
DE69710757D1 (de) 2002-04-04
JP2000516946A (ja) 2000-12-19
DE69710757T2 (de) 2004-11-04
DK0939626T3 (da) 2002-05-27
EP0939626B1 (fr) 2002-02-27

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Legal Events

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