ATE208192T1 - Formulierungen mit gesteuerter freisetzung für schwerlösliche arzneistoffe - Google Patents
Formulierungen mit gesteuerter freisetzung für schwerlösliche arzneistoffeInfo
- Publication number
- ATE208192T1 ATE208192T1 AT96921053T AT96921053T ATE208192T1 AT E208192 T1 ATE208192 T1 AT E208192T1 AT 96921053 T AT96921053 T AT 96921053T AT 96921053 T AT96921053 T AT 96921053T AT E208192 T1 ATE208192 T1 AT E208192T1
- Authority
- AT
- Austria
- Prior art keywords
- core
- controlled release
- poorly soluble
- formulation
- tablets
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 238000013270 controlled release Methods 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000004480 active ingredient Substances 0.000 abstract 3
- 238000009472 formulation Methods 0.000 abstract 3
- 239000011248 coating agent Substances 0.000 abstract 2
- 238000000576 coating method Methods 0.000 abstract 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 abstract 2
- 239000007962 solid dispersion Substances 0.000 abstract 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- RZTAMFZIAATZDJ-HNNXBMFYSA-N 5-o-ethyl 3-o-methyl (4s)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)[C@@H]1C1=CC=CC(Cl)=C1Cl RZTAMFZIAATZDJ-HNNXBMFYSA-N 0.000 abstract 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 abstract 1
- 229930105110 Cyclosporin A Natural products 0.000 abstract 1
- 108010036949 Cyclosporine Proteins 0.000 abstract 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 abstract 1
- ZBBHBTPTTSWHBA-UHFFFAOYSA-N Nicardipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN(C)CC=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 ZBBHBTPTTSWHBA-UHFFFAOYSA-N 0.000 abstract 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 abstract 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 abstract 1
- 229960001265 ciclosporin Drugs 0.000 abstract 1
- 229960005132 cisapride Drugs 0.000 abstract 1
- DCSUBABJRXZOMT-IRLDBZIGSA-N cisapride Chemical compound C([C@@H]([C@@H](CC1)NC(=O)C=2C(=CC(N)=C(Cl)C=2)OC)OC)N1CCCOC1=CC=C(F)C=C1 DCSUBABJRXZOMT-IRLDBZIGSA-N 0.000 abstract 1
- DCSUBABJRXZOMT-UHFFFAOYSA-N cisapride Natural products C1CC(NC(=O)C=2C(=CC(N)=C(Cl)C=2)OC)C(OC)CN1CCCOC1=CC=C(F)C=C1 DCSUBABJRXZOMT-UHFFFAOYSA-N 0.000 abstract 1
- 229930182912 cyclosporin Natural products 0.000 abstract 1
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 abstract 1
- 229960001259 diclofenac Drugs 0.000 abstract 1
- 229960003580 felodipine Drugs 0.000 abstract 1
- 229960001680 ibuprofen Drugs 0.000 abstract 1
- 229960000905 indomethacin Drugs 0.000 abstract 1
- 239000008185 minitablet Substances 0.000 abstract 1
- 229960001783 nicardipine Drugs 0.000 abstract 1
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 abstract 1
- 229960001597 nifedipine Drugs 0.000 abstract 1
- 239000008188 pellet Substances 0.000 abstract 1
- 229960000502 poloxamer Drugs 0.000 abstract 1
- 229920001983 poloxamer Polymers 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- 229960000351 terfenadine Drugs 0.000 abstract 1
- 229960000278 theophylline Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IE950492A IE80467B1 (en) | 1995-07-03 | 1995-07-03 | Controlled release formulations for poorly soluble drugs |
| US89795P | 1995-07-06 | 1995-07-06 | |
| PCT/IE1996/000039 WO1997002017A1 (en) | 1995-07-03 | 1996-07-01 | Controlled release formulations for poorly soluble drugs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE208192T1 true ATE208192T1 (de) | 2001-11-15 |
Family
ID=26319833
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96921053T ATE208192T1 (de) | 1995-07-03 | 1996-07-01 | Formulierungen mit gesteuerter freisetzung für schwerlösliche arzneistoffe |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0836475B1 (de) |
| JP (1) | JPH11508587A (de) |
| KR (1) | KR19990028693A (de) |
| AT (1) | ATE208192T1 (de) |
| AU (1) | AU700654B2 (de) |
| BG (1) | BG102228A (de) |
| BR (1) | BR9609663A (de) |
| CA (1) | CA2226008A1 (de) |
| CZ (1) | CZ413497A3 (de) |
| DE (1) | DE69616795T2 (de) |
| HU (1) | HUP9900231A2 (de) |
| IE (1) | IE80467B1 (de) |
| IL (1) | IL122663A0 (de) |
| NO (1) | NO975872L (de) |
| NZ (1) | NZ311145A (de) |
| PL (1) | PL324402A1 (de) |
| SK (1) | SK175997A3 (de) |
| TW (1) | TW426528B (de) |
| WO (1) | WO1997002017A1 (de) |
| ZA (1) | ZA965609B (de) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1283029B1 (it) * | 1996-05-17 | 1998-04-03 | Resa Farma | Composizioni farmaceutiche a base di diclofenac |
| FR2736550B1 (fr) | 1995-07-14 | 1998-07-24 | Sandoz Sa | Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule |
| US6126970A (en) * | 1995-12-01 | 2000-10-03 | Janssen Pharmaceutica N.V. | Cisapride sustained release |
| WO1998029095A2 (en) * | 1997-01-03 | 1998-07-09 | Elan Corporation, Plc | Sustained release cisapride mini-tablet formulation |
| DE19710009A1 (de) * | 1997-03-12 | 1998-09-24 | Knoll Ag | Mehrphasige wirkstoffhaltige Zubereitungsformen |
| US6312724B1 (en) | 1997-04-04 | 2001-11-06 | Isa Odidi | Sustained release pharmaceutical matrix tablet of pharmaceutically acceptable salts of diclofenac and process for preparation thereof |
| NZ328751A (en) * | 1997-09-16 | 1999-01-28 | Bernard Charles Sherman | Solid medicament containing an anionic surfactant and cyclosporin |
| WO1999017744A1 (en) * | 1997-10-07 | 1999-04-15 | Fuisz Technologies Ltd. | Immediate release drug delivery forms |
| US6013280A (en) * | 1997-10-07 | 2000-01-11 | Fuisz Technologies Ltd. | Immediate release dosage forms containing microspheres |
| NZ333474A (en) | 1998-01-02 | 1999-06-29 | Mcneil Ppc Inc | A chewable tablet containing ibuprofen, fumaric acid and a non hydrocolloid binder e.g. a wax or a fat |
| IE980115A1 (en) * | 1998-02-16 | 2000-02-09 | Biovail Internat Ltd | Solubilizing delivery systems and method of manufacture |
| US6787157B1 (en) | 1998-03-10 | 2004-09-07 | Abbott Laboratories | Multiphase active ingredient-containing formulations |
| AU4679999A (en) * | 1998-06-11 | 1999-12-30 | Em Industries, Inc. | Micro-osmotic controlled drug delivery systems |
| TW407058B (en) * | 1998-07-17 | 2000-10-01 | Dev Center Biotechnology | Oral cisapride dosage forms with an extended duration |
| IE981008A1 (en) * | 1998-12-02 | 2000-06-14 | Fuisz Internat Ltd | Microparticles Containing Water Insoluble Active Agents |
| ES2310164T3 (es) * | 1999-02-10 | 2009-01-01 | Pfizer Products Inc. | Dispositivo de liberacion controlada por la matriz. |
| US6706283B1 (en) | 1999-02-10 | 2004-03-16 | Pfizer Inc | Controlled release by extrusion of solid amorphous dispersions of drugs |
| EP1064938A1 (de) * | 1999-06-28 | 2001-01-03 | Sanofi-Synthelabo | Pharmazeutische Dosierungsformen zur kontrollierte Wirkstoffabgabe mit mindenstens ein pulsierendem Zeitverlauf |
| SE9902742D0 (sv) * | 1999-07-20 | 1999-07-20 | Astra Ab | New pharmaceutical formultion |
| KR100379299B1 (ko) * | 2000-01-15 | 2003-04-10 | 주식회사 중외제약 | 펠로디핀의 가용화 방법 및 방출제어형 제제 |
| JP2004525109A (ja) | 2001-02-15 | 2004-08-19 | キング・ファーマシューティカルズ・インコーポレイティッド | 安定化された甲状腺ホルモン医薬組成物、及びその製法 |
| CZ20033211A3 (cs) * | 2001-05-03 | 2004-09-15 | F. Hoffmann-La Roche Ag | Farmaceutická léková forma amorfního nelfinavir mesylátu |
| AR033711A1 (es) * | 2001-05-09 | 2004-01-07 | Novartis Ag | Composiciones farmaceuticas |
| US7101569B2 (en) | 2001-08-14 | 2006-09-05 | Franz G Andrew | Methods of administering levothyroxine pharmaceutical compositions |
| TWI252111B (en) * | 2001-12-14 | 2006-04-01 | Solvay Pharm Gmbh | Matrix film tablet with controlled release of a natural mixture of conjugated estrogens |
| US20050232995A1 (en) | 2002-07-29 | 2005-10-20 | Yam Nyomi V | Methods and dosage forms for controlled delivery of paliperidone and risperidone |
| KR20040011248A (ko) * | 2002-07-30 | 2004-02-05 | 환인제약 주식회사 | 암로디핀의 고체분산체와 그 제조방법 및 그를 포함하는약학적 조성물 |
| AU2002350719A1 (en) * | 2002-11-29 | 2004-06-23 | Janssen Pharmaceutica N.V. | Pharmaceutical compositions comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base |
| US20050163839A1 (en) * | 2003-01-29 | 2005-07-28 | Sun Pharmaceutical Industries Limited | Oral controlled release pharmaceutical composition containing metaxalone as active agent |
| JP2006518380A (ja) | 2003-01-31 | 2006-08-10 | スミスクライン・ビーチャム・コーポレイション | 固体分散体組成物 |
| EP1608347B1 (de) * | 2003-03-28 | 2014-08-13 | Sigmoid Pharma Limited | Solide orale dosierform mit nahtlosen mikrokapseln |
| US20050106242A1 (en) * | 2003-11-13 | 2005-05-19 | Dong Yan | Melt blend dispersions |
| WO2005065653A1 (en) * | 2003-12-19 | 2005-07-21 | E.I. Du Pont De Nemours And Company | Intimate coating of ibuprofen with poloxamers to enhance aqueous dissolution |
| EP1701704A2 (de) | 2003-12-31 | 2006-09-20 | Pfizer Products Inc. | Feste zusammensetzungen von arzneimitteln mit geringer lölslichkeit und poloxameren |
| KR100598326B1 (ko) | 2004-04-10 | 2006-07-10 | 한미약품 주식회사 | ＨＭＧ-ＣｏＡ 환원효소 억제제의 경구투여용 서방형 제제및 이의 제조방법 |
| RU2403013C2 (ru) * | 2005-12-16 | 2010-11-10 | Ханми Фарм. Ко., Лтд. | Твердая дисперсия, содержащая активный ингредиент с низкой температурой плавления, и содержащая ее таблетка для перорального введения |
| WO2008021347A2 (en) | 2006-08-16 | 2008-02-21 | Novartis Ag | Method for making solid dispersions of highly crystalline therapeutic compounds |
| US20100136111A1 (en) * | 2007-03-30 | 2010-06-03 | Ramakant Gundu | Pharmaceutical compositions of diclofenac and misoprostol |
| EP2061440A2 (de) | 2007-04-04 | 2009-05-27 | Sigmoid Pharma Limited | Pharmazeutische tacrolimus-zusammensetzung |
| ES2963291T3 (es) | 2007-04-26 | 2024-03-26 | Sublimity Therapeutics Ltd | Fabricación de múltiples minicápsulas |
| CA2759123C (en) | 2009-04-24 | 2019-01-15 | Iceutica Pty Ltd | Compositions of diclofenac acid with improved dissolution |
| CA2759109A1 (en) | 2009-04-24 | 2010-10-28 | Iceutica Pty Ltd | A solid dosage form of ciprofloxacin having small particle size and improved powder handling characteristics |
| EP2471518B1 (de) | 2009-05-18 | 2017-08-23 | Sigmoid Pharma Limited | Zusammensetzung mit oltropfen |
| EP2464341B1 (de) | 2009-08-12 | 2022-07-06 | Sublimity Therapeutics Limited | Immunmodulatorische zusammensetzungen mit einer polymermatrix und einer ölphase |
| FR2967577B1 (fr) * | 2010-11-18 | 2013-07-12 | Advicenne Pharma | Composition pharmaceutique comprenant du sel de bicarbonate, et son utilisation comme medicament |
| FR2967576B1 (fr) * | 2010-11-18 | 2013-07-12 | Advicenne Pharma | Composition pharmaceutique comprenant du sel precurseur du cycle de krebs, en particulier du sel de citrate, et son utilisation comme medicament |
| GB201020032D0 (en) | 2010-11-25 | 2011-01-12 | Sigmoid Pharma Ltd | Composition |
| DE102012105512A1 (de) * | 2012-06-25 | 2014-04-24 | Hennig Arzneimittel Gmbh & Co. Kg | Arzneiform zur verlängerten Freisetzung von Wirkstoffen |
| GB201212010D0 (en) | 2012-07-05 | 2012-08-22 | Sigmoid Pharma Ltd | Formulations |
| CN102784128B (zh) * | 2012-07-31 | 2015-01-07 | 北京协和药厂 | 一种非洛地平缓释制剂及其制备方法 |
| GB201319791D0 (en) | 2013-11-08 | 2013-12-25 | Sigmoid Pharma Ltd | Formulations |
| US9526734B2 (en) | 2014-06-09 | 2016-12-27 | Iceutica Pty Ltd. | Formulation of meloxicam |
| WO2016071515A1 (en) | 2014-11-07 | 2016-05-12 | Sigmoid Pharma Limited | Compositions comprising cyclosporin |
| CN112118830B (zh) * | 2018-05-14 | 2023-11-10 | 比利时胶囊公司 | 高活性剂载量的固体剂型 |
| CN113350309B (zh) * | 2021-08-09 | 2021-11-12 | 北京五和博澳药业股份有限公司 | 一种难溶性药物渗透泵控释片剂及其制备方法 |
| WO2025253271A1 (en) * | 2024-06-05 | 2025-12-11 | Lai Yue Tak | A self-dissolving encapsulation system, a method of preparation and a self-dissolving tablet thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3871343D1 (de) * | 1987-11-25 | 1992-06-25 | American Cyanamid Co | System fuer die verzoegerte (kontrollierte) freisetzung von substituierten dihydropyridin-calciumantagonisten. |
-
1995
- 1995-07-03 IE IE950492A patent/IE80467B1/en not_active IP Right Cessation
-
1996
- 1996-07-01 AU AU62394/96A patent/AU700654B2/en not_active Ceased
- 1996-07-01 HU HU9900231A patent/HUP9900231A2/hu unknown
- 1996-07-01 IL IL12266396A patent/IL122663A0/xx unknown
- 1996-07-01 CA CA002226008A patent/CA2226008A1/en not_active Abandoned
- 1996-07-01 SK SK1759-97A patent/SK175997A3/sk unknown
- 1996-07-01 CZ CZ974134A patent/CZ413497A3/cs unknown
- 1996-07-01 KR KR1019970710016A patent/KR19990028693A/ko not_active Ceased
- 1996-07-01 NZ NZ311145A patent/NZ311145A/xx unknown
- 1996-07-01 AT AT96921053T patent/ATE208192T1/de active
- 1996-07-01 WO PCT/IE1996/000039 patent/WO1997002017A1/en not_active Ceased
- 1996-07-01 BR BR9609663A patent/BR9609663A/pt not_active Application Discontinuation
- 1996-07-01 EP EP96921053A patent/EP0836475B1/de not_active Expired - Lifetime
- 1996-07-01 JP JP9504959A patent/JPH11508587A/ja active Pending
- 1996-07-01 PL PL96324402A patent/PL324402A1/xx unknown
- 1996-07-01 DE DE69616795T patent/DE69616795T2/de not_active Expired - Fee Related
- 1996-07-02 ZA ZA965609A patent/ZA965609B/xx unknown
- 1996-08-28 TW TW085110466A patent/TW426528B/zh not_active IP Right Cessation
-
1997
- 1997-12-12 NO NO975872A patent/NO975872L/no not_active Application Discontinuation
-
1998
- 1998-02-02 BG BG102228A patent/BG102228A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL324402A1 (en) | 1998-05-25 |
| KR19990028693A (ko) | 1999-04-15 |
| IE80467B1 (en) | 1998-07-29 |
| ZA965609B (en) | 1997-01-27 |
| AU700654B2 (en) | 1999-01-14 |
| DE69616795T2 (de) | 2002-08-08 |
| DE69616795D1 (de) | 2001-12-13 |
| NZ311145A (en) | 1999-06-29 |
| MX9710413A (es) | 1998-07-31 |
| IL122663A0 (en) | 1998-08-16 |
| CZ413497A3 (cs) | 1998-04-15 |
| JPH11508587A (ja) | 1999-07-27 |
| CA2226008A1 (en) | 1997-01-23 |
| WO1997002017A1 (en) | 1997-01-23 |
| AU6239496A (en) | 1997-02-05 |
| NO975872D0 (no) | 1997-12-12 |
| BG102228A (en) | 1998-10-30 |
| SK175997A3 (en) | 1998-06-03 |
| NO975872L (no) | 1998-03-03 |
| BR9609663A (pt) | 1999-05-18 |
| TW426528B (en) | 2001-03-21 |
| HUP9900231A2 (hu) | 1999-06-28 |
| EP0836475B1 (de) | 2001-11-07 |
| EP0836475A1 (de) | 1998-04-22 |
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