BR9609663A - Formulações para desprendimento controlado de medicamentos fracamente soluveis - Google Patents
Formulações para desprendimento controlado de medicamentos fracamente soluveisInfo
- Publication number
- BR9609663A BR9609663A BR9609663A BR9609663A BR9609663A BR 9609663 A BR9609663 A BR 9609663A BR 9609663 A BR9609663 A BR 9609663A BR 9609663 A BR9609663 A BR 9609663A BR 9609663 A BR9609663 A BR 9609663A
- Authority
- BR
- Brazil
- Prior art keywords
- core
- controlled release
- formulation
- poorly soluble
- formulations
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IE950492A IE80467B1 (en) | 1995-07-03 | 1995-07-03 | Controlled release formulations for poorly soluble drugs |
| US89795P | 1995-07-06 | 1995-07-06 | |
| PCT/IE1996/000039 WO1997002017A1 (en) | 1995-07-03 | 1996-07-01 | Controlled release formulations for poorly soluble drugs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9609663A true BR9609663A (pt) | 1999-05-18 |
Family
ID=26319833
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9609663A BR9609663A (pt) | 1995-07-03 | 1996-07-01 | Formulações para desprendimento controlado de medicamentos fracamente soluveis |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0836475B1 (pt) |
| JP (1) | JPH11508587A (pt) |
| KR (1) | KR19990028693A (pt) |
| AT (1) | ATE208192T1 (pt) |
| AU (1) | AU700654B2 (pt) |
| BG (1) | BG102228A (pt) |
| BR (1) | BR9609663A (pt) |
| CA (1) | CA2226008A1 (pt) |
| CZ (1) | CZ413497A3 (pt) |
| DE (1) | DE69616795T2 (pt) |
| HU (1) | HUP9900231A2 (pt) |
| IE (1) | IE80467B1 (pt) |
| IL (1) | IL122663A0 (pt) |
| NO (1) | NO975872L (pt) |
| NZ (1) | NZ311145A (pt) |
| PL (1) | PL324402A1 (pt) |
| SK (1) | SK175997A3 (pt) |
| TW (1) | TW426528B (pt) |
| WO (1) | WO1997002017A1 (pt) |
| ZA (1) | ZA965609B (pt) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1283029B1 (it) * | 1996-05-17 | 1998-04-03 | Resa Farma | Composizioni farmaceutiche a base di diclofenac |
| BE1009856A5 (fr) * | 1995-07-14 | 1997-10-07 | Sandoz Sa | Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule. |
| EP0866707A1 (en) * | 1995-12-01 | 1998-09-30 | Janssen Pharmaceutica N.V. | Cisapride sustained release |
| AU7888298A (en) * | 1997-01-03 | 1998-07-31 | Elan Corporation, Plc | Sustained release cisapride minitablet formulation |
| DE19710009A1 (de) * | 1997-03-12 | 1998-09-24 | Knoll Ag | Mehrphasige wirkstoffhaltige Zubereitungsformen |
| US6312724B1 (en) | 1997-04-04 | 2001-11-06 | Isa Odidi | Sustained release pharmaceutical matrix tablet of pharmaceutically acceptable salts of diclofenac and process for preparation thereof |
| NZ328751A (en) * | 1997-09-16 | 1999-01-28 | Bernard Charles Sherman | Solid medicament containing an anionic surfactant and cyclosporin |
| KR20000069356A (ko) * | 1997-10-07 | 2000-11-25 | 리차드 디. 슈미트 | 급속방출식 약물전달 제형 |
| US6013280A (en) * | 1997-10-07 | 2000-01-11 | Fuisz Technologies Ltd. | Immediate release dosage forms containing microspheres |
| NZ333474A (en) | 1998-01-02 | 1999-06-29 | Mcneil Ppc Inc | A chewable tablet containing ibuprofen, fumaric acid and a non hydrocolloid binder e.g. a wax or a fat |
| IE980115A1 (en) * | 1998-02-16 | 2000-02-09 | Biovail Internat Ltd | Solubilizing delivery systems and method of manufacture |
| US6787157B1 (en) | 1998-03-10 | 2004-09-07 | Abbott Laboratories | Multiphase active ingredient-containing formulations |
| CN1272785A (zh) * | 1998-06-11 | 2000-11-08 | Em工业股份有限公司 | 微渗透药物控释系统 |
| TW407058B (en) * | 1998-07-17 | 2000-10-01 | Dev Center Biotechnology | Oral cisapride dosage forms with an extended duration |
| IE981008A1 (en) * | 1998-12-02 | 2000-06-14 | Fuisz Internat Ltd | Microparticles Containing Water Insoluble Active Agents |
| US6706283B1 (en) | 1999-02-10 | 2004-03-16 | Pfizer Inc | Controlled release by extrusion of solid amorphous dispersions of drugs |
| EP1027887B1 (en) * | 1999-02-10 | 2008-08-13 | Pfizer Products Inc. | Matrix controlled release device |
| EP1064938A1 (en) * | 1999-06-28 | 2001-01-03 | Sanofi-Synthelabo | Pharmaceutical dosage forms for controlled release producing at least a timed pulse |
| SE9902742D0 (sv) * | 1999-07-20 | 1999-07-20 | Astra Ab | New pharmaceutical formultion |
| KR100379299B1 (ko) * | 2000-01-15 | 2003-04-10 | 주식회사 중외제약 | 펠로디핀의 가용화 방법 및 방출제어형 제제 |
| HU229938B1 (en) * | 2001-05-03 | 2015-01-28 | Hoffmann La Roche | Pharmaceutical dosage form of amorphous nelfinavir mesylate |
| AR033711A1 (es) * | 2001-05-09 | 2004-01-07 | Novartis Ag | Composiciones farmaceuticas |
| TWI252111B (en) * | 2001-12-14 | 2006-04-01 | Solvay Pharm Gmbh | Matrix film tablet with controlled release of a natural mixture of conjugated estrogens |
| US20050232995A1 (en) | 2002-07-29 | 2005-10-20 | Yam Nyomi V | Methods and dosage forms for controlled delivery of paliperidone and risperidone |
| KR20040011248A (ko) * | 2002-07-30 | 2004-02-05 | 환인제약 주식회사 | 암로디핀의 고체분산체와 그 제조방법 및 그를 포함하는약학적 조성물 |
| WO2004050068A1 (en) * | 2002-11-29 | 2004-06-17 | Janssen Pharmaceutica N.V. | Pharmaceutical compositions comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base |
| WO2004066981A1 (en) * | 2003-01-29 | 2004-08-12 | Sun Pharmaceutical Industries Limited | Oral controlled release pharmaceutical composition containing metaxalone as active agent |
| US7423004B2 (en) | 2003-01-31 | 2008-09-09 | Smithkline Beecham Corporation | Solid dispersion compositions |
| IE20040202A1 (en) * | 2003-03-28 | 2004-10-06 | Sigmoid Biotechnologies Ltd | Solid oral dosage form containing seamless microcapsules |
| KR20060123279A (ko) * | 2003-11-13 | 2006-12-01 | 알자 코포레이션 | 용융된 블렌드 현탁액 |
| WO2005065653A1 (en) * | 2003-12-19 | 2005-07-21 | E.I. Du Pont De Nemours And Company | Intimate coating of ibuprofen with poloxamers to enhance aqueous dissolution |
| CA2548376A1 (en) | 2003-12-31 | 2005-07-21 | Pfizer Products Inc. | Solid compositions of low-solubility drugs and poloxamers |
| KR100598326B1 (ko) | 2004-04-10 | 2006-07-10 | 한미약품 주식회사 | ＨＭＧ-ＣｏＡ 환원효소 억제제의 경구투여용 서방형 제제및 이의 제조방법 |
| JP2009519326A (ja) * | 2005-12-16 | 2009-05-14 | ハンミ ファーム． シーオー．， エルティーディー． | 低融点の活性成分を含む溶融状の固体分散体、及びこれを含む経口投与用錠剤 |
| BRPI0714963A2 (pt) | 2006-08-16 | 2013-07-30 | Novartis Ag | processo de fabricaÇço de dispersÕes sàlidas de compostos terapÊuticos altamente cristalinos |
| EP2142175A2 (en) * | 2007-03-30 | 2010-01-13 | Wockhardt Research Centre | Pharmaceutical compositions of diclofenac and misoprostol |
| CA2683415C (en) | 2007-04-04 | 2020-12-08 | Sigmoid Pharma Limited | An oral pharmaceutical composition |
| ES2963291T3 (es) | 2007-04-26 | 2024-03-26 | Sublimity Therapeutics Ltd | Fabricación de múltiples minicápsulas |
| SG175314A1 (en) | 2009-04-24 | 2011-11-28 | Iceutica Pty Ltd | A novel formulation of diclofenac |
| EP2432455B1 (en) | 2009-05-18 | 2014-11-12 | Sigmoid Pharma Limited | Composition comprising oil drops |
| BR112012002963A2 (pt) | 2009-08-12 | 2017-10-24 | Sigmoid Pharma Ltd | composições imunomoduladoras compreendendo uma matriz de polímero e uma fase oleosa |
| FR2967576B1 (fr) * | 2010-11-18 | 2013-07-12 | Advicenne Pharma | Composition pharmaceutique comprenant du sel precurseur du cycle de krebs, en particulier du sel de citrate, et son utilisation comme medicament |
| FR2967577B1 (fr) * | 2010-11-18 | 2013-07-12 | Advicenne Pharma | Composition pharmaceutique comprenant du sel de bicarbonate, et son utilisation comme medicament |
| GB201020032D0 (en) | 2010-11-25 | 2011-01-12 | Sigmoid Pharma Ltd | Composition |
| DE102012105512A1 (de) * | 2012-06-25 | 2014-04-24 | Hennig Arzneimittel Gmbh & Co. Kg | Arzneiform zur verlängerten Freisetzung von Wirkstoffen |
| GB201212010D0 (en) | 2012-07-05 | 2012-08-22 | Sigmoid Pharma Ltd | Formulations |
| CN102784128B (zh) * | 2012-07-31 | 2015-01-07 | 北京协和药厂 | 一种非洛地平缓释制剂及其制备方法 |
| GB201319791D0 (en) | 2013-11-08 | 2013-12-25 | Sigmoid Pharma Ltd | Formulations |
| US9526734B2 (en) | 2014-06-09 | 2016-12-27 | Iceutica Pty Ltd. | Formulation of meloxicam |
| ES2858517T3 (es) | 2014-11-07 | 2021-09-30 | Sublimity Therapeutics Ltd | Composiciones que comprenden ciclosporina |
| EP3793527A1 (en) * | 2018-05-14 | 2021-03-24 | Capsugel Belgium NV | Solid dosage forms with high active agent loading |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3871343D1 (de) * | 1987-11-25 | 1992-06-25 | American Cyanamid Co | System fuer die verzoegerte (kontrollierte) freisetzung von substituierten dihydropyridin-calciumantagonisten. |
-
1995
- 1995-07-03 IE IE950492A patent/IE80467B1/en not_active IP Right Cessation
-
1996
- 1996-07-01 CZ CZ974134A patent/CZ413497A3/cs unknown
- 1996-07-01 AT AT96921053T patent/ATE208192T1/de active
- 1996-07-01 WO PCT/IE1996/000039 patent/WO1997002017A1/en not_active Application Discontinuation
- 1996-07-01 EP EP96921053A patent/EP0836475B1/en not_active Expired - Lifetime
- 1996-07-01 KR KR1019970710016A patent/KR19990028693A/ko not_active Application Discontinuation
- 1996-07-01 AU AU62394/96A patent/AU700654B2/en not_active Ceased
- 1996-07-01 NZ NZ311145A patent/NZ311145A/xx unknown
- 1996-07-01 PL PL96324402A patent/PL324402A1/xx unknown
- 1996-07-01 JP JP9504959A patent/JPH11508587A/ja active Pending
- 1996-07-01 SK SK1759-97A patent/SK175997A3/sk unknown
- 1996-07-01 DE DE69616795T patent/DE69616795T2/de not_active Expired - Fee Related
- 1996-07-01 CA CA002226008A patent/CA2226008A1/en not_active Abandoned
- 1996-07-01 HU HU9900231A patent/HUP9900231A2/hu unknown
- 1996-07-01 BR BR9609663A patent/BR9609663A/pt not_active Application Discontinuation
- 1996-07-01 IL IL12266396A patent/IL122663A0/xx unknown
- 1996-07-02 ZA ZA965609A patent/ZA965609B/xx unknown
- 1996-08-28 TW TW085110466A patent/TW426528B/zh not_active IP Right Cessation
-
1997
- 1997-12-12 NO NO975872A patent/NO975872L/no not_active Application Discontinuation
-
1998
- 1998-02-02 BG BG102228A patent/BG102228A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69616795T2 (de) | 2002-08-08 |
| ATE208192T1 (de) | 2001-11-15 |
| MX9710413A (es) | 1998-07-31 |
| SK175997A3 (en) | 1998-06-03 |
| NO975872D0 (no) | 1997-12-12 |
| HUP9900231A2 (hu) | 1999-06-28 |
| JPH11508587A (ja) | 1999-07-27 |
| KR19990028693A (ko) | 1999-04-15 |
| NZ311145A (en) | 1999-06-29 |
| NO975872L (no) | 1998-03-03 |
| IE80467B1 (en) | 1998-07-29 |
| EP0836475B1 (en) | 2001-11-07 |
| CZ413497A3 (cs) | 1998-04-15 |
| DE69616795D1 (de) | 2001-12-13 |
| PL324402A1 (en) | 1998-05-25 |
| EP0836475A1 (en) | 1998-04-22 |
| TW426528B (en) | 2001-03-21 |
| AU700654B2 (en) | 1999-01-14 |
| BG102228A (en) | 1998-10-30 |
| WO1997002017A1 (en) | 1997-01-23 |
| IL122663A0 (en) | 1998-08-16 |
| ZA965609B (en) | 1997-01-27 |
| AU6239496A (en) | 1997-02-05 |
| CA2226008A1 (en) | 1997-01-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB36 | Technical and formal requirements: requirement - article 36 of industrial property law | ||
| FA8 | Dismissal: dismissal - article 36, par. 1 of industrial property law |