FR2736549B1 - Esters d'acides gras iodes, acides gras iodes et leurs derives, obtenus par iodohydrination faisant intervenir des derives alkylsilyles avec des iodures alcalins et leurs activites pharmacologiques - Google Patents

Esters d'acides gras iodes, acides gras iodes et leurs derives, obtenus par iodohydrination faisant intervenir des derives alkylsilyles avec des iodures alcalins et leurs activites pharmacologiques

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Publication number
FR2736549B1
FR2736549B1 FR9508582A FR9508582A FR2736549B1 FR 2736549 B1 FR2736549 B1 FR 2736549B1 FR 9508582 A FR9508582 A FR 9508582A FR 9508582 A FR9508582 A FR 9508582A FR 2736549 B1 FR2736549 B1 FR 2736549B1
Authority
FR
France
Prior art keywords
fatty acids
derivatives
iodine
iodine fatty
iodohydrination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9508582A
Other languages
English (en)
French (fr)
Other versions
FR2736549A1 (fr
Inventor
Louis Jung
Yves Ingenbleek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9508582A priority Critical patent/FR2736549B1/fr
Application filed by Individual filed Critical Individual
Priority to BR9609610-1A priority patent/BR9609610A/pt
Priority to RO98-00028A priority patent/RO120337B1/ro
Priority to HU9901340A priority patent/HUP9901340A3/hu
Priority to DE69629928T priority patent/DE69629928T2/de
Priority to PCT/FR1996/001075 priority patent/WO1997003038A1/fr
Priority to AU65234/96A priority patent/AU6523496A/en
Priority to EA199800120A priority patent/EA001719B1/ru
Priority to EP96924964A priority patent/EP0840720B1/fr
Priority to GEAP19964133A priority patent/GEP20002238B/en
Priority to TR1998/00031T priority patent/TR199800031T1/xx
Priority to US08/981,931 priority patent/US6124357A/en
Priority to APAP/P/1998/001180A priority patent/AP874A/en
Priority to PL96324383A priority patent/PL185807B1/pl
Priority to AT96924964T priority patent/ATE249414T1/de
Priority to CN96107188A priority patent/CN1077880C/zh
Priority to MA24310A priority patent/MA23935A1/fr
Priority to IN1552DE1996 priority patent/IN185195B/en
Priority to UA98020668A priority patent/UA56142C2/uk
Publication of FR2736549A1 publication Critical patent/FR2736549A1/fr
Application granted granted Critical
Publication of FR2736549B1 publication Critical patent/FR2736549B1/fr
Priority to MXPA/A/1998/000322A priority patent/MXPA98000322A/xx
Priority to OA9800001A priority patent/OA10650A/fr
Priority to BG102234A priority patent/BG63802B1/bg
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/307—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fats And Perfumes (AREA)
FR9508582A 1995-07-11 1995-07-11 Esters d'acides gras iodes, acides gras iodes et leurs derives, obtenus par iodohydrination faisant intervenir des derives alkylsilyles avec des iodures alcalins et leurs activites pharmacologiques Expired - Fee Related FR2736549B1 (fr)

Priority Applications (22)

Application Number Priority Date Filing Date Title
FR9508582A FR2736549B1 (fr) 1995-07-11 1995-07-11 Esters d'acides gras iodes, acides gras iodes et leurs derives, obtenus par iodohydrination faisant intervenir des derives alkylsilyles avec des iodures alcalins et leurs activites pharmacologiques
PL96324383A PL185807B1 (pl) 1995-07-11 1996-07-10 Sposób otrzymywania jodowanego kwasu tłuszczowegoSposób otrzymywania jodowanego kwasu tłuszczowegolub jodowanego estru kwasu tłuszczowego lub ich jolub jodowanego estru kwasu tłuszczowego lub ich jodowanych pochodnych oraz ich zastosowanie do wytwadowanych pochodnych oraz ich zastosowanie do wytwarzania leków i do wytwarzania produktu kontrastowerzania leków i do wytwarzania produktu kontrastowegogo
HU9901340A HUP9901340A3 (en) 1995-07-11 1996-07-10 Iodinated fatty acid esters, iodinated fatty acids and derivatives thereof, produced by iodohydrination using alkylsilylated derivatives and alkaline iodides, and pharmacological acitivities thereof
DE69629928T DE69629928T2 (de) 1995-07-11 1996-07-10 Verfahren zur herstellung jodierter fettsäuren und ihrer derivate durch jodwasserstoffanlagerung unter anwendung von alkylsilylderivaten mit alkalijodiden und deren pharmakologischen aktivitäten
PCT/FR1996/001075 WO1997003038A1 (fr) 1995-07-11 1996-07-10 Esters d'acides gras iodes, acides gras iodes et leurs derives, obtenus par iodohydrination, faisant intervenir des derives alkylsilyles avec des iodures alcalins et leurs activites pharmacologiques
AU65234/96A AU6523496A (en) 1995-07-11 1996-07-10 Iodinated fatty acid esters, iodinated fatty acids and derivtives thereof, produced by iodohydrination using alkylsilylaed derivatives and alkaline iodides, and pharmacological actvities thereof
EA199800120A EA001719B1 (ru) 1995-07-11 1996-07-10 Эфиры иодированных жирных кислот, иодированные жирные кислоты и их производные, способ их получения и применение в фармакологии
EP96924964A EP0840720B1 (fr) 1995-07-11 1996-07-10 Prodede pour obtenir acides gras iodes et leurs derives par iodohydrination, faisant intervenir des derives alkylsilyles avec des iodures alcalins et leurs activites pharmacologiques
GEAP19964133A GEP20002238B (en) 1995-07-11 1996-07-10 Iodinated Fatty Acid Esters, Iodinated Fatty Acids, Derivatives Thereof and Their Use
RO98-00028A RO120337B1 (ro) 1995-07-11 1996-07-10 Procedeu de preparare a unor acizi graşi iodaţi, esteri ai acizilor graşi iodaţi şi a derivaţilor lor iodaţi şi utilizări farmaceutice ale acestora
US08/981,931 US6124357A (en) 1995-07-11 1996-07-10 Iodinated fatty acid esters iodinated fatty acids and derivatives thereof produced by iodohydrination using alkylsilylated derivatives and alkaline iodides and the pharmacological activities thereof
APAP/P/1998/001180A AP874A (en) 1995-07-11 1996-07-10 Iodinated fatty acid esters, iodinated fatty acids and derivatives thereof, produced by iodohydrination using alkysilylated derivatives and alkaline iodides, and pharmacological activities thereof.
BR9609610-1A BR9609610A (pt) 1995-07-11 1996-07-10 ésteres de ácidos graxos iodados, ácidos graxos iodados e seus derivados, obtidos por iodohidrinação, envolvendo a introdução de derivados alquilsililados com iodetos alcalinos e suas atividades farmacológicas
AT96924964T ATE249414T1 (de) 1995-07-11 1996-07-10 Verfahren zur herstellung jodierter fettsäuren und ihrer derivate durch jodwasserstoffanlagerung unter anwendung von alkylsilylderivaten mit alkalijodiden und deren pharmakologischen aktivitäten
TR1998/00031T TR199800031T1 (xx) 1995-07-11 1996-07-10 �yodohidrinlemeyle elde edilen iyotlanm�� ya� asidi esterleri.
CN96107188A CN1077880C (zh) 1995-07-11 1996-07-11 碘代脂肪酸酯、碘代脂肪酸及其衍生物,及其药理学活性
MA24310A MA23935A1 (fr) 1995-07-11 1996-07-11 Esters d'acides gras iodes, acides gras iodes et leurs derives, obtenus par iodohydrination, faisant intervenir des derives alkylsilyles avec des iodures alcalins et leurs activites pharmacologiques
IN1552DE1996 IN185195B (show.php) 1995-07-11 1996-07-11
UA98020668A UA56142C2 (uk) 1995-07-11 1996-10-07 Йодована жирна кислота або естер йодованої жирної кислоти, або їх йодовані похідні, спосіб їх одержання
MXPA/A/1998/000322A MXPA98000322A (en) 1995-07-11 1998-01-09 Esters of iodine fatty acids, iodine fatty acids and derivatives thereof, produced by iodohidrination using alkilsililated derivatives and alkaline iodues, and their activities farmacologi
OA9800001A OA10650A (fr) 1995-07-11 1998-01-09 Esters d'acides gras iodés acides gras iodés et leurs dérivés obtenus par iodohydrination faisant intervenir des dérivés alkylsilylés avec iodures alcalins et leurs activités pharmacologiques
BG102234A BG63802B1 (bg) 1995-07-11 1998-02-05 Метод за получаване на естери на йодирани мастни киселини, йодирани мастни киселини и техни производни

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9508582A FR2736549B1 (fr) 1995-07-11 1995-07-11 Esters d'acides gras iodes, acides gras iodes et leurs derives, obtenus par iodohydrination faisant intervenir des derives alkylsilyles avec des iodures alcalins et leurs activites pharmacologiques

Publications (2)

Publication Number Publication Date
FR2736549A1 FR2736549A1 (fr) 1997-01-17
FR2736549B1 true FR2736549B1 (fr) 1997-10-10

Family

ID=9481022

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9508582A Expired - Fee Related FR2736549B1 (fr) 1995-07-11 1995-07-11 Esters d'acides gras iodes, acides gras iodes et leurs derives, obtenus par iodohydrination faisant intervenir des derives alkylsilyles avec des iodures alcalins et leurs activites pharmacologiques

Country Status (21)

Country Link
US (1) US6124357A (show.php)
EP (1) EP0840720B1 (show.php)
CN (1) CN1077880C (show.php)
AP (1) AP874A (show.php)
AT (1) ATE249414T1 (show.php)
AU (1) AU6523496A (show.php)
BG (1) BG63802B1 (show.php)
BR (1) BR9609610A (show.php)
DE (1) DE69629928T2 (show.php)
EA (1) EA001719B1 (show.php)
FR (1) FR2736549B1 (show.php)
GE (1) GEP20002238B (show.php)
HU (1) HUP9901340A3 (show.php)
IN (1) IN185195B (show.php)
MA (1) MA23935A1 (show.php)
OA (1) OA10650A (show.php)
PL (1) PL185807B1 (show.php)
RO (1) RO120337B1 (show.php)
TR (1) TR199800031T1 (show.php)
UA (1) UA56142C2 (show.php)
WO (1) WO1997003038A1 (show.php)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6426367B1 (en) * 1999-09-09 2002-07-30 Efa Sciences Llc Methods for selectively occluding blood supplies to neoplasias
FR2891461B1 (fr) * 2005-09-30 2010-09-03 Jacques Theron Preparation medicamenteuse visqueuse injectable comprenant de l'ethanol et un compose liposoluble opaque aux rayons x.
CN101245007B (zh) * 2008-03-13 2011-03-23 武汉工程大学 一种稳定的碘化植物油脂肪酸乙酯的制备方法
FR2976491B1 (fr) * 2011-06-14 2015-07-10 R I P H Esters d'acides gras iodes contenant au minimum 50 pour cent d'esters d'acide monoiodo stearique ou derives sous forme de capsule molle ou de gelule, utile lors d'un accident nucleaire.
CN107287029B (zh) * 2016-05-30 2021-04-06 江苏恒瑞医药股份有限公司 一种碘化植物油脂肪酸乙酯的制备方法
CN109251144B (zh) * 2017-07-12 2021-06-18 财团法人食品工业发展研究所 碘化脂肪酸乙酯的制备方法
CN109251142A (zh) * 2017-07-12 2019-01-22 财团法人食品工业发展研究所 碘化脂肪酸乙酯的制备方法
AU2018314406B2 (en) 2017-08-07 2024-08-15 Université De Genève Nanoemulsion of iodinated fatty acids for CT imaging
CN110387286A (zh) * 2018-04-18 2019-10-29 江苏恒瑞医药股份有限公司 一种碘化植物油脂肪酸乙酯的制备方法
CN109438240B (zh) * 2018-09-10 2022-05-03 季珉 一种稳定的碘化亚油酸酯的制备方法
JP7522744B2 (ja) 2019-02-13 2024-07-25 ウニヴァシテ デ ジュネーブ 悪液質を検出するためのｃｔ造影剤
CN114606055B (zh) * 2020-12-08 2024-02-13 成都西岭源药业有限公司 一种去除碘化植物油脂肪酸乙酯中结合不稳定的碘的方法
EP4380687A1 (en) * 2021-08-02 2024-06-12 Microvention, Inc. Iodinated fatty acids for medical imaging
PL245039B1 (pl) * 2022-02-15 2024-04-22 Centrum Badan I Rozwoju Tech Dla Przemyslu Spolka Akcyjna Świeca bioaktywna oraz sposób wytwarzania świecy bioaktywnej.
WO2025145066A1 (en) * 2023-12-28 2025-07-03 Navinta, Llc An improved process for preparation of ethiodized oil

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53119817A (en) * 1977-03-26 1978-10-19 Sinloihi Co Ltd Glycerilltri*22iodoohexadecanoate* and process for preparing same
DE3513323A1 (de) * 1985-04-13 1986-10-23 Merck Patent Gmbh, 6100 Darmstadt Stabilisierte iodfette und verfahren zu deren herstellung

Also Published As

Publication number Publication date
EP0840720B1 (fr) 2003-09-10
DE69629928D1 (de) 2003-10-16
BG63802B1 (bg) 2003-01-31
AU6523496A (en) 1997-02-10
HUP9901340A3 (en) 1999-11-29
US6124357A (en) 2000-09-26
MX9800322A (es) 1998-09-30
GEP20002238B (en) 2000-09-25
UA56142C2 (uk) 2003-05-15
DE69629928T2 (de) 2004-07-22
EP0840720A1 (fr) 1998-05-13
AP874A (en) 2000-09-13
PL185807B1 (pl) 2003-08-29
TR199800031T1 (xx) 1998-05-21
EA001719B1 (ru) 2001-08-27
BR9609610A (pt) 2002-05-07
PL324383A1 (en) 1998-05-25
OA10650A (fr) 2002-09-18
BG102234A (en) 1998-09-30
CN1143067A (zh) 1997-02-19
IN185195B (show.php) 2000-12-02
RO120337B1 (ro) 2005-12-30
MA23935A1 (fr) 1997-04-01
CN1077880C (zh) 2002-01-16
ATE249414T1 (de) 2003-09-15
EA199800120A1 (ru) 1998-10-29
HUP9901340A2 (hu) 1999-09-28
FR2736549A1 (fr) 1997-01-17
WO1997003038A1 (fr) 1997-01-30

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Effective date: 20150331