HUP9901340A2 - Jódozott zsírsav-észterek, jódozott zsírsavak, származékaik, előállításuk és alkalmazásuk - Google Patents

Jódozott zsírsav-észterek, jódozott zsírsavak, származékaik, előállításuk és alkalmazásuk

Info

Publication number
HUP9901340A2
HUP9901340A2 HU9901340A HUP9901340A HUP9901340A2 HU P9901340 A2 HUP9901340 A2 HU P9901340A2 HU 9901340 A HU9901340 A HU 9901340A HU P9901340 A HUP9901340 A HU P9901340A HU P9901340 A2 HUP9901340 A2 HU P9901340A2
Authority
HU
Hungary
Prior art keywords
derivatives
acid esters
fatty acid
iodinated fatty
iodohydrination
Prior art date
Application number
HU9901340A
Other languages
English (en)
Inventor
Yves Ingenbleek
Louis Jung
Original Assignee
Yves Ingenbleek
Louis Jung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yves Ingenbleek, Louis Jung filed Critical Yves Ingenbleek
Publication of HUP9901340A2 publication Critical patent/HUP9901340A2/hu
Publication of HUP9901340A3 publication Critical patent/HUP9901340A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/307—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fats And Perfumes (AREA)

Abstract

A találmány tárgya stabilis, főlyékőny gyógyszerek hatóanyagkéntalkalmazható, jódőzőtt zsírsav-észterek, jódőzőtt zsírsavak ésszármazékaik. Ezek előállítását a jódhidrinezési reakcióval végzik,szerves közegben, trimetil-szilil-klőrid típűsú alkil-szililezettreagensekkel, amelyeket alkálifém-jődiddal (példáűl nátriűm-jődiddal)reagáltatnak, és ezt követően víz hatására in sitű jódhidrőgénsavatképeznek, amelyet példáűl zsírsav-észterekkel reagáltatnak. Zsírsav-észterek főrrásai közül elsősőrban a repcemagőlaj vehető számításba,amely gépkőcsimőtőrők hajtására használt, őlcsó hajtóanyag. A kapőttjódőzőtt származékőkat endémiás gőlyvától sújtőtt területeken (főkéntAfrikában) alkalmazzák a jódhiány kiküszöbölésére. ŕ
HU9901340A 1995-07-11 1996-07-10 Iodinated fatty acid esters, iodinated fatty acids and derivatives thereof, produced by iodohydrination using alkylsilylated derivatives and alkaline iodides, and pharmacological acitivities thereof HUP9901340A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9508582A FR2736549B1 (fr) 1995-07-11 1995-07-11 Esters d'acides gras iodes, acides gras iodes et leurs derives, obtenus par iodohydrination faisant intervenir des derives alkylsilyles avec des iodures alcalins et leurs activites pharmacologiques

Publications (2)

Publication Number Publication Date
HUP9901340A2 true HUP9901340A2 (hu) 1999-09-28
HUP9901340A3 HUP9901340A3 (en) 1999-11-29

Family

ID=9481022

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9901340A HUP9901340A3 (en) 1995-07-11 1996-07-10 Iodinated fatty acid esters, iodinated fatty acids and derivatives thereof, produced by iodohydrination using alkylsilylated derivatives and alkaline iodides, and pharmacological acitivities thereof

Country Status (21)

Country Link
US (1) US6124357A (hu)
EP (1) EP0840720B1 (hu)
CN (1) CN1077880C (hu)
AP (1) AP874A (hu)
AT (1) ATE249414T1 (hu)
AU (1) AU6523496A (hu)
BG (1) BG63802B1 (hu)
BR (1) BR9609610A (hu)
DE (1) DE69629928T2 (hu)
EA (1) EA001719B1 (hu)
FR (1) FR2736549B1 (hu)
GE (1) GEP20002238B (hu)
HU (1) HUP9901340A3 (hu)
IN (1) IN185195B (hu)
MA (1) MA23935A1 (hu)
OA (1) OA10650A (hu)
PL (1) PL185807B1 (hu)
RO (1) RO120337B1 (hu)
TR (1) TR199800031T1 (hu)
UA (1) UA56142C2 (hu)
WO (1) WO1997003038A1 (hu)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6426367B1 (en) * 1999-09-09 2002-07-30 Efa Sciences Llc Methods for selectively occluding blood supplies to neoplasias
FR2891461B1 (fr) * 2005-09-30 2010-09-03 Jacques Theron Preparation medicamenteuse visqueuse injectable comprenant de l'ethanol et un compose liposoluble opaque aux rayons x.
CN101245007B (zh) * 2008-03-13 2011-03-23 武汉工程大学 一种稳定的碘化植物油脂肪酸乙酯的制备方法
FR2976491B1 (fr) * 2011-06-14 2015-07-10 R I P H Esters d'acides gras iodes contenant au minimum 50 pour cent d'esters d'acide monoiodo stearique ou derives sous forme de capsule molle ou de gelule, utile lors d'un accident nucleaire.
CN107287029B (zh) * 2016-05-30 2021-04-06 江苏恒瑞医药股份有限公司 一种碘化植物油脂肪酸乙酯的制备方法
CN109251144B (zh) * 2017-07-12 2021-06-18 财团法人食品工业发展研究所 碘化脂肪酸乙酯的制备方法
CN109251142A (zh) * 2017-07-12 2019-01-22 财团法人食品工业发展研究所 碘化脂肪酸乙酯的制备方法
CA3072282A1 (en) 2017-08-07 2019-02-14 Laurent VINET Nanoemulsion of iodinated fatty acids for ct imaging
CN110387286A (zh) * 2018-04-18 2019-10-29 江苏恒瑞医药股份有限公司 一种碘化植物油脂肪酸乙酯的制备方法
CN109438240B (zh) * 2018-09-10 2022-05-03 季珉 一种稳定的碘化亚油酸酯的制备方法
CN114606055B (zh) * 2020-12-08 2024-02-13 成都西岭源药业有限公司 一种去除碘化植物油脂肪酸乙酯中结合不稳定的碘的方法
US20240336552A1 (en) * 2021-08-02 2024-10-10 Microvention, Inc. Compounds
PL245039B1 (pl) * 2022-02-15 2024-04-22 Centrum Badan I Rozwoju Tech Dla Przemyslu Spolka Akcyjna Świeca bioaktywna oraz sposób wytwarzania świecy bioaktywnej.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53119817A (en) * 1977-03-26 1978-10-19 Sinloihi Co Ltd Glycerilltri*22iodoohexadecanoate* and process for preparing same
DE3513323A1 (de) * 1985-04-13 1986-10-23 Merck Patent Gmbh, 6100 Darmstadt Stabilisierte iodfette und verfahren zu deren herstellung

Also Published As

Publication number Publication date
WO1997003038A1 (fr) 1997-01-30
ATE249414T1 (de) 2003-09-15
DE69629928D1 (de) 2003-10-16
EA001719B1 (ru) 2001-08-27
BG63802B1 (bg) 2003-01-31
FR2736549A1 (fr) 1997-01-17
EP0840720B1 (fr) 2003-09-10
PL185807B1 (pl) 2003-08-29
US6124357A (en) 2000-09-26
FR2736549B1 (fr) 1997-10-10
DE69629928T2 (de) 2004-07-22
CN1077880C (zh) 2002-01-16
AU6523496A (en) 1997-02-10
AP874A (en) 2000-09-13
OA10650A (fr) 2002-09-18
MA23935A1 (fr) 1997-04-01
HUP9901340A3 (en) 1999-11-29
IN185195B (hu) 2000-12-02
EA199800120A1 (ru) 1998-10-29
RO120337B1 (ro) 2005-12-30
GEP20002238B (en) 2000-09-25
EP0840720A1 (fr) 1998-05-13
MX9800322A (es) 1998-09-30
UA56142C2 (uk) 2003-05-15
BG102234A (en) 1998-09-30
TR199800031T1 (xx) 1998-05-21
CN1143067A (zh) 1997-02-19
PL324383A1 (en) 1998-05-25
BR9609610A (pt) 2002-05-07

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