FR2736266A1 - Inhibiteur de l'agregation plaquettaire et procede pour preparer celui-ci - Google Patents

Inhibiteur de l'agregation plaquettaire et procede pour preparer celui-ci Download PDF

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Publication number
FR2736266A1
FR2736266A1 FR9510049A FR9510049A FR2736266A1 FR 2736266 A1 FR2736266 A1 FR 2736266A1 FR 9510049 A FR9510049 A FR 9510049A FR 9510049 A FR9510049 A FR 9510049A FR 2736266 A1 FR2736266 A1 FR 2736266A1
Authority
FR
France
Prior art keywords
platelet aggregation
salmosa
venom
salmosin
korean
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
FR9510049A
Other languages
English (en)
French (fr)
Inventor
Cheol Kang In
Hoe Chung Kwang
Jung Lee Soo
Sik Kim Doo
Dai Kim Hak
Dae Yun Yung
Hyeok Yoon Jeong
Mo Moon Hong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mogam Biotechnology Research Institute
Original Assignee
Mogam Biotechnology Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mogam Biotechnology Research Institute filed Critical Mogam Biotechnology Research Institute
Publication of FR2736266A1 publication Critical patent/FR2736266A1/fr
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
FR9510049A 1995-07-05 1995-08-24 Inhibiteur de l'agregation plaquettaire et procede pour preparer celui-ci Pending FR2736266A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019950019685A KR0142606B1 (ko) 1995-07-05 1995-07-05 혈소판 응집 억제 펩타이드 및 그의 제조방법

Publications (1)

Publication Number Publication Date
FR2736266A1 true FR2736266A1 (fr) 1997-01-10

Family

ID=19419881

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9510049A Pending FR2736266A1 (fr) 1995-07-05 1995-08-24 Inhibiteur de l'agregation plaquettaire et procede pour preparer celui-ci

Country Status (3)

Country Link
JP (1) JP2679780B2 (ko)
KR (1) KR0142606B1 (ko)
FR (1) FR2736266A1 (ko)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0967276A2 (en) * 1998-06-23 1999-12-29 Doo-Sik Kim Anti-tumor agent comprising salmosin
WO2000018421A1 (en) * 1998-09-29 2000-04-06 The University Of Southern California Contortrostatin (cn) and methods for its use in preventing metastasis and other conditions
WO2001041791A1 (en) * 1999-12-10 2001-06-14 The University Of Southern California Contortrostatin (cn) and methods for its use in preventing metastasis and other conditions
US6710030B1 (en) * 1993-10-22 2004-03-23 University Of Southern California Contortrostain (CN) and methods for its use in preventing metastasis and other conditions
US7220724B2 (en) 1993-10-22 2007-05-22 University Of Southern California Contortrostatin CN and methods for its use in preventing metastasis and other conditions

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1184313C (zh) 2000-07-26 2005-01-12 郑光会 衍生自黑眉蝮蛇的新型蛋白以及制备该蛋白的方法
KR20020010188A (ko) * 2000-07-27 2002-02-04 정광회 뱀의 독소로부터 유래된 혈소판 응집억제 단백질 및 그의제조방법

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990008772A1 (en) * 1989-01-27 1990-08-09 Biogen, Inc. Processes for producing polypeptide inhibitors of platelet activation and methods, combinations and compositions using them
EP0382451A2 (en) * 1989-02-07 1990-08-16 Merck & Co. Inc. Viper venom Polypeptides and variants
WO1990015072A1 (en) * 1989-06-07 1990-12-13 Genentech, Inc. Platelet aggregation inhibitors and related molecules
JPH05255395A (ja) * 1990-10-26 1993-10-05 Takeda Chem Ind Ltd ポリペプチドおよびその製造法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990008772A1 (en) * 1989-01-27 1990-08-09 Biogen, Inc. Processes for producing polypeptide inhibitors of platelet activation and methods, combinations and compositions using them
EP0382451A2 (en) * 1989-02-07 1990-08-16 Merck & Co. Inc. Viper venom Polypeptides and variants
WO1990015072A1 (en) * 1989-06-07 1990-12-13 Genentech, Inc. Platelet aggregation inhibitors and related molecules
JPH05255395A (ja) * 1990-10-26 1993-10-05 Takeda Chem Ind Ltd ポリペプチドおよびその製造法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE GCG-GENESEQ_P Derwent; *
DATABASE WPI Section Ch Week 9344, Derwent World Patents Index; Class B04, AN 93-348481, XP002048503 *
M.S. DENNIS ET AL.: "Platelet glycoprotein IIb-IIa protein antagonists from snake venoms: Evidence for a family of platelet-aggregation inhibitors", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 87, April 1989 (1989-04-01), WASHINGTON US, pages 2471 - 2475, XP002048502 *
T.-F. HUANG ET AL.: "Halysin, an Antiplatelet Arg-Gly-Asp- Containing Snake Venom Peptide, as Fibrinogen Receptor Antagonists", BIOCHEMICAL PHARMACOLOGY, vol. 42, no. 6, 22 August 1991 (1991-08-22), pages 1209 - 1219, XP002048570 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6710030B1 (en) * 1993-10-22 2004-03-23 University Of Southern California Contortrostain (CN) and methods for its use in preventing metastasis and other conditions
US7220724B2 (en) 1993-10-22 2007-05-22 University Of Southern California Contortrostatin CN and methods for its use in preventing metastasis and other conditions
US7718615B2 (en) 1993-10-22 2010-05-18 University Of Southern California Contortrostatin (CN) and methods for its use in preventing metastasis and other conditions
EP0967276A2 (en) * 1998-06-23 1999-12-29 Doo-Sik Kim Anti-tumor agent comprising salmosin
EP0967276A3 (en) * 1998-06-23 2001-04-18 Doo-Sik Kim Anti-tumor agent comprising salmosin
WO2000018421A1 (en) * 1998-09-29 2000-04-06 The University Of Southern California Contortrostatin (cn) and methods for its use in preventing metastasis and other conditions
WO2001041791A1 (en) * 1999-12-10 2001-06-14 The University Of Southern California Contortrostatin (cn) and methods for its use in preventing metastasis and other conditions

Also Published As

Publication number Publication date
KR0142606B1 (ko) 1998-07-01
JPH0920797A (ja) 1997-01-21
JP2679780B2 (ja) 1997-11-19
KR970006318A (ko) 1997-02-19

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