FR2666335B1 - Arylalkylamines, procede pour leur preparation et compositions pharmaceutiques les contenant. - Google Patents

Arylalkylamines, procede pour leur preparation et compositions pharmaceutiques les contenant.

Info

Publication number
FR2666335B1
FR2666335B1 FR9011039A FR9011039A FR2666335B1 FR 2666335 B1 FR2666335 B1 FR 2666335B1 FR 9011039 A FR9011039 A FR 9011039A FR 9011039 A FR9011039 A FR 9011039A FR 2666335 B1 FR2666335 B1 FR 2666335B1
Authority
FR
France
Prior art keywords
arylalkylamines
preparation
pharmaceutical compositions
compositions containing
pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR9011039A
Other languages
English (en)
Other versions
FR2666335A1 (fr
Inventor
Emonds-Alt Xavier
Goulaouic Pierre
Proietto Vincenzo
Broeck Van Didier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Priority to FR9011039A priority Critical patent/FR2666335B1/fr
Priority to IL9932091A priority patent/IL99320A/en
Priority to IE308291A priority patent/IE913082A1/en
Priority to AU83542/91A priority patent/AU657272B2/en
Priority to BR919103802A priority patent/BR9103802A/pt
Priority to PT98849A priority patent/PT98849B/pt
Priority to NZ239661A priority patent/NZ239661A/en
Priority to ZA917017A priority patent/ZA917017B/xx
Priority to SU5001435/04A priority patent/RU2070196C1/ru
Priority to UA5001435A priority patent/UA27224C2/uk
Priority to PL91291618A priority patent/PL167994B1/pl
Priority to CA002050639A priority patent/CA2050639C/fr
Priority to FI914174A priority patent/FI98457C/fi
Priority to HU9102863A priority patent/HU222351B1/hu
Priority to NO913469A priority patent/NO177226C/no
Priority to ES91402382T priority patent/ES2127722T3/es
Priority to AT91402382T priority patent/ATE174332T1/de
Priority to KR1019910015523A priority patent/KR100194823B1/ko
Priority to US07/755,454 priority patent/US5236921A/en
Priority to SG1996003908A priority patent/SG47703A1/en
Priority to JP3254730A priority patent/JP2620435B2/ja
Priority to EP91402382A priority patent/EP0474561B1/fr
Priority to CS912724A priority patent/CZ285994B6/cs
Priority to MYPI91001612A priority patent/MY142065A/en
Priority to DK91402382T priority patent/DK0474561T3/da
Priority to DE69130597T priority patent/DE69130597T2/de
Publication of FR2666335A1 publication Critical patent/FR2666335A1/fr
Application granted granted Critical
Publication of FR2666335B1 publication Critical patent/FR2666335B1/fr
Priority to LVP-93-139A priority patent/LV10606B/en
Priority to LTIP585A priority patent/LT3442B/lt
Priority to US08/105,677 priority patent/US5350852A/en
Priority to HU95P/P00521P priority patent/HU211893A9/hu
Priority to HK98104394A priority patent/HK1005290A1/xx
Priority to GR990400518T priority patent/GR3029435T3/el
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
FR9011039A 1990-09-05 1990-09-05 Arylalkylamines, procede pour leur preparation et compositions pharmaceutiques les contenant. Expired - Lifetime FR2666335B1 (fr)

Priority Applications (32)

Application Number Priority Date Filing Date Title
FR9011039A FR2666335B1 (fr) 1990-09-05 1990-09-05 Arylalkylamines, procede pour leur preparation et compositions pharmaceutiques les contenant.
IL9932091A IL99320A (en) 1990-09-05 1991-08-27 Arylalkylamines, their preparation and pharmaceutical preparations containing them
IE308291A IE913082A1 (en) 1990-09-05 1991-09-02 Arylalkylamines, process for preparing them and¹pharmaceutical compositions containing them
BR919103802A BR9103802A (pt) 1990-09-05 1991-09-03 Composto,processo para a preparacao do mesmo e composicao farmaceutico
PT98849A PT98849B (pt) 1990-09-05 1991-09-03 Processo para a obtencao de arilalquilaminas substituidas, nomeadamente, com piperidinilo substituido
AU83542/91A AU657272B2 (en) 1990-09-05 1991-09-03 Arylalkylamines, process for preparing them and pharmaceutical compositions containing them
NZ239661A NZ239661A (en) 1990-09-05 1991-09-04 Piperidine and piperazine derivatives and pharmaceutical compositions
SU5001435/04A RU2070196C1 (ru) 1990-09-05 1991-09-04 Арилалкиламины и фармацевтическая композиция на их основе
UA5001435A UA27224C2 (uk) 1990-09-05 1991-09-04 Арилалкіламіни, спосіб їх одержання та фармацевтична композиція
PL91291618A PL167994B1 (pl) 1990-09-05 1991-09-04 Sposób wytwarzania nowych aryloalkiloamin PL PL PL PL PL PL
CA002050639A CA2050639C (fr) 1990-09-05 1991-09-04 Arylalkylamines, mode de preparation et compositions pharmaceutiques quien contiennent
FI914174A FI98457C (fi) 1990-09-05 1991-09-04 Menetelmä piperidyylialkyyliamiinien valmistamiseksi
HU9102863A HU222351B1 (hu) 1990-09-05 1991-09-04 Aril-alkil-aminok, eljárás ezek előállítására és az ezeket tartalmazó gyógyszerkészítmények
NO913469A NO177226C (no) 1990-09-05 1991-09-04 Analogifremgangsmåte for fremstilling av terapeutisk aktive arylalkylaminer
ZA917017A ZA917017B (en) 1990-09-05 1991-09-04 Arylalkylamines,process for preparing them and pharmaceutical compositions containing them
KR1019910015523A KR100194823B1 (ko) 1990-09-05 1991-09-05 아릴알킬아민, 이의 제조방법 및 이를 함유하는 약제학적 조성물
ES91402382T ES2127722T3 (es) 1990-09-05 1991-09-05 Aralquilaminas, procedimiento para su preparacion y composiciones farmaceuticas que las contienen.
US07/755,454 US5236921A (en) 1990-09-05 1991-09-05 Arylalkylamines, process for preparing them and pharmaceutical compositions containing them
SG1996003908A SG47703A1 (en) 1990-09-05 1991-09-05 Arylalkylamines process for preparing them and pharmaceutical compositions containing them
JP3254730A JP2620435B2 (ja) 1990-09-05 1991-09-05 アリールアルキルアミン類、その製造方法およびこれを含有する薬剤組成物
EP91402382A EP0474561B1 (fr) 1990-09-05 1991-09-05 Arylalkylamines, procédé pour leur préparation et compositions pharmaceutiques les contenant
CS912724A CZ285994B6 (cs) 1990-09-05 1991-09-05 Arylalkylaminy, způsob jejich přípravy a farmaceutické kompozice tyto arylalkylaminy obsahující
MYPI91001612A MY142065A (en) 1990-09-05 1991-09-05 Arylalkylamines, process for preparing them and pharmaceutical compositions containing them
DK91402382T DK0474561T3 (da) 1990-09-05 1991-09-05 Arylalkylaminer, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse
DE69130597T DE69130597T2 (de) 1990-09-05 1991-09-05 Arylalkylamine, Verfahren zur Herstellung und diese enthaltende Arzneimittel
AT91402382T ATE174332T1 (de) 1990-09-05 1991-09-05 Arylalkylamine, verfahren zur herstellung und diese enthaltende arzneimittel
LVP-93-139A LV10606B (en) 1990-09-05 1993-02-25 Arylalkylamines, process for preparing them and pharmaceutical compositions containing them
LTIP585A LT3442B (en) 1990-09-05 1993-05-31 Arylalkylamines, process for their preparation and pharmaceutical compositions containing the same
US08/105,677 US5350852A (en) 1990-09-05 1993-08-13 Arylalkylamines, process for preparing them and pharmaceutical compositions containing them
HU95P/P00521P HU211893A9 (en) 1990-09-05 1995-06-28 Arylalkylamines, process for preparing them and pharmaceutical compositions containing them
HK98104394A HK1005290A1 (en) 1990-09-05 1998-05-21 Arylalkylamines process for their preparation and pharmaceutical compositions containing them
GR990400518T GR3029435T3 (en) 1990-09-05 1999-02-17 Arylalkylamines, process for their preparation and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9011039A FR2666335B1 (fr) 1990-09-05 1990-09-05 Arylalkylamines, procede pour leur preparation et compositions pharmaceutiques les contenant.

Publications (2)

Publication Number Publication Date
FR2666335A1 FR2666335A1 (fr) 1992-03-06
FR2666335B1 true FR2666335B1 (fr) 1992-12-11

Family

ID=9400105

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9011039A Expired - Lifetime FR2666335B1 (fr) 1990-09-05 1990-09-05 Arylalkylamines, procede pour leur preparation et compositions pharmaceutiques les contenant.

Country Status (3)

Country Link
FR (1) FR2666335B1 (fr)
LT (1) LT3442B (fr)
ZA (1) ZA917017B (fr)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4751327A (en) * 1985-06-28 1988-06-14 Xerox Corporation Photoconductive imaging members with unsymmetrical squaraine compounds
FR2613719B1 (fr) * 1987-04-10 1991-03-22 Sanofi Sa Derives aromatiques, leur preparation et leur utilisation comme antimicrobiens
GB8807921D0 (en) 1988-04-05 1988-05-05 Fujisawa Pharmaceutical Co Ws-9326 & its derivatives
NZ229552A (en) 1988-06-20 1992-06-25 Merrell Dow Pharma Neurokinin a antagonists

Also Published As

Publication number Publication date
FR2666335A1 (fr) 1992-03-06
ZA917017B (en) 1992-12-30
LTIP585A (en) 1994-12-27
LT3442B (en) 1995-10-25

Similar Documents

Publication Publication Date Title
FR2665453B1 (fr) Polylactides purifies, procede pour leur preparation et compositions pharmaceutiques les contenant.
MA26687A1 (fr) 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinoleines, procede pour leur preparation et compositions pharmaceutiques les contenant
MA26424A1 (fr) Derives de 6-phenylpyridyl-2-amine, procede pour leur preparation et compositions pharmaceutiques les contenant.
MA26438A1 (fr) Derives 6,5-heterobicycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2595351B1 (fr) Derives d'indole, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2780057B1 (fr) Phenoxypropanolamines, procede pour leur preparation et compositions pharmaceutiques les contenant
MA26472A1 (fr) Derives de n-hydroxy-b-sulfonylpropionamide, procede pour leur preparation et compositions pharmaceutiques les contenant.
MA26471A1 (fr) Derives d'acide arylsulfonylaminohydroxamique, procede pour leur preparation et compositions pharmaceutiques les contenant.
MA26415A1 (fr) Composes heterocycliques, procede pour la preparation et compositions pharmaceutiques les contenant
MA22521A1 (fr) Compositions anti- transpirantes en batonnets-gels contenant un derive de la 2-oxazolidinone, et procede pour leur preparation
MA26630A1 (fr) 4-phenylpyperidines nouvelles, procede pour leur preparation et compositions pharmaceutiques les contenant
MA26508A1 (fr) Formulations pharmaceutiques contenant du variconazole, et procede pour leur preparation.
MA26433A1 (fr) Derives de pyridylpyrrole, procede pour leur preparation et compositions pharmaceutiques les contenant
MA26558A1 (fr) Derives nouveaux de 6-0-methylerythromycine a, procede pour leur preparation et compositions pharmaceutiques les contenant.
MC1390A1 (fr) Derives de pyrazolopyridazine,procede pour leur preparation et compositions pharmaceutiques les contenant
MA26519A1 (fr) Derives d'azetidinylpropylpiperidine, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2751334B1 (fr) Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant
MA26567A1 (fr) Trifluoromethylethers cycliques a fonction piperidinylaminomethule, procede pour leur preparation et compositions pharmaceutiques les contenant
DZ2155A1 (fr) Aazétidines, procédé pour leur préparation, et co mpositions pharmaceutiques les contenant.
MA26552A1 (fr) Derives d'isoquinoleine nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2567519B1 (fr) Nouvelles isoindolinyl-alcoyl-piperazines, compositions pharmaceutiques les contenant, et leur procede de preparation
FR2728901B1 (fr) Derives de phenyl-4-thiazoles substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
MA26441A1 (fr) Derives de pyrrolidinyl- et pyrrolinyl- ethylamine, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2563519B1 (fr) Derives d'iminothiazolidine, procede pour leur preparation et compositions pharmaceutiques les contenant
MA26437A1 (fr) Derives de trans-piperazine-1-yl-spiro (cyclohexane-1,1'-isobenzofuranne), procede pour leur preparation et compositions pharmaceutiques les contenant.

Legal Events

Date Code Title Description
CA Change of address
CD Change of name or company name
TP Transmission of property
CD Change of name or company name