FR2563222B1 - Composes du type 1,4-dihydropyridine-3-carboxylate, procede pour leur fabrication et compositions pharmaceutiques renfermant ces composes a titre d'element actif - Google Patents

Composes du type 1,4-dihydropyridine-3-carboxylate, procede pour leur fabrication et compositions pharmaceutiques renfermant ces composes a titre d'element actif

Info

Publication number
FR2563222B1
FR2563222B1 FR8505174A FR8505174A FR2563222B1 FR 2563222 B1 FR2563222 B1 FR 2563222B1 FR 8505174 A FR8505174 A FR 8505174A FR 8505174 A FR8505174 A FR 8505174A FR 2563222 B1 FR2563222 B1 FR 2563222B1
Authority
FR
France
Prior art keywords
dihydropyridine
compounds
manufacture
active ingredient
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8505174A
Other languages
English (en)
Other versions
FR2563222A1 (fr
Inventor
Kiyoshi Kimura
Iwao Morita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Publication of FR2563222A1 publication Critical patent/FR2563222A1/fr
Application granted granted Critical
Publication of FR2563222B1 publication Critical patent/FR2563222B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
    • C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FR8505174A 1984-04-19 1985-04-04 Composes du type 1,4-dihydropyridine-3-carboxylate, procede pour leur fabrication et compositions pharmaceutiques renfermant ces composes a titre d'element actif Expired FR2563222B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59079560A JPS60248693A (ja) 1984-04-19 1984-04-19 ピリジン誘導体及び製法

Publications (2)

Publication Number Publication Date
FR2563222A1 FR2563222A1 (fr) 1985-10-25
FR2563222B1 true FR2563222B1 (fr) 1989-06-09

Family

ID=13693390

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8505174A Expired FR2563222B1 (fr) 1984-04-19 1985-04-04 Composes du type 1,4-dihydropyridine-3-carboxylate, procede pour leur fabrication et compositions pharmaceutiques renfermant ces composes a titre d'element actif

Country Status (15)

Country Link
US (1) US5036059A (fr)
EP (1) EP0159040B1 (fr)
JP (1) JPS60248693A (fr)
KR (1) KR850007603A (fr)
AT (1) ATE83237T1 (fr)
AU (1) AU570552B2 (fr)
BE (1) BE902210A (fr)
DE (1) DE3586879D1 (fr)
ES (1) ES8606276A1 (fr)
FR (1) FR2563222B1 (fr)
GB (1) GB2157695A (fr)
IT (1) IT1209945B (fr)
NL (1) NL8500909A (fr)
SE (1) SE464028B (fr)
ZA (1) ZA852591B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6163688A (ja) * 1984-08-03 1986-04-01 Nissan Chem Ind Ltd ジヒドロピリジン−５−ホスホン酸環状エステル類
CN1016063B (zh) 1986-01-22 1992-04-01 日产化学工业株式会社 二氢吡啶-5-膦酸环亚丙基酯的制备
US4885284A (en) * 1986-01-22 1989-12-05 Nissan Chemical Industries Ltd. Dihydropyridine-5-phosphonic acid cyclic propylene ester
UA5590A1 (uk) * 1986-01-23 1994-12-28 Ніссан Кемікал Індастріз Лтд Спосіб одержання пропіленглікового ефіру заміщеної 1,4-дігідропіріділ-5-фосфорної кислоти, або його фармацевтично прийнятной солі або сольвата
JPS63115890A (ja) * 1986-10-31 1988-05-20 Nippon Shinyaku Co Ltd ２位置換１，４−ジヒドロピリジン誘導体
JPH01275591A (ja) * 1988-04-27 1989-11-06 Nissan Chem Ind Ltd ジヒドロピリジン−５−ホスホン酸誘導体
JP2850376B2 (ja) * 1988-08-02 1999-01-27 日産化学工業株式会社 抗癌剤薬効増強剤
CA1334752C (fr) * 1988-08-02 1995-03-14 Ryozo Sakoda Agent favorisant les effets des medicaments antitumoraux
US20020119201A1 (en) * 2000-09-08 2002-08-29 Novozymes A/S Lubricated granules
NZ542681A (en) 2003-03-28 2009-01-31 Nissan Chemical Ind Ltd T-type calcium channel blockers comprising optically active 1,4-dihydropyridines

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2094678A5 (fr) * 1970-06-30 1972-02-04 Pepro
DE2508181A1 (de) * 1975-02-26 1976-09-09 Bayer Ag 1,4-dihydropyridincarbonsaeurearal- kylester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
JPS59161392A (ja) * 1983-03-04 1984-09-12 Nippon Shinyaku Co Ltd ジヒドロピリジン誘導体及びその製法
EP0141222B1 (fr) * 1983-09-26 1989-04-12 Nissan Chemical Industries Ltd. Ester cyclique de l'acide dihydropyridine-phosphonique-5

Also Published As

Publication number Publication date
EP0159040A3 (en) 1988-08-17
US5036059A (en) 1991-07-30
JPH0259835B2 (fr) 1990-12-13
GB2157695A (en) 1985-10-30
ES542378A0 (es) 1986-04-01
SE464028B (sv) 1991-02-25
NL8500909A (nl) 1985-11-18
BE902210A (fr) 1985-10-17
ATE83237T1 (de) 1992-12-15
EP0159040A2 (fr) 1985-10-23
SE8501882D0 (sv) 1985-04-17
JPS60248693A (ja) 1985-12-09
EP0159040B1 (fr) 1992-12-09
AU570552B2 (en) 1988-03-17
AU4140585A (en) 1985-10-24
IT1209945B (it) 1989-08-30
DE3586879D1 (de) 1993-01-21
GB8507897D0 (en) 1985-05-01
FR2563222A1 (fr) 1985-10-25
KR850007603A (ko) 1985-12-07
ES8606276A1 (es) 1986-04-01
ZA852591B (en) 1986-01-29
SE8501882L (sv) 1985-10-20
IT8547862A0 (it) 1985-03-25

Similar Documents

Publication Publication Date Title
FR2314731A1 (fr) Azacycloalcan-2-ones 1-substituees et compositions pharmaceutiques contenant ces composes a titre d'excipients
BE843140A (fr) Aazacycloalcan-2-ones 1-substituees et compositions pharmaceutiques contenant ces composes a titre d'excipients
CA2029599A1 (fr) Medicaments contenant comme substance active des acides carboxyliques renfermant du soufre
PT64840B (fr) Procede de preparation d'esteres aralquiliques d'acide 1,4-dihydrapiridinocarboxilique a effet coronaire et antihypertensive application des memes pour la preparation de compositions pharmaceutiques a effet coronaire et antihypertensive et application de ces compositions pharmaceutiques pour le traitement de maladies de lacirculation sanguine
FR2563222B1 (fr) Composes du type 1,4-dihydropyridine-3-carboxylate, procede pour leur fabrication et compositions pharmaceutiques renfermant ces composes a titre d'element actif
FR2615512B1 (fr) Composes de benzamides substitues pharmacologiquement actifs, compositions pharmaceutiques contenant ces composes, et leur procede de preparation
ATE40126T1 (de) 1,5-benzothiazepinderivate, verfahren zu ihrer herstellung und arzneimittel.
ES8702427A1 (es) Un procedimiento para preparar derivados de 1,3-difosfonato
DE3586935D1 (de) Hemmungsstoffe enkephalinase-b deren herstellung und deren pharmazeutische zusammensetzungen.
HUT50334A (en) Process for producing arylpiperazinyl-alkilenephenyl-p-heterocycluc compounds, pharmaceutically acceptable acid addition salts thereof and pharmaceutical compositions comprising the compounds as active ingredient
FR2432520A1 (fr) Nouvelles imidazoquinoxalines et leurs sels, leur procede de preparation, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
FR2507605B1 (fr) Procede de preparation d'esters d'acides apovincaminiques, esters ainsi obtenus et compositions pharmaceutiques preparees avec ces esters
FR2347381A1 (fr) Nouveaux derives d'anthracycline-glycosides, en particulier designes sous le nom d'antibiotiques ma 144-m1 et ma 144-m2, leurs procedes de preparation et compositions pharmaceutiques contenant lesdits composes comme agents antitumeurs
FR2691149B1 (fr) Nouveaux composes thiochromaniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
ATE40127T1 (de) 1,5-benzothiazepinderivate, verfahren zu ihrer herstellung und arzneimittel.
ATE37369T1 (de) Eine thiazinverbindung, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
FR2434804A1 (fr) Derives de la n-phenyl-indoline, leur preparation et leur application comme medicaments
FR2540498B1 (fr) Nouveaux medicaments derives d'amides d'acide mercaptoacetique et de l'acide 3-mercaptopropionique et les compositions pharmaceutiques les renfermant
DE69434002D1 (de) 2,3 diaryl-1-benzopyrame zur behandlung von dermatitis
ATE73330T1 (de) Verwendung von pharmaceutischen zusammensetzungen fuer die herstellung von arzneimitteln fuer die behandlung psychiatrischer stoerungen.
DE3372772D1 (en) Quinazolinone derivatives, process for their preparation and their use in medicaments
FR2529550B1 (fr) Derives d'acide apovincaminique, procede pour leur preparation et compositions pharmaceutiques contenant ces derives
FR2572889B1 (fr) Nouveaux derives d'acide (trifluoromethyl)-phenoxy-benzoique, procede pour leur preparation et fongicides contenant ces composes comme ingredient actif.
DE176053T1 (de) 1,4-dihydropyridin-derivate und diese enthaltende pharmazeutische praeparate.
FR2554441B1 (fr) Derives de fluorene, agent anti-inflammatoires et/ou analgesiques et/ou anti-pyretiques contenant au moins l'un de ces composes en tant qu'ingredient actif et procede de fabrication de ces composes

Legal Events

Date Code Title Description
ST Notification of lapse