FR2533568B1 - Nouveaux antibiotiques de la classe des carbapenems, et leur application pharmaceutique - Google Patents
Nouveaux antibiotiques de la classe des carbapenems, et leur application pharmaceutiqueInfo
- Publication number
- FR2533568B1 FR2533568B1 FR838315069A FR8315069A FR2533568B1 FR 2533568 B1 FR2533568 B1 FR 2533568B1 FR 838315069 A FR838315069 A FR 838315069A FR 8315069 A FR8315069 A FR 8315069A FR 2533568 B1 FR2533568 B1 FR 2533568B1
- Authority
- FR
- France
- Prior art keywords
- pharmaceutical application
- novel carbapenem
- class antibiotics
- carbapenem class
- antibiotics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 229940088710 antibiotic agent Drugs 0.000 title 1
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical class C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/26—Radicals substituted by sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65611—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. penicillins and analogs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42575582A | 1982-09-28 | 1982-09-28 | |
| US53001183A | 1983-09-09 | 1983-09-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2533568A1 FR2533568A1 (fr) | 1984-03-30 |
| FR2533568B1 true FR2533568B1 (fr) | 1990-01-26 |
Family
ID=27026797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR838315069A Expired - Fee Related FR2533568B1 (fr) | 1982-09-28 | 1983-09-22 | Nouveaux antibiotiques de la classe des carbapenems, et leur application pharmaceutique |
Country Status (29)
| Country | Link |
|---|---|
| KR (1) | KR890002228B1 (sv) |
| AR (1) | AR241785A1 (sv) |
| AT (1) | AT382621B (sv) |
| AU (1) | AU575541B2 (sv) |
| CA (1) | CA1269978A (sv) |
| CH (1) | CH656130A5 (sv) |
| CS (1) | CS247168B2 (sv) |
| DD (1) | DD212255A5 (sv) |
| DE (1) | DE3334937A1 (sv) |
| DK (1) | DK442383A (sv) |
| ES (1) | ES8503354A1 (sv) |
| FI (1) | FI78094C (sv) |
| FR (1) | FR2533568B1 (sv) |
| GB (1) | GB2128187B (sv) |
| GR (1) | GR78696B (sv) |
| HU (1) | HU191066B (sv) |
| IE (1) | IE55947B1 (sv) |
| IL (1) | IL69824A (sv) |
| IT (1) | IT1163944B (sv) |
| LU (1) | LU85021A1 (sv) |
| NL (1) | NL8303310A (sv) |
| NO (1) | NO163284C (sv) |
| NZ (1) | NZ205626A (sv) |
| OA (1) | OA07548A (sv) |
| PT (1) | PT77404B (sv) |
| SE (1) | SE461734B (sv) |
| SU (1) | SU1493108A3 (sv) |
| YU (1) | YU43196B (sv) |
| ZW (1) | ZW20783A1 (sv) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683296A (en) * | 1983-03-07 | 1987-07-28 | Bristol-Myers Company | Carbapenem intermediates |
| CA1273012A (en) * | 1984-07-02 | 1990-08-21 | Burton G. Christensen | 1-methylcarbapenems having an externally alkylated mono- of bicyclic 2-quarternary heteroarylalkylthio substituent |
| CA1273011A (en) * | 1984-07-02 | 1990-08-21 | Susan M. Schmitt | Carbapenems having an externally alkylated mono- or bicyclic 2-quaternary heteroarylalkylthio substituent |
| US4680292A (en) * | 1984-12-13 | 1987-07-14 | Merck & Co., Inc. | Carbapenems and 1-methylcarbapenems having a 2-heteroaryliumaliphatic substituent |
| US4725594A (en) * | 1984-12-13 | 1988-02-16 | Merck & Co., Inc. | Carbapenems having an internally or externally alkylated mono- or bicyclic 2-quaternary heteroarylalxyl heteromethyl substituent |
| US4729993A (en) * | 1984-12-13 | 1988-03-08 | Merck & Co., Inc. | Carbapenems and 1-methylcarbapenems having an externally alkylated mono- or bicyclic 2-quaternary heteroarylalkyl substituent |
| US4665169A (en) * | 1985-09-11 | 1987-05-12 | Bristol-Myers Company | Carbapenem antibiotics |
| US4880922A (en) * | 1985-11-22 | 1989-11-14 | Bristol-Myers Company | Carbapenems with quaternized heterothioalkylthio substitution at position 2 |
| NZ219892A (en) * | 1986-04-15 | 1991-02-26 | Merck & Co Inc | N-amino quaternised heteroarylium carbapenem derivatives and pharmaceutical compositions thereof |
| DK168047B1 (da) * | 1987-12-07 | 1994-01-24 | Lederle Japan Ltd | (1r,5s,6s)-2-substitueret thio-6-oe(r)-1-hydroxyethylaa-1-methyl-carbapenem-3-carboxylsyrederivater, fremgangsmaade til remstilling deraf, midler og praeparater indeholdende den krystallinske forbindelse samt dens anvendelse. |
| US6174877B1 (en) | 1996-01-12 | 2001-01-16 | Takeda Chemical Industries, Ltd. | Carbapenem compound, their production and use |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0082133A3 (en) * | 1979-04-19 | 1983-07-20 | Merck & Co. Inc. | A process for preparing intermediates useful for preparing 2-substituted-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids |
| IE52147B1 (en) * | 1980-03-27 | 1987-07-08 | Merck & Co Inc | 4-(3-carboxy-2-oxopropyl)-azetidin-2-ones and process for their preparation |
| EP0038869A1 (en) * | 1980-04-30 | 1981-11-04 | Merck & Co. Inc. | Process for the preparation of 1-carbapenems, and intermediates for their preparation |
| PT73791B (en) * | 1980-10-17 | 1983-10-14 | Merck & Co Inc | Process for preparing 2-carbamimidoyl-6-substituted-1- -carbadethiapen-2-em-3-carboxylic acids |
| EP0050927B1 (en) * | 1980-10-25 | 1985-03-27 | Beecham Group Plc | The preparation of beta-lactam antibiotics |
| US4552873A (en) * | 1981-08-19 | 1985-11-12 | Sankyo Company Limited | Carbapenem compounds, and compositions containing them |
| EP0074599A1 (en) * | 1981-09-09 | 1983-03-23 | Takeda Chemical Industries, Ltd. | 5,6-cis-Carbapenem derivatives, their production and use |
-
1983
- 1983-09-16 NZ NZ205626A patent/NZ205626A/en unknown
- 1983-09-16 CA CA000436924A patent/CA1269978A/en not_active Expired - Lifetime
- 1983-09-21 AU AU19342/83A patent/AU575541B2/en not_active Ceased
- 1983-09-22 GR GR72509A patent/GR78696B/el unknown
- 1983-09-22 YU YU1906/83A patent/YU43196B/xx unknown
- 1983-09-22 FR FR838315069A patent/FR2533568B1/fr not_active Expired - Fee Related
- 1983-09-23 FI FI833417A patent/FI78094C/sv not_active IP Right Cessation
- 1983-09-27 SE SE8305217A patent/SE461734B/sv not_active IP Right Cessation
- 1983-09-27 IT IT23022/83A patent/IT1163944B/it active
- 1983-09-27 GB GB08325744A patent/GB2128187B/en not_active Expired
- 1983-09-27 IE IE2266/83A patent/IE55947B1/en not_active IP Right Cessation
- 1983-09-27 SU SU833648007A patent/SU1493108A3/ru active
- 1983-09-27 ES ES525983A patent/ES8503354A1/es not_active Expired
- 1983-09-27 PT PT77404A patent/PT77404B/pt not_active IP Right Cessation
- 1983-09-27 CS CS837049A patent/CS247168B2/cs unknown
- 1983-09-27 HU HU833351A patent/HU191066B/hu not_active IP Right Cessation
- 1983-09-27 OA OA58118A patent/OA07548A/xx unknown
- 1983-09-27 DE DE19833334937 patent/DE3334937A1/de active Granted
- 1983-09-27 NL NL8303310A patent/NL8303310A/nl not_active Application Discontinuation
- 1983-09-27 AR AR83294329A patent/AR241785A1/es active
- 1983-09-27 IL IL69824A patent/IL69824A/xx unknown
- 1983-09-27 DK DK442383A patent/DK442383A/da not_active Application Discontinuation
- 1983-09-27 NO NO833479A patent/NO163284C/no unknown
- 1983-09-28 KR KR1019830004574A patent/KR890002228B1/ko not_active IP Right Cessation
- 1983-09-28 LU LU85021A patent/LU85021A1/fr unknown
- 1983-09-28 CH CH5263/83A patent/CH656130A5/de not_active IP Right Cessation
- 1983-09-28 ZW ZW207/83A patent/ZW20783A1/xx unknown
- 1983-09-28 DD DD83255191A patent/DD212255A5/de not_active IP Right Cessation
- 1983-09-28 AT AT0344983A patent/AT382621B/de not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FR2509310B1 (fr) | Nouvelles cephalosporines, leur procede de preparation et leur application en therapeutique | |
| PT72465A (pt) | Beta-lactam antibiotics | |
| FR2511682B1 (fr) | Derives de cephalosporine, leur procede de preparation et leur application therapeutique | |
| FR2528847B1 (fr) | Produits nouveaux de la classe des carbapenems et leur application en tant qu'antibiotiques | |
| DE3687279D1 (de) | Beta-lactam-antibiotika. | |
| OA08444A (fr) | Nouveaux céphèmes et procédés pour leur préparation. | |
| FR2533568B1 (fr) | Nouveaux antibiotiques de la classe des carbapenems, et leur application pharmaceutique | |
| FR2557571B1 (fr) | Antibiotiques du type cephalosporine, leur procede de preparation, intermediaires pour leur preparation et compositions therapeutiques les contenant | |
| FR2580653B1 (fr) | Composes intermediaires de carbapenem et leur procede de preparation | |
| FI851340A0 (fi) | Foerfarande och apparat foer maetning av egenskaperna speciellt foertaetningsbarheten av en troeg, gjutbar massa. | |
| FI851998A0 (fi) | Foerfarande och apparat foer avvattning av en suspension. | |
| BE896086A (fr) | Nouveaux derives de cephalosporine, leur procede de preparation et composition antibacterienne les contenant | |
| FI861788A0 (fi) | Saett och apparat foer framstaellning av en materilbana. | |
| AU572090B2 (en) | Carbapenem antibiotics | |
| FR2421903B1 (fr) | Nouveaux antibiotiques du type b-lactame, leur procede de production et medicament les contenant | |
| FR2524888B1 (fr) | Nouveaux antibiotiques de type carbapenem | |
| FI861789A0 (fi) | Saett och apparat foer framstaellning av en materialbana. | |
| FR2624861B1 (fr) | Carbamates tricycliques, leur procede de preparation et leur application en therapeutique | |
| FR2430951B1 (fr) | Antibiotiques, leur preparation et culture de preparation | |
| MC1740A1 (fr) | Glyocides et procede pour leur preparation | |
| IT8522317A0 (it) | Carbapenem antibiotici eprocedimento per la loro preparazione. | |
| FR2564095B1 (fr) | Antibiotiques de cephalosporine, leur preparation et compositions pharmaceutiques les contenant | |
| IT1212876B (it) | Antibiotici cefalosporinici,procedimento per prepararli e composizioni farmaceutiche che li contengono | |
| FR2570697B1 (fr) | Nouveaux hydroxy-thia alcenes, leur procede de preparation et applications | |
| IT1175800B (it) | Antibiotici,cefalosporinici,procedimento per prepararli e composizioni farmaceutiche li contengono |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CD | Change of name or company name | ||
| ST | Notification of lapse |