FR2504010B1 - Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation - Google Patents

Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation

Info

Publication number
FR2504010B1
FR2504010B1 FR8107596A FR8107596A FR2504010B1 FR 2504010 B1 FR2504010 B1 FR 2504010B1 FR 8107596 A FR8107596 A FR 8107596A FR 8107596 A FR8107596 A FR 8107596A FR 2504010 B1 FR2504010 B1 FR 2504010B1
Authority
FR
France
Prior art keywords
ricin
preparation
products containing
medicinal products
cancer medicinal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8107596A
Other languages
English (en)
French (fr)
Other versions
FR2504010A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Priority to FR8107596A priority Critical patent/FR2504010B1/fr
Priority to MA19633A priority patent/MA19429A1/fr
Priority to IE815/82A priority patent/IE53009B1/en
Priority to IL65441A priority patent/IL65441A0/xx
Priority to CA000400606A priority patent/CA1195248A/en
Priority to AU82510/82A priority patent/AU556641B2/en
Priority to AT82400651T priority patent/ATE17653T1/de
Priority to DE8282400651T priority patent/DE3268752D1/de
Priority to CS822564A priority patent/CZ256482A3/cs
Priority to EP82400651A priority patent/EP0063988B1/fr
Priority to GR67862A priority patent/GR69199B/el
Priority to AR289058A priority patent/AR228394A1/es
Priority to PT74741A priority patent/PT74741B/pt
Priority to NO821198A priority patent/NO154905C/no
Priority to OA57657A priority patent/OA07069A/xx
Priority to ES511433A priority patent/ES8303918A1/es
Priority to YU00830/82A priority patent/YU83082A/xx
Priority to SU823427002A priority patent/SU1329604A3/ru
Priority to FI821304A priority patent/FI76693C/fi
Priority to ZA822528A priority patent/ZA822528B/xx
Priority to US06/368,434 priority patent/US4414148A/en
Priority to DK167482A priority patent/DK159277C/da
Priority to EG205/82A priority patent/EG15718A/xx
Priority to DD82238983A priority patent/DD204849A5/de
Priority to HU821135A priority patent/HU188314B/hu
Priority to NZ200302A priority patent/NZ200302A/en
Priority to PH27142A priority patent/PH20846A/en
Priority to PL1982235981A priority patent/PL135800B1/pl
Priority to JP57061857A priority patent/JPS57179124A/ja
Priority to KR8201664A priority patent/KR880001045B1/ko
Publication of FR2504010A1 publication Critical patent/FR2504010A1/fr
Application granted granted Critical
Publication of FR2504010B1 publication Critical patent/FR2504010B1/fr
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/44—Antibodies bound to carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3053—Skin, nerves, brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817—Toxins
    • A61K47/6819—Plant toxins
    • A61K47/6825—Ribosomal inhibitory proteins, i.e. RIP-I or RIP-II, e.g. Pap, gelonin or dianthin
    • A61K47/6827—Ricin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6865—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from skin, nerves or brain cancer cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806—Antigenic peptides or proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/828—Cancer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Botany (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR8107596A 1981-04-15 1981-04-15 Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation Expired FR2504010B1 (fr)

Priority Applications (30)

Application Number Priority Date Filing Date Title
FR8107596A FR2504010B1 (fr) 1981-04-15 1981-04-15 Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation
MA19633A MA19429A1 (fr) 1981-04-15 1982-04-01 Procede de preparation de produits utiles pour le traitement des melanomes
IL65441A IL65441A0 (en) 1981-04-15 1982-04-06 Anti-cancer drugs containing a derivative of antimelanoma antibody and their preparation
IE815/82A IE53009B1 (en) 1981-04-15 1982-04-06 Anti-cancer drugs containing the a chain of ricin associated with antimelanoma antibody and method for preparing them
CA000400606A CA1195248A (en) 1981-04-15 1982-04-07 Anti-cancer drugs for the treatment of melanomas and method for preparing thereof
AU82510/82A AU556641B2 (en) 1981-04-15 1982-04-08 Production of human antimelanoma monoclonal antibody
AT82400651T ATE17653T1 (de) 1981-04-15 1982-04-09 Mit einem antimelanoma-antikoerper verbundene ricin-a-kette enthaltende antikrebs-heilmittel und verfahren zu ihrer herstellung.
DE8282400651T DE3268752D1 (en) 1981-04-15 1982-04-09 Anticancer medicaments containing a ricin a-chain associated with an antimelanoma antibody, and process for their preparation
CS822564A CZ256482A3 (en) 1981-04-15 1982-04-09 Medicaments suitable particularly for treating melanoma and process for preparing thereof
EP82400651A EP0063988B1 (fr) 1981-04-15 1982-04-09 Médicaments anticancéreux contenant la chaîne A de la ricine associée à un anticorps antimélanome et procédé pour leur préparation
GR67862A GR69199B (enrdf_load_stackoverflow) 1981-04-15 1982-04-09
AR289058A AR228394A1 (es) 1981-04-15 1982-04-12 Procedimiento para la preparacion de productos utiles para el tratamiento de los melanomas
NO821198A NO154905C (no) 1981-04-15 1982-04-13 Fremgangsmaate for fremstilling av preparater for behandling av melanomer.
OA57657A OA07069A (fr) 1981-04-15 1982-04-13 Médicaments anticancéreux contenant la chaîne A de la ricine associée à un anticorps antimélanome et procédé pour leur préparation.
PT74741A PT74741B (fr) 1981-04-15 1982-04-13 Procede de preparation de produits utiles pour le traitement des melanomes
HU821135A HU188314B (en) 1981-04-15 1982-04-14 Process for production of preparatives suitable for treating of melanoma
SU823427002A SU1329604A3 (ru) 1981-04-15 1982-04-14 Способ получени конъюгированного соединени ,специфичного по отношению к клеткам меланомы
FI821304A FI76693C (fi) 1981-04-15 1982-04-14 Saett att framstaella ett aktivaemne, vilket aer anvaendbart saosom laekemedel vid behandling av melanomer.
ZA822528A ZA822528B (en) 1981-04-15 1982-04-14 Anti-cancer drugs for the treatment of melanomas and method for preparing thereof
US06/368,434 US4414148A (en) 1981-04-15 1982-04-14 Anti-cancer drugs for the treatment of melanomas and method for preparing thereof
DK167482A DK159277C (da) 1981-04-15 1982-04-14 Analogifremgangsmaade til fremstilling af produkter, der er anvendelige til behandling af melanomer
EG205/82A EG15718A (en) 1981-04-15 1982-04-14 Method for preparing products useful for the treatment of melanomas
ES511433A ES8303918A1 (es) 1981-04-15 1982-04-14 "procedimiento de preparacion de productos utiles particularmente en medicamentos utilizables para el tratamiento de melanomas".
YU00830/82A YU83082A (en) 1981-04-15 1982-04-14 Process for obtaining products for the treatment of melanoma
NZ200302A NZ200302A (en) 1981-04-15 1982-04-14 Antimelanoma drugs containing antibodies
DD82238983A DD204849A5 (de) 1981-04-15 1982-04-14 Verfahren zur herstellung von produkten fuer die behandlung von melanomen
PH27142A PH20846A (en) 1981-04-15 1982-04-15 Method of treating melanomas using chain a of ricin associated with an antimelanoma antibody
PL1982235981A PL135800B1 (en) 1981-04-15 1982-04-15 Method of obtaining a product of coupling a chain of castor oil with human antimelanotic antibody
JP57061857A JPS57179124A (en) 1981-04-15 1982-04-15 Anticancer and preparation
KR8201664A KR880001045B1 (ko) 1981-04-15 1982-04-15 흑색종 치료에 유용한 물질의 제조방법

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8107596A FR2504010B1 (fr) 1981-04-15 1981-04-15 Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation

Publications (2)

Publication Number Publication Date
FR2504010A1 FR2504010A1 (fr) 1982-10-22
FR2504010B1 true FR2504010B1 (fr) 1985-10-25

Family

ID=9257448

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8107596A Expired FR2504010B1 (fr) 1981-04-15 1981-04-15 Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation

Country Status (30)

Country Link
US (1) US4414148A (enrdf_load_stackoverflow)
EP (1) EP0063988B1 (enrdf_load_stackoverflow)
JP (1) JPS57179124A (enrdf_load_stackoverflow)
KR (1) KR880001045B1 (enrdf_load_stackoverflow)
AR (1) AR228394A1 (enrdf_load_stackoverflow)
AT (1) ATE17653T1 (enrdf_load_stackoverflow)
AU (1) AU556641B2 (enrdf_load_stackoverflow)
CA (1) CA1195248A (enrdf_load_stackoverflow)
CZ (1) CZ256482A3 (enrdf_load_stackoverflow)
DD (1) DD204849A5 (enrdf_load_stackoverflow)
DE (1) DE3268752D1 (enrdf_load_stackoverflow)
DK (1) DK159277C (enrdf_load_stackoverflow)
EG (1) EG15718A (enrdf_load_stackoverflow)
ES (1) ES8303918A1 (enrdf_load_stackoverflow)
FI (1) FI76693C (enrdf_load_stackoverflow)
FR (1) FR2504010B1 (enrdf_load_stackoverflow)
GR (1) GR69199B (enrdf_load_stackoverflow)
HU (1) HU188314B (enrdf_load_stackoverflow)
IE (1) IE53009B1 (enrdf_load_stackoverflow)
IL (1) IL65441A0 (enrdf_load_stackoverflow)
MA (1) MA19429A1 (enrdf_load_stackoverflow)
NO (1) NO154905C (enrdf_load_stackoverflow)
NZ (1) NZ200302A (enrdf_load_stackoverflow)
OA (1) OA07069A (enrdf_load_stackoverflow)
PH (1) PH20846A (enrdf_load_stackoverflow)
PL (1) PL135800B1 (enrdf_load_stackoverflow)
PT (1) PT74741B (enrdf_load_stackoverflow)
SU (1) SU1329604A3 (enrdf_load_stackoverflow)
YU (1) YU83082A (enrdf_load_stackoverflow)
ZA (1) ZA822528B (enrdf_load_stackoverflow)

Families Citing this family (147)

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FR2523445A1 (fr) * 1982-03-17 1983-09-23 Sanofi Sa Nouveaux conjugues associant, par liaison covalente, une enzyme et un anticorps, et associations medicamenteuses utilisant lesdits conjugues
ATE25197T1 (de) * 1982-05-12 1987-02-15 Harvard College Hybridproteinekodierende fusionierte gene, sie enthaltende klonierungsvektoren und deren verwendung.
US4520226A (en) * 1982-07-19 1985-05-28 The United States Of America As Represented By The Department Of Health And Human Services Treatment of graft versus host disease using a mixture of T-lymphocyte specific monoclonal antibody: ricin conjugates
JPS5990052A (ja) * 1982-11-16 1984-05-24 Katsu Taniguchi モノクロ−ナル特異抗体を用いたメラノ−マ診断薬
US4916213A (en) * 1983-02-22 1990-04-10 Xoma Corporation Ribosomal inhibiting protein-immunoglobulin conjugates with specificity for tumor cell surface antigens, and mixtures thereof
US4591572A (en) * 1983-04-01 1986-05-27 Sloan-Kettering Institute For Cancer Research Pigmentation associated, differentiation antigen of human melanoma and autologous antibody
JPS59186924A (ja) * 1983-04-08 1984-10-23 Kureha Chem Ind Co Ltd ヒト免疫グロブリン結合抗腫瘍剤
US4664911A (en) * 1983-06-21 1987-05-12 Board Of Regents, University Of Texas System Immunotoxin conjugates employing toxin B chain moieties
GB2142428A (en) * 1983-06-23 1985-01-16 Erba Farmitalia Adenocarcinoma related antigenic determinants and antibodies specific thereto
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US4831122A (en) * 1986-01-09 1989-05-16 Regents Of The University Of Minnesota Radioimmunotoxins
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US5009995A (en) * 1986-10-27 1991-04-23 Sloan-Kettering Institute For Cancer Research Monoclonal antibodies to melanoma cells
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US5582862A (en) * 1988-04-04 1996-12-10 General Hospital Corporation Antibodies that bind to α2-antiplasmin crosslinked to fibrin which do not inhibit plasma α2-antiplasmin
US5609869A (en) * 1988-08-19 1997-03-11 The General Hospital Corporation Hybrid immunoglobulin-thrombolytic enzyme molecules which specifically bind a thrombus, and methods of their production and use
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US4414148A (en) 1983-11-08
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