FR24C1049I1 - Formulations liquides et lyophilisées stabilisées de adamts13 - Google Patents

Formulations liquides et lyophilisées stabilisées de adamts13

Info

Publication number
FR24C1049I1
FR24C1049I1 FR24C1049C FR24C1049C FR24C1049I1 FR 24C1049 I1 FR24C1049 I1 FR 24C1049I1 FR 24C1049 C FR24C1049 C FR 24C1049C FR 24C1049 C FR24C1049 C FR 24C1049C FR 24C1049 I1 FR24C1049 I1 FR 24C1049I1
Authority
FR
France
Prior art keywords
adamts13
lyophilized formulations
stabilized liquid
stabilized
liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR24C1049C
Other languages
English (en)
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Co Ltd filed Critical Takeda Pharmaceutical Co Ltd
Publication of FR24C1049I1 publication Critical patent/FR24C1049I1/fr
Active legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24087—ADAMTS13 endopeptidase (3.4.24.87)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
FR24C1049C 2009-09-21 2024-12-10 Formulations liquides et lyophilisées stabilisées de adamts13 Active FR24C1049I1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US24435309P 2009-09-21 2009-09-21
PCT/US2010/049723 WO2011035335A2 (en) 2009-09-21 2010-09-21 Stabilized liquid and lyophilized adamts13 formulations
EP10759786.6A EP2480198B9 (en) 2009-09-21 2010-09-21 Stabilized liquid and lyophilized adamts13 formulations
EP15203085.4A EP3167897B1 (en) 2009-09-21 2010-09-21 Stabilized liquid and lyophilized adamts13 formulations

Publications (1)

Publication Number Publication Date
FR24C1049I1 true FR24C1049I1 (fr) 2025-01-17

Family

ID=43598388

Family Applications (1)

Application Number Title Priority Date Filing Date
FR24C1049C Active FR24C1049I1 (fr) 2009-09-21 2024-12-10 Formulations liquides et lyophilisées stabilisées de adamts13

Country Status (21)

Country Link
US (9) US8623352B2 (OSRAM)
EP (5) EP3167897B1 (OSRAM)
JP (2) JP5819303B2 (OSRAM)
KR (6) KR20250008986A (OSRAM)
CN (2) CN102573792B (OSRAM)
AU (1) AU2010295299B2 (OSRAM)
BR (1) BR112012006283B1 (OSRAM)
CA (1) CA2774556A1 (OSRAM)
DK (4) DK4218797T5 (OSRAM)
EA (1) EA024267B1 (OSRAM)
ES (4) ES2579906T3 (OSRAM)
FI (2) FI4218797T3 (OSRAM)
FR (1) FR24C1049I1 (OSRAM)
HR (1) HRP20160295T1 (OSRAM)
HU (1) HUE028688T2 (OSRAM)
IN (1) IN2012DN02645A (OSRAM)
MX (3) MX339205B (OSRAM)
NZ (1) NZ598839A (OSRAM)
PL (4) PL3834841T3 (OSRAM)
PT (2) PT4218797T (OSRAM)
WO (1) WO2011035335A2 (OSRAM)

Families Citing this family (21)

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AU2009322367B2 (en) 2008-12-05 2015-03-26 Takeda Pharmaceutical Company Limited Methods of measuring ADAMTS13-mediated in vivo cleavage of von Willebrand factor and uses thereof
PL3834841T3 (pl) 2009-09-21 2023-07-24 Takeda Pharmaceutical Company Limited Stabilizowane ciekłe i liofilizowane preparaty adamts13
DK2814514T3 (en) * 2012-02-16 2017-12-18 Atyr Pharma Inc Histidyl tRNA synthetases for the treatment of autoimmune and inflammatory diseases
CN103566362B (zh) * 2012-07-21 2015-07-29 复旦大学 重组adamts13在制备脑出血药物中的用途
US10441531B2 (en) * 2012-11-09 2019-10-15 Bloodworks Protein stabilizing factors
AU2013203062C1 (en) * 2013-03-15 2018-06-28 Takeda Pharmaceutical Company Limited Subcutaneous administration of adamts13
JP6397479B2 (ja) 2013-03-15 2018-09-26 エータイアー ファーマ， インコーポレイテッド ヒスチジル−ｔＲＮＡシンテターゼＦｃコンジュゲート
MX377774B (es) * 2014-06-26 2025-03-11 Amgen Inc Formulaciones de proteinas.
GB201510870D0 (en) * 2015-05-26 2015-08-05 Baxalta Inc And Katholieke Universiteit Leuven And Baxalta Gmbh Treatment of infarction
EP3988938B1 (en) 2016-01-08 2024-06-12 Kyoto University Medicine comprising adamts13 as main ingredient
MX2019001255A (es) * 2016-08-04 2019-05-20 Baxalta Inc Uso de una desintegrina y metaloproteinasa con motivo tipo 1 de trombospondina, miembro-13 (adamts13) para tratar, mejorar y/o prevenir crisis vaso-oclusiva en enfermedad de celulas falciformes, lesion pulmonar aguda y/o sindrome de insuficiencia respiratoria aguda.
BR112019009113A2 (pt) 2016-11-04 2019-07-16 Baxalta GmbH formulações de vírus adenoassociado
EP3612215B1 (en) 2017-04-20 2024-08-28 aTyr Pharma, Inc. Compositions for treating lung inflammation
KR102720834B1 (ko) * 2017-07-25 2024-10-23 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 Il-15 단백질 복합체 약학 조성물 및 이의 용도
BR112021000327A2 (pt) * 2018-07-11 2021-04-06 Baxalta Incorporated Composições de aav
WO2021067668A1 (en) 2019-10-04 2021-04-08 The Children's Medical Center Corporation Adamts13 treatment to enhance graft survival
BR112022019817A2 (pt) 2020-04-02 2022-12-06 Takeda Pharmaceuticals Co Variante de adamts13, composições e usos das mesmas
WO2021234458A1 (en) 2020-05-22 2021-11-25 Takeda Pharmaceutical Company Limited Adamts13 compositions and methods for treating and diagnosing complications of coronavirus disease
EP4196147A4 (en) * 2020-08-13 2024-08-21 Hadasit Medical Research Services and Development Ltd. DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN TYPE 1 MOTIF, MUTANTS OF ELEMENT 13 (ADAMTS-13), COMPOSITIONS AND THERAPEUTIC METHODS THEREFOR
IL315475A (en) 2022-03-08 2024-11-01 Equashield Medical Ltd A position for transferring liquids in a robotic system for preparing medicines
WO2024151093A1 (ko) * 2023-01-11 2024-07-18 주식회사 녹십자 혈전성 질환의 예방 또는 치료를 위한 신규한 액상 제형물

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PL3834841T3 (pl) * 2009-09-21 2023-07-24 Takeda Pharmaceutical Company Limited Stabilizowane ciekłe i liofilizowane preparaty adamts13
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Also Published As

Publication number Publication date
HRP20160295T1 (hr) 2016-05-20
KR20250008986A (ko) 2025-01-16
EP3167897B1 (en) 2021-01-27
EP3834841B1 (en) 2023-05-17
PT4218797T (pt) 2024-12-09
EA024267B1 (ru) 2016-09-30
JP2015063556A (ja) 2015-04-09
US20160375111A1 (en) 2016-12-29
US20190247475A1 (en) 2019-08-15
US20250099559A1 (en) 2025-03-27
KR101891646B1 (ko) 2018-08-27
US20110229455A1 (en) 2011-09-22
US8623352B2 (en) 2014-01-07
JP2013505270A (ja) 2013-02-14
WO2011035335A2 (en) 2011-03-24
IN2012DN02645A (OSRAM) 2015-09-11
KR20190137954A (ko) 2019-12-11
FI4218797T3 (fi) 2024-12-07
KR20120099646A (ko) 2012-09-11
MX2012003414A (es) 2012-06-19
KR20210054598A (ko) 2021-05-13
EP3834841A1 (en) 2021-06-16
US10758599B2 (en) 2020-09-01
US11564979B2 (en) 2023-01-31
EP4218797B9 (en) 2025-04-30
EP3167897A1 (en) 2017-05-17
DK3167897T3 (da) 2021-04-19
US12178861B2 (en) 2024-12-31
US10238720B2 (en) 2019-03-26
HK1173968A1 (zh) 2013-05-31
EP4218797B1 (en) 2024-09-11
BR112012006283B1 (pt) 2022-03-15
PL2480198T3 (pl) 2016-09-30
ES3001509T3 (en) 2025-03-05
AU2010295299A1 (en) 2012-04-12
DK2480198T3 (en) 2016-03-29
EP4218797A1 (en) 2023-08-02
PL3834841T3 (pl) 2023-07-24
PL3167897T3 (pl) 2021-09-27
EA201200519A1 (ru) 2012-09-28
US9572778B2 (en) 2017-02-21
US9351935B2 (en) 2016-05-31
ES2579906T3 (es) 2016-08-17
EP4467160A2 (en) 2024-11-27
PL4218797T3 (pl) 2025-02-10
US20180207245A1 (en) 2018-07-26
DK4218797T3 (da) 2024-12-09
HUE028688T2 (en) 2017-01-30
EP4467160A3 (en) 2025-01-15
EP2480198A2 (en) 2012-08-01
US20170112906A1 (en) 2017-04-27
WO2011035335A3 (en) 2011-12-01
FI3834841T3 (fi) 2023-06-05
DK4218797T5 (da) 2025-07-21
US20140178357A1 (en) 2014-06-26
BR112012006283A2 (pt) 2016-05-31
US9937244B2 (en) 2018-04-10
MX362382B (es) 2019-01-14
CN104224705B (zh) 2018-02-02
EP2480198B1 (en) 2016-03-09
MX339205B (es) 2016-05-16
NZ598839A (en) 2014-03-28
CN102573792A (zh) 2012-07-11
ES2948612T3 (es) 2023-09-14
KR20180095738A (ko) 2018-08-27
CN104224705A (zh) 2014-12-24
AU2010295299B2 (en) 2015-12-24
US20200376098A1 (en) 2020-12-03
CN102573792B (zh) 2014-10-15
ES2865250T3 (es) 2021-10-15
MX2019000547A (es) 2020-11-12
EP2480198B9 (en) 2016-11-23
CA2774556A1 (en) 2011-03-24
DK3834841T3 (da) 2023-06-06
US20230130866A1 (en) 2023-04-27
KR20220139456A (ko) 2022-10-14
JP5819303B2 (ja) 2015-11-24
PT3834841T (pt) 2023-06-19

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