FR2498603A1 - Nouveaux derives spiro-1 isobenzofuranniques et spiro-1 isobenzothiopheniques, leur procede de preparation et leur application en therapeutique - Google Patents

Nouveaux derives spiro-1 isobenzofuranniques et spiro-1 isobenzothiopheniques, leur procede de preparation et leur application en therapeutique Download PDF

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Publication number
FR2498603A1
FR2498603A1 FR8101692A FR8101692A FR2498603A1 FR 2498603 A1 FR2498603 A1 FR 2498603A1 FR 8101692 A FR8101692 A FR 8101692A FR 8101692 A FR8101692 A FR 8101692A FR 2498603 A1 FR2498603 A1 FR 2498603A1
Authority
FR
France
Prior art keywords
sep
formula
compounds
nch3
oxygen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8101692A
Other languages
English (en)
French (fr)
Other versions
FR2498603B1 (enExample
Inventor
Michel Langlois
Bernard Bucher
Philippe Dostert
Alain Lacour
Gerard Moinet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Priority to FR8101692A priority Critical patent/FR2498603A1/fr
Priority to US06/341,415 priority patent/US4395416A/en
Priority to SE8200320A priority patent/SE8200320L/xx
Priority to GR67080A priority patent/GR75187B/el
Priority to ZA82461A priority patent/ZA82461B/xx
Priority to LU83893A priority patent/LU83893A1/fr
Priority to IT19267/82A priority patent/IT1190669B/it
Priority to ES509028A priority patent/ES8304990A1/es
Priority to CA000394968A priority patent/CA1169863A/en
Priority to GB8202188A priority patent/GB2092143B/en
Priority to BE0/207161A priority patent/BE891928A/fr
Priority to AU79933/82A priority patent/AU7993382A/en
Priority to JP57011906A priority patent/JPS57181076A/ja
Priority to DE19823202893 priority patent/DE3202893A1/de
Priority to NL8200343A priority patent/NL8200343A/nl
Publication of FR2498603A1 publication Critical patent/FR2498603A1/fr
Application granted granted Critical
Publication of FR2498603B1 publication Critical patent/FR2498603B1/fr
Granted legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
FR8101692A 1981-01-29 1981-01-29 Nouveaux derives spiro-1 isobenzofuranniques et spiro-1 isobenzothiopheniques, leur procede de preparation et leur application en therapeutique Granted FR2498603A1 (fr)

Priority Applications (15)

Application Number Priority Date Filing Date Title
FR8101692A FR2498603A1 (fr) 1981-01-29 1981-01-29 Nouveaux derives spiro-1 isobenzofuranniques et spiro-1 isobenzothiopheniques, leur procede de preparation et leur application en therapeutique
US06/341,415 US4395416A (en) 1981-01-29 1982-01-21 1-Spiro isobenzofuranic and 1-spiro isobenzothiophenic derivatives the process for preparing the same and their use in therapeutics
SE8200320A SE8200320L (sv) 1981-01-29 1982-01-21 Nya derivat av spiro-1 isobensofuraner och spiro-1 isobensotiofener, derasframstellningssett och terapeutiska anvendning
GR67080A GR75187B (enExample) 1981-01-29 1982-01-21
LU83893A LU83893A1 (fr) 1981-01-29 1982-01-25 Nouveaux derives spiro-1 isobenzofuranniques et spiro-1 isobenzothiopheniques,leur procede de preparation et leur application en therapeutique
IT19267/82A IT1190669B (it) 1981-01-29 1982-01-25 Derivati 1-spiro-isobenzofurnanici e 1-spiro-isobenzotiofenici,loro procedimento di preparazione e loro applicazione in terapia
ES509028A ES8304990A1 (es) 1981-01-29 1982-01-25 Procedimiento para la preparacion de derivados espiro-1 farmaceuticamente activos.
ZA82461A ZA82461B (en) 1981-01-29 1982-01-25 New 1-spiro isobenzofuranic and 1-spiro isobenzothiophenic derivatives,the process for preparing the same and their use in therapeutic
CA000394968A CA1169863A (en) 1981-01-29 1982-01-26 1-spiro isobenzofuranic and 1-spiro isobenzothiophenic derivatives, the process for preparing the same and their use in therapeutic
GB8202188A GB2092143B (en) 1981-01-29 1982-01-26 1-spiro isobenzofuranic and 1-spiro isobenzothiophenic derivatives the process for preparing the same and their use in therapeutics
BE0/207161A BE891928A (fr) 1981-01-29 1982-01-28 Nouveaux derives, spiro-1 isobenzofuranniques et spiro-1 isobenzothiopheniques, leur procede de preparation et leur application en therapeutique
AU79933/82A AU7993382A (en) 1981-01-29 1982-01-28 I-spiro isobenzofuranic and i-spiro isobenzothiophenic derivatives
JP57011906A JPS57181076A (en) 1981-01-29 1982-01-29 Spiro-1-isobenzofuranic and spiro-1- isobenzothiophenic derivatives, manufacture and drug containing them
DE19823202893 DE3202893A1 (de) 1981-01-29 1982-01-29 Neue 1-spiro-isobenzofuran- und 1-spiro-isobenzothiophen-derivate, verfahren zu ihrer herstellung und diese derivate enthaltende arzneimittel
NL8200343A NL8200343A (nl) 1981-01-29 1982-01-29 Nieuwe 1-spiroisobenzofuran- en 1-spiroisobenzothiofeenverbindingen alsmede werkwijze ter bereiding en de therapeutische toepassing van deze verbindingen.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8101692A FR2498603A1 (fr) 1981-01-29 1981-01-29 Nouveaux derives spiro-1 isobenzofuranniques et spiro-1 isobenzothiopheniques, leur procede de preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FR2498603A1 true FR2498603A1 (fr) 1982-07-30
FR2498603B1 FR2498603B1 (enExample) 1983-09-02

Family

ID=9254636

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8101692A Granted FR2498603A1 (fr) 1981-01-29 1981-01-29 Nouveaux derives spiro-1 isobenzofuranniques et spiro-1 isobenzothiopheniques, leur procede de preparation et leur application en therapeutique

Country Status (3)

Country Link
JP (1) JPS57181076A (enExample)
FR (1) FR2498603A1 (enExample)
ZA (1) ZA82461B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0071919A3 (en) * 1981-08-07 1983-08-24 Hoechst-Roussel Pharmaceuticals Incorporated Spiro(benzofuran-2(3h),4'(2'h)-isoquinoline)s, a process for their preparation and their use as medicaments

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL96507A0 (en) * 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2254332A1 (enExample) * 1973-12-12 1975-07-11 Hoechst Ag
EP0002283A1 (de) * 1977-12-02 1979-06-13 Hoechst Aktiengesellschaft Substituierte 1,3-Dihydrospiro (benzo(c)thiophene), Verfahren zu deren Herstellung und diese Verbindungen zur Verwendung als Arzneimittel

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2254332A1 (enExample) * 1973-12-12 1975-07-11 Hoechst Ag
EP0002283A1 (de) * 1977-12-02 1979-06-13 Hoechst Aktiengesellschaft Substituierte 1,3-Dihydrospiro (benzo(c)thiophene), Verfahren zu deren Herstellung und diese Verbindungen zur Verwendung als Arzneimittel

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CA1964 *
EXBK/77 *
EXBK/80 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0071919A3 (en) * 1981-08-07 1983-08-24 Hoechst-Roussel Pharmaceuticals Incorporated Spiro(benzofuran-2(3h),4'(2'h)-isoquinoline)s, a process for their preparation and their use as medicaments

Also Published As

Publication number Publication date
ZA82461B (en) 1982-12-29
FR2498603B1 (enExample) 1983-09-02
JPS57181076A (en) 1982-11-08

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