FR2463771A1 - Procede de preparation de derives d'acide quinoleinecarboxylique et nouveaux produits ainsi obtenus, a activite antibacterienne - Google Patents

Procede de preparation de derives d'acide quinoleinecarboxylique et nouveaux produits ainsi obtenus, a activite antibacterienne Download PDF

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Publication number
FR2463771A1
FR2463771A1 FR8018279A FR8018279A FR2463771A1 FR 2463771 A1 FR2463771 A1 FR 2463771A1 FR 8018279 A FR8018279 A FR 8018279A FR 8018279 A FR8018279 A FR 8018279A FR 2463771 A1 FR2463771 A1 FR 2463771A1
Authority
FR
France
Prior art keywords
piperazinyl
dihydro
acid
oxo
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8018279A
Other languages
English (en)
French (fr)
Other versions
FR2463771B1 (enrdf_load_stackoverflow
Inventor
Tsutomu Irikura
Hiroshi Koga
Satoshi Murayama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyorin Pharmaceutical Co Ltd
Original Assignee
Kyorin Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Pharmaceutical Co Ltd filed Critical Kyorin Pharmaceutical Co Ltd
Publication of FR2463771A1 publication Critical patent/FR2463771A1/fr
Application granted granted Critical
Publication of FR2463771B1 publication Critical patent/FR2463771B1/fr
Granted legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
FR8018279A 1979-08-22 1980-08-21 Procede de preparation de derives d'acide quinoleinecarboxylique et nouveaux produits ainsi obtenus, a activite antibacterienne Granted FR2463771A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP10677679A JPS5630964A (en) 1979-08-22 1979-08-22 Novel substituted quinolinecarboxylic acid and its preparation
BE2/58706A BE884824A (fr) 1979-08-22 1980-08-19 Derives de l'acide quinoleine-carboxylique et procede pour leur preparation
BE2059018 1981-02-19

Publications (2)

Publication Number Publication Date
FR2463771A1 true FR2463771A1 (fr) 1981-02-27
FR2463771B1 FR2463771B1 (enrdf_load_stackoverflow) 1983-04-22

Family

ID=27159608

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8018279A Granted FR2463771A1 (fr) 1979-08-22 1980-08-21 Procede de preparation de derives d'acide quinoleinecarboxylique et nouveaux produits ainsi obtenus, a activite antibacterienne

Country Status (16)

Country Link
JP (1) JPS5630964A (enrdf_load_stackoverflow)
AU (1) AU533141B2 (enrdf_load_stackoverflow)
BE (2) BE884824A (enrdf_load_stackoverflow)
CA (1) CA1159454A (enrdf_load_stackoverflow)
CH (1) CH645641A5 (enrdf_load_stackoverflow)
DE (1) DE3031767C3 (enrdf_load_stackoverflow)
ES (1) ES8104233A1 (enrdf_load_stackoverflow)
FR (1) FR2463771A1 (enrdf_load_stackoverflow)
GB (1) GB2057440B (enrdf_load_stackoverflow)
HK (1) HK98486A (enrdf_load_stackoverflow)
HU (1) HU184817B (enrdf_load_stackoverflow)
IT (1) IT1132392B (enrdf_load_stackoverflow)
MY (1) MY8700155A (enrdf_load_stackoverflow)
SE (1) SE440353B (enrdf_load_stackoverflow)
SG (1) SG71386G (enrdf_load_stackoverflow)
SU (2) SU978727A3 (enrdf_load_stackoverflow)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0140116A1 (en) * 1983-09-19 1985-05-08 Hokuriku Pharmaceutical Co.,Ltd A 6-fluoro-1,4-dihydro-4-oxo-7-substituted piperazinyl-quinoline-3-carboxylic acid derivative and the method for preparing the same
US4599418A (en) * 1983-02-22 1986-07-08 Kyorin Seiyaku Kabushiki Kaisha Benzoquinolizine carboxylic acid derivatives, and process for preparation thereof

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4416884A (en) * 1978-04-12 1983-11-22 Otsuka Pharmaceutical Co., Ltd. Piperazinylbenzoheterocyclic compounds
NO156828C (no) * 1980-11-10 1987-12-02 Otsuka Pharma Co Ltd Analogifremgangsm te for fremstilling av antibakterielt virksomme benzoheterocykliske forbindelser.
JPS57176987A (en) * 1981-04-24 1982-10-30 Otsuka Pharmaceut Co Ltd Pyrrolo(3,2,1-ij)quinoline-5-carboxylic acid derivative
SE440354B (sv) * 1981-02-19 1985-07-29 Kyorin Seiyaku Kk Kinolinkarboxylsyraderivat
JPS58105965A (ja) * 1981-12-15 1983-06-24 Nippon Shinyaku Co Ltd 置換キノリンカルボン酸誘導体
US4472405A (en) * 1982-11-12 1984-09-18 Riker Laboratories, Inc. Antimicrobial 6,7-dihydro-5,8-dimethyl-9 fluoro-1-oxo-1H, 5H-benzo (ij) quinolizine-2-carboxylic acid and derivatives
US4472406A (en) * 1982-11-12 1984-09-18 Riker Laboratories, Inc. Antimicrobial 6,7-dihydro-8-(imidazol-1-yl)-5-methyl-1-oxo-1H,5H-benzo [ij]quinolizine-2-carboxylic acids and derivatives
JPS59128383A (ja) * 1982-12-29 1984-07-24 Kanebo Ltd 新規キノリンカルボン酸誘導体および該化合物を有効成分とする抗菌剤
DE3308908A1 (de) * 1983-03-12 1984-09-13 Bayer Ag, 5090 Leverkusen Bakterizide mittel
DE3318145A1 (de) * 1983-05-18 1984-11-22 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
JPS59195842U (ja) * 1983-06-13 1984-12-26 クラリオン株式会社 ラジオ受信機
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
GB8412094D0 (en) * 1984-05-11 1984-06-20 Scras Quinoline derivatives
DE3420743A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US5468861A (en) * 1984-06-04 1995-11-21 Bayer Aktiengesellschaft 8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and alkyl esters thereof
US4550104A (en) * 1984-07-20 1985-10-29 Warner-Lambert Company Antibacterial thiazolo-quinolines and thiazolo-naphthyridines
US4550103A (en) * 1984-07-20 1985-10-29 Warner-Lambert Company Antibacterial 1-oxo-benzoquinolizine-2-carboxylic acids
JPS61118370A (ja) * 1985-10-30 1986-06-05 Kyorin Pharmaceut Co Ltd キノロンカルボン酸とその製造方法
ZA859283B (en) * 1984-12-06 1987-07-29 Pfizer Substituted dihydroquinolone carboxylic acids and anti-bacterial compositions containing them
JPS61143363A (ja) * 1984-12-17 1986-07-01 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体の製造方法
JPS61143364A (ja) * 1984-12-17 1986-07-01 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体の製造方法
JPS61205258A (ja) * 1985-03-08 1986-09-11 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体及びその製造方法
HUT40639A (en) * 1985-03-08 1987-01-28 Kyorin Seiyaku Kk Process for producing quinolon-carboxylic acid derivative and pharmaceutical composition containing them
ATE77373T1 (de) * 1985-03-21 1992-07-15 Kyorin Seiyaku Kk Verfahren zur herstellung von chinolinsaeurederivaten.
GB8512143D0 (en) * 1985-05-14 1985-06-19 Beecham Group Plc Method of treatment
US4686221A (en) * 1985-10-01 1987-08-11 Kanebo, Ltd. Quinolinecarboxylic acid compounds and antimicrobial agent containing the same
JPS62228063A (ja) * 1985-12-27 1987-10-06 Sankyo Co Ltd キノリンカルボン酸誘導体
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
JPH0753715B2 (ja) * 1986-02-25 1995-06-07 大塚製薬株式会社 ベンゾヘテロ環化合物
JPS62205060A (ja) * 1986-03-04 1987-09-09 Kyorin Pharmaceut Co Ltd ８位置換キノロンカルボン酸誘導体
JPS62215572A (ja) * 1986-03-17 1987-09-22 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
ZA874696B (en) * 1986-07-03 1988-01-04 F. Hoffmann-La Roche & Co. Aktiengesellschaft Acyl derivatives
US5563138A (en) * 1987-04-16 1996-10-08 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
US4851418A (en) * 1987-08-21 1989-07-25 Warner-Lambert Company Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent
JPS6483068A (en) * 1987-09-25 1989-03-28 Otsuka Pharma Co Ltd Production of benzo-heterocyclic compound
JPH01175936A (ja) * 1987-12-28 1989-07-12 Kyorin Pharmaceut Co Ltd ６．８−ジフルオロ−１−（２−フルオロエチル）−１，４−ジヒドロ−７−（４−メチル−１−ピペラジニル）−４−オキソ−３−キノリンカルボン酸を有効成分とする錠剤
WO1991001308A1 (fr) * 1989-07-21 1991-02-07 Ss Pharmaceutical Co., Ltd. Derives de l'acide quinolonecarboxylique
JP2526128B2 (ja) * 1988-08-08 1996-08-21 エスエス製薬株式会社 キノロンカルボン酸誘導体
US5185337A (en) * 1989-03-29 1993-02-09 Otsuka Pharmaceutical Co., Ltd. Pyrroloquinoline derivatives and pharmaceutical compositions for antimicrobial use
FR2655545B1 (fr) * 1989-12-11 1994-06-10 Rhone Poulenc Sante Nouvelle application therapeutique des derives des fluoroquinolones.
FR2656611B1 (fr) * 1990-01-04 1992-05-07 Hoechst France Nouvelles quinolones, leurs sels, utiles comme agents antimicrobiens, procede de preparation et leur application a titre de medicaments et compositions les renfermant.
FR2673426B1 (fr) * 1991-03-01 1993-07-16 Bouchara Sa Nouvelles quinolones, leur procede de preparation et les compositions en refermant.
FR2675144B1 (fr) * 1991-04-10 1995-06-16 Bouchara Sa Nouvelles quinolones difluorees - leur procede de preparation et les compositions pharmaceutiques en renfermant.
US5532239A (en) * 1993-08-02 1996-07-02 Assistance Publique - Hopitaux De Paris Therapeutic application of fluoroquinolone derivatives
ATE223901T1 (de) * 1994-03-01 2002-09-15 Ishihara Sangyo Kaisha Verfahren zur herstellung von 5,7 dichlor-4- hydroxychinolin
SE9904108D0 (sv) 1999-11-15 1999-11-15 New Pharma Research Ab Nya föreningar
US7973022B2 (en) 2006-02-17 2011-07-05 Idexx Laboratories, Inc. Fluoroquinolone carboxylic acid salt compositions
US20070197548A1 (en) 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone compositions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2391210A1 (fr) * 1977-05-16 1978-12-15 Kyorin Seiyaku Kk Derives d'acides quinoleinecarboxyliques et leur utilisation comme agents antibacteriens
FR2422658A1 (fr) * 1978-04-12 1979-11-09 Otsuka Pharma Co Ltd Composes piperazinyl-benzoheterocycliques, leur preparation et leurs utilisations therapeutiques

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NL7101049A (enrdf_load_stackoverflow) * 1970-01-28 1971-07-30
BE793524A (fr) * 1971-12-30 1973-06-29 Riker Laboratories Inc Acides benzoquinolizine-carboxyliques et leurs derives
US4156726A (en) * 1974-12-07 1979-05-29 Fisons Limited 4-Oxo-2-carboxyl quinoline derivatives used as antiallergic compounds
JPS54112877A (en) 1978-02-20 1979-09-04 Sumitomo Chem Co Ltd Preparation of 1-substituted-1,4-dihydro-4-oxo-3-pyridine carboxylic acid derivatives
AU553415B2 (en) * 1983-09-19 1986-07-17 Abbott Japan Co., Ltd. 6-fluoro-1-4-dihydro-4-oxo-7-substituted piperazinyl- quinoline-3-carboxylic acids

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2391210A1 (fr) * 1977-05-16 1978-12-15 Kyorin Seiyaku Kk Derives d'acides quinoleinecarboxyliques et leur utilisation comme agents antibacteriens
FR2422658A1 (fr) * 1978-04-12 1979-11-09 Otsuka Pharma Co Ltd Composes piperazinyl-benzoheterocycliques, leur preparation et leurs utilisations therapeutiques

Non-Patent Citations (1)

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Title
CA1980 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599418A (en) * 1983-02-22 1986-07-08 Kyorin Seiyaku Kabushiki Kaisha Benzoquinolizine carboxylic acid derivatives, and process for preparation thereof
EP0140116A1 (en) * 1983-09-19 1985-05-08 Hokuriku Pharmaceutical Co.,Ltd A 6-fluoro-1,4-dihydro-4-oxo-7-substituted piperazinyl-quinoline-3-carboxylic acid derivative and the method for preparing the same

Also Published As

Publication number Publication date
SU978727A3 (ru) 1982-11-30
GB2057440B (en) 1983-10-12
SU1015827A3 (ru) 1983-04-30
FR2463771B1 (enrdf_load_stackoverflow) 1983-04-22
ES494352A0 (es) 1981-04-16
BE887574R (fr) 1981-06-15
HK98486A (en) 1986-12-24
SE8005534L (sv) 1981-02-23
AU533141B2 (en) 1983-11-03
BE884824A (fr) 1980-12-16
JPS5630964A (en) 1981-03-28
GB2057440A (en) 1981-04-01
HU184817B (en) 1984-10-29
IT8024111A0 (it) 1980-08-11
CA1159454A (en) 1983-12-27
MY8700155A (en) 1987-12-31
IT1132392B (it) 1986-07-02
CH645641A5 (de) 1984-10-15
DE3031767C3 (de) 1994-04-14
SG71386G (en) 1987-03-27
ES8104233A1 (es) 1981-04-16
SE440353B (sv) 1985-07-29
AU6112280A (en) 1981-02-26
DE3031767A1 (de) 1981-03-26
DE3031767C2 (enrdf_load_stackoverflow) 1994-04-14

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