FR2460935A1 - Nouvelles phenoxyamines heterocycliques substituees, leur methode de preparation et leur application comme anesthetiques locaux - Google Patents

Nouvelles phenoxyamines heterocycliques substituees, leur methode de preparation et leur application comme anesthetiques locaux Download PDF

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Publication number
FR2460935A1
FR2460935A1 FR7917610A FR7917610A FR2460935A1 FR 2460935 A1 FR2460935 A1 FR 2460935A1 FR 7917610 A FR7917610 A FR 7917610A FR 7917610 A FR7917610 A FR 7917610A FR 2460935 A1 FR2460935 A1 FR 2460935A1
Authority
FR
France
Prior art keywords
sep
pyrrolidine
methoxy
dichlorophenoxyethyl
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7917610A
Other languages
English (en)
French (fr)
Other versions
FR2460935B1 (Direct
Inventor
Michel Thominet
Jacqueline Franceschini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ILE DE FRANCE ETUDES SCIENTIFIQU
Original Assignee
ILE DE FRANCE ETUDES SCIENTIFIQU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ILE DE FRANCE ETUDES SCIENTIFIQU filed Critical ILE DE FRANCE ETUDES SCIENTIFIQU
Priority to FR7917610A priority Critical patent/FR2460935A1/fr
Priority to US06/162,796 priority patent/US4379161A/en
Priority to BG062115A priority patent/BG35746A3/xx
Priority to DE8383105420T priority patent/DE3071314D1/de
Priority to EP83105420A priority patent/EP0094102B1/fr
Priority to DE8080400999T priority patent/DE3069789D1/de
Priority to AT83105420T priority patent/ATE17119T1/de
Priority to YU1710/80A priority patent/YU42344B/xx
Priority to OA57149A priority patent/OA06561A/xx
Priority to EP80400999A priority patent/EP0024960B1/fr
Priority to AT80400999T priority patent/ATE10739T1/de
Priority to BG048341A priority patent/BG35039A3/xx
Priority to CS804693A priority patent/CS216933B2/cs
Priority to SU802938255A priority patent/SU1085507A3/ru
Priority to AU60028/80A priority patent/AU536482B2/en
Priority to BE1/9873A priority patent/BE884124A/fr
Priority to PT71482A priority patent/PT71482A/pt
Priority to IL60472A priority patent/IL60472A/xx
Priority to NZ194230A priority patent/NZ194230A/xx
Priority to RO110029A priority patent/RO85323B/ro
Priority to RO101590A priority patent/RO81532B/ro
Priority to HU822217A priority patent/HU186539B/hu
Priority to AR281635A priority patent/AR224012A1/es
Priority to HU80801658A priority patent/HU181147B/hu
Priority to CH5684/84A priority patent/CH655100A5/fr
Priority to GR62381A priority patent/GR69638B/el
Priority to MX80100439U priority patent/MX6366E/es
Priority to MA19091A priority patent/MA18893A1/fr
Priority to IE1392/80A priority patent/IE50060B1/en
Priority to ZA00804035A priority patent/ZA804035B/xx
Priority to MX8011334U priority patent/MX7642E/es
Priority to IT49163/80A priority patent/IT1188985B/it
Priority to LU82584A priority patent/LU82584A1/fr
Priority to IE1653/85A priority patent/IE50061B1/en
Priority to NO802027A priority patent/NO156086C/no
Priority to ES493111A priority patent/ES8103049A1/es
Priority to ZW152/80A priority patent/ZW15280A1/xx
Priority to CH5169/80A priority patent/CH648827A5/fr
Priority to PL1980225473A priority patent/PL127393B1/pl
Priority to FI872955A priority patent/FI872955A0/fi
Priority to DK289580A priority patent/DK157538C/da
Priority to FI802156A priority patent/FI74274C/fi
Priority to IN779/CAL/80A priority patent/IN153037B/en
Priority to JO19801077A priority patent/JO1077B1/en
Priority to PH24248A priority patent/PH16449A/en
Priority to JP9321680A priority patent/JPS5639065A/ja
Priority to DD222455A priority patent/DD153206A5/de
Priority to DD80234984A priority patent/DD201141A5/de
Priority to JP13751280A priority patent/JPS5649351A/ja
Publication of FR2460935A1 publication Critical patent/FR2460935A1/fr
Application granted granted Critical
Publication of FR2460935B1 publication Critical patent/FR2460935B1/fr
Priority to CA000417963A priority patent/CA1163273A/fr
Priority to YU2801/82A priority patent/YU42824B/xx
Priority to US06/456,523 priority patent/US4594428A/en
Priority to IL68854A priority patent/IL68854A0/xx
Priority to IN1246/CAL/83A priority patent/IN158706B/en
Priority to AU25260/84A priority patent/AU563009B2/en
Priority to NO861988A priority patent/NO861988L/no
Priority to HK558/89A priority patent/HK55889A/xx
Priority to HK556/89A priority patent/HK55689A/xx
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR7917610A 1979-06-07 1979-07-06 Nouvelles phenoxyamines heterocycliques substituees, leur methode de preparation et leur application comme anesthetiques locaux Granted FR2460935A1 (fr)

Priority Applications (58)

Application Number Priority Date Filing Date Title
FR7917610A FR2460935A1 (fr) 1979-07-06 1979-07-06 Nouvelles phenoxyamines heterocycliques substituees, leur methode de preparation et leur application comme anesthetiques locaux
US06/162,796 US4379161A (en) 1979-06-07 1980-06-25 Novel substituted heterocyclic phenoxyamines, the method of preparation thereof and the use thereof as local anaesthetics
BG062115A BG35746A3 (bg) 1979-07-06 1980-07-01 Метод за получаване на 1-циклохексенилметил прдукти
DE8383105420T DE3071314D1 (en) 1979-07-06 1980-07-01 1-(1-cyclohexanyl-methyl) pyrrolidine derivatives, and process for their preparation
EP83105420A EP0094102B1 (fr) 1979-07-06 1980-07-01 Nouveaux dérivés de 1-(1-cyclohexénylméthyl) pyrrolidine et leur procédé de préparation
DE8080400999T DE3069789D1 (en) 1979-07-06 1980-07-01 Substituted heterocyclic phenoxy amines, their preparation method and their use as local anaesthetics
AT83105420T ATE17119T1 (de) 1979-07-06 1980-07-01 1-(1-cyclohexenylmethyl)pyrrolidin-derivate und verfahren zu deren herstellung.
YU1710/80A YU42344B (en) 1979-07-06 1980-07-01 Process for obtaining new substituted heterocyclic phenoxyamines
OA57149A OA06561A (fr) 1979-07-06 1980-07-01 Nouvelles phénoxyamines hétérocycliques substituées, leur méthode de préparation et leur application comme anesthésiques locaux.
EP80400999A EP0024960B1 (fr) 1979-07-06 1980-07-01 Nouvelles phénoxyamines hétérocycliques substituées, procédé pour leur préparation et leur application comme anesthésiques locaux
AT80400999T ATE10739T1 (de) 1979-07-06 1980-07-01 Substituierte heterocyclische phenoxyamine, verfahren zu ihrer herstellung und ihre verwendung als mittel fuer lokale anaesthesie.
BG048341A BG35039A3 (bg) 1979-07-06 1980-07-01 Метод за получаване на заместени хетероциклични феноксиамини
CS804693A CS216933B2 (en) 1979-07-06 1980-07-01 Method of making the heterocyclic phenoxyemines
SU802938255A SU1085507A3 (ru) 1979-07-06 1980-07-01 Способ получени производных гетероциклических феноксиаминов
AU60028/80A AU536482B2 (en) 1979-07-06 1980-07-02 Pyrrolidine and hexamethyleneimine derivatives
BE1/9873A BE884124A (fr) 1979-07-06 1980-07-02 Nouvelles phenoxyamines heterocycliques substituees, leur methode de preparation et leur application comme anesthesiques locaux
PT71482A PT71482A (fr) 1979-07-06 1980-07-02 Procede de preparation de nouvelles phenoxyamines heterocycliques substituees utilisees a titre de medicaments nouveaux a activite anesthesique locale des formes optiquement actives et ainsi comme des produits intermediaires pour les memes composes
IL60472A IL60472A (en) 1979-07-06 1980-07-02 Substituted heterocyclic phenoxyamines,their preparation and pharmaceutical compositions containing them
NZ194230A NZ194230A (en) 1979-07-06 1980-07-03 Phenoxy-(alkyl)-heterocyclic compounds intermediates pharmaceutical compositions
RO110029A RO85323B (ro) 1979-07-06 1980-07-03 Procedeu pentru prepararea unor fenoxiamine heterociclice
RO101590A RO81532B (ro) 1979-07-06 1980-07-03 Procedeu de preparare a unor fenoxiamine heterociclice
HU822217A HU186539B (en) 1979-07-06 1980-07-03 Process for producing 1-bracket-1-cyclohexenyl-methyl-bracket closed-2-bracket-2-chloroethyl-bracket closed-pyrrolidine
AR281635A AR224012A1 (es) 1979-07-06 1980-07-03 Un procedimiento para la preparacion de nuevas fenoxiaminas heterociclicas sustituidas
HU80801658A HU181147B (en) 1979-07-06 1980-07-03 Process for preparing substituted heterocyclin phenoxamines
CH5684/84A CH655100A5 (fr) 1979-07-06 1980-07-04 1-cyclohexenyl-2-(hydroxy- ou chloro-)ethyl-pyrrolidine et procede pour sa preparation.
GR62381A GR69638B (Direct) 1979-07-06 1980-07-04
MX80100439U MX6366E (es) 1979-07-06 1980-07-04 Procedimiento para la preparacion de fenoxiaminas heterociclicas substituidas
MA19091A MA18893A1 (fr) 1979-07-06 1980-07-04 Nouvelles phenoxyamines heterocycliques substituees,leur methode de preparation et leur application comme anesthesiques locaux
IE1392/80A IE50060B1 (en) 1979-07-06 1980-07-04 Substituted heterocyclic phenoxyamines,method of preparation thereof and the use thereof as local anaesthetics
ZA00804035A ZA804035B (en) 1979-07-06 1980-07-04 Novel substituted heterocyclic phenoxyamines, the method of preparation thereof and the use thereof as local anaesthetics
MX8011334U MX7642E (es) 1979-07-06 1980-07-04 Procedimiento para preparar la 1-ciclo-hexenilmentil-2-cloroetil pirrolidina
IT49163/80A IT1188985B (it) 1979-07-06 1980-07-04 Fenossiammine eterocicliche sostituite procedimento per prepararle e composizioni farmaceutiche che le contengono
LU82584A LU82584A1 (fr) 1979-07-06 1980-07-04 Nouvelles phenoxyamines heterocycliques substituees,leur methode de preparation et leur application comme anesthesiques locaux
IE1653/85A IE50061B1 (en) 1979-07-06 1980-07-04 1-(1-cyclohexenylmethyl)pyrrolidine derivatives and process for their preparation
NO802027A NO156086C (no) 1979-07-06 1980-07-04 Analogifremgangsmaate for fremstilling av substituerte heterocykliske fenoksyaminer.
ES493111A ES8103049A1 (es) 1979-07-06 1980-07-04 Un procedimiento de preparacion de nuevas fenoxiaminas hete-rociclicas
ZW152/80A ZW15280A1 (en) 1979-07-06 1980-07-04 Novel substituted heterocyclic phenoxyamines the method of preparation thereof and the use thereof as local anaestheetics
CH5169/80A CH648827A5 (fr) 1979-07-06 1980-07-04 Phenoxyamines heterocycliques substituees, leur preparation et medicaments consistant de ou comprenant ces composes.
PL1980225473A PL127393B1 (en) 1979-07-06 1980-07-04 Method of obtaining new substituted heterocyclic phenoxyamines
FI872955A FI872955A0 (fi) 1979-07-06 1980-07-04 1-cyklohexenylmetyletyl-pyrrolidinderivat.
DK289580A DK157538C (da) 1979-07-06 1980-07-04 Analogifremgangsmaade til fremstilling af heterocycliske phenoxyaminer samt 1-cyclohexenylmethyl-pyrrolidiner til anvendelse som mellemprodukt ved fremgangsmaaden
FI802156A FI74274C (fi) 1979-07-06 1980-07-04 Foerfarande foer framstaellning av nya, saosom lokalanestetika anvaendbara substituerade heterocykliska fenoxiaminer.
IN779/CAL/80A IN153037B (Direct) 1979-07-06 1980-07-05
JO19801077A JO1077B1 (en) 1979-07-06 1980-07-05 New heterocyclic derivatives of phenoxiamine, methods of preparation and use as a local anesthetic.
PH24248A PH16449A (en) 1979-07-06 1980-07-07 Novel substituted heterocyclic phenoxyamines and their use thereof as local anaesthetic
JP9321680A JPS5639065A (en) 1979-07-06 1980-07-07 Novel phenoxy heterocyclic amine* its manufacture and local narcotic as active component thereof
DD222455A DD153206A5 (de) 1979-07-06 1980-07-07 Verfahren zur herstellung neuer substituierter heterozyklischer phenoxyamine
DD80234984A DD201141A5 (de) 1979-07-06 1980-07-07 Verfahren zur herstellung neuer substituierten heterozyklischer phenoxyamine
JP13751280A JPS5649351A (en) 1979-07-06 1980-09-30 Heterocyclic amine and its manufacture
CA000417963A CA1163273A (fr) 1979-07-06 1982-12-16 Phenoxyamines heterocycliques substituees, leur methode de preparation et leur application comme anesthesiques locaux
YU2801/82A YU42824B (en) 1979-07-06 1982-12-17 Process for obtaining new substituted pyrolidines
US06/456,523 US4594428A (en) 1979-07-06 1983-01-07 Novel substituted heterocyclic amines and methods of preparation thereof
IL68854A IL68854A0 (en) 1979-07-06 1983-06-01 Substituted 1-cyclohexenylmethyl 2-ethyl pyrrolidines and their preparation
IN1246/CAL/83A IN158706B (Direct) 1979-07-06 1983-10-10
AU25260/84A AU563009B2 (en) 1979-07-06 1984-03-02 1-(cyclohexenylmethylene)-pyrrolidine derivatives
NO861988A NO861988L (no) 1979-07-06 1986-05-20 Mellomprodukter for fremstilling av nye substituerte heterocykliske fenoksyaminer og fremgangsmaate for fremstilling derav.
HK558/89A HK55889A (en) 1979-07-06 1989-07-13 1-(1-cyclohexanyl-methyl)pyrrolidine derivatives,and process for their preparation
HK556/89A HK55689A (en) 1979-07-06 1989-07-13 Substituted heterocyclic phenoxy amines,their preparation method and their use as local anaesthetics

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7917610A FR2460935A1 (fr) 1979-07-06 1979-07-06 Nouvelles phenoxyamines heterocycliques substituees, leur methode de preparation et leur application comme anesthetiques locaux

Publications (2)

Publication Number Publication Date
FR2460935A1 true FR2460935A1 (fr) 1981-01-30
FR2460935B1 FR2460935B1 (Direct) 1982-12-03

Family

ID=9227617

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7917610A Granted FR2460935A1 (fr) 1979-06-07 1979-07-06 Nouvelles phenoxyamines heterocycliques substituees, leur methode de preparation et leur application comme anesthetiques locaux

Country Status (2)

Country Link
FR (1) FR2460935A1 (Direct)
ZA (1) ZA804035B (Direct)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE543876C (de) * 1928-04-25 1932-02-11 C H Boehringer Sohn Akt Ges Verfahren zur Darstellung von Piperidinalkinen
GB1096441A (en) * 1964-01-15 1967-12-29 Bristol Myers Co Ethers of benzyl phenols and a process for the preparation thereof
DE2026688A1 (de) * 1969-06-12 1970-12-17 Pfizer Corp., Colon (Panama) Orthosubstituierte Phenoxyamine mit antihistaminischer Wirkung
EP0002672A2 (de) * 1977-12-02 1979-07-11 Byk Gulden Lomberg Chemische Fabrik GmbH Substituierte Pyrrolidine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
EP0004288A2 (de) * 1978-03-18 1979-10-03 MERCK PATENT GmbH Phenoxyalkylamine, diese enthaltende pharmazeutische Zubereitungen und Verfahren zu ihrer Herstellung

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE543876C (de) * 1928-04-25 1932-02-11 C H Boehringer Sohn Akt Ges Verfahren zur Darstellung von Piperidinalkinen
GB1096441A (en) * 1964-01-15 1967-12-29 Bristol Myers Co Ethers of benzyl phenols and a process for the preparation thereof
DE2026688A1 (de) * 1969-06-12 1970-12-17 Pfizer Corp., Colon (Panama) Orthosubstituierte Phenoxyamine mit antihistaminischer Wirkung
EP0002672A2 (de) * 1977-12-02 1979-07-11 Byk Gulden Lomberg Chemische Fabrik GmbH Substituierte Pyrrolidine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
EP0004288A2 (de) * 1978-03-18 1979-10-03 MERCK PATENT GmbH Phenoxyalkylamine, diese enthaltende pharmazeutische Zubereitungen und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
ZA804035B (en) 1981-06-24
FR2460935B1 (Direct) 1982-12-03

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