FR2459797A2 - Derives de phenyl-1 piperazine et leur application en therapeutique - Google Patents

Derives de phenyl-1 piperazine et leur application en therapeutique Download PDF

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Publication number
FR2459797A2
FR2459797A2 FR7916029A FR7916029A FR2459797A2 FR 2459797 A2 FR2459797 A2 FR 2459797A2 FR 7916029 A FR7916029 A FR 7916029A FR 7916029 A FR7916029 A FR 7916029A FR 2459797 A2 FR2459797 A2 FR 2459797A2
Authority
FR
France
Prior art keywords
phenyl
ethanol
therapeutic application
piperazine derivatives
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7916029A
Other languages
English (en)
French (fr)
Other versions
FR2459797B2 (da
Inventor
Henry Najer
Philippe Michel
Jacques Manoury
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7822672A external-priority patent/FR2432515A1/fr
Priority claimed from FR7833105A external-priority patent/FR2442234A2/fr
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to FR7916029A priority Critical patent/FR2459797A2/fr
Priority to DE19792930440 priority patent/DE2930440A1/de
Priority to NZ191140A priority patent/NZ191140A/xx
Priority to NL7905810A priority patent/NL7905810A/nl
Priority to AU49309/79A priority patent/AU4930979A/en
Priority to GB7926224A priority patent/GB2027703A/en
Priority to IT24749/79A priority patent/IT1123497B/it
Priority to NO792502A priority patent/NO792502L/no
Priority to LU81562A priority patent/LU81562A1/fr
Priority to DK321479A priority patent/DK321479A/da
Priority to IL57920A priority patent/IL57920A0/xx
Priority to BE0/196538A priority patent/BE877994A/fr
Priority to PT70007A priority patent/PT70007A/pt
Priority to SE7906507A priority patent/SE7906507L/xx
Priority to ES483003A priority patent/ES483003A1/es
Priority to JP9858679A priority patent/JPS5522690A/ja
Priority to FI792401A priority patent/FI792401A7/fi
Priority to GR59710A priority patent/GR69703B/el
Publication of FR2459797A2 publication Critical patent/FR2459797A2/fr
Publication of FR2459797B2 publication Critical patent/FR2459797B2/fr
Application granted granted Critical
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR7916029A 1978-08-01 1979-06-22 Derives de phenyl-1 piperazine et leur application en therapeutique Granted FR2459797A2 (fr)

Priority Applications (18)

Application Number Priority Date Filing Date Title
FR7916029A FR2459797A2 (fr) 1978-08-01 1979-06-22 Derives de phenyl-1 piperazine et leur application en therapeutique
DE19792930440 DE2930440A1 (de) 1978-08-01 1979-07-26 1-phenyl-piperazinderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
NZ191140A NZ191140A (en) 1978-08-01 1979-07-27 1-phenylpiperazine derivatives pharmaceutical compositions
NL7905810A NL7905810A (nl) 1978-08-01 1979-07-27 Werkwijze voor het bereiden van farmaceutisch preparaat op basis van een piperazinederivaat, dat actief is ten aanzien van het centrale zenuwstelsel en een pijnstil- lend middel is, werkwijze ter bereiding van het piperazinederivaat en het aldus bereide farmaceutische preparaat.
AU49309/79A AU4930979A (en) 1978-08-01 1979-07-27 1-phenylpiperazine derivatives
GB7926224A GB2027703A (en) 1978-08-01 1979-07-27 1-Phenylpiperazine derivatives
IT24749/79A IT1123497B (it) 1978-08-01 1979-07-27 Derivati di fenil-1 piperazina
IL57920A IL57920A0 (en) 1978-08-01 1979-07-30 1-phenylpiperazine derivatives,their preparation and pharmaceutical compositions containing them
DK321479A DK321479A (da) 1978-08-01 1979-07-30 Fremgangsmaade til fremstilling af 1-phenylpiperazinderivater
LU81562A LU81562A1 (fr) 1978-08-01 1979-07-30 Derives de phenyl-1 piperazine
NO792502A NO792502L (no) 1978-08-01 1979-07-30 Fremgangsmaate for fremstilling av fenylpiperazinderivater
JP9858679A JPS5522690A (en) 1978-08-01 1979-07-31 11phenylpiperazine derivative and its manufacture
ES483003A ES483003A1 (es) 1978-08-01 1979-07-31 Procedimiento de preparacion de derivados de fenil-1-pipera-zina
PT70007A PT70007A (fr) 1978-08-01 1979-07-31 Procede de preparation de derives de phenyl-1 piperazine
SE7906507A SE7906507L (sv) 1978-08-01 1979-07-31 Fenyl-1-piperazinderivat
BE0/196538A BE877994A (fr) 1978-08-01 1979-07-31 Derives de phenyl-1 piperazine
FI792401A FI792401A7 (fi) 1978-08-01 1979-08-01 1-fenyyli-piperatsiinijohdannaisia.
GR59710A GR69703B (da) 1978-08-01 1980-07-27

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR7822672A FR2432515A1 (fr) 1978-08-01 1978-08-01 Derives de phenyl-1 piperazine et leur application en therapeutique
FR7833105A FR2442234A2 (fr) 1978-08-01 1978-11-23 Derives de phenyl-1 piperazine et leur application en therapeutique
FR7916029A FR2459797A2 (fr) 1978-08-01 1979-06-22 Derives de phenyl-1 piperazine et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FR2459797A2 true FR2459797A2 (fr) 1981-01-16
FR2459797B2 FR2459797B2 (da) 1982-05-14

Family

ID=27250847

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7916029A Granted FR2459797A2 (fr) 1978-08-01 1979-06-22 Derives de phenyl-1 piperazine et leur application en therapeutique

Country Status (18)

Country Link
JP (1) JPS5522690A (da)
AU (1) AU4930979A (da)
BE (1) BE877994A (da)
DE (1) DE2930440A1 (da)
DK (1) DK321479A (da)
ES (1) ES483003A1 (da)
FI (1) FI792401A7 (da)
FR (1) FR2459797A2 (da)
GB (1) GB2027703A (da)
GR (1) GR69703B (da)
IL (1) IL57920A0 (da)
IT (1) IT1123497B (da)
LU (1) LU81562A1 (da)
NL (1) NL7905810A (da)
NO (1) NO792502L (da)
NZ (1) NZ191140A (da)
PT (1) PT70007A (da)
SE (1) SE7906507L (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2582288B1 (fr) * 1985-05-21 1987-08-07 Massonnet Henry Poubelle compacteuse perfectionnee
SE9904723D0 (sv) 1999-12-22 1999-12-22 Carlsson A Research Ab New modulators of dopamine neurotransmission II
USRE46117E1 (en) 1999-12-22 2016-08-23 Teva Pharmaceuticals International Gmbh Modulators of dopamine neurotransmission
SE9904724D0 (sv) * 1999-12-22 1999-12-22 Carlsson A Research Ab New modulators of dopamine neurotransmission I
DE602005021641D1 (de) 2004-06-08 2010-07-15 Nsab, Filial Af Neurosearch Sweden Ab Neue disubstituierte phenylpiperidine und piperazine als modulatoren der dopamin-neurotransmission
JP2008501749A (ja) 2004-06-08 2008-01-24 ニューロサーチ スウェーデン アクチボラゲット ドーパミン及びセロトニン神経伝達のモジュレーターとしての新規なジ置換フェニルピペリジン
US7851629B2 (en) 2004-06-08 2010-12-14 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Disubstituted phenylpiperidines as modulators of dopamine and serotonin neurotransmission
CA2584831C (en) 2004-10-13 2013-09-17 Neurosearch Sweden Ab Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-n-propyl-piperidine
SE529246C2 (sv) 2005-10-13 2007-06-12 Neurosearch Sweden Ab Nya disubstituerade fenyl-piperidiner som modulatorer för dopaminneurotransmission
MX347209B (es) 2011-12-08 2017-04-19 Teva Pharmaceuticals Int Gmbh La sal de bromhidrato de pridopidina.

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2976290A (en) * 1959-04-24 1961-03-21 Parke Davis & Co Piperazine derivatives and methods for their production
CH353743A (fr) * 1955-06-29 1961-04-30 Parke Davis & Co Procédé de préparation de pipérazines
FR2224464A1 (en) * 1973-04-05 1974-10-31 Synthelabo N-Phenyl-N'-beta-hydroxy-ethyl piperazines - as analgesic and anti-inflammatory agents

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH353743A (fr) * 1955-06-29 1961-04-30 Parke Davis & Co Procédé de préparation de pipérazines
US2976290A (en) * 1959-04-24 1961-03-21 Parke Davis & Co Piperazine derivatives and methods for their production
FR2224464A1 (en) * 1973-04-05 1974-10-31 Synthelabo N-Phenyl-N'-beta-hydroxy-ethyl piperazines - as analgesic and anti-inflammatory agents

Also Published As

Publication number Publication date
DE2930440A1 (de) 1980-02-28
PT70007A (fr) 1979-08-01
AU4930979A (en) 1980-02-07
FI792401A7 (fi) 1981-01-01
BE877994A (fr) 1980-01-31
NL7905810A (nl) 1980-02-05
DK321479A (da) 1980-02-02
FR2459797B2 (da) 1982-05-14
GR69703B (da) 1982-07-09
LU81562A1 (fr) 1981-03-24
NZ191140A (en) 1981-01-23
GB2027703A (en) 1980-02-27
JPS5522690A (en) 1980-02-18
NO792502L (no) 1980-02-04
IT1123497B (it) 1986-04-30
IL57920A0 (en) 1979-11-30
ES483003A1 (es) 1980-04-16
IT7924749A0 (it) 1979-07-27
SE7906507L (sv) 1980-02-02

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