FR2447928A1 - Reactifs d'halogenation phosphite de triaryle/halogene et leur procede de preparation - Google Patents
Reactifs d'halogenation phosphite de triaryle/halogene et leur procede de preparationInfo
- Publication number
- FR2447928A1 FR2447928A1 FR8001967A FR8001967A FR2447928A1 FR 2447928 A1 FR2447928 A1 FR 2447928A1 FR 8001967 A FR8001967 A FR 8001967A FR 8001967 A FR8001967 A FR 8001967A FR 2447928 A1 FR2447928 A1 FR 2447928A1
- Authority
- FR
- France
- Prior art keywords
- halogenation
- triaryl
- preparation process
- bromine
- designates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000026030 halogenation Effects 0.000 title abstract 4
- 238000005658 halogenation reaction Methods 0.000 title abstract 4
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 title abstract 3
- 239000003153 chemical reaction reagent Substances 0.000 title abstract 2
- 150000002367 halogens Chemical class 0.000 title abstract 2
- 229910052736 halogen Inorganic materials 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical compound BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 4
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229930186147 Cephalosporin Natural products 0.000 abstract 1
- -1 HYDROXY GROUP Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229940124587 cephalosporin Drugs 0.000 abstract 1
- HOKIDJSKDBPKTQ-GLXFQSAKSA-N cephalosporin C Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H](N)C(O)=O)[C@@H]12 HOKIDJSKDBPKTQ-GLXFQSAKSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/141—Esters of phosphorous acids
- C07F9/146—Esters of phosphorous acids containing P-halide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/141—Esters of phosphorous acids
- C07F9/145—Esters of phosphorous acids with hydroxyaryl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/062—Organo-phosphoranes without P-C bonds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Manufacture Of Macromolecular Shaped Articles (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
L'INVENTION CONCERNE DE NOUVEAUX AGENTS D'HALOGENATION DE FORMULE DEVELOPPEE: (CF DESSIN DANS BOPI) OU X DESIGNE LE CHLORE OU LE BROME ET Z DESIGNE UN ATOME D'HYDROGENE OU D'HALOGENE OU UN GROUPEMENT ALKYLE OU ALCOXY EN C-C, COMPOSE QUE L'ON OBTIENT PAR REGULATION CINETIQUE DE LA REACTION D'UN PHOSPHITE DE TRIARYLE AVEC LE CHLORE OU LE BROME DANS UN SOLVANT ORGANIQUE INERTE ESSENTIELLEMENT ANHYDRE. CES COMPOSES SONT DES INTERMEDIAIRES CINETIQUES DANS LA FORMATION DES DIHALOGENURES DE PHOSPHITE DE TRIARYLE STABLES AU POINT DE VUE THERMODYNAMIQUE ET, DANS CERTAINES CONDITIONS, ILS PEUVENT ETRE PREPARES ET ISOLES. CE SONT D'EXCELLENTS REACTIFS D'HALOGENATION, EN PARTICULIER POUR L'HALOGENATION DU GROUPEMENT HYDROXY EN POSITION C-3 DE CEPHALOSPORINES ANTIBIOTIQUES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/008,469 US4230644A (en) | 1979-02-01 | 1979-02-01 | Halogenating reagents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2447928A1 true FR2447928A1 (fr) | 1980-08-29 |
| FR2447928B1 FR2447928B1 (fr) | 1986-01-24 |
Family
ID=21731778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8001967A Expired FR2447928B1 (fr) | 1979-02-01 | 1980-01-30 | Reactifs d'halogenation phosphite de triaryle/halogene et leur procede de preparation |
Country Status (42)
| Country | Link |
|---|---|
| US (1) | US4230644A (fr) |
| EP (1) | EP0015079B1 (fr) |
| JP (1) | JPS55104291A (fr) |
| KR (1) | KR840000298B1 (fr) |
| AT (1) | AT386209B (fr) |
| AU (1) | AU532614B2 (fr) |
| BE (1) | BE881424A (fr) |
| BG (1) | BG34462A3 (fr) |
| CA (1) | CA1133007A (fr) |
| CH (1) | CH643855A5 (fr) |
| CS (1) | CS215128B2 (fr) |
| DD (1) | DD148954A1 (fr) |
| DE (1) | DE3072025D1 (fr) |
| DK (1) | DK147886C (fr) |
| ES (1) | ES8101614A1 (fr) |
| FI (1) | FI72728C (fr) |
| FR (1) | FR2447928B1 (fr) |
| GB (1) | GB2044266B (fr) |
| GR (1) | GR71613B (fr) |
| GT (1) | GT198061668A (fr) |
| HK (1) | HK42088A (fr) |
| HU (1) | HU182094B (fr) |
| IE (1) | IE49505B1 (fr) |
| IL (1) | IL59267A (fr) |
| IT (1) | IT1212406B (fr) |
| LU (1) | LU82119A1 (fr) |
| MA (1) | MA18714A1 (fr) |
| MW (1) | MW680A1 (fr) |
| MX (1) | MX6199E (fr) |
| MY (2) | MY8500571A (fr) |
| NL (1) | NL192107C (fr) |
| NO (1) | NO161260C (fr) |
| NZ (1) | NZ192747A (fr) |
| OA (1) | OA06450A (fr) |
| PL (1) | PL120667B1 (fr) |
| PT (1) | PT70743A (fr) |
| RO (1) | RO79358A (fr) |
| SG (1) | SG3688G (fr) |
| SU (1) | SU982545A3 (fr) |
| YU (1) | YU22680A (fr) |
| ZA (1) | ZA80520B (fr) |
| ZM (1) | ZM1180A1 (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2008079A1 (fr) * | 1989-01-23 | 1990-07-23 | Ian G. Wright | Procede d'halogenation |
| CN103588790A (zh) * | 2013-11-29 | 2014-02-19 | 中国科学院长春应用化学研究所 | 7-氨基-3-氯-3-头孢-4-羧酸-对硝基苄基酯的制备方法 |
| CN114591199B (zh) * | 2022-03-17 | 2024-03-12 | 诚弘制药(威海)有限责任公司 | 一种溴乙腈的制备方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3925372A (en) * | 1973-02-23 | 1975-12-09 | Lilly Co Eli | Alpha-aminoacyl-3-halo cephalosporins |
-
1979
- 1979-02-01 US US06/008,469 patent/US4230644A/en not_active Expired - Lifetime
-
1980
- 1980-01-29 IL IL59267A patent/IL59267A/xx unknown
- 1980-01-29 NL NL8000544A patent/NL192107C/nl not_active IP Right Cessation
- 1980-01-29 HU HU80191A patent/HU182094B/hu unknown
- 1980-01-29 ZA ZA00800520A patent/ZA80520B/xx unknown
- 1980-01-29 GR GR61066A patent/GR71613B/el unknown
- 1980-01-29 AU AU55027/80A patent/AU532614B2/en not_active Expired
- 1980-01-29 YU YU00226/80A patent/YU22680A/xx unknown
- 1980-01-29 PT PT70743A patent/PT70743A/pt active IP Right Revival
- 1980-01-29 MA MA18911A patent/MA18714A1/fr unknown
- 1980-01-29 NZ NZ192747A patent/NZ192747A/xx unknown
- 1980-01-30 GT GT198061668A patent/GT198061668A/es unknown
- 1980-01-30 CA CA344,681A patent/CA1133007A/fr not_active Expired
- 1980-01-30 BE BE1/9700A patent/BE881424A/fr not_active IP Right Cessation
- 1980-01-30 FR FR8001967A patent/FR2447928B1/fr not_active Expired
- 1980-01-30 BG BG8046410A patent/BG34462A3/xx unknown
- 1980-01-31 DK DK41280A patent/DK147886C/da active
- 1980-01-31 NO NO800250A patent/NO161260C/no unknown
- 1980-01-31 AT AT0050080A patent/AT386209B/de not_active IP Right Cessation
- 1980-01-31 LU LU82119A patent/LU82119A1/fr unknown
- 1980-01-31 GB GB8003292A patent/GB2044266B/en not_active Expired
- 1980-01-31 IE IE189/80A patent/IE49505B1/en not_active IP Right Cessation
- 1980-01-31 JP JP1196580A patent/JPS55104291A/ja active Granted
- 1980-01-31 EP EP80300282A patent/EP0015079B1/fr not_active Expired
- 1980-01-31 IT IT8019608A patent/IT1212406B/it active
- 1980-01-31 CS CS80659A patent/CS215128B2/cs unknown
- 1980-01-31 CH CH79680A patent/CH643855A5/fr not_active IP Right Cessation
- 1980-01-31 DE DE8080300282T patent/DE3072025D1/de not_active Expired
- 1980-02-01 ZM ZM11/80A patent/ZM1180A1/xx unknown
- 1980-02-01 FI FI800302A patent/FI72728C/fi not_active IP Right Cessation
- 1980-02-01 SU SU802877706A patent/SU982545A3/ru active
- 1980-02-01 ES ES488230A patent/ES8101614A1/es not_active Expired
- 1980-02-01 DD DD80218817A patent/DD148954A1/xx unknown
- 1980-02-01 KR KR1019800000399A patent/KR840000298B1/ko not_active IP Right Cessation
- 1980-02-01 OA OA57010A patent/OA06450A/fr unknown
- 1980-02-01 MX MX808626U patent/MX6199E/es unknown
- 1980-02-01 PL PL1980221746A patent/PL120667B1/pl unknown
- 1980-02-01 MW MW6/80A patent/MW680A1/xx unknown
- 1980-02-01 RO RO80100057A patent/RO79358A/fr unknown
-
1985
- 1985-12-30 MY MY571/85A patent/MY8500571A/xx unknown
-
1987
- 1987-09-22 MY MYPI87001867A patent/MY102552A/en unknown
-
1988
- 1988-01-08 SG SG36/88A patent/SG3688G/en unknown
- 1988-06-02 HK HK420/88A patent/HK42088A/xx not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3925372A (en) * | 1973-02-23 | 1975-12-09 | Lilly Co Eli | Alpha-aminoacyl-3-halo cephalosporins |
Non-Patent Citations (1)
| Title |
|---|
| EXBK/56 * |
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