FR2440376A1 - Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir - Google Patents

Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir

Info

Publication number
FR2440376A1
FR2440376A1 FR7831357A FR7831357A FR2440376A1 FR 2440376 A1 FR2440376 A1 FR 2440376A1 FR 7831357 A FR7831357 A FR 7831357A FR 7831357 A FR7831357 A FR 7831357A FR 2440376 A1 FR2440376 A1 FR 2440376A1
Authority
FR
France
Prior art keywords
same
mucopolysaccharidic
regulatory
composition
medicament containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7831357A
Other languages
English (en)
French (fr)
Other versions
FR2440376B1 (enExample
Inventor
Jean-Claude Lormeau
Jean Goulay
Jean Choay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Choay SA
Original Assignee
Choay SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9214520&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2440376(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to FR7831357A priority Critical patent/FR2440376A1/fr
Application filed by Choay SA filed Critical Choay SA
Priority to SE7909087A priority patent/SE449753B/sv
Priority to JP14314579A priority patent/JPS5569601A/ja
Priority to GB7938474A priority patent/GB2035349B/en
Priority to IT27064/79A priority patent/IT1126319B/it
Priority to DE2944792A priority patent/DE2944792C3/de
Publication of FR2440376A1 publication Critical patent/FR2440376A1/fr
Application granted granted Critical
Publication of FR2440376B1 publication Critical patent/FR2440376B1/fr
Priority to US06/301,611 priority patent/US4486420A/en
Priority to US06/323,567 priority patent/US4500519A/en
Priority to US06/702,509 priority patent/US4804652A/en
Priority to US06/726,178 priority patent/US4692435A/en
Priority to JP2321340A priority patent/JPH03243601A/ja
Priority to US08/574,761 priority patent/USRE35770E/en
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
    • G01N2333/8121—Serpins
    • G01N2333/8128—Antithrombin III
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/38—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, Konjac gum, Locust bean gum or Guar gum
    • G01N2400/40—Glycosaminoglycans, i.e. GAG or mucopolysaccharides, e.g. chondroitin sulfate, dermatan sulfate, hyaluronic acid, heparin, heparan sulfate, and related sulfated polysaccharides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Epidemiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
FR7831357A 1978-11-06 1978-11-06 Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir Granted FR2440376A1 (fr)

Priority Applications (12)

Application Number Priority Date Filing Date Title
FR7831357A FR2440376A1 (fr) 1978-11-06 1978-11-06 Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
SE7909087A SE449753B (sv) 1978-11-06 1979-11-01 Mukopolysackaridkomposition med reglerande verkan pa koagulation, lekemedel innehallande densamma samt forfarande for framstellning derav
JP14314579A JPS5569601A (en) 1978-11-06 1979-11-05 Mucopolysaccharide composition having controllability of blood coagulation*vedicine containing it and its manufacture
GB7938474A GB2035349B (en) 1978-11-06 1979-11-06 Mucopolysaccharide composition having a regulatory action on coagulation medicament containtaining it and process for preparing it
IT27064/79A IT1126319B (it) 1978-11-06 1979-11-06 Composizione di mucopolisaccaride avente un'azione regolatrice della coagulazione,medicamento contenente tale composizione e procedimento per prepararla
DE2944792A DE2944792C3 (de) 1978-11-06 1979-11-06 Mucopolysaccharidfraktion, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
US06/301,611 US4486420A (en) 1978-11-06 1981-09-14 Mucopolysaccharide composition having a regulatory action on coagulation, medicament process for preparation and method of use
US06/323,567 US4500519A (en) 1978-11-06 1981-11-20 Mucopolysaccharides having biological properties, preparation and method of use
US06/702,509 US4804652A (en) 1978-11-06 1985-02-19 Mucopolysaccharides having biological properties, preparation and application thereof as drugs
US06/726,178 US4692435A (en) 1978-11-06 1985-04-23 Mucopolysaccharide composition having a regulatory action on coagulation, medicament containing same and process of preparation
JP2321340A JPH03243601A (ja) 1978-11-06 1990-11-27 血液凝固の制御能をもつムコ多糖組成物およびその製造方法
US08/574,761 USRE35770E (en) 1978-11-06 1995-12-19 Oligosaccharides having anti-Xa activity and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7831357A FR2440376A1 (fr) 1978-11-06 1978-11-06 Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir

Publications (2)

Publication Number Publication Date
FR2440376A1 true FR2440376A1 (fr) 1980-05-30
FR2440376B1 FR2440376B1 (enExample) 1981-06-12

Family

ID=9214520

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7831357A Granted FR2440376A1 (fr) 1978-11-06 1978-11-06 Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir

Country Status (3)

Country Link
US (1) US4804652A (enExample)
JP (1) JPS5569601A (enExample)
FR (1) FR2440376A1 (enExample)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1981002737A1 (fr) * 1980-03-20 1981-10-01 Choay Sa Mucopolysaccharides possedant des proprietes biologiques, leur preparation et leur application en tant que medicaments
FR2495935A1 (fr) * 1980-12-15 1982-06-18 Choay Sa Fractions mucopolysaccharidiques possedant des proprietes biologiques, leur procede de preparation et leur application en tant que medicaments
FR2553287A1 (fr) * 1983-10-18 1985-04-19 Choay Sa Compositions a base de mucopolysaccharides ou d'oligosaccharides, notamment a base de fractions ou fragments d'heparine, appropriees au traitement de desordres de la proliferation cellulaire
EP0027089B1 (fr) * 1979-10-05 1986-01-22 Choay S.A. Fractions oligosaccharidiques et oligosaccharides possédant des propriétés biologiques, leurs procédés de préparation et leurs applications en tant que médicaments
FR2568774A2 (fr) * 1984-05-30 1986-02-14 Choay Sa Medicaments favorisant les proprietes d'ecoulement du sang et leur utilisation en therapeutique
FR2572080A1 (fr) * 1984-10-18 1986-04-25 Dropic Procede de preparation de compositions de mucopolysaccharides dotees d'une activite antithrombotique elevee, les compositions obtenues et leur application en tant que medicaments
EP0181252A1 (fr) * 1984-10-18 1986-05-14 Choay S.A. Procédé de préparation de compositions de mucopolysaccharides dotées d'une activité antithrombotique élevée
FR2584606A1 (fr) * 1985-07-12 1987-01-16 Dropic Utilisation de poly- et oligosaccharides pour l'obtention de medicaments actifs dans les pathologies du tissu conjonctif
EP2314632A2 (en) 2004-03-24 2011-04-27 Aventis Pharma S.A. Oligosaccharidic compounds derived from heparin
US8614314B2 (en) 2008-05-30 2013-12-24 Momenta Pharmaceuticals, Inc. Saccharide structures and methods of making and using such structures
WO2021007429A1 (en) 2019-07-09 2021-01-14 Optimvia Llc Methods for synthesizing anticoagulant polysaccharides
WO2022015794A1 (en) 2020-07-14 2022-01-20 Optimvia, Llc Methods for synthesizing non-anticoagulant heparan sulfate

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1195497B (it) * 1983-03-08 1988-10-19 Opocrin Spa Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina
IT1214609B (it) * 1985-05-17 1990-01-18 Opocrin Spa Esosaminoglicani solfati depolimerizzati ad attivita'antitrombotica, fibrinolitica, antinfiammatoria, loro procedimento di preparazione e composizioni farmaceutiche che li contengono.
IT1213384B (it) * 1986-11-24 1989-12-20 Lab Derivati Organici Mediolan Processo per la preparazione controllata di gilcosaminoglicani a basso peso molecolare.
FR2614026B1 (fr) * 1987-04-16 1992-04-17 Sanofi Sa Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
GB8826448D0 (en) * 1988-11-11 1988-12-14 Thrombosis Res Inst Improvements in/relating to organic compounds
US5705178A (en) * 1991-05-31 1998-01-06 Gliatech, Inc. Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers
US5605938A (en) * 1991-05-31 1997-02-25 Gliatech, Inc. Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
FR2704226B1 (fr) * 1993-04-22 1995-07-21 Sanofi Elf 3-desoxy oligosaccharides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
EA002475B1 (ru) * 1996-11-27 2002-06-27 Авентис Фармасьютикалз Продактс Инк. Фармкомпозиция, содержащая соединения с анти-ха активностью и соединения антагониста агрегации тромбоцитов, их применение, набор, содержащий эти соединения, способ лечения или профилактики заболеваний, сопутствующих тромбообразованию
WO2005018564A2 (en) * 2003-08-22 2005-03-03 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and a low-molecular-weight heparin for the treatment of central nervous system damage
ITMO20040199A1 (it) * 2004-07-29 2004-10-29 Biofer Spa Procedimento per la purificazione da gruppi e n no rsidui di eparine a basso peso molecolare ottentite tramite nitrosazione.
JP4946139B2 (ja) * 2006-04-03 2012-06-06 パナソニック株式会社 高周波加熱装置
JP4516947B2 (ja) * 2006-10-03 2010-08-04 有機合成薬品工業株式会社 微細に分割された酸性ムコ多糖類塩粒子の製造方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2552507A (en) * 1949-05-24 1951-05-15 Squibb & Sons Inc Purification and fractionation of heparin preparations
DE1129148B (de) * 1960-10-19 1962-05-10 Egyt Gyogyszervegyeszeti Gyar Verfahren zur Herstellung von Heparin-Derivaten zytostatisch wirkender Stoffe
US3985618A (en) * 1975-05-02 1976-10-12 Irving Innerfield Method for detection of thrombosis and prethrombosis
US4122250A (en) * 1977-08-22 1978-10-24 Gottfried Schmer Separation of high-activity heparin by affinity chromatography

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3766167A (en) * 1971-03-26 1973-10-16 Research Corp Orally active anticoagulant
JPS5318520B2 (enExample) * 1972-07-05 1978-06-15
CA1042001A (en) * 1973-04-13 1978-11-07 Choay S.A. Mixed heparin salts
US4175182A (en) * 1978-07-03 1979-11-20 Research Corporation Separation of high-activity heparin by affinity chromatography on supported protamine
CA1136620A (en) * 1979-01-08 1982-11-30 Ulf P.F. Lindahl Heparin fragments having selective anticoagulation activity
US4281108A (en) * 1980-01-28 1981-07-28 Hepar Industries, Inc. Process for obtaining low molecular weight heparins endowed with elevated pharmacological properties, and product so obtained
US4351938A (en) * 1980-05-19 1982-09-28 Riker Laboratories, Inc. Anticoagulant substance
US4550519A (en) * 1984-04-05 1985-11-05 Simmons Harold J Fishing rod holder with automatic hook setter

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2552507A (en) * 1949-05-24 1951-05-15 Squibb & Sons Inc Purification and fractionation of heparin preparations
DE1129148B (de) * 1960-10-19 1962-05-10 Egyt Gyogyszervegyeszeti Gyar Verfahren zur Herstellung von Heparin-Derivaten zytostatisch wirkender Stoffe
US3985618A (en) * 1975-05-02 1976-10-12 Irving Innerfield Method for detection of thrombosis and prethrombosis
US4122250A (en) * 1977-08-22 1978-10-24 Gottfried Schmer Separation of high-activity heparin by affinity chromatography

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CA1978 *
EXRV/55 *

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0027089B1 (fr) * 1979-10-05 1986-01-22 Choay S.A. Fractions oligosaccharidiques et oligosaccharides possédant des propriétés biologiques, leurs procédés de préparation et leurs applications en tant que médicaments
WO1981002737A1 (fr) * 1980-03-20 1981-10-01 Choay Sa Mucopolysaccharides possedant des proprietes biologiques, leur preparation et leur application en tant que medicaments
EP0037319A1 (fr) * 1980-03-20 1981-10-07 D.R.O.P.I.C. (Société Civile) Mucopolysaccharides possédant des propriétés biologiques, leur préparation et leur application en tant que médicaments
FR2495935A1 (fr) * 1980-12-15 1982-06-18 Choay Sa Fractions mucopolysaccharidiques possedant des proprietes biologiques, leur procede de preparation et leur application en tant que medicaments
FR2553287A1 (fr) * 1983-10-18 1985-04-19 Choay Sa Compositions a base de mucopolysaccharides ou d'oligosaccharides, notamment a base de fractions ou fragments d'heparine, appropriees au traitement de desordres de la proliferation cellulaire
EP0140781A3 (en) * 1983-10-18 1985-06-19 Dropic Societe Civile De Gestion De Droit De Propriete Industrielle Choay Compositions containing heparin derivatives, especially useful in the treatment of disturbances by cell proliferation
FR2568774A2 (fr) * 1984-05-30 1986-02-14 Choay Sa Medicaments favorisant les proprietes d'ecoulement du sang et leur utilisation en therapeutique
EP0181252A1 (fr) * 1984-10-18 1986-05-14 Choay S.A. Procédé de préparation de compositions de mucopolysaccharides dotées d'une activité antithrombotique élevée
FR2572080A1 (fr) * 1984-10-18 1986-04-25 Dropic Procede de preparation de compositions de mucopolysaccharides dotees d'une activite antithrombotique elevee, les compositions obtenues et leur application en tant que medicaments
FR2584606A1 (fr) * 1985-07-12 1987-01-16 Dropic Utilisation de poly- et oligosaccharides pour l'obtention de medicaments actifs dans les pathologies du tissu conjonctif
EP0208623A3 (fr) * 1985-07-12 1989-12-27 Sanofi Utilisation de poly- et oligosaccharides pour l'obtention de médicaments actifs dans les pathologies du tissu conjonctif
EP2314632A2 (en) 2004-03-24 2011-04-27 Aventis Pharma S.A. Oligosaccharidic compounds derived from heparin
US8614314B2 (en) 2008-05-30 2013-12-24 Momenta Pharmaceuticals, Inc. Saccharide structures and methods of making and using such structures
US9163047B2 (en) 2008-05-30 2015-10-20 Momenta Pharmaceuticals, Inc. Saccharide structures and methods of making and using such structures
WO2021007429A1 (en) 2019-07-09 2021-01-14 Optimvia Llc Methods for synthesizing anticoagulant polysaccharides
US11542534B2 (en) 2019-07-09 2023-01-03 Optimvia, Llc Methods for synthesizing anticoagulant polysaccharides
WO2022015794A1 (en) 2020-07-14 2022-01-20 Optimvia, Llc Methods for synthesizing non-anticoagulant heparan sulfate

Also Published As

Publication number Publication date
US4804652A (en) 1989-02-14
JPS5569601A (en) 1980-05-26
FR2440376B1 (enExample) 1981-06-12
JPH0323528B2 (enExample) 1991-03-29

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