FR2430930A1 - Procede de preparation du d-camphorate de l-carnitinamide et du d-camphorate de d-carnitinamide - Google Patents

Procede de preparation du d-camphorate de l-carnitinamide et du d-camphorate de d-carnitinamide

Info

Publication number
FR2430930A1
FR2430930A1 FR7917828A FR7917828A FR2430930A1 FR 2430930 A1 FR2430930 A1 FR 2430930A1 FR 7917828 A FR7917828 A FR 7917828A FR 7917828 A FR7917828 A FR 7917828A FR 2430930 A1 FR2430930 A1 FR 2430930A1
Authority
FR
France
Prior art keywords
carnitinamide
camphorate
solution
preparation
solid phase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7917828A
Other languages
English (en)
Other versions
FR2430930B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of FR2430930A1 publication Critical patent/FR2430930A1/fr
Application granted granted Critical
Publication of FR2430930B1 publication Critical patent/FR2430930B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/06—Saturated compounds having a carboxyl group bound to a five-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention est relative à un procédé de préparation de D-camphorate de L-carnitinamide et de D-camphorate de D-carnitinamide, caractérisé en ce qu'il consiste : a. à convertir une solution du chlorhydrate de D, L carnitinamide en une solution de base libre de D, L carnitinamide ; b. à faire réagir la solution de la base libre de D, L carnitinamide directement avec l'acide D-camphorique, pour obtenir ainsi une solution de D-camphorate de D, L-carnitinamide ; c. à sécher la solution du stade b et à reprendre le résidu dans un alcanol inférieur contenant de 1 à 5 atomes de carbone pour former une solution alcoolique, de sorte qu'une phase solide, comprenant le D-camphorate de L-carnitinamide cristallise dans la solution alcoolique ; et d. à séparer cette phase solide de la solution alcoolique comprenant le D-camphorate de D-carnitinamide.
FR7917828A 1978-07-10 1979-07-10 Procede de preparation du d-camphorate de l-carnitinamide et du d-camphorate de d-carnitinamide Granted FR2430930A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT50222/78A IT1156852B (it) 1978-07-10 1978-07-10 Procedimento industriale per la preparazione del d'canforato della l carnitinammide e del d canforato della d carnitinammide e sue applicazioni

Publications (2)

Publication Number Publication Date
FR2430930A1 true FR2430930A1 (fr) 1980-02-08
FR2430930B1 FR2430930B1 (fr) 1983-12-23

Family

ID=11272520

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7917828A Granted FR2430930A1 (fr) 1978-07-10 1979-07-10 Procede de preparation du d-camphorate de l-carnitinamide et du d-camphorate de d-carnitinamide

Country Status (20)

Country Link
US (1) US4254053A (fr)
JP (1) JPS5513299A (fr)
AT (1) AT370086B (fr)
AU (1) AU526044B2 (fr)
BE (1) BE877609A (fr)
CA (1) CA1117977A (fr)
CH (1) CH643236A5 (fr)
DE (1) DE2927672A1 (fr)
DK (1) DK149842C (fr)
ES (1) ES482327A1 (fr)
FR (1) FR2430930A1 (fr)
GB (1) GB2025412B (fr)
GR (1) GR69678B (fr)
IE (1) IE48908B1 (fr)
IL (1) IL57745A (fr)
IT (1) IT1156852B (fr)
LU (1) LU81482A1 (fr)
NL (1) NL190755C (fr)
NO (1) NO150879C (fr)
SE (1) SE446264B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH648287A5 (de) * 1981-01-21 1985-03-15 Lonza Ag Verfahren zur herstellung von carnitinamid.
CH658857A5 (de) * 1984-04-04 1986-12-15 Lonza Ag Optisch aktives di-(3-chlor-2-oxy-propyltrimethylammonium)-tartrat.
GB2195630B (en) * 1986-08-26 1990-07-18 Chuo Kaseihin Co Inc Method for producing carnitine, l-carnitineamide hydrolase and method for producing same
JP2588930B2 (ja) * 1988-05-13 1997-03-12 鐘淵化学工業株式会社 カルニチンの製造方法
JP2581156B2 (ja) * 1988-05-26 1997-02-12 日立電子エンジニアリング株式会社 レーザ共振器のレーザパワー密度測定方式
IT1256705B (it) * 1992-12-21 1995-12-12 Sigma Tau Ind Farmaceuti Procedimento per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.
IT1261230B (it) * 1993-04-08 1996-05-09 Sigma Tau Ind Farmaceuti Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da suoi precursori aventi opposta configurazione.
KR100255039B1 (ko) 1997-07-28 2000-05-01 박영구 L-카르니틴의제조방법
NZ517597A (en) * 1999-09-03 2003-11-28 Sigma Tau Healthscience S L-carnitine with a particle size that can pass through a 100 USBS mesh sieve, methods of preparing the same, compositions containing the same, and methods of using the same
US20070087975A1 (en) * 2005-10-17 2007-04-19 Sigma-Tau Industrie Farmaceutiche Riunite Spa Compound useful for the prevention and treatment of left ventricular hypertrophy in dialysed patients
EP1852416A1 (fr) * 2006-05-04 2007-11-07 Universita'degli Studi Di Milano Resolution enantiomère d'une salt de Carnitinamide par cristallisation préférentielle
CN101573326B (zh) 2006-11-09 2013-05-01 三菱丽阳株式会社 甜菜碱的制造方法
JP2008231046A (ja) * 2007-03-22 2008-10-02 Mitsubishi Rayon Co Ltd 光学活性カルニチンアミドハロゲン化物の精製方法
EP2353596A1 (fr) 2010-02-02 2011-08-10 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. Composition combinée comprenant en tant que principes actifs de la L-carnitine ou de la propionyl L-carnitine pour la prévention d'une insuffisance veineuse chronique
EP2363126A1 (fr) 2010-03-04 2011-09-07 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. Composition comprenant une L-carnitine en tant que principe actif en combinaison avec le glucoside de l'hydroxykynurénine, pour la prévention et/ou le traitement de pathologies de l'oeil dues au rayonnement ultraviolet
PL2582368T3 (pl) 2010-06-16 2018-08-31 Alfasigma S.P.A. Acetylo-karnityna do zastosowania w sposobie zwiększania neurogenezy w tkance nerwowej
US9114120B2 (en) 2010-11-22 2015-08-25 Sigma-Tau Industrie Farmaceutiche Riunite, S.P.A. Therapeutical method for the treatment of the Leber optic neuropathy
US20140294921A1 (en) 2010-12-09 2014-10-02 Sigma-Tau Industrie Famaceutiche Riunite S.P.A. Composition for tipical use for treating skin disorders
EP2586438A1 (fr) 2011-10-28 2013-05-01 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. Composé utile pour la prévention des troubles de déficit cognitif chez un nouveau-né d'une femme séropositive pour le VIH traitée par azidothymidine
EP2783695A1 (fr) 2013-03-28 2014-10-01 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. Supplément physioloqiue ou médicament à usage ophtalmique contenant de la L-carnitine ou des L-carnitines alcanoyles en combinaison avec eledoisin
KR102376425B1 (ko) 2013-12-05 2022-03-18 알파시그마 에스.피.에이. 여성 가임능 촉진용 조성물
HRP20231572T1 (hr) 2014-07-03 2024-03-15 Silti Ag Postupci i pripravci za liječenje pretilosti, sprečavanje dobivanja na težini, promicanje gubitka težine, promicanje mršavljenja, ili liječenje ili prevenciju razvoja dijabetesa

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE660039A (fr) * 1965-02-22 1965-08-23
FR1464344A (fr) * 1965-02-03 1966-12-30 Belge Produits Chimiques Sa Procédé de préparation du chlorure de d, 1-, de 1- et de d-carnitinamide et chlorures des carnitinamides optiquement actives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3632623A (en) * 1967-11-21 1972-01-04 Basf Ag Beta-carbamyl-beta-hydroxyethyl)-alkylammonium salts

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1464344A (fr) * 1965-02-03 1966-12-30 Belge Produits Chimiques Sa Procédé de préparation du chlorure de d, 1-, de 1- et de d-carnitinamide et chlorures des carnitinamides optiquement actives
BE660039A (fr) * 1965-02-22 1965-08-23
FR1466696A (fr) * 1965-02-22 1967-01-20 Belge Produits Chimiques Sa d-camphorate de 1-carnitinamide et son procédé de préparation

Also Published As

Publication number Publication date
GB2025412B (en) 1983-03-02
NO792281L (no) 1980-01-11
IE48908B1 (en) 1985-06-12
LU81482A1 (fr) 1979-10-31
GB2025412A (en) 1980-01-23
NO150879C (no) 1985-01-09
IL57745A0 (en) 1979-11-30
ATA473779A (de) 1982-07-15
DK149842C (da) 1987-06-15
JPS6320217B2 (fr) 1988-04-26
IL57745A (en) 1982-03-31
DK149842B (da) 1986-10-13
AU4878079A (en) 1980-01-17
NL190755B (nl) 1994-03-01
NO150879B (no) 1984-09-24
DE2927672C2 (fr) 1989-06-01
AU526044B2 (en) 1982-12-16
CA1117977A (fr) 1982-02-09
GR69678B (fr) 1982-07-07
FR2430930B1 (fr) 1983-12-23
US4254053A (en) 1981-03-03
DE2927672A1 (de) 1980-01-31
CH643236A5 (it) 1984-05-30
IT7850222A0 (it) 1978-07-10
AT370086B (de) 1983-02-25
BE877609A (fr) 1979-11-05
NL190755C (nl) 1994-08-01
DK288679A (da) 1980-01-11
JPS5513299A (en) 1980-01-30
ES482327A1 (es) 1980-04-01
IT1156852B (it) 1987-02-04
SE446264B (sv) 1986-08-25
NL7905349A (nl) 1980-01-14
IE791310L (en) 1980-01-10
SE7905968L (sv) 1980-01-11

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