ES482327A1 - Procedimiento para preparar d-caforato de l-carnitinamida y d-canforato de d-carnitinamida. - Google Patents

Procedimiento para preparar d-caforato de l-carnitinamida y d-canforato de d-carnitinamida.

Info

Publication number
ES482327A1
ES482327A1 ES482327A ES482327A ES482327A1 ES 482327 A1 ES482327 A1 ES 482327A1 ES 482327 A ES482327 A ES 482327A ES 482327 A ES482327 A ES 482327A ES 482327 A1 ES482327 A1 ES 482327A1
Authority
ES
Spain
Prior art keywords
carnitinamide
camphorate
solution
manufacturing
isopropanol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES482327A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of ES482327A1 publication Critical patent/ES482327A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/06—Saturated compounds having a carboxyl group bound to a five-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedimiento para preparar D-canforato de L- carnitinamida y D-canforato de D-carnitinamida, que comprende: (1) convertir una solución de clorhidrato de D,L-carnitinamida en una solución de D,L-carnitinamida, base libre; (2) hacer reaccionar la solución de D,L-carnitinamida, bas3e libre, directamente con ácido D-canfórico, obteniendo así una solución de D-canforato de D,L- carnitinamida; (3)secar la solución de la etapa (2) y recoger el residuo con un alcanol inferior que tiene de 1 a 5 átomos de carbono, para formar una solución alcohólica, tras lo cual se separa de la solución alcohólica, por cristalización, una fase sólida que comprende el D-canforato de L- carnitinamida; y (4) separar dicha fase sólida de la solución alcohólica que comprende el D- canforato de D-carnitinamida.
ES482327A 1978-07-10 1979-07-09 Procedimiento para preparar d-caforato de l-carnitinamida y d-canforato de d-carnitinamida. Expired ES482327A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT50222/78A IT1156852B (it) 1978-07-10 1978-07-10 Procedimento industriale per la preparazione del d'canforato della l carnitinammide e del d canforato della d carnitinammide e sue applicazioni

Publications (1)

Publication Number Publication Date
ES482327A1 true ES482327A1 (es) 1980-04-01

Family

ID=11272520

Family Applications (1)

Application Number Title Priority Date Filing Date
ES482327A Expired ES482327A1 (es) 1978-07-10 1979-07-09 Procedimiento para preparar d-caforato de l-carnitinamida y d-canforato de d-carnitinamida.

Country Status (20)

Country Link
US (1) US4254053A (es)
JP (1) JPS5513299A (es)
AT (1) AT370086B (es)
AU (1) AU526044B2 (es)
BE (1) BE877609A (es)
CA (1) CA1117977A (es)
CH (1) CH643236A5 (es)
DE (1) DE2927672A1 (es)
DK (1) DK149842C (es)
ES (1) ES482327A1 (es)
FR (1) FR2430930A1 (es)
GB (1) GB2025412B (es)
GR (1) GR69678B (es)
IE (1) IE48908B1 (es)
IL (1) IL57745A (es)
IT (1) IT1156852B (es)
LU (1) LU81482A1 (es)
NL (1) NL190755C (es)
NO (1) NO150879C (es)
SE (1) SE446264B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH648287A5 (de) * 1981-01-21 1985-03-15 Lonza Ag Verfahren zur herstellung von carnitinamid.
CH658857A5 (de) * 1984-04-04 1986-12-15 Lonza Ag Optisch aktives di-(3-chlor-2-oxy-propyltrimethylammonium)-tartrat.
GB2195630B (en) * 1986-08-26 1990-07-18 Chuo Kaseihin Co Inc Method for producing carnitine, l-carnitineamide hydrolase and method for producing same
JP2588930B2 (ja) * 1988-05-13 1997-03-12 鐘淵化学工業株式会社 カルニチンの製造方法
JP2581156B2 (ja) * 1988-05-26 1997-02-12 日立電子エンジニアリング株式会社 レーザ共振器のレーザパワー密度測定方式
IT1256705B (it) * 1992-12-21 1995-12-12 Sigma Tau Ind Farmaceuti Procedimento per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.
IT1261230B (it) * 1993-04-08 1996-05-09 Sigma Tau Ind Farmaceuti Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da suoi precursori aventi opposta configurazione.
KR100255039B1 (ko) 1997-07-28 2000-05-01 박영구 L-카르니틴의제조방법
PT1218001E (pt) * 1999-09-03 2009-03-31 Sigma Tau Ind Farmaceuti L-carnitina ultrafina, métodos de preparação da mesma, composições contendo a mesma, e métodos de utilização da mesma
US20070087975A1 (en) * 2005-10-17 2007-04-19 Sigma-Tau Industrie Farmaceutiche Riunite Spa Compound useful for the prevention and treatment of left ventricular hypertrophy in dialysed patients
EP1852416A1 (en) * 2006-05-04 2007-11-07 Universita'degli Studi Di Milano Enantiomeric resolution of a carnitinamide salt by preferential crystallization
US8334132B2 (en) 2006-11-09 2012-12-18 Mitsubishi Rayon Co., Ltd. Process for production of a betaine such as carnitine
JP2008231046A (ja) * 2007-03-22 2008-10-02 Mitsubishi Rayon Co Ltd 光学活性カルニチンアミドハロゲン化物の精製方法
EP2353596A1 (en) 2010-02-02 2011-08-10 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. Combination composition, comprising as active ingredients L-carnitine or propionyl L-carnitine, for the prevention or treatment of chronic venous insufficiency
EP2363126A1 (en) 2010-03-04 2011-09-07 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. Composition comprising as active ingredient L-carnitine in combination with hydroxykynurenine-O-beta-DL-glucoside, for the prevention and/or treatment of pathologies of the eye due to ultraviolet radiation
SG185692A1 (en) 2010-06-16 2013-01-30 Sigma Tau Ind Farmaceuti Acetyl-carnitine for use in a method for increasing neurogenesis in neural tissue
US9114120B2 (en) 2010-11-22 2015-08-25 Sigma-Tau Industrie Farmaceutiche Riunite, S.P.A. Therapeutical method for the treatment of the Leber optic neuropathy
US20140294921A1 (en) 2010-12-09 2014-10-02 Sigma-Tau Industrie Famaceutiche Riunite S.P.A. Composition for tipical use for treating skin disorders
EP2586438A1 (en) 2011-10-28 2013-05-01 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. Compound useful for preventing cognitive deficit disorders in a new born from HIV-seropositive pregnant female who is in treatment with azidothymidine
EP2783695A1 (en) 2013-03-28 2014-10-01 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. Physiological supplement or medicament for ophthalmic use containing L-carnitine or alkanoyl L-carnitines in combination with eledoisin
TWI633882B (zh) 2013-12-05 2018-09-01 義大利商阿爾法西格瑪公司 適用於提高女性生育力的組合物
WO2016004363A2 (en) 2014-07-03 2016-01-07 NAN Global, LLC Methods and compositions for treating obesity, preventing weight gain, promoting weight loss, promoting slimming, or treating or preventing the development of diabetes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE659194A (es) * 1965-02-03 1965-08-03
BE660039A (es) * 1965-02-22 1965-08-23
US3632623A (en) * 1967-11-21 1972-01-04 Basf Ag Beta-carbamyl-beta-hydroxyethyl)-alkylammonium salts

Also Published As

Publication number Publication date
IE48908B1 (en) 1985-06-12
FR2430930A1 (fr) 1980-02-08
DE2927672C2 (es) 1989-06-01
NL190755B (nl) 1994-03-01
DK149842C (da) 1987-06-15
IT7850222A0 (it) 1978-07-10
JPS5513299A (en) 1980-01-30
IE791310L (en) 1980-01-10
LU81482A1 (fr) 1979-10-31
US4254053A (en) 1981-03-03
JPS6320217B2 (es) 1988-04-26
IT1156852B (it) 1987-02-04
IL57745A0 (en) 1979-11-30
NL7905349A (nl) 1980-01-14
NL190755C (nl) 1994-08-01
NO792281L (no) 1980-01-11
SE446264B (sv) 1986-08-25
GB2025412B (en) 1983-03-02
GR69678B (es) 1982-07-07
DE2927672A1 (de) 1980-01-31
AU526044B2 (en) 1982-12-16
CA1117977A (en) 1982-02-09
BE877609A (fr) 1979-11-05
FR2430930B1 (es) 1983-12-23
DK288679A (da) 1980-01-11
SE7905968L (sv) 1980-01-11
IL57745A (en) 1982-03-31
NO150879B (no) 1984-09-24
DK149842B (da) 1986-10-13
CH643236A5 (it) 1984-05-30
GB2025412A (en) 1980-01-23
AU4878079A (en) 1980-01-17
ATA473779A (de) 1982-07-15
AT370086B (de) 1983-02-25
NO150879C (no) 1985-01-09

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