FR2424277A1 - 8b-ethyl-(ou methyl)-4,5a-epoxymorphinane-6-ones, leur procede de production et medicaments les contenant - Google Patents
8b-ethyl-(ou methyl)-4,5a-epoxymorphinane-6-ones, leur procede de production et medicaments les contenantInfo
- Publication number
- FR2424277A1 FR2424277A1 FR7903388A FR7903388A FR2424277A1 FR 2424277 A1 FR2424277 A1 FR 2424277A1 FR 7903388 A FR7903388 A FR 7903388A FR 7903388 A FR7903388 A FR 7903388A FR 2424277 A1 FR2424277 A1 FR 2424277A1
- Authority
- FR
- France
- Prior art keywords
- tetrahydrofurofuryle
- group
- methyl
- ethyl
- cyclopropylmethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
L'INVENTION A TRAIT AU DOMAINE DE LA CHIMIE PHARMACEUTIQUE. ELLE CONCERNE DES COMPOSES DE FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE R EST UN ATOME D'HYDROGENE OU UN GROUPE METHYLE, R EST UN GROUPE ALLYLE, CYCLOPROPYLMETHYLE, CYCLOBUTYLMETHYLE OU TETRAHYDROFURFURYLE, A CONDITION QUE LORSQUE R EST UN GROUPE CYCLOBUTYLMETHYLE OU TETRAHYDROFURFURYLE, R SOIT UN ATOME D'HYDROGENE ET R EST UN GROUPE ETHYLE OU METHYLE A CONDITION QUE LORSQUE R EST UN GROUPE METHYLE, R SOIT UN GROUPE CYCLOBUTYLMETHYLE, ET LEURS SELS D'ADDITION D'ACIDES ACCEPTABLES DU POINT DE VUE PHARMACOLOGIQUE. LES COMPOSES DE L'INVENTION SONT DOUES D'ACTIVITE ANALGESIQUE ET D'ACTIVITE ANTAGONISTE ENVERS LES NARCOTIQUES.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87664078A | 1978-02-10 | 1978-02-10 | |
US91193978A | 1978-06-02 | 1978-06-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2424277A1 true FR2424277A1 (fr) | 1979-11-23 |
FR2424277B1 FR2424277B1 (fr) | 1982-03-12 |
Family
ID=27128411
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7903388A Granted FR2424277A1 (fr) | 1978-02-10 | 1979-02-09 | 8b-ethyl-(ou methyl)-4,5a-epoxymorphinane-6-ones, leur procede de production et medicaments les contenant |
Country Status (7)
Country | Link |
---|---|
JP (1) | JPS54117499A (fr) |
AU (1) | AU507873B2 (fr) |
CA (1) | CA1106369A (fr) |
DE (1) | DE2900918A1 (fr) |
FR (1) | FR2424277A1 (fr) |
GB (1) | GB2014141B (fr) |
IL (1) | IL56222A (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4272541A (en) * | 1978-06-02 | 1981-06-09 | Miles Laboratories, Inc. | 7,8 and 7-8 Substituted 4,5α-epoxymorphinan-6-one compounds, and methods of treating pain and drug dependence with them |
US4259329A (en) * | 1979-10-17 | 1981-03-31 | Miles Laboratories, Inc. | 17-Cyclobutylmethyl-3-hydroxy-β-methyl-6-methylene morphinane, and methods of treating pain with them |
US4275205A (en) * | 1980-05-05 | 1981-06-23 | Miles Laboratories, Inc. | 7,7-Ditosyloxymethyl-4,5α-epoxy-morphinan-6-ols |
DE3381877D1 (de) * | 1982-03-16 | 1990-10-18 | Univ Rockefeller | Verwendung von opium antagonisten zur herstellung von arzneimitteln zur behebung gastro-intestinaler stoerungen. |
JPH0174251U (fr) * | 1987-11-02 | 1989-05-19 | ||
JPH043470U (fr) * | 1990-04-24 | 1992-01-13 | ||
US5194637A (en) * | 1991-08-22 | 1993-03-16 | Syracuse University | Method and apparatus for synthesis of highly isomerically pure stereoisomers of glycidol derivatives |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1355143A (fr) * | 1963-04-05 | 1964-03-13 | Shionogi & Co | Dérivés du morphinane et procédé de fabrication |
-
1978
- 1978-12-15 IL IL56222A patent/IL56222A/xx unknown
-
1979
- 1979-01-11 DE DE19792900918 patent/DE2900918A1/de not_active Withdrawn
- 1979-01-26 CA CA320,321A patent/CA1106369A/fr not_active Expired
- 1979-02-06 GB GB7904029A patent/GB2014141B/en not_active Expired
- 1979-02-08 JP JP1288479A patent/JPS54117499A/ja active Granted
- 1979-02-08 AU AU44090/79A patent/AU507873B2/en not_active Ceased
- 1979-02-09 FR FR7903388A patent/FR2424277A1/fr active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1355143A (fr) * | 1963-04-05 | 1964-03-13 | Shionogi & Co | Dérivés du morphinane et procédé de fabrication |
Also Published As
Publication number | Publication date |
---|---|
GB2014141B (en) | 1982-09-15 |
DE2900918A1 (de) | 1979-08-16 |
FR2424277B1 (fr) | 1982-03-12 |
JPS54117499A (en) | 1979-09-12 |
CA1106369A (fr) | 1981-08-04 |
IL56222A0 (en) | 1979-03-12 |
AU4409079A (en) | 1979-08-16 |
GB2014141A (en) | 1979-08-22 |
JPS5757476B2 (fr) | 1982-12-04 |
IL56222A (en) | 1981-11-30 |
AU507873B2 (en) | 1980-02-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FR2421871A1 (fr) | Nouveaux derives d'amines et amidines de glycerols et propanediols et medicament les contenant | |
FR2416012A1 (fr) | Derives de l'imidazole et medicament contenant ces substances | |
FR2453853A1 (fr) | Nouveaux derives d'o-(4-diphenylmethylpiperidino)-alcanophenones utiles notamment comme antihistaminiques, et leur procede de preparation | |
FR2603584A1 (fr) | Nouveaux composes benzoheterocycliques utiles comme agents antimicrobiens, procede pour leur preparation et medicament les contenant | |
JPS6075454A (ja) | 鎮痛用新規化合物および組成物 | |
FR2424917A1 (fr) | Nouvelles 4-quinolinylaminobenzoyl-piperidines, leur procede de production et medicament les contenant | |
FR2424908A1 (fr) | Nouveaux analogues de prostacycline, leur procede de production et medicament les contenant | |
FR2455048A1 (fr) | Nouvelles 14-methoxymorphinane-6-ones, leur procede de production et medicament les contenant | |
FR2432519A1 (fr) | Nouveaux derives de purine et medicament les contenant | |
FR2424277A1 (fr) | 8b-ethyl-(ou methyl)-4,5a-epoxymorphinane-6-ones, leur procede de production et medicaments les contenant | |
FR2448531A1 (fr) | Nouveaux derives de 4-(naphtylmethyl)piperidine, utiles notamment comme agents antipsychotiques et leur procede de preparation | |
FR2408584A1 (fr) | Composes guanidinobenzoiques et possedant une activite antifibrinolysine et antitrypsine et leur procede de preparation | |
FR2453866A1 (fr) | Derives peptidiques, procede pour leur preparation et leur application dans des preparations pharmaceutiques | |
FR2393577A1 (fr) | Medicament a base d'acide b-(p-halogenophenyl)-g-aminobutyrique destine au traitement de la nevrose d'angoisse | |
FR2450820A1 (fr) | Nouveaux derives d'acides 1- (o-mercaptoacyl) -4,5-dihydropyrazole-5-carboxyliques, utiles notamment comme agents hypotenseurs, et leur procede de preparation | |
FR2429019A1 (fr) | Medicaments contenant des esters de 1-b-d-arabinofuranosylcytosine-5'-phosphate | |
FR2426039A1 (fr) | Derives de di-o-n-alkylglycerols et medicament immuno-stimulant les contenant | |
FR2411843A1 (fr) | Nouvelles 6-deoxyneamines eventuellement 1-n-alkylees et intermediaires necessaires a leur preparation | |
FR2453152A1 (fr) | Nouveaux derives de prostaglandine et medicament les contenant | |
EP0366561A3 (fr) | Nouveaux dérivés 1-azabicycloalkanes, leur procédé de préparation et leur application comme médicaments | |
DE69217613D1 (de) | Stickstoff enthaltende bizyklische Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen | |
TNSN99114A1 (fr) | Oxo-thia-azabicyclooctenes, preparations pharmaceutiques les contenant, et leur utilisation pour le traitement et la prophylaxie de maladies infectieuses | |
HU903092D0 (en) | Process for the preparation of buten-carboxylic acid derivatives and pharmaceutical compositions containing such compounds | |
FR2450837A1 (fr) | Acides penicillaniques 6-b-substitues inhibiteurs de b-lactamase, leur procede de production et composition pharmaceutique les contenant | |
FR2411840A1 (fr) | Esters methoxymethyliques d'acides 7-imidazolidinyl-3-methyl-3-cephem-4-carboxyliques substitues et medicament les contenant |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |