GB2014141A - 8???-ethyl- and 8???-methyl-4,5??? epoxymorphinan-6-one compounds - Google Patents
8???-ethyl- and 8???-methyl-4,5??? epoxymorphinan-6-one compoundsInfo
- Publication number
- GB2014141A GB2014141A GB7904029A GB7904029A GB2014141A GB 2014141 A GB2014141 A GB 2014141A GB 7904029 A GB7904029 A GB 7904029A GB 7904029 A GB7904029 A GB 7904029A GB 2014141 A GB2014141 A GB 2014141A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- methyl
- ethyl
- cyclobutylmethyl
- epoxymorphinan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compounds having the structural formula <IMAGE> in which R1 is a hydrogen atom or methyl group, R2 is an allyl, cyclopropylmethyl, cyclobutylmethyl or tetrahydrofurfuryl group, provided that when R2 is a cyclobutylmethyl or tetrahydrofurfuryl group then R1 is hydrogen, and R3 is an ethyl or methyl group, provided that when R3 is methyl, then R2 is cyclobutylmethyl, and pharmacologically acceptable acid addition salts thereof are novel and possess analgesic and narcotic antagonist activity. Methods for preparation and use of these compounds are described.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87664078A | 1978-02-10 | 1978-02-10 | |
US91193978A | 1978-06-02 | 1978-06-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
GB2014141A true GB2014141A (en) | 1979-08-22 |
GB2014141B GB2014141B (en) | 1982-09-15 |
Family
ID=27128411
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB7904029A Expired GB2014141B (en) | 1978-02-10 | 1979-02-06 | 8 -ethyl and 8 -methyl 4,5a-epoxymorphinan -6- one compounds |
Country Status (7)
Country | Link |
---|---|
JP (1) | JPS54117499A (en) |
AU (1) | AU507873B2 (en) |
CA (1) | CA1106369A (en) |
DE (1) | DE2900918A1 (en) |
FR (1) | FR2424277A1 (en) |
GB (1) | GB2014141B (en) |
IL (1) | IL56222A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0023576A1 (en) * | 1979-07-11 | 1981-02-11 | Miles Laboratories, Inc. | 7- and 7,8-substituted 4,5-alpha-epoxymorphinan-6-ones and therapeutically active compositions containing them |
EP0027925A1 (en) * | 1979-10-17 | 1981-05-06 | Miles Laboratories, Inc. | 17-Cycloalkylmethyl-6-methylene-morphinane-derivatives |
EP0555453A1 (en) * | 1991-08-22 | 1993-08-18 | Syracuse University | Method and apparatus for synthesis of highly isomerically pure stereoisomers of glycidol derivatives |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4275205A (en) * | 1980-05-05 | 1981-06-23 | Miles Laboratories, Inc. | 7,7-Ditosyloxymethyl-4,5α-epoxy-morphinan-6-ols |
DE3381877D1 (en) * | 1982-03-16 | 1990-10-18 | Univ Rockefeller | USE OF OPIUM ANTAGONISTS FOR THE PRODUCTION OF MEDICINAL PRODUCTS FOR THE REMEDY OF GASTRO-INTESTINAL DISORDERS. |
JPH0174251U (en) * | 1987-11-02 | 1989-05-19 | ||
JPH043470U (en) * | 1990-04-24 | 1992-01-13 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1355143A (en) * | 1963-04-05 | 1964-03-13 | Shionogi & Co | Morphinan derivatives and manufacturing process |
-
1978
- 1978-12-15 IL IL56222A patent/IL56222A/en unknown
-
1979
- 1979-01-11 DE DE19792900918 patent/DE2900918A1/en not_active Withdrawn
- 1979-01-26 CA CA320,321A patent/CA1106369A/en not_active Expired
- 1979-02-06 GB GB7904029A patent/GB2014141B/en not_active Expired
- 1979-02-08 AU AU44090/79A patent/AU507873B2/en not_active Ceased
- 1979-02-08 JP JP1288479A patent/JPS54117499A/en active Granted
- 1979-02-09 FR FR7903388A patent/FR2424277A1/en active Granted
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0023576A1 (en) * | 1979-07-11 | 1981-02-11 | Miles Laboratories, Inc. | 7- and 7,8-substituted 4,5-alpha-epoxymorphinan-6-ones and therapeutically active compositions containing them |
EP0027925A1 (en) * | 1979-10-17 | 1981-05-06 | Miles Laboratories, Inc. | 17-Cycloalkylmethyl-6-methylene-morphinane-derivatives |
EP0555453A1 (en) * | 1991-08-22 | 1993-08-18 | Syracuse University | Method and apparatus for synthesis of highly isomerically pure stereoisomers of glycidol derivatives |
EP0555453A4 (en) * | 1991-08-22 | 1994-11-23 | Univ Syracuse | Method and apparatus for synthesis of highly isomerically pure stereoisomers of glycidol derivatives |
Also Published As
Publication number | Publication date |
---|---|
JPS5757476B2 (en) | 1982-12-04 |
FR2424277A1 (en) | 1979-11-23 |
IL56222A0 (en) | 1979-03-12 |
CA1106369A (en) | 1981-08-04 |
GB2014141B (en) | 1982-09-15 |
AU507873B2 (en) | 1980-02-28 |
JPS54117499A (en) | 1979-09-12 |
IL56222A (en) | 1981-11-30 |
FR2424277B1 (en) | 1982-03-12 |
AU4409079A (en) | 1979-08-16 |
DE2900918A1 (en) | 1979-08-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |