GB2014141A - 8???-ethyl- and 8???-methyl-4,5??? epoxymorphinan-6-one compounds - Google Patents

8???-ethyl- and 8???-methyl-4,5??? epoxymorphinan-6-one compounds

Info

Publication number
GB2014141A
GB2014141A GB7904029A GB7904029A GB2014141A GB 2014141 A GB2014141 A GB 2014141A GB 7904029 A GB7904029 A GB 7904029A GB 7904029 A GB7904029 A GB 7904029A GB 2014141 A GB2014141 A GB 2014141A
Authority
GB
United Kingdom
Prior art keywords
compounds
methyl
ethyl
cyclobutylmethyl
epoxymorphinan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7904029A
Other versions
GB2014141B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Laboratories Inc filed Critical Miles Laboratories Inc
Publication of GB2014141A publication Critical patent/GB2014141A/en
Application granted granted Critical
Publication of GB2014141B publication Critical patent/GB2014141B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compounds having the structural formula <IMAGE> in which R1 is a hydrogen atom or methyl group, R2 is an allyl, cyclopropylmethyl, cyclobutylmethyl or tetrahydrofurfuryl group, provided that when R2 is a cyclobutylmethyl or tetrahydrofurfuryl group then R1 is hydrogen, and R3 is an ethyl or methyl group, provided that when R3 is methyl, then R2 is cyclobutylmethyl, and pharmacologically acceptable acid addition salts thereof are novel and possess analgesic and narcotic antagonist activity. Methods for preparation and use of these compounds are described.
GB7904029A 1978-02-10 1979-02-06 8 -ethyl and 8 -methyl 4,5a-epoxymorphinan -6- one compounds Expired GB2014141B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87664078A 1978-02-10 1978-02-10
US91193978A 1978-06-02 1978-06-02

Publications (2)

Publication Number Publication Date
GB2014141A true GB2014141A (en) 1979-08-22
GB2014141B GB2014141B (en) 1982-09-15

Family

ID=27128411

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7904029A Expired GB2014141B (en) 1978-02-10 1979-02-06 8 -ethyl and 8 -methyl 4,5a-epoxymorphinan -6- one compounds

Country Status (7)

Country Link
JP (1) JPS54117499A (en)
AU (1) AU507873B2 (en)
CA (1) CA1106369A (en)
DE (1) DE2900918A1 (en)
FR (1) FR2424277A1 (en)
GB (1) GB2014141B (en)
IL (1) IL56222A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0023576A1 (en) * 1979-07-11 1981-02-11 Miles Laboratories, Inc. 7- and 7,8-substituted 4,5-alpha-epoxymorphinan-6-ones and therapeutically active compositions containing them
EP0027925A1 (en) * 1979-10-17 1981-05-06 Miles Laboratories, Inc. 17-Cycloalkylmethyl-6-methylene-morphinane-derivatives
EP0555453A1 (en) * 1991-08-22 1993-08-18 Syracuse University Method and apparatus for synthesis of highly isomerically pure stereoisomers of glycidol derivatives

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4275205A (en) * 1980-05-05 1981-06-23 Miles Laboratories, Inc. 7,7-Ditosyloxymethyl-4,5α-epoxy-morphinan-6-ols
DE3381877D1 (en) * 1982-03-16 1990-10-18 Univ Rockefeller USE OF OPIUM ANTAGONISTS FOR THE PRODUCTION OF MEDICINAL PRODUCTS FOR THE REMEDY OF GASTRO-INTESTINAL DISORDERS.
JPH0174251U (en) * 1987-11-02 1989-05-19
JPH043470U (en) * 1990-04-24 1992-01-13

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1355143A (en) * 1963-04-05 1964-03-13 Shionogi & Co Morphinan derivatives and manufacturing process

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0023576A1 (en) * 1979-07-11 1981-02-11 Miles Laboratories, Inc. 7- and 7,8-substituted 4,5-alpha-epoxymorphinan-6-ones and therapeutically active compositions containing them
EP0027925A1 (en) * 1979-10-17 1981-05-06 Miles Laboratories, Inc. 17-Cycloalkylmethyl-6-methylene-morphinane-derivatives
EP0555453A1 (en) * 1991-08-22 1993-08-18 Syracuse University Method and apparatus for synthesis of highly isomerically pure stereoisomers of glycidol derivatives
EP0555453A4 (en) * 1991-08-22 1994-11-23 Univ Syracuse Method and apparatus for synthesis of highly isomerically pure stereoisomers of glycidol derivatives

Also Published As

Publication number Publication date
JPS5757476B2 (en) 1982-12-04
FR2424277A1 (en) 1979-11-23
IL56222A0 (en) 1979-03-12
CA1106369A (en) 1981-08-04
GB2014141B (en) 1982-09-15
AU507873B2 (en) 1980-02-28
JPS54117499A (en) 1979-09-12
IL56222A (en) 1981-11-30
FR2424277B1 (en) 1982-03-12
AU4409079A (en) 1979-08-16
DE2900918A1 (en) 1979-08-16

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee